Global ETD Search

721	Ariadne’s Thread - memory, interconnection and the poetic in contemporary art Fries, Katherine January 2008 (has links) Master of Visual Arts / This Dissertation explores the metaphor of Ariadne’s thread in terms of interconnection, when an element from the everyday is used as a locus linking broader concepts of time and space. Such experiences and associations are reflected in the work of Louise Bourgeois, Eva Hesse, Doris Salcedo, Lucio Fontana, Richard Tuttle, Mona Hatoum, Simone Mangos, Anya Gallaccio and Yoshihiro Suda. In relation to my own work, the metaphor of interconnecting thread allows a sense of freedom and journey of discovery. My studio and related research are closely aligned in developing my understanding of interconnection, through my studio process of making and continuing experiences of looking at and interpreting others artists’ work. contemporary art Ariadne’s thread poetic memory interconnection sculpture painting installation photography Kath Fries drawing The Greek myth of Ariadne’s thread The metaphor of the labyrinth Threads, webs and narratives The Fates of ancient Greece Spiderwoman creation myths Louise Bourgeois Eva Hesse Tracing scars, cracks and ruptures Doris Salcedo Lucio Fontana Richard Tuttle Interwoven Memories Mona Hatoum Simone Mangos Anya Gallaccio Yoshihiro Suda the everyday in contemporary art slumbering artwork Life-support Dancing with Silence Shibboleth Wall whispers Unfurl I wanted to tell you To have and to hold Mirror, Mirror Encroach
722	Reversing Cancer Cell Fate: Driving Therapeutic Differentiation of Hepatoblastoma to Functional Hepatocyte-Like Cells Smith, Jordan L. 20 March 2020 (has links) Background & Aims: Despite advances in surgical care and chemotherapeutic regimens, the five-year survival rate for Stage IV Hepatoblastoma (HB), the predominant pediatric liver tumor, remains at 27%. YAP1 and β-Catenin co-activation occurs in 80% of children’s HB; however, a lack of conditional genetic models precludes exploration of tumor maintenance and therapeutic targets. Thus, the clinical need for a targeted therapy remains unmet. Given the predominance of YAP1 and β-catenin activation in children’s tumors, I sought to evaluate YAP1 as a therapeutic target in HB. Approach & Results: Herein, I engineered the first conditional murine model of HB using hydrodynamic injection to deliver transposon plasmids encoding inducible YAP1S127A, constitutive β-CateninDelN90, and a luciferase reporter to murine liver. Tumor regression was evaluated using in vivo bioluminescent imaging, and tumor landscape characterized using RNA sequencing, ATAC sequencing and DNA foot-printing. Here I show that YAP1 withdrawal in mice mediates >90% tumor regression with survival for 230+ days. Mechanistically, YAP1 withdrawal promotes apoptosis in a subset of tumor cells and in remaining cells induces a cell fate switch driving therapeutic differentiation of HB tumors into Ki-67 negative “hbHep cells.” hbHep cells have hepatocyte-like morphology and partially restored mature hepatocyte gene expression. YAP1 withdrawal drives formation of hbHeps by modulating liver differentiation transcription factor (TF) occupancy. Indeed, tumor-derived hbHeps, consistent with their reprogrammed transcriptional landscape, regain partial hepatocyte function and can rescue liver damage in mice. Conclusions: YAP1 withdrawal, without modulation of oncogenic β-Catenin, significantly regresses hepatoblastoma, providing the first in vivo data to support YAP1 as a therapeutic target for HB. Modulating YAP1 expression alone is sufficient to drive long-term regression in hepatoblastoma because it promotes cell death in a subset of tumor cells and modulates transcription factor occupancy to reverse the fate of residual tumor cells to mimic functional hepatocytes. Therapeutic Differentiation Targeted Therapy Pediatric Cancer Oncogene Liver cancer Mouse Model Conditional Model Genetic Inducible Hepatoblastoma Oncogene Addiction Tumor Dormancy Drug Discovery YAP B-Catenin Hydrodynamic Injection Sleeping Beauty System Tranposase Lineage Tracing Cancer Biology Cell Biology Digestive System Digestive System Diseases Disease Modeling Gastroenterology Genetic Processes Genetics Hepatology Laboratory and Basic Science Research Medical Molecular Biology Molecular Genetics Neoplasms Oncology Pediatrics Translational Medical Research
