Submitted by Rosivalda Pereira (mrs.pereira@ufma.br) on 2017-06-02T20:34:02Z No. of bitstreams: 1 KayniLima.pdf: 2329691 bytes, checksum: f4483166f9b35c9a8cce0606f988ddb5 (MD5) / Made available in DSpace on 2017-06-02T20:34:02Z (GMT). No. of bitstreams: 1 KayniLima.pdf: 2329691 bytes, checksum: f4483166f9b35c9a8cce0606f988ddb5 (MD5) Previous issue date: 2016-07-27 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / The present work describes the development of a novel platform for the electrocatalysis of isoniazid (INH) employing a glassy carbon electrode (GCE) modified with 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) adsorbed on reduced graphene oxide (rGO). The modified electrode (GCE/OGr/DDQ) was covered with a Náfion® film to avoid the leaching out of the composite from electrodic surface. The materials rGO, DDQ and rGO/DDQ were characterized by Fourier transform infrared spectroscopy (FTIR) and the analytical response of the sensor for the analyte was studied by cyclic voltammetry (CV) and amperometry techniques. The sensor showed excellent electrocatalytic activity for INH oxidation with a decrease in the overpotential about 660 mV vs Ag/AgCl and anodic peak current about 4 times higher than the observed response at an electrode unmodified. The increase of the reaction rate for INH was attributed to the efficient electron transfer between the studied specie and immobilized material on the surface of the GCE surface. The number of electrons determined in the INH oxidation process on the modified electrode was equal to 2. Under the optimized operational and experimental conditions, the sensor showed a wide linear range for INH from 0.5 to 380 µmol L-1 for n = 16 (r2 = 0.999); good sensibility and limit of detection equal to 0.42 µA µmol-1 L, and 0.15 µmol L-1, respectively. The proposed sensor was successfully applied for INH determination in drug samples used in the tuberculosis treatment and results obtained in studies of addition and recovery showed that the proposed method has good accuracy with recovery values between 98.46 and 101 % to INH. / O presente trabalho descreve o desenvolvimento de uma nova plataforma para a eletrocatálise de isoniazida (INH) empregando um eletrodo de carbono vítreo (ECV) modificado com 2,3-dicloro-5,6-diciano-p-benzoquinona (DDQ) adsorvido em óxido de grafeno reduzido (OGr). O eletrodo modificado (ECV/OGr/DDQ) foi coberto com um filme de náfion® para evitar o lixiviamento do compósito da superfície eletródica. Os materiais OGr, DDQ e OGr/DDQ foram caracterizados por Espectroscopia no infravermelho com transformada de Fourier (FTIR) e a resposta analítica do sensor para o analito foi estudada através das técnicas voltametria cíclica (CV) e amperometria. O sensor apresentou uma excelente atividade eletrocatalítica para a oxidação de INH com uma diminuição do sobrepotencial cerca de 660 mV vs Ag/AgCl e corrente de pico anódica quatro vezes maior que a resposta observada em um eletrodo não modificado. O aumento na velocidade de reação para a INH foi atribuído à eficiente transferência eletrônica entre a espécie estudada e os materiais imobilizados na superfìcie do ECV. O número de elétrons determinado no processo de oxidação de INH sobre o eletrodo modificado foi igual a 2. Sob as condições experimentais e operacionais otimizadas, o sensor apresentou uma relação linear para a INH de 0,5 à 380 µmol L-1 para n=16 (r2 = 0,999); boa sensibilidade e limite de detecção igual a 0,42 µA µmol-1 L e 0,15 µmol L-1, respectivamente. O sensor proposto foi utilizado com sucesso para a determinação INH em amostras de medicamentos utilizadas no respectivo tratamento da tuberculose e os resultados obtidos nos estudos de adição e recuperação mostraram que o método proposto apresenta boa exatidão com valores de recuperação entre 98,46 e 101% para a INH.

