Memoria para optar al Título Profesional de Médico Veterinario / Se determinó la prevalencia de discoespondilitis, espondilosis, inestabilidad lumbosacra y mineralización de disco intervertebral, en una población de 154 Ovejero Alemán y 32 Labrador Retriever de trabajo. Se obtuvieron dos imágenes radiográficas por ejemplar; una vista ventro dorsal y una en posicion latero lateral, para el segmento comprendido entre T10 y el sacro. Estas enfermedades fueron diagnosticadas en un 57,8 % de los ejemplares Ovejero Alemán y en 56,3% de los Labrador Retriever. Mediante Chi cuadrado se determinó que existe independencia entre su presentación y la raza de los ejemplares. La espondilosis y la inestabilidad lumbosacra se observaron con mayor frecuencia tanto en Ovejero Alemán como en Labrador Retriever. Por otro lado, la presencia de osteofitos y el espacio intervertebral lumbosacral en cuña fueron los signos radiográficos más frecuentes en ambas razas. En la raza Ovejero Alemán se observó que existe asociación positiva entre edad y peso y la presencia de ambas enfermedades. Sólo la presentación de espondilosis se vio asociada a los Ovejero Alemán machos

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Made available in DSpace on 2014-06-11T19:31:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-02-26Bitstream added on 2014-06-13T19:41:07Z : No. of bitstreams: 1 souza_ap_dr_jabo.pdf: 811812 bytes, checksum: 25bce5312ab6b25601cdee2a32e17491 (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / A Distrofia Muscular de Duchenne (DMD) é uma doença genética recessiva e hereditária, ligada ao cromossomo X, caracterizada pela ausência ou insuficiência da proteína distrofina no sarcolema das fibras musculares. É uma doença muscular progressiva, que afeta um em cada 3.500 meninos. Atualmente, os cães da raça Golden Retriever, portadores da distrofia muscular do Golden Retriever (GRMD), que exibem mudanças musculares, patogenia, bem como o fenótipo, comparáveis aos vistos nos casos de DMD, vêm sendo considerados o melhor modelo animal para o estudo da DMD. Nos GRMDs a fraqueza muscular inicia-se a partir do segundo mês de vida e é progressiva, portanto, a expectativa de vida destes cães é muito reduzida. Histologicamente, os músculos mostram necrose, fibrose e regeneração. As manifestações patológicas da GRMD já se iniciam na vida intra-uterina com o desenvolvimento de lesões nos músculos da língua. A hipertrofia da língua está associada com disfunção da faringe e do esôfago, o que resulta em disfagia, regurgitação e sialorréia. A pesquisa com células-tronco tem um potencial para avanços significativos no nosso conhecimento da diferenciação celular com a promessa de excitantes e inovadoras aplicações terapêuticas para desordens genéticas e degenerativas incuráveis... / Duchenne’s Muscular Dystrophy (DMD) is a lethal childhood disease, a X-linked recessive disorder, caused by mutations of the dystrophyn gene, a protein that has a vital role in maintaining muscle structure and function. DMD is a progressive muscular disease, that affects 1:3500 born boys. At this moment, the dogs with Golden Retriever Muscular Dystrophy (GRMD), is the best animal model to study DMD. GRMD dog exhibits muscle changes, pathogenesis and phenotype comparable with the DMD boys. In GRMDs the muscular weakness beginning with 60 days of life and this is progressive. Histologically, the muscles show necrosis, fibrosis, degeneration and regeneration. The pathogenesis manifests in utero with the development of lingual muscle lesions. The tongue hypertrophy is associated with pharyngeal and esophageal dysfunction, and results in dysphagia, regurgitation and drooling. The research with steam-cells has a great potential to significative advances in owner knowledge about cellular differentiation, with the promise of therapeutic applications in genetic disorders and in degenerative or incurable diseases...(Complete abstract, click electronic access below)

