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Publikation von Partituren im InternetDrude, Matthias 28 May 2009 (has links) (PDF)
Der Artikel informiert über die Möglichkeit, Partituren von Kompositionen als pdf-Dateien unter www.qucosa.de zu publizieren.
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Effektivisering av konstruktörens arbete i produktutvecklingsprocessen med hjälp av 3D-modeller och detaljritningar / Efficiency of the designer’s workflow in the product development process by using 3D-models and 2D-drawingsFrydén, Cecilia, Omri, Nadia January 2017 (has links)
I kursen Examensarbete i integrerad produktutveckling har ett projekt utförts av designingenjörsstudenterna Cecilia Frydén och Nadia Omri våren 2017 på Högskolan i Skövde. Projektet genomfördes i samarbete med konsultföretaget ÅF Industry AB i Skövde och några av deras externa tillverkare. I ÅF:s produkt-utvecklingsprocess ägnar konstruktörerna många timmar åt att framställa tillverkningsunderlag, 3D-modeller och detaljritningar. Tillverkningsunderlagen misstänks innehålla överflödig information som inte används av tillverkarna, vilket innebär att konstruktören ägnar tid åt arbetsmoment i onödan. Av den anledningen vill ÅF att det undersöks vilken information i tillverknings-underlaget som är överflödig och att alternativ på hur det utformas tas fram. Aktionsforskning är den övergripande metodiken som används. Projektet har varit fokuserat på att kartlägga arbetsflödet, identifiera mottagarna av tillverkningsunderlaget och deras behov samt definiera tekniska möjligheter för att generera lösningsförslag på alternativa arbetsmetoder. Lösningsförslagen har utvärderats med både konstruktörer och med mottagarna hos tillverkarna. Utifrån utvärderingarna har ett lösningsförslag valts som består av en 3D-modell med Model Based Definition (MBD) där Product Manufacturing Information (PMI) reducerats och förmedlas tillsammans med en 3D-PDF. / This project was made for the Bachelor Degree Project in Product Design Engineering course at the University of Skövde by Cecilia Frydén and Nadia Omri in cooperation with the engineering company ÅF during the spring of 2017. ÅF’s designers spends several hours creating 3D-models and detail drawings as manufacturing information for the manufacturing phase of the product development. Some of this time is suspected to be spent unnecessary since some of the information generated by the designers might not be used during the manufacturing process. The aim of the project is to generate a solution to increase the efficiency of the designer’s workflow while generating Product Manufacturing Information (PMI) without compromising the manufacturer’s understanding of the information. Research upon the product manufacturing information generation and handling was done in order to identify its main issues. Observation and interviews were done in order to identify its users and clarify the main purpose of the manufacturing information. The result provides reduced PMI in the 3D-model and uses a 3D-PDF to communicate the PMI to the manufacturers. This was decided from evaluations with the manufacturers and designers and is believed to improve the communication between them but also to make the designer’s workflow more efficient.