Submitted by Maria Aparecida (cidazen@gmail.com) on 2017-11-16T13:16:54Z No. of bitstreams: 1 JOSÉ RIBAMAR NASCIMENTO DOS SANTOS.pdf: 1283725 bytes, checksum: 4c5d6eba4cec82d8cb883aa89b0a81f6 (MD5) / Made available in DSpace on 2017-11-16T13:16:54Z (GMT). No. of bitstreams: 1 JOSÉ RIBAMAR NASCIMENTO DOS SANTOS.pdf: 1283725 bytes, checksum: 4c5d6eba4cec82d8cb883aa89b0a81f6 (MD5) Previous issue date: 2017-09-19 / CAPES / The electro-oxidation of ethanol was evaluated on a pyrolytic graphite electrode (PGE) chemically modified with the nickel(II)-bis(1,10-phenanthroline) complex (Ni(II)(Phen)2) supported on reduced graphene oxide (RGO) (rGO/Ni(II)(Phen)2/PGE). The Ni(II)(Phen)2 complex, reduced graphene oxide (rGO) and the rGO/Ni(II)(Phen)2 composite were prepared and characterized by the techniques of Spectroscopy in the UV-Vis, Fourier Transform Infrared Spectroscopy and Diffraction of X-rays. The electrocatalytic activity of the material was evaluated by cyclic voltammetry and chronoamperometry. In alkaline solution, the voltamograms obtained for rGO/Ni(II)(Phen)2/PGE showed the formation of well defined redox peaks associated with the Ni(II)/Ni(III) redox couple. The results showed that the RGO/Ni(II)(Phen)2 composite significantly increases the electrocatalytic activity for ethanol oxidation compared to the electrode modified only with the Ni(II)(Phen)2 complex. Using the Laviron theory, the charge transfer rate constant (ks) and the electron transfer coefficient (α) of the electrode reaction were calculated to be 0.56 s-1 and 0.61, respectively. A investigation of the electro-oxidation of ethanol was performed by evaluating the effect of different parameters such as potential scan rate, OH- concentration and alcohol concentration. The chronoamperometric experiments were used to determine the diffusion coefficient of ethanol (D = 4.7 Χ 10-6 cm2 s-1) and the catalytic rate constant (kcat = 1.26 Χ 107 cm3 mol-1 s-1). The results obtained in this study clearly indicate the viability of rGO/Ni(II)(Phen)2/PGE as an electrocatalyst for ethanol oxidation. / A eletro-oxidação do etanol foi avaliada em um eletrodo de grafite pirolítico (PGE) quimicamente modificado com o complexo de níquel(II)-bis(1,10-fenantrolina) (Ni(II)(Phen)2) suportado em óxido de grafeno reduzido (rGO) (rGO/Ni(II)(Phen)2/PGE). O complexo Ni(II)(Phen)2, o óxido de grafeno reduzido (rGO), e o compósito rGO/Ni(II)(Phen)2 foram preparados e caracterizados pelas técnicas de Espectroscopia na região do UV-Vis, Espectroscopia de Infravermelho com Transformada de Fourier e Difração de Raios X. A atividade eletrocatalítica do material foi avaliada por voltametria cíclica e cronoamperometria. Em solução alcalina, os voltamogramas obtidos para rGO/Ni(II)(Phen)2/PGE mostraram processos redox bem definidos associados ao par redox Ni(II)/Ni(III). Os resultados mostraram que o compósito rGO/Ni(II)(Phen)2 aumenta significativamente a atividade eletrocatalítica para a oxidação do etanol em comparação com o eletrodo modificado apenas com o complexo Ni(II)(Phen)2 adsorvido na superfície do eletrodo. Usando a teoria de Laviron, a constante de velocidade de transferência de carga (ks) e o coeficiente de transferência de elétrons (α) da reação do eletrodo foram calculados sendo 0,56 s-1 e 0,61, respectivamente. Uma investigação da eletro-oxidação do etanol foi realizada avaliando o efeito de diferentes parâmetros, como a velocidade de varredura do potencial, a concentração de OH- e a concentração de álcool. Os experimentos cronoamperométricos foram utilizados para determinar o coeficiente de difusão do etanol (D = 4,7 Χ 10-6 cm2 s-1) e a constante de velocidade catalítica (kcat = 1,26 Χ 107 cm3 mol-1 s-1). Os resultados obtidos neste estudo indicam, claramente, a viabilidade do rGO/Ni(II)(Phen)2/PGE como eletrocatalisador da oxidação de etanol.

