Esta tese propõe o estudo das relações entre o método infraordinário de observação do cotidiano, desenvolvido por Georges Perec, tendo como foco os romances La Vie mode demploi (1978), do próprio Perec, e Los detectives salvajes (1998), de Roberto Bolaño. O objetivo é, primeiramente, defender a ideia de que Bolaño foi uma espécie de plagiário original de Perec, reconhecendo no romance La Vie mode demploi ressonâncias para a produção de sua mais celebrada obra. Num segundo momento se faz uma analogia entre produção literária e imanência do comum, com destaque para a teoria oulipiana (Oulipo Ouvroir de Littérature Potentielle, espécie de Sala de Costura da Literatura Potencial) como uma arte combinatória. Por fim, apontando semelhanças e diferenças entre esses autores, defendemos a tese de que, apesar das distâncias culturais e geográficas, podemos correlacioná-los pela maneira como potencializam os objetos em suas descrições, revisitam o passado, e tentam subverter a tradição literária. Pode-se afirmar que as possíveis relações entre Perec e Bolaño remontam à revolução narrativa dos anos 70, com a prosa de ambos rasurando certo horizonte estético. E em ambos os romances visualiza-se uma espécie de puzzle literário. Todas essas possibilidades de leitura, interpretação e combinação se encontram nas referidas obras dos escritores elencados. Desse modo, acreditamos que com o método infraordinário de Georges Perec é possível compreender e interpretar melhor alguns escritos de Roberto Bolaño / This thesis proposes the study of relations between linfra-ordinaire method of observing the everyday, developed by Georges Perec, focusing on the novels La Vie mode d' emploi (1978 ), Perec 's own, and Los detectives salvajes (1998 ), Roberto Bolaño. The aim is, first, to defend the idea that Bolaño was a kind of original plagiarist Perec, recognizing the novel La Vie mode d' emploi resonances for the production of his most celebrated work. Secondly it makes an analogy between literary production and immanence of the ordinary, especially the theory oulipiana (Oulipo - Ouvroir of Littérature Potentielle, sort of Sewing Room of Potential Literature) as a combinatory art. Finally, pointing out similarities and differences between these authors, we defend the thesis that, despite cultural and geographical distances, we can correlate them by way potentiate the objects in their descriptions, revisit the past, and attempt to subvert the literary tradition. It can be stated that the possible relations between Perec Bolaño and go back to narrative revolution of the 70s, with prose both rasurando certain aesthetic horizon. In this novels visualized a kind of literary puzzle. All these possibilities of reading, interpretation and combination are listed in these works of writers. Thus, we believe that with Georges Perec linfra-ordinaire method can better understand and interpret the writings of Roberto Bolaño some

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / Esta dissertação tem como proposta investigar as psicoses ordinárias e suas invenções. Partimos dos impasses de nossa prática clínica relativo ao diagnóstico diferencial, buscando identificar quais seriam os principais conceitos utilizados em referência ao mesmo. Sobretudo, apuramos de que maneira estes conceitos se mostram operativos no tratamento possível das psicoses. De forma que o esclarecimento da noção da psicose em psicanálise favorece a compreensão das psicoses ordinárias. Deduzimos que as psicoses, de forma ampla, possuem um aspecto multifacetário e, neste sentido, que as psicoses ordinárias pertencem à diversidade do campo. Estas últimas possuem uma apresentação discreta de fenômenos elementares. Embora a psicose ordinária não seja uma categoria de Jacques Lacan, averiguamos que pode ser depreendida da clínica lacaniana, extraída de uma perspectiva original do autor. Lacan nos faz avançar na ideia de uma direção de tratamento que privilegia a invenção de um significante novo que cumpre a função de sinthoma, exemplificado a partir das elaborações sobre James Joyce e o nó borromeano. O sinthoma é um artifício inventado para dar sustentação ao nó borromeano que é composto pelas instâncias separadas do imaginário, simbólico e real. Supomos que o mais específico das psicoses ordinárias se encontra no modo pelo qual ocorrem suas invenções de amarração do nó borromeano, ou seja, como surgem as compensações da foraclusão do Nome-do-Pai. Nossos dados indicam que a noção de compensação ou suplência que comportam as psicoses ordinárias produz uma forma inédita de apurar suas singularidades, facilitando não apenas o diagnóstico como também a direção do tratamento. / This dissertation is proposed to investigate the common psychoses and their inventions. We left the impasses of our clinical practice for the differential diagnosis in order to identify what are the main concepts used in reference to it. Especially apuramos how these concepts are shown operating in possible treatment of psychosis. In order to clarify the concept of psychosis in psychoanalysis favors the common understanding of psychosis. We deduce that the psychoses, broadly, have a multifaceted aspect and in this sense, that the ordinary psychoses belong to the diversity of the field. The latter have a presentation discrete elementary phenomena. Although psychosis is not an ordinary category of Jacques Lacan, then used to establish what can be deduced from the Lacanian clinic, extracted from a unique perspective of the author. Lacan makes us move towards the idea of a treatment that focuses on a significant new invention that fulfills the function of sinthome exemplified from elaborations on James Joyce and the Borromean knot. The sinthome is a device invented to sustain the Borromean knot which is composed of separate instances of imaginary, symbolic and real. We assume that the more specific psychoses ordinary is occurring in the way of his inventions mooring Borromean knot, or arise as compensation the foreclosure of the Name of the Father. Our data indicate that the notion of compensation or substitutive that involve psychosis ordinary produces a unique way of ascertaining their singularities, facilitating not only the diagnosis but also the direction of treatment.

