O presente estudo teve como objetivo avaliar o perfil da molécula relacionada à inflamação (ICAM-1), citocinas e da atividade das NTPDases como potencial influência sobre a genotoxicicdade em trabalhadores expostos ocupacionalmente a HPA. Este estudo incluiu 45 taxistas e 40 indivíduos com atividades administrativas (não-expostos ocupacionalmente), ambos nãi fumantes. O monitoramento biológico foi realizado pela quantificação do 1-hidroxipireno (1-pireno OH) urinário. A expressão de ICAM-1 (CD54) em neutrófilos foi realizada por citometria de fluxo. O perfil de hidrólise das NTPDases em plaquetas foi determinada pelo método colorimétrico. Além disso, os níveis de malondialdeído no plasma (MDA), citoquinas inflamatórias (IL-1β, IL-6, IL-10, TNF-α e IFN-γ) e o dano ao DNA (ensaio cometa e do micronúcleo) foram também avaliados. Os resultados demonstraram que os níveis de 1-OH pireno foram significativamente aumentados nos motoristas de táxi em comparação com o grupo não exposto ocupacionamente (p <0.0001); também foi positivamente correlacionada com neutrófilos ICAM-1, níveis de MDA e biomarcadores de danos no DNA. A expressão de ICAM-1 em neutrófilos foi significativamente elevado em motoristas de táxi (p <0.05), bem como os níveis de MDA (p <0.01), sendo a última positivamente correlacionada com a % de DNA na Cauda e frequência de MN. Aumento da hidrólise de ATP e ADP forma encontrados nos taxistas. Concentrações dos marcadores pró-inflamatórios foram aumentadas e anti-inflamatórias (IL-10) diminuída no grupo exposto. Para o teste de ensaio de micronúcleos e cometa, houve aumento significativo em motoristas de táxi, inclusive depois da adição de enzimas de reparo. Correlações positivas foram encontradas entre IL-1β, IL-6, TNF-α, IFN-γ e preditores de danos no DNA (% de DNA na cauda e frequência de MN), enquanto que a IL-10 está negativamente correlacionada com os biomarcadores de lesão ao DNA. Em resumo, a exposição ocupacional à poluição do ar pode levar a anormalidade homeostática como potencial contribuição para o processo aterosclerótico. Este estudo mostrou também que a exposição crônica à poluição do ar pode causar danos no DNA relacionado com a peroxidação lipídica e processo inflamatório. / The present study aimed to evaluate the profile of inflammatory molecule (ICAM-1), cytokines and the NTPDases activity as potential influence on genotoxicity process in workers exposed occupationally to PAH. This study included 45 taxi drivers and 40 non-occupationally exposed subjects, both non smorkers. Biological monitoring was performed by quantification of urinary 1-hydroxypyrene (1-OH pyrene). The expression of ICAM-1 (CD54) in neutrophil was performed and the hydrolysis profile of the NTPDases in platelets was determined. Plasma malondialdehyde (MDA) levels, inflammatory cytokines and DNA damage (comet and micronucleus assays) were also evaluated. The results demonstrated that the 1-OH pyrene levels were significantly increased in taxi drivers (p<0.0001); were also positively correlated to neutrophil ICAM-1 expression, MDA levels and biomarkers of DNA damage. ICAM-1 expression in neutrophil was significantly elevated in taxi drivers (p<0.05), as well as MDA levels (p<0.01), being the last positively correlated with % Tail DNA and MN frequency. ATP and ADP hydrolysis was increased in taxi drivers. Pro-inflammatory markers concentrations were increased and anti-inflammatory (IL-10) was decreased in exposed group. For the comet assay and micronucleus test, increase was significant in taxi drivers, inclusive after repair enzymes. Positively correlations were found between IL-1β, IL-6, TNF-α, IFN-γ and predictors of DNA damage (%Tail DNA and MN frequency), while IL-10 is negatively correlated with the biomarkers of DNA lesion. In summary, occupational exposure to air pollution, especially to PAHs, may be related with homeostatic abnormality as potential contribute to atherosclerosis process. This study showed also that the chronic exposure to outdoor air pollution may cause DNA damage related with lipid peroxidation and inflammatory process.