Uncertainty Quantification (UQ) has been an active area of research in recent years with a wide range of applications in data and imaging sciences. In many problems, the source of uncertainty stems from an unknown parameter in the model. In physical and engineering systems for example, the parameters of the partial differential equation (PDE) that model the observed data may be unknown or incompletely specified. In such cases, one may use a probabilistic description based on prior information and formulate a forward UQ problem of characterising the uncertainty in the PDE solution and observations in response to that in the parameters. Conversely, inverse UQ encompasses the statistical estimation of the unknown parameters from the available observations, which can be cast as a Bayesian inverse problem. The contributions of the thesis focus on examining the aforementioned forward and inverse UQ problems for the low-frequency, time-harmonic Maxwell equations, where the model uncertainty emanates from the lack of knowledge of the material conductivity parameter. The motivation comes from the Controlled-Source Electromagnetic Method (CSEM) that aims to detect and image hydrocarbon reservoirs by using electromagnetic field (EM) measurements to obtain information about the conductivity profile of the sub-seabed. Traditionally, algorithms for deterministic models have been employed to solve the inverse problem in CSEM by optimisation and regularisation methods, which aside from the image reconstruction provide no quantitative information on the credibility of its features. This work employs instead stochastic models where the conductivity is represented as a lognormal random field, with the objective of providing a more informative characterisation of the model observables and the unknown parameters. The variational formulation of these stochastic models is analysed and proved to be well-posed under suitable assumptions. For computational purposes the stochastic formulation is recast as a deterministic, parametric problem with distributed uncertainty, which leads to an infinite-dimensional integration problem with respect to the prior and posterior measure. One of the main challenges is thus the approximation of these integrals, with the standard choice being some variant of the Monte-Carlo (MC) method. However, such methods typically fail to take advantage of the intrinsic properties of the model and suffer from unsatisfactory convergence rates. Based on recently developed theory on high-dimensional approximation, this thesis advocates the use of Sparse Quadrature (SQ) to tackle the integration problem. For the models considered here and under certain assumptions, we prove that for forward UQ, Sparse Quadrature can attain dimension-independent convergence rates that out-perform MC. Typical CSEM models are large-scale and thus additional effort is made in this work to reduce the cost of obtaining forward solutions for each sampling parameter by utilising the weighted Reduced Basis method (RB) and the Empirical Interpolation Method (EIM). The proposed variant of a combined SQ-EIM-RB algorithm is based on an adaptive selection of training sets and a primal-dual, goal-oriented formulation for the EIM-RB approximation. Numerical examples show that the suggested computational framework can alleviate the computational costs associated with forward UQ for the pertinent large-scale models, thus providing a viable methodology for practical applications.

Submitted by Ricardo Cedraz Duque Moliterno (ricardo.moliterno@uefs.br) on 2015-08-05T22:00:05Z No. of bitstreams: 1 DISSERTACAO_FELIPE_DLA_PPGDCI.pdf: 4763694 bytes, checksum: 6f8b30d04543619f033603fcd6034795 (MD5) / Made available in DSpace on 2015-08-05T22:00:05Z (GMT). No. of bitstreams: 1 DISSERTACAO_FELIPE_DLA_PPGDCI.pdf: 4763694 bytes, checksum: 6f8b30d04543619f033603fcd6034795 (MD5) Previous issue date: 2014-10-24 / This dissertation discusses the concepts of accessibility in university space for school inclusion and consequent social inclusion of people with disabilities or reduced mobility through a diagnosis of physical architectural structure, more specifically in the areas of external movement of pedestrian users, conducted in main campus of the State University of Feira de Santana. Were pre-selected nine routes, five parallel and four perpendicular, to cover all locations on campus. The checklist was performed according to ABNT / NBR 9050, which in this study included: structure of sidewalks, parking and access to the building - external circulation; and doors, door handles, ramps, lifts, stairs and toilets - internal circulation of some of the