The notion of an environmental crisis or catastrophe conjures connotations of rupture, emergency, and impermanence: an intermediary moment of chaos in which the normal order of things collapses in on itself only to be brought back to life—or “recovered”—after the crisis is finished. It is by definition an event out of the ordinary, which in turn is idealised as the realm of routine, repetition, and the reproduction of the social order. But how might such crises permeate the body, home, and other ecologies of everyday life? And how might these ecologies be marshalled and transformed in a time of unfolding change? California is currently caught in a cascade of intersecting environmental crises, erupting most spectacularly with the state’s “historic” drought, which lasted from 2011 to 2017 and peaked in 2014/2015. Alongside the drought and its second order ramifications like wild fires and dust storms, the local manifestations of a changing climate are converging to generate among Californians a sense of near-constant crisis that is both powerful and widespread. Based on thirteen months' fieldwork from June 2014 to July 2015 in the arid lands of Central and Southern California, this thesis examines everyday lived experiences of space and time amidst this scene of instability and uncertainty. Each chapter tracks from a different vantage point the ways in which people are experimenting with the material, practical, and symbolic elements of “the ordinary” in response to the discontinuities introduced into daily life by forces beyond their control. It is my assertion that these ongoing and open-ended practices are poorly captured by the concept of “recovery”—a recurrent figure in the anthropology of disaster—which strongly suggests a telos of return to some or another pre-disaster way of life. The central argument of the thesis, then, is that these processes of experimentation must be understood in an analytical framework that embraces rather than disavows the mutual absorption of the ordinary and the event. As such, the thesis examines the improvisational as well as the habitual aspects of everyday life, whilst also directing attention to the generative as well as destructive dimensions of environmental crisis. Sure enough, environmental crises can incite shock and trauma in those that live through them. At their most extreme, they may also reduce life to a state of bare survival. Yet my interlocutors also took great pride in their collective capacities not only to “weather the storm” but also to invent new modes of self-sufficiency in response to their altered physical circumstances. In doing so, they all drew heavily upon images of California’s past in order to make sense of their present and chart paths for future action. As such, the thesis will contribute to anthropologies of disaster, the ordinary, and historical imagination and practice in the contemporary United States.