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Integrative Approaches to Decode the Co-translational Role of the Phage Vp16 Peptide Deformylase and how it Compromises Host Viability / Approches intégratives visant à décoder le rôle de co-traduction de la peptide déformylase du phage Vp16 et comment il compromet la viabilité de l'hôteLavecchia, Francesco 31 January 2019 (has links)
L'excision de la méthionine N-terminale (NME) est la première modification se produisant au N-terminal des protéines (NPM). Les peptides déformylases (PDF) sont les enzymes impliquées dans ce processus co-traductionnel essentiel et conservé. Les PDFs suppriment le groupe formyle lié à la méthionine initiatrice (iMet) présente au début de toutes les chaînes procaryotes naissantes. Les PDFs agissent au niveau du tunnel de sortie des ribosomes, plaque tournante de nombreux facteurs de biogénèse des protéines associées aux ribosomes (PRB), impliqués non seulement sur les MNP, mais également dans le repliement et la translocation des protéines. La déformylation N-terminale implique 95% du protéome bactérien et contribue directement à la stabilité des protéines. Le récent séquençage à haut débit de milliers de génomes a révolutionné notre perception de la distribution des PDFs dans les différents règnes, révélant des PDFs putatives dans tous les organismes, y compris les virus. En particulier, les études concernant les virus présents dans les échantillons microbiens océaniques ont permis d’identifier des gènes inhabituels de PDF chez les phages, constituant la famille la plus abondante de protéines auxiliaires conservées de ces génomes. La comparaison des séquences identifiées révèle que les PDF virales présentent une forte conservation des trois motifs constituant le site catalytique. Cependant, ces PDFs virales ne présentent pas d'extension C-terminale, région réputée importante des PDFs des autres organismes. Sachant que cette extension est impliquée dans la liaison de la PDF d’E. coli au ribosome et est requise pour son activité déformylase in vivo, il était incertain que les PDFs de phage découvertes avaient une activité déformylase classique. Ainsi, la découverte de ces PDFs virales soulève un certain nombre de questions parmi lesquelles: a) Ces PDFs virales présentent-elles une activité déformylase classique? b) Ces PDFs sont-elles capables de se lier aux ribosomes ? c) Pourquoi autant de virus portent-ils une ou plusieurs déformylases ? Dans ce contexte, l’objectif de ma thèse a été d’entreprendre la caractérisation de ces PDFs de phages marins et en particulier la PDF de Vp16 provenant de bactériophages isolés à l’origine de la souche 16 de Vibrio parahaemolyticus. Nos études révèlent que ces PDFs de phages présentent une activité déformylase à la fois in vitro et in vivo, avec une spécificité de substrat similaire à celle des autres PDFs bactériennes. D'autre part, nous avons montré par des études biochimiques et structurales, combinées à des analyses par mutagenèse dirigée, que les propriétés de la PDF de Vp16 diffèrent significativement de celle des autres PDFs caractérisées précédemment. Il faut aussi noter que l'expression de la PDF Vp16 dans les souches d'E. Coli, même à de faibles concentrations, montre un effet bactéricide marqué à une température inférieure à 37 °C. L’effet bactéricide de la PDF Vp16 est indépendant de la présence de la PDF endogène bactérienne et repose strictement sur son activité déformylase. La caractérisation de ce phénotype a révélé que la létalité induite par Vp16 PDF montrait un lien génétique fort avec des gènes codants pour des facteurs cellulaires impliqués dans le ciblage et le repliement précoce des protéines (Trigger Factor et Sec). Contrairement à ce qui a été montré pour les PDFs bactériennes, Vp16 PDF a une forte affinité pour le ribosome bactérien d’E. coli en cours de traduction, interagissant avec une région ribosomale chevauchant celles des facteurs impliqués dans le transit des protéines vers les voies de sécrétion. Une compétition au niveau du ribosome entre Vp16 PDF et ces RPBs pourrait contribuer à la lyse cellulaire de l’hôte. Mon travail suggère un nouveau mécanisme utilisé par les bactériophages permettant de contrôler la viabilité de l'hôte. / N-terminal Methionine Excision (NME) is the first occurring N-terminal Protein Modification (NPMs). Peptide deformylases (PDFs) are the enzymes involved in this essential and conserved co-translational process. PDFs remove the formyl group bound to the iMet present at the beginning of all prokaryotic nascent chains. PDFs act on the nascent chain at the level of the ribosome exit tunnel, a central hub for a number of Ribosome-associated Protein Biogenesis factors (RPBs) involved not only on NPMs but also in protein folding and translocation. Deformylation involves 95% of bacterial proteome and it is suggested to directly contribute to protein stability. Recent high-throughput sequencing of thousands of genomes has strongly contributed to revolutionizing our perception of the distribution of PDFs among kingdoms, revealing putative PDFs in all organisms, including viruses. In particular, studies