main buildings. Added to this critical / observational analysis, an interview was conducted with 28 people (16 with and 12 without reduced mobility reduced mobility) in order to understand the views of users about the accessibility of the campus in its effective use. We observed any problems as barriers to full accessibility, such as inadequacy, malfunction, or structures in a state of degradation. The majority (60.71%) of research participants do NOT consider the UEFS campus accessible. The creation of accessible routes arises as a possibility adequacy of physical space, in favor of universal design as a way to ensure equal access, independent of personal physical condition. The UEFS, as a public university, owes the commitment to present and implement solutions to this problem in order to make a space that would allow exchanges, encourage the establishment of relationships and reduce the differences as a way of overcoming social inequalities of people physically different, to fulfill its role of social and institutional change agent. / A presente Disserta??o discute os conceitos de acessibilidade no espa?o universit?rio para a inclus?o escolar e consequente inclus?o social, de pessoas com defici?ncia ou mobilidade reduzida atrav?s de um diagn?stico da estrutura f?sico-arquitet?nica em rela??o ? mobilidade, mais especificamente das ?reas de circula??o externa dos usu?rios pedestres, realizado no campus principal da Universidade Estadual de Feira de Santana, em Feira de Santana. Foram pr?-selecionadas nove rotas, cinco paralelas e quatro perpendiculares, de forma a abranger todas as localidades do campus. A lista de verifica??es foi realizada de acordo com a ABNT/NBR 9050, que nesse trabalho incluiu: estrutura de cal?adas, estacionamento e acesso ? edifica??o ? circula??o externa; e portas, ma?anetas, rampas, elevadores, escadas e sanit?rios ? circula??o interna, de alguns dos pr?dios principais. Somado a essa an?lise cr?tica/observacional, uma entrevista foi realizada com 28 pessoas (16 com mobilidade reduzida e 12 sem mobilidade reduzida) a fim de compreender a percep??o dos usu?rios sobre a acessibilidade do campus em sua efetiva utiliza??o. Foram constatados diversos problemas quanto ? acessibilidade plena como obst?culos, inadequa??es, mau funcionamento, ou estruturas em estado de degrada??o. A maioria (60,71%) dos usu?rios participantes da pesquisa N?O considera o campus da UEFS acess?vel. A cria??o de rotas acess?veis surge como uma possibilidade de adequa??o do espa?o f?sico, em prol do desenho universal, como forma de garantir o acesso igualit?rio, independente da condi??o f?sica individual. A UEFS, na condi??o de universidade p?blica, deve o compromisso de apresentar e executar solu??es para essa problem?tica visando tornar-se um espa?o capaz de permitir trocas, estimular o estabelecimento de rela??es e atenuar as diferen?as como forma de supera??o das desigualdades sociais de pessoas fisicamente diferentes, para cumprir seu papel de agente de transforma??o social e institucional.

Objetivos. Avaliar o papel do transplante de células hematopoiéticas (TCH) e da interleucina 6 (IL – 6) sobre vários parâmetros de estresse oxidativo em pacientes com Adrenoleucodistrofia ligada ao cromossomo X (X-ALD). Métodos. A concentração de malondialdeído (MDA), o conteúdo de carbolinas e sulfidrilas e a concentração de ácido hexacosanóico (C26:0) foram quantificados no plasma de pacientes X-ALD antes e após serem submetidos ao TCH. E, a concentração de MDA, a formação de carbonilas e a concentração de IL-6 foram quantificados em plasma e o conteúdo de glutationa reduzida (GSH) foi quantificado em eritrócitos de pacientes X-ALD com fenótipos cerebral infantil (cALD) ou assintomáticos no momento diagnóstico. Resultados. Observamos um aumento significativo na concentração de MDA em plasma de pacientes X-ALD antes e após o TCH em comparação ao grupo controle e uma redução significativa nesses valores após o transplante em comparação aos anteriores ao procedimento. Verificamos uma redução significativa no conteúdo de sulfidrilas no plasma de pacientes X-ALD antes do TCH em comparação ao grupo controle e um aumento significativo desses níveis após o TCH. Não observamos diferenças significativas no conteúdo de carbonilas no plasma de X-ALD antes e após o TCH, em comparação aos controles, apesar de observarmos uma redução significativa nesta determinação nos pacientes após o transplante em relação a antes do TCH. Os pacientes X-ALD apresentam níveis plasmáticos de C26:0 significativamente aumentados antes do TCH em comparação aos controles e, após o TCH, as concentrações de C26:0 foram reduzidas. Observamos