O presente trabalho tem por objeto de análise seqüências de discordância levadas adiante por correções pelo outro, e seu objetivo é caracterizar a ocorrência de correções pelo outro, sublinhando suas implicações e distinções em relação a outros recursos para discordar. Seguindo a tradição de pesquisa em Análise da Conversa, em que a relação entre correção e discordância tem sido apontada mas não elucidada por completo, cerca de oito horas de registros audiovisuais de interações cotidianas foram geradas, e, nesse corpus, localizadas e reunidas instâncias em que a correção pelo outro levava adiante uma discordância entre os interlocutores. Observou-se que, ocorrendo no início, no meio ou no fim de uma discordância, a correção produz não apenas um questionamento de um item/expressão equivocado no turno do interlocutor, mas centralmente implica o questionamento da apresentação do interlocutor como conhecedor do tópico em debate. Observou-se, ainda, a redução de índices de despreferência por discordância ao longo da seqüência, evidenciando a orientação dos participantes para acentuar progressivamente o debate. Comparando-se com outros recursos para discordar, observou-se que a correção pelo outro intervém mais diretamente no turno do opositor, implica necessariamente anulação da proposta do opositor, permite um monitoramento do ponto em que a discordância foi abandonada (quando é o caso) e, ao implicar a legitimidade do falante sobre o tópico em debate, implica necessariamente a falta de autoridade do interlocutor. Conclui-se, portanto, que a correção pelo outro é um recurso bastante mais agravado do que outros para produzir discordâncias, evidenciando, nas seqüências em que ocorre, a orientação dos participantes para sublinhar a oposição, em lugar de mitigá-la. / This study is aimed at characterizing the occurrence of other-correction in disagreement sequences by focusing on its implication to the sequence and its particularities in relation to other methods for disagreeing. Based on the framework of Conversation Analysis, within which the relationship between other-correction and disagreement has been pointed out, though not yet accounted for in detailed analysis, roughly eight hours of daily interaction were recorded, and instances of other-correction in disagreement sequences were identified. Othercorrections were observed to be implicated in the beginning, middle or end of disagreement sequences, focusing not only on trouble in an item/expression in previous turn, but implying crucially the questioning of the presentation of previous speaker as knowledgeable about the topic. The orientation to preference for disagreement as the sequence progressed was also observed, evidencing participants’ orientation to aggravate the dispute. In comparison to other methods for disagreeing, other-correction was observed to be more directly opposed to previous turn, to imply the opponent’s position as necessarily invalid, to allow the monitoring of moves to abort the sequence (when this is the case), and to necessarily impute lack of authority on the topic to the interlocutor. Other-correction is concluded to be a method engendering much more aggravation than other methods for disagreeing, evidencing the orientation of participants to invest in, rather than mitigate, the opposition.

abstract: Combination therapy has shown to improve success for cancer treatment. Oncolytic virotherapy is cancer treatment that uses engineered viruses to specifically infect and kill cancer cells, without harming healthy cells. Immunotherapy boosts the body's natural defenses towards cancer. The combination of oncolytic virotherapy and immunotherapy is explored through deterministic systems of nonlinear differential equations, constructed to match experimental data for murine melanoma. Mathematical analysis was done in order to gain insight on the relationship between cancer, viruses and immune response. One extension of the model focuses on clinical needs, with the underlying goal to seek optimal treatment regimens; for both frequency and dose quantity. The models in this work were first used to estimate parameters from preclinical experimental data, to identify biologically realistic parameter values. Insight gained from the mathematical analysis in the first model, allowed for numerical analysis to explore optimal treatment regimens of combination oncolytic virotherapy and dendritic vaccinations. Permutations accounting for treatment scheduled were done to find regimens that reduce tumor size. Observations from the produced data lead to in silico exploration of immune-viral interactions. Results suggest under optimal settings, combination treatment works better than monotherapy of either type. The most optimal result suggests treatment over a longer period of time, with fractioned doses, while reducing the total dendritic vaccination quantity, and maintaining the maximum virotherapy used in the experimental work. / Dissertation/Thesis / Doctoral Dissertation Applied Mathematics for the Life and Social Sciences 2016

abstract: Cancer is a major health problem in the world today and is expected to become an even larger one in the future. Although cancer therapy has improved for many cancers in the last several decades, there is much room for further improvement. Mathematical modeling has the advantage of being able to test many theoretical therapies without having to perform clinical trials and experiments. Mathematical oncology will continue to be an important tool in the future regarding cancer therapies and management. This dissertation is structured as a growing tumor. Chapters 2 and 3 consider spheroid models. These models are adept at describing 'early-time' tumors, before the tumor needs to co-opt blood vessels to continue sustained growth. I consider two partial differential equation (PDE) models for spheroid growth of glioblastoma. I compare these models to in vitro experimental data for glioblastoma tumor cell lines and other proposed models. Further, I investigate the conditions under which traveling wave solutions exist and confirm numerically. As a tumor grows, it can no longer be approximated by a spheroid, and it becomes necessary to use in vivo data and more sophisticated modeling to model the growth and diffusion. In Chapter 4, I explore experimental data and computational models for describing growth and diffusion of glioblastoma in murine brains. I discuss not only how the data was obtained, but how the 3D brain geometry is created from Magnetic Resonance (MR) images. A 3D finite-difference code is used to model tumor growth using a basic reaction-diffusion equation. I formulate and test hypotheses as to why there are large differences between the final tumor sizes between the mice. Once a tumor has reached a detectable size, it is diagnosed, and treatment begins. Chapter 5 considers modeling the treatment of prostate cancer. I consider a joint model with hormonal therapy as well as immunotherapy. I consider a timing study to determine whether changing the vaccine timing has any effect on the outcome of the patient. In addition, I perform basic analysis on the six-dimensional ordinary differential equation (ODE). I also consider the limiting case, and perform a full global analysis. / Dissertation/Thesis / Doctoral Dissertation Applied Mathematics 2016