Made available in DSpace on 2014-06-11T19:33:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-02-26Bitstream added on 2014-06-13T21:06:06Z : No. of bitstreams: 1 miyazato_lg_dr_jabo.pdf: 12108110 bytes, checksum: 389387edb66af6afc5029abc0101e08a (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / Fatec / O objetivo deste estudo foi o de caracterizar lesões musculares em cães com Distrofia Muscular do golden retriever (DMGR), de diferentes idades, por análises histopatológica e imunoistoquímica. Foram utilizados vinte e cinco cães machos classificados e distribuídos em grupos de acordo com a idade: grupo I – distróficos até 1 ano; grupo II – distróficos acima de 1 ano; grupo III - controle até 1 ano; grupo IV - controle acima de 1 ano. Uma amostra de cada músculo foi fixada em solução de formol, processadas pelas técnicas usuais de inclusão em parafina, coradas com HE e TGM para análise histopatológica e processadas para a análise imunoistoquímica de linfócitos T-CD3+, antígeno MHC II e vimentina. Outras amostras foram congeladas em nitrogênio líquido e processadas pelas técnicas usuais para realização das reações imunoistoquímicas para marcação dos linfócitos T-CD4+, TCD8+ e do antígeno MHC I. Os resultados mostraram que as lesões nos músculos distróficos do grupo I foram moderadas comparativamente às do grupo II que foram severas. Nos músculos distróficos, os linfócitos T-CD3+, T-CD4+ e T-CD8+ concentravam-se nas áreas de degeneração e necrose. O número de linfócitos T-CD3+ e T-CD4+ foi significativamente maior (p < 0.05) em todos os músculos distróficos em comparação aos controles, demonstrando a participação dos linfócitos T na doença. O número de linfócitos T-CD8+ foi significativamente maior (p < 0.05) nos distróficos, exceto para os músculos sartório cranial no grupo I, diafragma e bíceps femoral no grupo II. A imunoexpressão do MHC I intensificou-se com a idade nos animais distróficos, ao contrário do MHC II que se manteve. A imunoexpressão da vimentina e do VEGF nos músculos distróficos foi discreta (escore 1) em todos os músculos avaliados. Destes resultados podemos... / The purpose of this study was to characterize the lesions in dystrophic muscles of DMGR dogs of different ages, by means of histopathological and immunohistochemistry analysis. Twenty-five male dogs were classified and distributed into groups according to the age: Group I - dystrophic up to 1 year, group II - dystrophic over 1 year, group III - control up to 1 year, group IV - control over 1 year. One sample from each muscle was fixed in formalin solution, processed by usual techniques of paraffin embedding, stained with HE and TGM for histopathological purposes and processed for immunohistochemical analysis of the distribution of T-lymphocytes CD3+, MHC II and vimentin. Other samples were frozen in liquid nitrogen, processed by usual techniques of freezing in order to perform the techniques of immunohistochemical labelling for CD4+ T-lymphocytes, T-CD8+ and MHC I. The results of histopathological analysis showed that the lesions in dystrophic muscles in the Group I were moderate compared to that ones in the Group II which were severe. The CD3+, CD4+ and CD8+ Tlymphocytes were more numerous in dystrophic muscles especially in areas of degeneration and necrosis. The number of CD3+ and CD4+ T-lymphocytes was found to be significantly higher (p <0.05) in all dystrophic muscles compared to controls demonstrating the involvement of T-lymphocytes in the disease. The number of CD8+ Tlymphocytes was found to be significantly higher (p <0.05) in dystrophics, except for the cranial sartorius muscles in the Group I and the diaphragm and biceps femoris in the Group II. The immunoexpression of MHC I increased with age in dystrophic animals, in contrast to MHC II that remained the same. The immunoexpression of vimentin and VEGF in the dystrophic muscles was mild (score 1) upon all muscles. From these results we can conclude that in dystrophic muscle immunoexpression of... (Complete abstract click electronic access below)

Orientadora: Mirela Bonafim Carvalho / Banca: Carlos Roberto Daleck / Banca: Wilter Ricardo Russiano Vicente / Banca: Maria Angélica Miglino / Banca: Carlos Eduardo Ambrósio / Resumo: A Distrofia Muscular de Duchenne (DMD) é uma doença genética recessiva e hereditária, ligada ao cromossomo X, caracterizada pela ausência ou insuficiência da proteína distrofina no sarcolema das fibras musculares. É uma doença muscular progressiva, que afeta um em cada 3.500 meninos. Atualmente, os cães da raça Golden Retriever, portadores da distrofia muscular do Golden Retriever (GRMD), que exibem mudanças musculares, patogenia, bem como o fenótipo, comparáveis aos vistos nos casos de DMD, vêm sendo considerados o melhor modelo animal para o estudo da DMD. Nos GRMDs a fraqueza muscular inicia-se a partir do segundo mês de vida e é progressiva, portanto, a expectativa de vida destes cães é muito reduzida. Histologicamente, os músculos mostram necrose, fibrose e regeneração. As manifestações patológicas da GRMD já se iniciam na vida intra-uterina com o desenvolvimento de lesões nos músculos da língua. A hipertrofia da língua está associada com disfunção da faringe e do esôfago, o que resulta em disfagia, regurgitação e sialorréia. A pesquisa com células-tronco tem um potencial para avanços significativos no nosso conhecimento da diferenciação celular com a promessa de excitantes e inovadoras aplicações terapêuticas para desordens genéticas e degenerativas incuráveis...(Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Duchenne's Muscular Dystrophy (DMD) is a lethal childhood disease, a X-linked recessive disorder, caused by mutations of the dystrophyn gene, a protein that has a vital role in maintaining muscle structure and function. DMD is a progressive muscular disease, that affects 1:3500 born boys. At this moment, the dogs with Golden Retriever Muscular Dystrophy (GRMD), is the best animal model to study DMD. GRMD dog exhibits muscle changes, pathogenesis and phenotype comparable with the DMD boys. In GRMDs the muscular weakness beginning with 60 days of life and this is progressive. Histologically, the muscles show necrosis, fibrosis, degeneration and regeneration. The pathogenesis manifests in utero with the development of lingual muscle lesions. The tongue hypertrophy is associated with pharyngeal and esophageal dysfunction, and results in dysphagia, regurgitation and drooling. The research with steam-cells has a great potential to significative advances in owner knowledge about cellular differentiation, with the promise of therapeutic applications in genetic disorders and in degenerative or incurable diseases...(Complete abstract, click electronic access below) / Doutor

Thesis (Ph. D.)--University of Missouri--Columbia, 2002. / Typescript. Vita. Includes bibliographical references (leaves 141-160). Also issued on the Internet.