uma correlação negativa significativa entre a medida do conteúdo de sulfidrilas e os níveis plasmáticos de C26:0 de indivíduos X-ALD antes do TCH. Também evidenciamos elevados níveis de MDA e da formação de carbonilas no plasma de pacientes cALD e assintomáticos em comparação ao grupo controle. Ainda, observamos redução significativa do conteúdo de GSH nos dois grupos testados comparados aos controles. A quantificação de IL-6 foi significativamente maior nos pacientes cALD, o que não foi observado nos pacientes assintomáticos, apesar destes mostrarem uma tendência de aumento da concentração de IL-6. Conclusões. Os resultados obtidos a partir do plasma de pacientes X-ALD antes e após o TCH demonstram que esta terapia, quando bem indicada e bem sucedida, tem alta efetividade em reduzir a concentração plasmática de C26:0 e é eficaz em reduzir a peroxidação lipídica e o dano oxidativo às proteínas nos pacientes X-ALD. Ainda, é possível relacionar o acúmulo de C26:0 e o dano oxidativo na patogênese da X-ALD. Nossos dados permitem sugerir que a lipoperoxidação e o dano oxidativo às proteínas possam de alguma forma estar envolvidos na fisiopatologia da X-ALD. Além disso, podemos presumir que, nos pacientes X-ALD assintomáticos estudados, o dano oxidativo e os aspectos inflamatórios desempenham papéis importantes na evolução e nas futuras manifestações do fenótipo neuronal. Também podemos supor que a administração de antioxidantes deve ser considerada como uma terapia adjuvante potencial para os pacientes assintomáticos e sintomáticos afetados pela X-ALD, inclusive para aqueles submetidos ao TCH. / Objective. We aimed to evaluate the role of hematopoietic stem cell transplantation (HSCT) and interleukin 6 (IL – 6) on various parameters of oxidative stress in X-linked adrenoleukodystrophy (X-ALD) patients. Methods. Malondialdehyde (MDA), sulfhydryl, carbonyl and hexacosanoic acid (C26:0) levels were measured in plasma from X-ALD patients before and after HSCT. And, MDA, carbonyl and IL-6 levels were measured in plasma and reduced glutathione (GSH) content was measured in erythrocytes from X-ALD patients with different phenotype (asymptomatic and childhood cerebral (CCER patients) at diagnosis moment. Results. We observed increased levels of MDA in plasma from X-ALD before and after HSCT compared to control group, but there was a significant reduction in MDA values after transplantation compared to levels found before the procedure. We verified a significant decrease in sulfhydryl content in plasma of X-ALD patients before HSCT compared with the control group and we also verified a significant increase in the levels of sulfhydryl content after HSCT. No significant differences were observed in carbonyl content in plasma of X-ALD before and after HSCT, compared to controls. However, we observed a significant reduction of plasma carbonyl content from X-ALD patients after HSCT compared to before HSCT. X-ALD patients presented a significant increase of C26:0 plasma level before HSCT when compared to controls and an important reduction of C26:0 plasma concentration in X-ALD patients after HSCT when compared to before HSCT C26:0 levels. We observed an inverse significant correlation between sulfhydryl content and plasma C26:0 levels of X-ALD individuals before HSCT. We also evidenced high levels of MDA and carbonyl formation in plasma from CCER and asymptomatic patients compared to controls. Still, we observed a significant decrease of GSH content in both groups tested compared to controls. The quantification of IL-6 is significantly higher in CCER patients, which is not observed in asymptomatic patients, despite these patients show a tendency of increased concentration of IL-6. Conclusions. The results obtained from plasma of X-ALD patients before and after HSCT demonstrate that this therapy, when well indicated and successful, has high effectiveness in reducing C26:0 plasma and is effective in reducing lipid peroxidation and oxidative damage to proteins in X-ALD patients. Still, it is possible to relate the accumulation of C26:0 and oxidative damage in the pathogenesis of X-ALD. Our data also suggest that lipid peroxidation and protein damage may somehow be involved in the pathophysiology of X-ALD. Moreover, we can assume that in our asymptomatic X-ALD patients, oxidative damage and inflammatory issues seem to play an important role in the evolution and future manifestations of neuronal phenotype. We can also assume that the administration of antioxidants should be considered as a potential adjuvant therapy for asymptomatic and symptomatic patients affected by X-ALD, including those that are submitted to HSCT.