Submitted by ÉVERTON DE TOLEDO HANSER null (cebolamat@yahoo.com.br) on 2016-06-29T18:10:55Z No. of bitstreams: 1 dissertacao - Éverton.pdf: 1347372 bytes, checksum: f12e0b124e947f94dfa18b18550ab0ff (MD5) / Approved for entry into archive by Ana Paula Grisoto (grisotoana@reitoria.unesp.br) on 2016-07-04T12:23:32Z (GMT) No. of bitstreams: 1 hanser_et_me_rcla.pdf: 1347372 bytes, checksum: f12e0b124e947f94dfa18b18550ab0ff (MD5) / Made available in DSpace on 2016-07-04T12:23:33Z (GMT). No. of bitstreams: 1 hanser_et_me_rcla.pdf: 1347372 bytes, checksum: f12e0b124e947f94dfa18b18550ab0ff (MD5) Previous issue date: 2016-06-02 / O objetivo principal deste trabalho é o estudo da teoria de sistemas de equações diferenciais ordinárias autônomas e suas aplicações em modelos matemáticos, enfatizando os sistemas bidimensionais. / The main objective of this work is to study the theory of autonomous ordinary differential equations and their applications in mathematical models, emphasing the two-dimensional systems.

Made available in DSpace on 2015-05-14T12:11:49Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 1248438 bytes, checksum: bfc3b3826f54c039526b533b09e8644b (MD5) Previous issue date: 2013-02-05 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / With its emergence in antiquity to serve therapeutic purposes, the skepticism, unfolded on various facets throughout the history of philosophy. Among them, that seem to have established a time in epistemological debates is one whose formulations are still in modernity along with a project of infallible knowledge of the world. Since then it has become common land in the theory of knowledge lead to a doubt until ultimately suspending so all our knowledge of the world. This text wants to present a Contextualist Theory of Epistemic Justification as an alternative to skepticism. Our main goal is to show that by separating the philosophical context, where skepticism ourselves, context of our everyday lives that common knowledge of the world that we believe possess can be safeguarded. / Com seu surgimento na antiguidade para servir a propósitos terapêuticos, o ceticismo, desdobrou-se sobre várias facetas ao longo da história da filosofia. Dentre elas a que parece ter se estabelecido por vez nos debates epistemológicos é aquela cujas formulações encontran-se ainda na modernidade junto a um projeto de conhecimento infalível do mundo. Desde então tornou-se terreno comum em teoria do conhecimento levar a dúvida até sua ultima instância suspendendo assim todo nosso conhecimento do mundo. Esse texto pretende apresentar a Teoria Contextualista da Justificação Epistêmico como uma alternativa ao ceticismo. Nosso principal objetivo é mostrar que ao separar o contexto filosófico, onde o ceticismo se estabeleceu, do contexto de nossas vidas cotidianas aquele conhecimento comum do mundo que acreditamos possuir pode ser salvaguardado.

Made available in DSpace on 2014-12-17T14:20:11Z (GMT). No. of bitstreams: 1 MairaMCL_TESE_parcial.pdf: 1110322 bytes, checksum: 9dfc9a015f2342535a92e5b767dcb38e (MD5) Previous issue date: 2013-05-17 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / The following research aims to address the image of the ordinary person in the films of the Pontos de Cultura (Culture Points) in Natal-RN. About ten years the Federal Government of Brazil created the Cultura Viva (Living Culture) program. It enabled the State to support financially civil society organizations that had developed cultural works in communities across the country. Along with the resources the program developed, in parallel, another action, Cultura Digital (Digital culture), intended to bring the tools of digital technology for people who have never had access to them. As a result of these initiatives were produced short films. These films were characterized by the presence of the image of the ordinary person. The creation of this type of cultural product was benefited by state initiative, however, it was inserted within a historical, political and cultural construction whose research was necessary for this image understood to be understood by its importance: it is the expression of emancipation the ordinary person and not just as a consumer of culture, it identifies them as the protagonists of the society and recognizes their vital role in its organization / Este trabalho visou tratar da imagem da pessoa comum nos filmes dos Pontos de Cultura de Natal/RN. A partir de 2003 o Governo Federal do Brasil criou o programa Cultura Viva. Por meio de edital, possibilitou-se que o Estado apoiasse financeiramente organiza??es da sociedade civil que tivessem a??es culturais desenvolvidas em comunidades por todo o pa?s. Juntamente com os recursos, o programa desenvolvia paralelamente outra a??o: a Cultura digital; que pretendia levar novas tecnologias para pessoas que nunca tiveram acesso a elas. Como resultado dessas iniciativas, foram elaborados pequenos filmes. Esses, por sua vez, se caracterizaram pela presen?a da imagem da pessoa comum. A cria??o desse tipo de produto cultural foi beneficiada pela iniciativa dos Pontos de Cultura. Estes se fizeram inseridos dentro de uma conjuntura hist?rica, pol?tica e cultural espec?fica cuja investiga??o se fez necess?ria para que essa imagem pudesse ser entendida pela sua import?ncia: a express?o da emancipa??o da pessoa comum como produtora e n?o apenas consumidora cultural e sua identifica??o como protagonista na organiza??o da sociedade