Esta dissertação é resultado de uma pesquisa que objetivou descrever e analisar como se constitui a estratégia de inventar a vida de taxista no exercício do trabalho imaterial, considerando o medo característico da sociedade líquido-moderna. Para tanto, em termos teóricos e com o objetivo de sustentar a dissertação, trabalhou-se com conceitos de vida líquida, sociedade líquido-moderna, medo e estilo de vida apoiados especialmente em Bauman (1999, 2001, 2003, 2004, 2007a, 2007b, 2008, 2009), Gaulejac (2007), Sennett (2012a), Giddens (2002), Deleuze (1992, 1998); de trabalho imaterial amparado em autores tais como Grisci (2008), Mansano (2009b), Gorz (2005), Lazzarato e Negri (2001). Foram entrevistados quinze taxistas, bem como um representante sindical e um instrutor do curso de formação profissional para taxistas. As entrevistas semiestruturadas foram realizadas em diversos pontos da cidade de Porto Alegre. Foi feita observação participante no curso de formação profissional para taxistas totalizando quarenta e sete horas e trinta minutos de observação participante. Foi realizado um grupo focal com seis participantes do curso de formação profissional para taxistas. A análise dos dados foi realizada de maneira qualitativa e seguiu as orientações propostas por Minayo (2001). Os resultados da pesquisa indicaram que os medos característicos do trabalho de taxista, tem relação com os medos da sociedade líquido-moderna, sendo relativos ao sustento próprio e de terceiros; à circulação pela cidade, e ao transporte de passageiros. Em relação a estratégia de inventar a vida de taxista, os resultados apontaram que ela está pautada em elementos de afirmação e negação. / This dissertation is the result from a research that aimed to describe and analyze the strategy to invent the life of taxi drivers in the exercise of immaterial work, considering the fear characteristics of liquid-modern society. In order to do so, the theoretical basis of the present dissertation the use the following concepts: liquid life, liquid-modern society, fear and lifestyle especially supported in Bauman (1999, 2001, 2003, 2004, 2007a, 2007b, 2008, 2009), Gaulejac (2007), Sennett (2012a), Giddens (2002), Deleuze (1992, 1998); immaterial work supported in authors such as Grisci (2008), Mansano (2009b), Gorz (2005), Lazzarato and Negri (2001). The interviews were conducted with fifteen taxi drivers, one syndicate representative and one instructor from a professional training course for taxi drivers. The semi-structured interviews were conducted at various points in the city of Porto Alegre. A participant observation was also conducted in the professional training course for taxi drivers, summing up to forty-seven hours and thirty minutes of participant observation. Additionally, a focus group was carried with six participants from the taxi driver training course. The collected data were analyzed in a qualitative way following the guidelines proposed by Minayo (2001). The results indicated that the characteristic fear of taxi driver worker relates with fears of liquid-modern society, it is related to the support of themselves and others, driving in the city and the transport of passengers. About the strategy to invent the life of taxi driver, the results showed that it is guided by elements of affirmation and negation.

The sharing economy is a topic that is discussed continuously in the media as it continues to grow and large corporations continue to flourish. This disruptive technology in coalition with regulatory question marks has allowed sharing economy companies to change the business landscape in a number of industries in a short amount of time. However, there has been little investigation into how consumers perceive risk when using sharing economy companies in comparison to their traditional counterpart. This thesis looks at both the dimensions of perceived risk in addition to the antecedents of perceived risk in order to establish what makes a consumer perceive something as ‘risky’. A qualitative study was carried out through semi-structured interviews with drivers at UberPOP and Taxi Stockholm, as well as with passengers that have travelled with both companies. From our analysis we conclude that consumers perceived risks as higher in traditional companies in comparison to sharing economy companies.

Esta dissertação é resultado de uma pesquisa que objetivou descrever e analisar como se constitui a estratégia de inventar a vida de taxista no exercício do trabalho imaterial, considerando o medo característico da sociedade líquido-moderna. Para tanto, em termos teóricos e com o objetivo de sustentar a dissertação, trabalhou-se com conceitos de vida líquida, sociedade líquido-moderna, medo e estilo de vida apoiados especialmente em Bauman (1999, 2001, 2003, 2004, 2007a, 2007b, 2008, 2009), Gaulejac (2007), Sennett (2012a), Giddens (2002), Deleuze (1992, 1998); de trabalho imaterial amparado em autores tais como Grisci (2008), Mansano (2009b), Gorz (2005), Lazzarato e Negri (2001). Foram entrevistados quinze taxistas, bem como um representante sindical e um instrutor do curso de formação profissional para taxistas. As entrevistas semiestruturadas foram realizadas em diversos pontos da cidade de Porto Alegre. Foi feita observação participante no curso de formação profissional para taxistas totalizando quarenta e sete horas e trinta minutos de observação participante. Foi realizado um grupo focal com seis participantes do curso de formação profissional para taxistas. A análise dos dados foi realizada de maneira qualitativa e seguiu as orientações propostas por Minayo (2001). Os resultados da pesquisa indicaram que os medos característicos do trabalho de taxista, tem relação com os medos da sociedade líquido-moderna, sendo relativos ao sustento próprio e de terceiros; à circulação pela cidade, e ao transporte de passageiros. Em relação a estratégia de inventar a vida de taxista, os resultados apontaram que ela está pautada em elementos de afirmação e negação. / This dissertation is the result from a research that aimed to describe and analyze the strategy to invent the life of taxi drivers in the exercise of immaterial work, considering the fear characteristics of liquid-modern society. In order to do so, the theoretical basis of the present dissertation the use the following concepts: liquid life, liquid-modern society, fear and lifestyle especially supported in Bauman (1999, 2001, 2003, 2004, 2007a, 2007b, 2008, 2009), Gaulejac (2007), Sennett (2012a), Giddens (2002), Deleuze (1992, 1998); immaterial work supported in authors such as Grisci (2008), Mansano (2009b), Gorz (2005), Lazzarato and Negri (2001). The interviews were conducted with fifteen taxi drivers, one syndicate representative and one instructor from a professional training course for taxi drivers. The semi-structured interviews were conducted at various points in the city of Porto Alegre. A participant observation was also conducted in the professional training course for taxi drivers, summing up to forty-seven hours and thirty minutes of participant observation. Additionally, a focus group was carried with six participants from the taxi driver training course. The collected data were analyzed in a qualitative way following the guidelines proposed by Minayo (2001). The results indicated that the characteristic fear of taxi driver worker relates with fears of liquid-modern society, it is related to the support of themselves and others, driving in the city and the transport of passengers. About the strategy to invent the life of taxi driver, the results showed that it is guided by elements of affirmation and negation.