Les nouvelles technologies mécatroniques permettent de réduire fortement la consommation d'énergie et les émissions des véhicules individuels, en introduisant des ruptures indispensables pour une chaîne de traction électrifiée complémentaire ou alternative aux moteurs thermiques. Les assemblages en électronique de puissance utilisés dans les systèmes alterno-démarreurs emploient des alliages de brasure dont il s'agit de trouver des substituants, sans plomb, en accord avec les normes internationales. Cette thèse contribue à la caractérisation métallurgique et mécanique de deux joints brasés sans plomb innovants riches en étain. Ces joints sont produits industriellement par un procédé de brasage laser qui leur confère une microstructure de solidification très hétérogène, peu reproductible, multiphasée et qui présente un grand nombre de défauts. L'objectif de cette thèse est d'apporter une meilleure compréhension à la tenue mécanique de ces joints brasés au cours du vieillissement thermomécanique des assemblages. Les sollicitations thermiques engendrent des contraintes et des déformations plastiques à cause de la dilatation différentielle qui existe entre les différentes couches des matériaux brasés. Des lois de comportement isotropes ont été identifiées à partir d'une base expérimentale d'essais de traction sur des matériaux massifs. Ces lois, utilisées dans des simulations aux éléments finis, ont permis d'évaluer l'effet négatif du défaut de porosité inhérent au procédé de brasage. Des essais de vieillissement couplés à des observations de l'évolution de la microstructure ont permis de montrer l'influence de l'orientation des grains d'étain sur l'amorçage de fissure. Nous n'avons pas pu proposer de volume élémentaire représentatif du fait de la complexité de la structure. Une méthode inverse a été mise en oeuvre en parallèle de la conception d'un banc d'essai de flexion in-situ sous profilomètre afin de placer les premières briques permettant la caractérisation mécanique de joints brasés industriels. / The new mechatronic technologies can significantly reduce the energy consumption and gas emissions of personal cars, by introducing rupture innovations in electrified powertrains complementarily or alternatively to combustion engines. The power electronics assemblies used in starter-alternator systems use solder joints which need to be substituted with lead-free solder in agreements with international standards. This thesis contributes to the metallurgical and mechanical characterization of two tin-based lead-free solder joints. These joints are produced industrially with a Die Laser Soldering process which leads to heterogeneous solidification microstructures, poorly reproducible, multiphased, and with defects. The objective of this thesis is to provide a better understanding of the solder joints lifetime during thermomechanical aging. Thermal aging generates stresses and plastic deformation due to the mismatch in the coefficients of thermal expansion between the different layers of the assemblies. Isotropic constitutive laws were identified from an experimental database of tensile tests on bulk specimens. Those constitutive laws were used in finite element simulations in order to assess the negative effect of the solder joint porosity, inherent flaw traced back to the soldering process. Aging tests coupled with observations of the microstructure evolution have shown the influence of tin grains orientation on crack initiation. The heterogeneity of the microstructure prevents us from proposing a representative volume element of the materials. An inverse method has been implemented in parallel with the development of an in situ bending test bench under a profilometer in order to build the first steps for the mechanical characterization of industrial solder joints.