Background: The number of IPOs has been numerous in recent years. Moreover, the returns of the IPOs managed to either be over and underpriced. IPO-firms are generally unknown before they get listed. Therefore, the media outlets play an essential role in the dissemination of information to new investors. Thus, it becomes noteworthy to investigate whether media attention could be an explanatory factor for the first-day returns and how it affects an IPO in the short-term perspective. Research Questions: i) If the amount of media coverage two months pre-IPO has any relation with the first trading day return and ii) If the amount of media coverage helps to predict the IPOs stock return volatility after a two-month period (44 trading days)? Purpose: This research will attempt to find evidence if the amount of media coverage pre- IPO may drive the demand for the IPO and the first-day return. For this purpose, it is also necessary to find the under and/or overpricing. Furthermore, a regression analysis will be applied during a two-month period after the first trading day to investigate if increasing volatility depends on the amount of media coverage. Delimitations: The sample consists of 165 IPOs in Sweden from Aktietorget and OMX Stockholm during the period 2005-2017. IPOs are initial introductions that are not unit IPOs, mergers &amp; acquisitions, right issues, spin-offs or buy-out firms. Method: The first research question is explained by a Pearson correlation where X is the media variable and tested against the degree of under or overpricing. Furthermore, a multiple-linear regression is examined where variables market index, Retriever data and trading volume is tested against stock return. Conclusion: It has been identified that Aktietorget has been overpriced 2005-2017 by 2.9% while OMXS has been underpriced 6.8%. In summary, the study did not manage statistically to ensure that the amount of media coverage significantly influenced the stock return volatility.

Studien tog avstamp i revisionsreformen 2010, som har inneburit att företag under satta gränsvärden frivilligt kunde välja revision eller avstå revision. Syftet med studien var att undersöka efterfrågan på revision hos mikrobolag genom en kvantitativ undersökning av dess karaktärsdrag. Teoretiska referensramen består av agentteori, informationsassymetri och intressentteori kopplat till området frivillig revision. Vidare baserades studien på tidigare forskning som undersökt efterfrågan genom karaktärsdrag i andra länder. De karaktärsdrag denna studie fokuserade på är storlek och agentkostnad, företagsrisk, beroendeställning till leverantör och kreditvärdighet. Genom en kvantitativ dokumentär metod samlades data in i form av årsredovisningar genom databasen Retriever Business. Data analyserades därefter genom deskriptiv statistik, Pearssons korrelationsmatris samt binär logistisk regression. Studiens resultat visar att det enbart går att finna signifikanta resultat kopplat till agentkostnader. Det finns en korrelation mellan flertalet variabler dock i regressionen är det endast för agentkostnader som resultatet var signifikant. Utifrån resultatet kunde två hypoteser styrkas och det går att dra slutsatsen att företag som väljer revision har storlek och agentkostnad som gemensam faktor. Företagsrisk, beroendeställning till leverantörer och kreditvärdighet hade inga signifikanta samband påverkar troligtvis inte valet av frivillig regression.

Background Traditional banks monopolized financial services, but the 2008 crisis spurred Fintech's emergence as an alternative. Fintech challenges banks with innovative solutions, while Sweden thrives as a Fintech hub. Profitability is vital due to the recent shift in focus from growth. Modern Fintech research is lacking, thus creating gaps in both knowledge and studies among the Swedish Fintech-sphere.  Purpose  The study analyzes leverage, return on equity, and bank size ratios in Swedish Fintech companies. It examines their impact on profit margin and aims to identify correlations. The results aim to enhance understanding and provide guidance for optimizing key figures to increase profitability among Swedish Fintech-companies.  Methodology The study utilized a quantitative approach with a deductive method and cross-sectional design. Data consisted of secondary data and was collected through the database Retriever Business. A total of 1198 observations were analyzed using correlation matrix, bivariate, and multivariate regression analyses.  Results  The quantitative analysis revealed that both debt to equity ratio and return on equity has a significant relationship, while bank size has only a partially significant relationship with profit margin.  Conclusion  Swedish Fintech-companies reveals a positive relationship between return on equity (ROE) and profitability. Furthermore, the leverage ratio also positively affects profitability. Moreover, Bank size shows a slight negative impact.