of viruses within oceanic microbial samples retrieved unusual PDFs genes as the most abundant family in most of phage genomes. Sequence comparisons reveal that viral PDFs show high conservation in the three motifs that build the catalytic site; however, viral PDFs do not display a C-terminal extension when compared to the different active PDFs from other organisms. Since this C-terminal extension was shown to be important for PDF-ribosome binding and is required for the in vivo deformylase activity of E. coli PDF, it was unclear whether the discovered phage PDFs might support a classical deformylase activity. Thus, the discovery of these viral PDFs raises a number of questions among which: a) Have these viral PDFs a classical deformylase activity? b) Are these PDFs able to still bind to the ribosomes? c) Why so many viruses carry a peptide deformylase? In this context, the objective of my thesis was to undertake the characterization of these marine phage PDFs and particularly Vp16 PDF derived from the bacteriophages originally isolated from Vibrio Parahaemolyticus strain 16. Our studies reveal that phage PDFs display deformylase activity both in vitro and in vivo with a substrate specificity similar to that of other bacterial PDFs. On the other hand, we showed by biochemical and structural data, combined with site-directed mutagenesis analyses, that Vp16 PDF significantly differs from previously characterized PDFs in terms of their properties, which can be related to its few uncommon peculiarities. Interestingly, expression of Vp16 PDF in E. coli strains, even at low concentrations, exhibited a severe bactericidal effect at temperature lower than 37 °C. This bactericidal effect of Vp16 PDF was independent of the presence of the bacterial endogenous PDF and strictly relied on its PDF activity. Characterization of this phenotype revealed that Vp16 PDF-induced lethality showed a strong genetic link with genes encoding cellular factors involved in nascent pre-secretory protein targeting and folding (Trigger Factor and Sec). Differently from bacterial PDF, I could show that Vp16 PDF has strong affinity for ribosomes with a specific nascent chain, interacting with a ribosomal region overlapping that of factors involved in pre-secretory protein targeting. A competition between Vp16 PDF and these RPBs at the level of the ribosome may contribute to the host lysis, revealing a possible new unrecognized mechanism developed by viruses to control host viability.
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La restructuration des documents graphiques destructurés / Restructure unstructured graphic dataPere-Laperne, Jacques 18 November 2019 (has links)
Cette thèse traite de la restructuration des documents déstructurés de type PDF contenant des éléments graphiques tels que les schémas, les plans et les dessins, dans l’objectif de les restructurer. En nous appuyant sur la méthode KDD (Knowledge Discovery in Database) pour la restructuration des données, nous introduisons la méthode (A)KDD (Antropocentric Knowledge Discovery in Database) que nous avons développé et qui est dérivée de la méthode KDD en ajoutant l’aspect incrémental et l’aspect centré sur l’utilisateur. Nous présentons, en particulier, une technique fondée sur le principe du tri par paquet pour extraire efficacement les symboles graphiques contenus dans un document PDF. Elle est comparée aux résultats de Puglissi sur les chaînes de caractères. Puis, nous formulons l’hypothèse selon laquelle la prise en compte de l’ordre chronologique présent dans les fichiers PDF dans le processus incrémental améliore la restructuration des documents. Nous montrons la validité de cette hypothèse sur un certain nombre d’exemples. Enfin, nous montrons l’efficacité du processus pour identifier les symboles en même temps que les équipotentielles. Le mémoire se conclut en montrant les avancées et les limites de la solution de la méthode (A)KDD et nous proposons des perspectives. / This thesis deals with the restructuring of unstructured PDF documents containing graphical elements such as schematics, plans and drawings, with the aim of restructuring them. Using the KDD (Knowledge Discovery in Database) method for data restructuring, we introduce the (A) KDD (Antropocentric Knowledge Discovery in Database) method that we developed which is derived from the KDD method by adding an incremental aspect and an user-centered approach. We present, in particular, a technique based on on the bucket sort algorithm pattern in order to extract with efficiency graphic symbols contained in a PDF file. It is compared to the results obtained by Puglissi on strings. Then, we formulate the hypothesis:”taking into account the chronological order present in the PDF files in the incremental process improves the restructuring of the documents”. We illustrate the validity of this hypothesis on several examples. Finally, we show the efficiency of the process in the identification of the symbols at the same time as the equipotentials. The thesis concludes by showing the advances and the limits of the solution of the (A) KDD method and we propose some perspectives.