La ferme attire une nouvelle population. Pour manger sainement, pour des vacances rurales ou même pour qu’elle devienne le lieu de vie et de travail. Souvent, cette visite ou ce séjour ne laissent pas les personnes qui les vivent indifférentes. « Que se passe-t-il ? » et « comment ça se passe ? » quand la ferme accueille deviennent la problématique de cette recherche. L’épistémologie dans laquelle elle s’inscrit est celle d’un rapport au monde, énacté, qui autorise la conception de la co-émergence du perçu et du percevant alliée à l’incomplétude. Ainsi « s’accueillir » s’apparente à une mise en mouvement, comme pour une danse de la corporéité. Le corpus qui sert de support à l’étude empirique est au départ une situation d’accueil à la ferme dont l’auteure est aussi paysanne. La méthodologie de traitement, essentiellement en première personne, et intégrant le jeu de l’analogie et des hiérarchies enchevêtrées, aboutit à la proposition d’une étoile à cinq brancjes comme modèle de l’accueil mosaïque. Cette modélisation d’un « s’accueillir » par et dans une sensibilité renouvelée intègre relaxation et intensité des pratiques. La contribution de cette modélisation interroge la mise en œuvre de dispositifs d’accueil à la ferme et hors la ferme, et incite à l’ouverture des champs du possible. / Farms attract new populations. They come in search of healthier food, for rural holidays and even to live and work. A visit rarely leaves people indifferent. “What is happening?” and “How does it work?” when a farm hosts visitors has become the problem of this research. The epistemology to which it belongs comes from the enactment of a relationship with the World that allows the development of co-emergence of the perceived and the perceiver, allied with incompleteness. “Hosting oneself” is therefore akin to setting in motion, a dance of corporeality. The body that serves as support for the empirical research is a situation of hosting at the farm where the author is also the farmer. The methodology adopted is essentially from the perspective of the first person, integrating rules by analogy and intricate hierarchies. The result is the proposition of a five-pointed star model of mosaic hosting. This modelisation of a “host oneself” - by and with a renewed sensitivity - integrates relaxation and the intensity of acts. The modelisation itself puts into question the implementation of hosting facilities on farms, but also outsideof farms, and encourages the field of possibilities to be opened. / Jende berri bat erakartzen du laborantza etxaldeak. Sanoki jateko, baserri munduan opor hartzeko edo berdin, bizi eta lan lekua bilakatzeko. Ardurenean, bisita edo egonaldi horrek, bizi izan duten jendeak hunkiturik uzten ditu. Etxaldea batzarri egile denean, « Zer gertatzen ote da? » eta « nola doaz gauzak? » galdeak aztertu nahi ditu ikerlan honek. Munduarekiko harreman enaktatu batean datza bere epistemologia; hautemana eta hautemailea batera agertzea baimentzen duen kontzeptuaren harremana, osatugabetasunari loturik. Ondorioz, « nork bere burua errezibitzea », mugimenduan jartzea bezala da, gorpuztasunaren dantza baten gisan. Hastapenean, ikerketa enpirikorako erabili korpusa, idazlea laborari daukan etxaldean egin errezibitze egoera bat da. Azterketa metodologia, nagusiki lehen pertsonan, analogia eta hierarkia nahasien jokoa sartuz, bost adarreko izar baten egitera heltzen da harrera mosaikoaren eredu gisa. Sentiberatasun berpiztu batez « nork bere burua errezibitze » hori moldatzeak bere baitan dakar, praktiken lasaitasuna eta bizitasuna. Moldatze horren ekarpenak etxaldeko eta etxaldetik kanpoko harrera baliabideen plantan ematea galdezkatzen du, eta aukeren zelaiaren irekitzera bultatzen.