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Resting-state functional connectivity in the brain and its relation to language development in preschool childrenXiao, Yaqiong 01 December 2017 (has links)
Human infants have been shown to have an innate capacity to acquire their mother tongue. In recent decades, the advent of the functional magnetic resonance imaging (fMRI) technique has made it feasible to explore the neural basis underlying language acquisition and processing in children, even in newborn infants (for reviews, see Kuhl & Rivera-Gaxiola, 2008; Kuhl, 2010) .
Spontaneous low-frequency (< 0.1 Hz) fluctuations (LFFs) in the resting brain have been shown to be physiologically meaningful in the seminal study (Biswal et al., 1995) . Compared to task-based fMRI, resting-state fMRI (rs-fMRI) has some unique advantages in neuroimaging research, especially in obtaining data from pediatric and clinical populations. Moreover, it enables us to characterize the functional organization of the brain in a systematic manner in the absence of explicit tasks. Among brain systems, the language network has been well investigated by analyzing LFFs in the resting brain.
This thesis attempts to investigate the functional connectivity within the language network in typically developing preschool children and the covariation of this connectivity with children’s language development by using the rs-fMRI technique. The first study (see Chapter 2.1; Xiao et al., 2016a) revealed connectivity differences in language-related regions between 5-year-olds and adults, and demonstrated distinct correlation patterns between functional connections within the language network and sentence comprehension performance in children. The results showed a left fronto-temporal connection for processing syntactically more complex sentences, suggesting that this connection is already in place at age 5 when it is needed for complex sentence comprehension, even though the whole functional network is still immature. In the second study (see Chapter 2.2; Xiao et al., 2016b), sentence comprehension performance and rs-fMRI data were obtained from a cohort of children at age 5 and a one-year follow-up. This study examined the changes in functional connectivity in the developing brain and their relation to the development of language abilities. The findings showed that the development of intrinsic functional connectivity in preschool children over the course of one year is clearly observable and individual differences in this development are related to the advancement in sentence comprehension ability with age.
In summary, the present thesis provides new insights into the relationship between intrinsic functional connectivity in the brain and language processing, as well as between the changes in intrinsic functional connectivity and concurrent language development in preschool children. Moreover, it allows for a better understanding of the neural mechanisms underlying language processing and the advancement of language abilities in the developing brain.
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Kindliche Entwicklung im Zusammenhang mit soziodemografischen Parametern: Ergebnisse der LIFE Child StudieSchild, Clara Elise 05 November 2024 (has links)
Objectives: To explore environmental and individual factors that are associated with child development and to investigate whether the strength of these associations
differs according to the age of the children.
Design: Cross-sectional study.
Setting: This study was part of the LIFE Child study, a large cohort study conducted in Leipzig, Germany.
Participants: 778 children aged between 0.5 and 6 years (48.6% girls, mean age=2.67 years).
Outcome measures: The outcomes were cognitive development, language development, body and hand motor skills, social- emotional development, and tracing skills, measured with a standardised development test. We analysed the associations between development and gestational age, socioeconomic status (SES), sex, behavioural difficulties, siblings, sleep duration, breastfeeding duration and overweight/obesity. We also tested for interactions between these variables and child
age or sex.
Results: Higher gestational age (b ranging between 0.12 and 0.26) and higher SES (b ranging between 0.08 and 0.21) were associated with better outcomes in almost all developmental domains (all p<0.019). Children with older siblings had improved body and hand motor skills compared with children without older siblings (both b=0.55, all p<0.029). Boys had poorer scores than girls in body and hand motor skills and tracing (b=−0.45, −0.68 and −1.5, all p<0.019). Children with behavioural difficulties had significantly poorer outcomes in most developmental domains. Some of the associations with SES and sex were stronger in older than in younger children. Associations between gestational age and motor development were weaker in older children. We did not find significant associations between child development and sleep
duration, breastfeeding duration or overweight/obesity.