El objetivo general del proyecto es diseñar y construir un sistema (a nivel de prototipo) para el registro de vales de servicio de transporte de empresa de radio taxis haciendo uso de teléfonos Smartphone y arquitecturas basadas en la WEB. El presente trabajo de título se enmarca en el rubro del transporte público, específicamente en el de los radio taxis en la Región Metropolitana. La idea principal es dar una solución al modo de registros de los servicios prestados por las empresas de radio taxis a clientes (empresas) en convenio. Las empresas de radiotaxis para efectuar cobros a otras organizaciones que tienen algún tipo de convenio, usan vales de servicio para registrar todas sus transacciones. Actualmente estos vales cumplen con el objetivo de registrar los movimientos pero se plantea que es una forma ineficiente de llevar esta información. Se propone una arquitectura introduciendo tecnologías de la información, de tal manera de digitalizar la información contenida en los vales de servicios. El uso de tecnologías como el GPS, red celular, teléfonos Smartphone, permitirá a las empresas de radio taxis, digitalizar el proceso de generación de vales de servicio, y hacer control de gestión de los vehículos de la empresa en pro de dar un mejor servicio. La arquitectura propuesta permitió capturar las posiciones del vehículo de prueba, y enviarlas, en conjunto con los datos del servicio prestado, al servidor remoto. Luego, desde una estación de trabajo se puedo ver los movimientos de una serie de transacciones previas. Las limitaciones, es que el estado de desarrollo del prototipo no permite comercializarlo, si bien cumple con lo ofrecido, pero para ir un paso más allá se debe adecuar a las necesidades de cada empresa que desee contar con las bondades del proyecto. En consecuencia, el diseño y construcción de la aplicación tiene como resultado un prototipo funcional el cual permite hacer lo propuesto en un comienzo: Digitalizar los vales de servicio. La eliminación de los vales de servicios físicos permitirá a las empresas de radio taxis optimizar su trabajo y poder así dar un mejor servicio a sus clientes. Sera posible ofrecerles nuevas funcionalidades que hasta el momento no existe en el mercado. El sistema propuesto tiene proyección a futuro siempre y cuando se profundicen sus funcionalidades de acorde a las necesidades de las empresas interesadas en el proyecto.

This master thesis focuses on selected concepts of air transport, which have a potential of increasing the competitiveness of the sector. The main objective of this paper is to analyze and quantify the economic and environmental benefits of introducing the electronic taxiing concept and the Free Route Airspace concept under conditions of use in the Czech Republic. First two parts of the thesis describe the theoretical background and important international aviation organizations. The main part describes the concepts, the methodology of benefit analyzes and presents the results. The results of analyzes show the main benefits of introducing both the concepts and the economic impact in case of airlines in the form of cost savings associated with fuel and environmental impact in terms of reducing the amount of produced gas emissions.

This Master´s Thesis is designed for services of the carriers on contractual personel transportation and taxi service especially in the Prague. Within the framework of this thesis legislative condition for personal transportation are examined. Thesis is describing the biggest carriers in personal transportation and taxi service. In the end the cell phone aplications, which deal with personal transportation are described.

Theoretical part of the Master's thesis called "Business plan in the area of commercial communication" describes the aspects of business plan as a document and partly the process of such document's evaluation and business financing in general. In the second part of the thesis a business plan of arising company AdGo is created with the use of previously gained knowledge. The primary aim is to create a complete business plan that will determine whether the project is viable or not. Based on the obtained results the project seems to be not only viable but it also seems to have a potential to be a long-life project under certain conditions.