723	Rhetoric or reality : US counterinsurgency policy reconsidered Todd, Maurice L. January 2015 (has links) This study explores the foundations of US counterinsurgency policy and doctrine in order to better understand the main historical influences on that policy and doctrine and how those influences have informed the current US approach to counterinsurgency. The results of this study indicate the US experience in counterinsurgency during the Greek Civil War and the Huk Rebellion in the Philippines had a significant influence on the development of US counterinsurgency policy and doctrine following World War II through the Kennedy presidency. In addition, despite a major diversion from the lessons of Greece and the Philippines during the Vietnam War, the lessons were re-institutionalized in US counterinsurgency policy and doctrine following the war and continue to have significant influence today, though in a highly sanitized and, therefore, misleading form. As a result, a major disconnect has developed between the “rhetoric and reality” of US counterinsurgency policy. This disconnect has resulted from the fact that many references that provide a more complete and accurate picture of the actual policies and actions taken to successfully defeat the insurgencies have remained out of the reach of non-government researchers and the general public. Accordingly, many subsequent studies of counterinsurgency overlook, or only provide a cursory treatment of, aspects that may have had a critical impact on the success of past US counterinsurgency operations. One such aspect is the role of US direct intervention in the internal affairs of a supported country. Another is the role of covert action operations in support of counterinsurgency operations. As a result, the counterinsurgency policies and doctrines that have been developed over the years are largely based on false assumptions, a flawed understanding of the facts, and a misunderstanding of the contexts concerning the cases because of misleading, or at least seriously incomplete, portrayals of the counterinsurgency operations. 355.02
724	Horizontal Inequalities in the Nagorno-Karabakh Conflict : Studying the Emergence of the Karabakh Movement Smbatyan, Hayk January 2022 (has links) Ethnic contentions would barely arise at the drop of a hat. To understand the roots of the Nagorno-Karabakh conflict, known as one of the most intractable ethnopolitical conflicts in the South Caucasus region, it is crucial to trace back to the Karabakh movement, a civic uprising that mobilized ethnic Armenians around a struggle for independence. What advantages would self-determination allow, that would not be achievable elsewise? To address this puzzle, I conducted a qualitative single-case study, designed as a deductive process-tracing, aimed at answering the research question why does political mass mobilization emerge (when it can possibly not)? Building upon relevant literature suggesting that horizontal inequalities lead to civil war, this research tests the following hypothesis: Perceived horizontal inequalities between coexisting ethnic groups are what underlie the emergence and evolvement of political mass mobilization. The comparative analysis of 11 in-depth interviews with Karabakh movement participants from Stepanakert and Yerevan, combined with an extensive investigation of over 120 secondary materials, suggests that, as was observed in the case explored, relative deprivation fed by experienced horizontal inequalities is what underlies the emergence of mass political movements, demonstrating strong explanatory potential within the theory on horizontal inequality. Nagorno-Karabakh conflict Karabakh movement horizontal inequality process-tracing conflict peace intractable conflict mass mobilization civic uprising ethnicity comparative analysis theory-testing social movements Armenia Azerbaijan Nagorno-Karabakh qualitative research карабахское движение конфликт мир массовая мобилизация этничность сравнительный анализ проверка теории Армения Азербайджан Нагорный Карабах Övrig annan samhällsvetenskap