Conclusion: Some factors had a protective, others an adverse effect on development of children under 6 years of age. The effect of SES and sex increased, while the effect of gestational age decreased with age.:Inhaltsverzeichnis
I. Abkürzungsverzeichnis
1 Einführung
1.1 Entwicklung
1.2 Entwicklungsdiagnostik
1.2.1 Der Entwicklungstest für Kinder zwischen 6 Monaten und 6 Jahren - Revision
1.3 Forschungsstand
1.3.1 Gestationsalter
1.3.2 Sozioökonomischer Status
1.3.3 Geschlecht
1.3.4 Verhalten
1.3.5 Ältere Geschwister
1.3.6 Schlafdauer
1.3.7 Stilldauer
1.3.8 Übergewicht/Adipositas
1.4 Ableitung der Rationale für die Studie
2 Publikation
3 Zusammenfassung der Arbeit
4 Literaturverzeichnis
II. Darstellung des eigenen Beitrags
III. Erklärung über die eigenständige Abfassung der Arbeit
IV. Lebenslauf
V. Danksagung
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Zur sprachlichen Frühförderung von Kindern mit Lippen-Kiefer-Gaumenspalte unter besonderer Berücksichtigung der Zusammenarbeit mit den ElternHorbank, Ulrike 21 August 2013 (has links)
Bereits im frühen Kindesalter zeigen Kinder mit Spaltbildungen im Vergleich zu Kindern ohne Spaltbildungen eine veränderte Sprachentwicklung. Untersucht wurden die Möglichkeiten einer von Geburt ansetzenden Sprachförderung von Kindern mit Spaltbildung unter intensiver Zusammenarbeit mit den Eltern im Hinblick auf eine physiologische Sprachentwicklung. Innerhalb der Arbeit wurde ein sprachliches Frühförderkonzept für Kinder mit Lippen-, Kiefer-, Gaumenspalte (LKG) für die Zeit der ersten zwei Lebensjahre entwickelt und mit sieben Kindern mit LKG (Untersuchungsgruppe) in Form von Hausbesuchen erprobt. Im Alter von zwei Jahren wurde die Sprachentwicklung dieser Kinder mit sieben Kindern ohne Spaltbildung (Vergleichsgruppe) verglichen. Für die Auswertung der Untersuchungen kamen die Testverfahren ELFRA-1, ELFRA-2 und SETK-2 sowie eine informelle Prüfung des Lautbestandes zum Einsatz. Die Ergebnisse bestätigten bei fünf Kindern der Untersuchungsgruppe Unterschiede im sprachlichen Entwicklungsverlauf, die sich in Tendenzen zu Sprachentwicklungsrückständen bzw. Auffälligkeiten auf phonetisch-phonologischer Ebene niederschlugen. Deutlichere Hinweise auf Symptome der Gaumenspaltensprache gab es nur bei zwei Probanden. Zwei Kinder der Untersuchungsgruppe zeigten eine altersgerechte sprachliche Entwicklung. Möglicherweise sind diese positiven Ergebnisse auch auf die frühe sprachtherapeutische Förderung zurückzuführen. Zukünftig müsste die Wirksamkeit frühsprachlicher Förderkonzepte anhand von größeren Probandengruppen und längerem Förderzeitraum untersucht werden. / Even in the earliest stages of speech and language development children with cleft lip and palate show differences compared to children without clefts. This study focussed on encouraging early speech development of children with cleft lip and palate and investigated an intensive cooperation between speech pathologist and parents straight after birth up to the age of two years. An early intervention speech program was developed for the first two years of life and tried out on seven children with cleft lip and palate (research group). At the age of two the speech and language development of these children was compared to seven children without clefts (control group). For the time of the investigation the speech pathologist visited the families at home on a regular basis. Evaluation was done with the help of the following instruments: parent questionnaire ELFRA-1, ELFRA-2, language test SETK-2 and an informal screening of the childrens’ sound inventory. The results show differences in speech development in five children with clefts that are reflected in tendencies for delayed speech development and decreased phonological abilities. However, only two children of the research group showed distinctive signs of cleft palate speech. Two children of this group even had speech and language outcomes without pathological findings. Tentatively, these positive results may also be attributed to the effects of the early speech intervention. In future, the effectivity of such programs must be evaluated by researching larger groups of children over a longer period of time.