El presente plan de negocio analiza la viabilidad del proyecto empresarial de TaxiAmiga S.A.C. Durante los últimos años se ha podido observar un gran aumento de la delincuencia en el país que, en su mayoría, la parte más afectada es la población femenina. Asimismo, se observa un aumento de mujeres que están optando por trabajar como conductoras de taxis. El proyecto empresarial consiste en la creación de una aplicación móvil de servicios de taxi, exclusivo para mujeres que buscan seguridad y comodidad al momento de trasladarse de un lugar a otro, una conductora mujer transmite dichas cualidades. Además de generar nueva fuente de ingreso para las conductoras, tendrán la tranquilidad de que sus pasajeros son del mismo género. Esta aplicación móvil tendrá una descarga y registro gratuito para usuarias y conductoras. Nuestra fuente de ingreso será la comisión que se cobrará a las conductoras por cada servicio de taxi, que obtendrán mediante las solicitudes por la aplicación móvil de TaxiAmiga. Dicha comisión corresponde al veinte por ciento (20%) del cobro por cada servicio que realice la conductora. Para iniciar el proyecto empresarial se necesitan S/. 109,652.00 que incluye la creación de la aplicación móvil, la adquisición de equipos de cómputo y capital de trabajo, con la cual dará inicio sus operaciones. Los accionistas aportaran el 60% de la cantidad que necesita el proyecto, pero se necesita inversores externos para completar el resto de la inversión. Se proyecta que en el mes diez (10), de iniciado operaciones, comenzara a obtener un flujo constante positivo culminando el primer año con 7,271 clientes con 135,965 servicios realizado. Además, se estima que al mes treinta y dos (32) se podrá recuperar la inversión inicial realizada. Los impulsores de este proyecto son: Clement Felix Aguilar Altamirano, estudiante del último ciclo de la carrera de Administración de Banca y Finanzas; Neglen Jerson Meza Puente, estudiante del último ciclo de la carrera de Administración de Banca y Finanzas; Nubeluz Ccoscco Soto, estudiante del último ciclo de la carrera de contabilidad y Bill Clinton Pozo Soto, estudiante del último ciclo de la carrera de contabilidad. Estamos convencidos de que el proyecto será rentable porqué se ha realizado un estudio de mercado utilizando distintas herramientas de medición y hemos obtenido una tasa de aceptación por parte del mercado objetivo al que nos dirigimos. Al momento de comenzar a utilizar nuestra aplicación de servicio de taxi y comprueben la seguridad que ofrecemos, estarán dispuestos a seguir utilizando nuestro aplicativo. / This business plan analyzes the viability of the TaxiAmiga SAC business project. In recent years, a large increase in crime has been observed in the country, most of which is the most affected part of the female population. Likewise, there is an increase in women who are choosing to work as taxi drivers. The business project consists of the creation of a mobile application for taxi services, exclusively for women seeking security and comfort when moving from one place to another, a female driver transmits these qualities. In addition to generating a new source of income for the drivers, they will have the peace of mind that their passengers are of the same gender. This mobile application will have a free download and registration for users and drivers. Our source of income will be the commission that will be charged to the drivers for each taxi service, which they will obtain through requests by the Taxi Amiga mobile application. Said commission corresponds to twenty percent (20%) of the charge for each service performed by the driver. To start the business project, S /. 109,652.00 which includes the creation of the mobile application, the acquisition of computer equipment and working capital with which it will be necessary to start the project operations. Shareholders will contribute 60% of the amount the project needs, but external investors are needed to complete the rest of the investment. It is projected that in month ten (10), from the start of operations, it would begin to obtain a positive constant flow, culminating the first year with 7,271 clients with 135,965 services performed. In addition, it is estimated that at month thirty-two (32) the initial investment made can be recovered. The promoters of this project are: Clement Felix Aguilar Altamirano, student of the last cycle of the degree in Banking and Finance Administration; Neglen Jerson Meza Puente, student of the last cycle of the career of Banking and Finance Administration; Nubeluz Ccoscco Soto, student of the last cycle of the accounting career and Bill Clinton Pozo Soto, student of the last cycle of the accounting career. We are convinced that the project will be profitable because a market study has been carried out using different measurement tools and we have obtained an acceptance rate by the target market we are targeting. When you start using our taxi service application and check the security we offer, you will be ready to continue using our application. / Trabajo de investigación

京都大学 / 新制・課程博士 / 博士(情報学) / 甲第23320号 / 情博第756号 / 新制||情||129(附属図書館) / 京都大学大学院情報学研究科社会情報学専攻 / (主査)教授 吉川 正俊, 教授 伊藤 孝行, 教授 畑山 満則 / 学位規則第4条第1項該当 / Doctor of Informatics / Kyoto University / DFAM