725	Aspects of money laundering in South African law Van Jaarsveld, Izelde Louise 04 1900 (has links) Money laundering involves activities which are aimed at concealing benefits that were acquired through criminal means for the purpose of making them appear legitimately acquired. Money laundering promotes criminal activities in South Africa because it allows criminals to keep the benefits that they acquired through their criminal activities. It takes place through a variety of schemes which include the use of banks. In this sense money laundering control is based on the premise that banks must be protected from providing criminals with the means to launder the benefits of their criminal activities. The Financial Intelligence Centre Act 38 of 2001 (‘FICA’) in aggregate with the Prevention of Organised Crime Act 121 of 1998 (‘POCA’) form the backbone of South Africa’s anti-money laundering regime. Like its international counterparts FICA imposes onerous duties on banks seeing that they are most often used by criminals as conduits to launder the benefits of crime. In turn, POCA criminalises activities in relation to the benefits of crime and delineates civil proceedings aimed at forfeiting the benefits of crime to the state. This study identifies the idiosyncrasies of the South African anti-money laundering regime and forwards recommendations aimed at improving its structure. To this end nine issues in relation to money laundering control and banks are investigated. The investigation fundamentally reveals that money laundering control holds unforeseen consequences for banks. In particular, a bank that receives the benefits of crimes such as fraud or theft faces prosecution if it fails to heed FICA’s money laundering control duties, for example, the filing of a suspicious transaction report. However, if the bank files a suspicious transaction report, it may be sued in civil court by the customer for breach of contract. In addition, if the bank parted with the benefits of fraud or theft whilst suspecting that the account holder may not be entitled to payment thereof, it may be sued by the victim of fraud or theft who seeks to recover loss suffered at the hand of the fraudster or thief from the bank. Ultimately, this study illustrates that amendment of some of the provisions of South Africa’s anti-money laundering legislation should enable banks to manage the aforementioned and other unforeseen consequences of money laundering control whilst at the same time contribute to the South African anti-money laundering effort. / Criminal and Procedural Law / Mercantile Law / LL.D. Money laudering control Banks Globalisation of criminal activity Money Bank-customer relationship Bank confidentiality Safe-harbour provisions Ownership of deposited money Proceeds of crime Statement of Principles Forty Recommendations Council of Europe Third Anti-Money Laundering Directive KYC Standard Customer due diligence Vienna Convention Strasbourg Convention Proceeds of Crime Act 2002 Bank Secrecy Act Patriot Act Financial Crimes Enforcement Network Common-law ownership remedies Constructive trust Tracing Rei vindicatio Quasi-vindictory action Actio Pauliana Interdicts Unjust enrichment condictiones Civil forfeiture Innocent owner defence 345.268068 Money laundering -- Prevention Banking law -- South Africa Banking law
726	Aspects of money laundering in South African law Van Jaarsveld, Izelde Louise 04 1900 (has links) Money laundering involves activities which are aimed at concealing benefits that were acquired through criminal means for the purpose of making them appear legitimately acquired. Money laundering promotes criminal activities in South Africa because it allows criminals to keep the benefits that they acquired through their criminal activities. It takes place through a variety of schemes which include the use of banks. In this sense money laundering control is based on the premise that banks must be protected from providing criminals with the means to launder the benefits of their criminal activities. The Financial Intelligence Centre Act 38 of 2001 (‘FICA’) in aggregate with the Prevention of Organised Crime Act 121 of 1998 (‘POCA’) form the backbone of South Africa’s anti-money laundering regime. Like its international counterparts FICA imposes onerous duties on banks seeing that they are most often used by criminals as conduits to launder the benefits of crime. In turn, POCA criminalises activities in relation to the benefits of crime and delineates civil proceedings aimed at forfeiting the benefits of crime to the state. This study identifies the idiosyncrasies of the South African anti-money laundering regime and forwards recommendations aimed at improving its structure. To this end nine issues in relation to money laundering control and banks are investigated. The investigation fundamentally reveals that money laundering control holds unforeseen consequences for banks. In particular, a bank that receives the benefits of crimes such as fraud or theft faces prosecution if it fails to heed FICA’s money laundering control duties, for example, the filing of a suspicious transaction report. However, if the bank files