Cette thèse traite de la modélisation dynamique des systèmes non-holonomes intermittents et de son application à la bicyclette 3D de Whipple. Pour cela, nous nous sommes appuyés sur un ensemble d'outils en mécanique géométrique (réduction Lagrangienne et projection dans le noyau des contraintes cinématiques essentiellement). Dans un premier temps, nous avons traité le cas de la bicyclette persistante. En définissant l'espace des configurations du vélo comme un fibré principal de groupe structural SE(3), nous avons obtenu un modèle des points de contact et des contraintes exempt de toute non-linéarité associée à un paramétrage de type coordonnées généralisées. Cette formulation nous a permis d'obtenir le noyau des contraintes sous une forme symbolique sans singularité. Nous avons alors produit un modèle symbolique de la dynamique de la bicyclette persistante en utilisant la méthode de réduction par projection de sa dynamique libre dans le sous espace de ses vitesses admissibles. Cette approche étend le cadre général mis au point ces dernières années pour la locomotion bio-inspirée. Profitant de la structure de SE(3), un modèle de la bicyclette intermittente a été proposé dans le cadre d'une approche événementielle. L'adoption du modèle physique de l'impact plastique, nous a permis d'étendre la méthode de réduction par projection au cas intermittent. Nous avons alors comparé notre approche "réduite" à l'approche classiquement utilisée et avons montré qu'elles partageaient une interprétation géométrique commune. Ces outils ont finalement été appliqués à la simulation de la bicyclette intermittente afin d'illustrer la richesse de sa dynamique. / This thesis deals with the dynamic modelling of intermittent non-holonomic systems andits application to the Whipple 3D bicycle. To that end, we relied on a set of tools in geometric mechanics (mainly Lagrangian reduction and the projection in the kernel of the kinematic constraints). In the first instance, we have addressed the case of the bicycle subjected to persistent contacts. By defining the space of the bicycle configurations as a principal fibre bundle with SE(3) as structural group, we obtained a model of the contact points and of the constraints free of any non-linearities associated with a generalized coordinate type configuration. This formulation allowed us to obtain the kernel of the constraints in a symbolic form without singularity. We then produced a symbolic model of the dynamics ofthe bicycle subjected to persistent contacts using the projection reduction method of its free dynamics in the subspace of its permissible speeds. This approach extends the general framework developed in recent years for bio-inspired locomotion. Taking advantage of the structure of SE(3), a model of the intermittent bicycle was proposed as part of an event-driven approach. Moreover, the adoption ofthe physical model of plastic impact has allowed us to extend the projection reduction method to the intermittent case. We then compared our "reduced" approach to the conventional approach and showed that they shared a common geometric interpretation. These tools were finally applied to the simulation of the intermittent bicycle to illustrate its rich dynamics.

<p>There is a growing need to understand the deformation mechanisms in titanium alloys due to their widespread use in the aerospace industry (especially within gas turbine engines), variation in their properties and performance based on their microstructure, and their tendency to undergo premature failure due to dwell and high cycle fatigue well below their yield strength. Crystal plasticity finite element (CPFE) modeling is a popular computational tool used to understand deformation in these polycrystalline alloys. With the advancement in experimental techniques such as electron backscatter diffraction, digital image correlation (DIC) and high-energy x-ray diffraction, more insights into the microstructure of the material and its deformation process can be attained. This research leverages data from a number of experimental techniques to develop well-informed and calibrated CPFE models for titanium alloys at multiple length-scales and use them to further understand the deformation in these alloys.</p> <p>The first part of the research utilizes experimental data from high-energy x-ray diffraction microscopy to initialize grain-level residual stresses and capture the correct grain morphology within CPFE simulations. Further, another method to incorporate the effect of grain-level residual stresses via geometrically necessary dislocations obtained from 2D material characterization is developed and implemented within the CPFE framework. Using this approach, grain level information about residual stresses obtained spatially over the region of interest, directly from the EBSD and high-energy x-ray diffraction microscopy, is utilized as an input to the model.</p> <p>The second part of this research involves calibrating the CPFE model based upon a systematic and detailed optimization routine utilizing experimental data in the form of macroscopic stress-strain curves coupled with lattice strains on different crystallographic planes for the α and β phases, obtained from high energy X-ray diffraction experiments for multiple material pedigrees with varying β volume fractions. This fully calibrated CPFE model is then used to gain a comprehensive understanding of deformation behavior of Ti-6Al-4V, specifically the effect of the relative orientation of the α and β phases within the microstructure.</p> <p>In the final part of this work, large and highly textured regions, referred to as macrozones or microtextured regions (MTRs), with sizes up to several orders of magnitude larger than that of the individual grains, found in dual phase Titanium alloys are modeled using a reduced order simulation strategy. This is done to overcome the computational challenges associated with modeling macrozones. The reduced order model is then used to investigate the strain localization within the microstructure and the effect of varying the misorientation tolerance on the localization of plastic strain within the macrozones.</p>

This dissertation studies the effects of radiation-induced single-event upsets (SEUs) on digital signal processing (DSP) systems designed for field-programmable gate arrays (FPGAs). It presents a novel method for evaluating the effects of radiation on DSP and digital communication systems. By using an application-specific measurement of performance in the presence of SEUs, this dissertation demonstrates that only 5-15% of SEUs affecting a communications receiver (i.e. 5-15% of sensitive SEUs) cause critical performance loss. It also reports that the most critical SEUs are those that affect the clock, global reset, and most significant bits (MSBs) of computation. This dissertation also demonstrates reduced-precision redundancy (RPR) as an effective and efficient alternative to the popular triple modular redundancy (TMR) for FPGA-based communications systems. Fault injection experiments show that RPR can improve the failure rate of a communications system by over 20 times over the unmitigated system at a cost less than half that of TMR by focusing on the critical SEUs. This dissertation contrasts the cost and performance of three different variations of RPR, one of which is a novel variation developed here, and concludes that the variation referred to as "Threshold RPR" is superior to the others for FPGA systems. Finally, this dissertation presents several methods for applying Threshold RPR to a system with the goal of reducing mitigation cost and increasing the system performance in the presence of SEUs. Additional fault injection experiments show that optimizing the application of RPR can result in a decrease in critical SEUs by as much 65% at no additional hardware cost.