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Sprachproduktionstest zu narrativen Kompetenzen in Deutscher Gebärdensprache (NaKom DGS) - eine TestadaptionKolbe, Vera 09 February 2023 (has links)
Diese Erwerbsstudie beschreibt die Adaption eines Testverfahrens aus der Britischen Gebärdensprache von Herman et al. (2004) in Deutsche Gebärdensprache (DGS). NaKom DGS ist ein Testverfahren das narrative und grammatische Kompetenzen in Kindererzählungen analysiert. NaKom DGS elizitiert Erzählungen mittels eines kurzen sprachfreien Stimulus-Videos und ist für Kinder im Alter von 4-11 Jahren validiert. In einer Querschnittsstudie wurde das Testverfahren mit 97 Kindern deutschlandweit durchgeführt, um das Testverfahren zu validieren. Die Referenzwerte für NaKom DGS basieren auf den Erzählungen von 72 Kindern mit Zugang zu DGS ab Geburt durch taube in DGS kommunizierende Eltern.
Durch diese Studie wurden neue Erkenntnisse zum Spracherwerb von DGS gewonnen. Die gefundenen Erwerbsverläufe bieten Wissenschaftler_innen in vielen der untersuchten Strukturen erste Anhaltspunkte für den Spracherwerb in DGS, mit denen zukünftige Forschungsergebnisse verglichen werden können.
Ausgewertet werden als narrative Kompetenzen Strukturelemente nach dem globalen Strukturmodell von Labov and Waletzky (1973), sowie Erzählinhalt und Reihenfolge der Erzählung. Als grammatische Kompetenzen werden in Anlehnung an Johnston (2016) auf kleiner satzähnlicher Ebene Verbmodifikationen analysiert: Modifikationen der Art und Weise, direktionale Modifikationen, aspektuelle Modifikationen und abbildende Verben. Auf Textebene, d.h. in Bezug zur gesamten Erzählung, wird konstruierte Aktion untersucht.
Die Referenzwerte von NaKom DGS werden cross-linguistisch mit den Ergebnissen des Grundlagentests, sowie einer weiteren Adaption in Amerikanische Gebärdensprache (Enns et al. 2019) verglichen und dadurch zusätzlich bestätigt. / This acquisition study describes the test adaptation process of the British Sign Language (BSL) Productive Skills test from Herman et al. (2004) to German Sign Language (DGS), resulting in the new assessment tool „Sprachproduktionstest zu narrativen Kompetenzen in Deutscher Gebärdensprache“ (NaKom DGS). NaKom DGS analyzes narrative and grammatical competences in children´s narrations, that are elicited via a short language free videoclip. In a nationwide cross-sectional study NaKom DGS was validated with data from 97 signing children, 4-11 years old. The standards for the test are derived from the results of 72 native signing children, that acquire DGS from Deaf DGS signing parents.
This study provides new insights in language acquisition in DGS. Up to now research in DGS acquisition is sparse, therefore the results of NaKom DGS are the first insights in many of the analyzed areas. The results provide scholars with first insights and stepping stones for future research.
This study focuses on narrative competences as the global structural elements from the model of Labov and Waletzky (1973), as well as narrative content and narrative sequence. Grammatic competences specifically modifications of verbs are analyzed on the level of small clause like units, following Johnston (2016): indicating directional modifications, depicting verbs, aspect and manner. On text level constructed action is analyzed across the whole narration.
Additionally the newly developed standards for NaKom DGS are compared to the standards from the BSL test as well as another adaptation to American Sign Language (Enns et al. 2019). This cross-linguistic comparison supports the validity of the German test results.
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