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Publikation von Partituren im InternetDrude, Matthias 28 May 2009 (has links)
Der Artikel informiert über die Möglichkeit, Partituren von Kompositionen als pdf-Dateien unter www.qucosa.de zu publizieren.
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Modernizace portálu fakturyonline.eu / Upgrade of fakturyonline.eu ServiceJahoda, Vojtěch January 2014 (has links)
Goal of this thesis is modernization and extension of established web portal serving to create and manage invoices. The design and implementation emphasis on feedback from users so changes are really a benefit and not a burden. Uses wide range of different technologies and implementation is done using incremental model. Analyzes the impact of changes to number of visitors and receives feedback from users.
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Webový systém pro správu elektronických dokumentů / Modification of web system for electronic document managementDufka, Zbyněk January 2015 (has links)
The aim of this diploma thesis is to provide a systematic study of Open Journal System, which is designed for electronic research papers publishing. Due to the nature of information published in this system, there is an elaborate approval process controlled by the editor. The main objective of this thesis is the realization of a system module, which would, at the end of the approval process, implement a stamp incorporating metadata of the source magazine to individual electronic documents. The thesis gives insight into the development of the structure of the Open Journal System and, briefly, describes the possibility of implementing this system. Another part of the work focuses on the sub-steps of the stamping module which was implemented into the system. This module allows editors to stamp individual electronic PDF documents that are published within the magazine and its various volumes. The module is designed to simplify the editing process of the journal with no prolongation or any other additional time required. Among other things, the reader learns how it is possible to create a block module, which can be used in the sidebar to display any system information. The work, also, previews the possibility to customize the user interface. Each implemented part contains solution proposals and, further, the implementation method and technical description is described in more detail. For better understanding and integrity of the work, stretches of the given code are also included, this might serve as an inspiration for users‘ modifications of the system.
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Nástroj pro ověřování elektronických podpisů na PDF dokumentech / A tool for validating electronic signatures on PDF documentsSelement, Pavel January 2013 (has links)
The subject of this graduation thesis is to study internal electronic signatures in PDF documents. The thesis introduces general principles of electronic signatures, deals with the internal structure of PDF documents including the connection of electronic signatures and describes the process of verifying an electronic signature. An integral part of this thesis is an implementation of an application, which performs verification of electronic signatures in a PDF document. The aim of this application is to verify the digital signature embedded in a PDF document according to the current legislation of the Czech Republic, while allowing users to change extensively the rules for evaluating the validity of the signature. Powered by TCPDF (www.tcpdf.org)
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Untersuchung der Strukturen von künstlich angeregten transitionellen Plattengrenzschichtströmungen mit Hilfe der Stereo und Multiplane Particle Image Velocimetry / Investigation of structures of artificially excited transitional flat plate boundary layer flows by means of Stereo and Multi-plane Particle Image VelocimetrySchröder, Andreas 22 August 2001 (has links)
No description available.
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Automatic conversion of PDF-based, layout-oriented typesetting data to DAISY: potentials and limitationsNikolaus, Ulrich, Dobroschke, Julia 24 June 2010 (has links) (PDF)
Only two percent of new books released in Germany are professionally edited for visually impaired people. However, more and more print publications are made available to the public in digital formats through online content delivery platforms like “libreka!”. The automatic conversion of such contents into DAISY would considerably increase the number of publications available in accessible formats. Still, most data available on “libreka!” is published as non-tagged PDF. In this paper, we examine the potential for automatic conversion of “libreka!”-based content into DAISY, while also analyzing the potentials and limitations of current conversion tools.
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