Dans les centrales nucléaires et thermiques, certaines installations sont sujettes à des couplages acousto-mécaniques pouvant nuire fortement à leur bon fonctionnement. La compréhension et la prédiction de ces couplages multi-physiques nécessitent le développement de modèles numériques de très grande précision. Ces modèles sont si coûteux à résoudre qu’il n’est pas envisageable de les utiliser dans des boucles de contrôle ou encore d’optimisation paramétrique. Dans ce manuscrit de thèse, le but est d’exploiter un nombre limité de calculs coûteux pour construire un modèle numérique qui soit de très faible dimension. Ces modèles numériques réduits doivent être capables, en temps réel, de reproduire ces calculs haute-fidélité mais aussi d’extrapoler ces résultats à d’autres points de fonctionnement plus ou moins proches. L’évolution dé petites perturbations compressibles au sein d’un écoulement complexe moyenné est modélisée à partir des équations d’Euler linéarisées dont la nature hyperbolique complique l’application des méthodes de réduction classiques. Les principales problématiques théoriques et numériques qui émergent lors de la construction du système réduit par méthode de projection sont alors exposées. En particulier, les problèmes fondamentaux de la préservation de la stabilité et du contrôle de l’énergie des systèmes réduits sont largement développés et une nouvelle méthode de stabilisation est proposée. Leur sensibilité paramétrique est aussi discutée. Les modèles réduits stables sont ensuite intégrées dans un code de calcul industriel pour prendre en compte des géométries complexes. De plus, la présence de solides dont les parois peuvent être fixes ou mobiles est abordée. En particulier, les petits déplacements de paroi sont modélisés avec une loi de transpiration. Cette condition aux limites est intégrée dans le formalisme du contrôle de façon à lever la difficulté induite par sa non homogénéité. Finalement, les modèles réduits sont exploités pour prédire en temps réel la réponse des systèmes à une loi de contrôle arbitraire. Par exemple, la fréquence et l’amplitude du chargement peuvent varier. Le code de calcul réduit ainsi développé a pour principale vocation de rendre possible des expertises aéroélastiques à faible coût. / In nuclear and thermal power stations, some installations produce acoustics/mechanics coupling which may cause important damage and bad operating performances. Prediction and understanding of these physical phenomena need the development of high-fidelity numerical models which are prohibitive to solve. Therefore, these models cannot be used for control or even parametric optimization applications. In this work, the goal is to use some high-fidelity solutions for building reduced-order models which are able to calculate again these solutions but in real-time, and also to predict solutions for other close configurations. Modelling of compressible disturbances in a complex mean flow is given by hyperbolic linearized Euler equations which create some difficulties to perform classical reduction methods. Theoretical and numerical problems are then introduced when a projection method is applied. In particular, the conservation of stability and the control of energy of reduced-order models are studied and a new stabilization procedure is proposed. Parametric sensitivity is also discussed. Afterwards, stable reduced-order models are developed in an industrial code to consider complex geometries. Furthermore, modelling of solids with fixed or vibrating walls are taken into account. Particularly, small vibrations are modelled thanks to a transpiration law. This boundary condition is implemented in the framework of linear control theory to apply reduction methods. Finally, reduced-order models are tested to predict solutions in real time. For instance, frequency and amplitude of the loading can change. The developed reduced order model should be used for aeroelastic industrial problems with more realistic costs.