a suspicious transaction report, it may be sued in civil court by the customer for breach of contract. In addition, if the bank parted with the benefits of fraud or theft whilst suspecting that the account holder may not be entitled to payment thereof, it may be sued by the victim of fraud or theft who seeks to recover loss suffered at the hand of the fraudster or thief from the bank. Ultimately, this study illustrates that amendment of some of the provisions of South Africa’s anti-money laundering legislation should enable banks to manage the aforementioned and other unforeseen consequences of money laundering control whilst at the same time contribute to the South African anti-money laundering effort. / Criminal and Procedural Law / Mercantile Law / LL.D. Money laudering control Banks Globalisation of criminal activity Money Bank-customer relationship Bank confidentiality Safe-harbour provisions Ownership of deposited money Proceeds of crime Statement of Principles Forty Recommendations Council of Europe Third Anti-Money Laundering Directive KYC Standard Customer due diligence Vienna Convention Strasbourg Convention Proceeds of Crime Act 2002 Bank Secrecy Act Patriot Act Financial Crimes Enforcement Network Common-law ownership remedies Constructive trust Tracing Rei vindicatio Quasi-vindictory action Actio Pauliana Interdicts Unjust enrichment condictiones Civil forfeiture Innocent owner defence 345.268068 Money laundering -- Prevention Banking law -- South Africa Banking law
727	Channel Probing for an Indoor Wireless Communications Channel Hunter, Brandon 13 March 2003 (has links) (PDF) The statistics of the amplitude, time and angle of arrival of multipaths in an indoor environment are all necessary components of multipath models used to simulate the performance of spatial diversity in receive antenna configurations. The model presented by Saleh and Valenzuela, was added to by Spencer et. al., and included all three of these parameters for a 7 GHz channel. A system was built to measure these multipath parameters at 2.4 GHz for multiple locations in an indoor environment. Another system was built to measure the angle of transmission for a 6 GHz channel. The addition of this parameter allows spatial diversity at the transmitter along with the receiver to be simulated. The process of going from raw measurement data to discrete arrivals and then to clustered arrivals is analyzed. Many possible errors associated with discrete arrival processing are discussed along with possible solutions. Four clustering methods are compared and their relative strengths and weaknesses are pointed out. The effects that errors in the clustering process have on parameter estimation and model performance are also simulated. multipath multipath propagation propagation environment indoor propagation indoor multipath indoor multipath propagation channel probing channel probing indoor wireless communications channel indoor wireless communications indoor wireless communications wireless communications wireless communications channel MIMO SISO multiple input multiple output single input single output antenna diversity antenna diversity antenna array channel modeling modeling model wireless propagation clustering methods clustering algorithms clustering parameter estimation parameter channel matrix h matrix ray tracing point spread function psf deconvolution clean algorithm clean algorithm antenna pattern network analyzer temporal pattern 2.4 ghz system 6 ghz system channel capacity capacity estimate channel capacity estimate propagation environment scattering transfer matrix matrix water filling solution water filling method water filling Saleh Valenzuela Saleh and Valenzuela Model arrival time of arrival angle of arrival direction of arrival arrival amplitude arrivals antenna positioner data simulations measurements angle of departure direction of departure correlation convolution errors error CFA CFAD constant false alarm constant false alarm detection signal signal dependent clutter clutter returns transmitter transmit receive receiver transmit antenna receive antenna spatial correlation system PSF system point spread function mapping fuzzy c-means clustering fuzzy clustering c-means clustering c-means fuzzy k-means euclidean distance time amplitude delay performance prediction performance prediction errors fuzzy weighted distance method rectangular method weighted rectangular method statistics statistical statistical model Electrical and Computer Engineering

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