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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
41

Os prantos e os banka : manifestações poeticas sobre a morte na literatura galego-portuguesa e japonesa

Soda, Nahomi 20 August 2002 (has links)
Orientador: Haquira Osakabe / Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Estudos da Linguagem / Made available in DSpace on 2018-08-02T00:34:18Z (GMT). No. of bitstreams: 1 Soda_Nahomi_M.pdf: 3780593 bytes, checksum: 69ffc1e683ec031ff11be8d87de7224c (MD5) Previous issue date: 2001 / Resumo: A dissertação compara um grupo de poemas associados ao gênero de lamentação fúnebre, presentes na lírica galego-portuguesa da Idade Média e na literatura japonesa da antigüidade. Na parte galego-portuguesa foram escolhidos poemas produzidos nas cortes feudais da Península Ibérica nos séculos XIII e XIV e conservados nos Cancioneiros. Na parte japonesa, foram estudados os poemas que figuram em três obras, a saber, duas historiografiasde caráter mítico-Iendárioe uma antologia lírica chamada Man' yõshú. Essas três obras japonesas foram compiladas nos séculos VII e VIII, quando o Japão se organizava em um Estado. Quanto à organização do trabalho, primeiramente as características de cada cultura lírica foram examinadas em separado e, na conclusão, foi realizado seu confronto. Embora duas manifestações líricas não tenham pertencido à mesma civilização nem a período idêntico, o gênero de lamentação, em ambas, mostra uma grande similaridade. No trabalho, discute-se sobretudo a função geral do gênero de lamentação nas sociedadese nos períodos focalizados / Abstract: This work examine one group of poetry associated to funeral lamentation, existing in the middle age of Galician-Portuguese lyric and in the antiquity of Japanese literature. Some poems realized in the feudal courts during the XII and XIVth century and preserved in the collective anthologies were picked up from the Galician-Portuguese literature. Fromthe Japanese literature, poems figured in three works, two historiography of mythical-legendary character called Kojild e Shoki, and one lyric anthology called Manyoshu, were chosen. These three works were prepared in the VIIth and VIIIth century while Japan was being organized into State. The characteristics of chosen poems of Galician-Portuguese literature and the Japanese literature, were studied separately and then were compared. The two literaturedid not belong to the same civilization nor the same period and thus, no direct relationshipwas found. However, their funerall amentation show a great similarity. This study might help to understand the general role of the lamentation in the focused society or period / Mestrado / Literatura Geral e Comparada / Mestre em Teoria e História Literária
42

The Court of Louis XIII, 1610-1643

Jaffre, Marc W. S. January 2017 (has links)
Louis XIII's reign has long garnered historians' and popular interest. The king of Cardinal Richelieu and the three musketeers, Louis is traditionally viewed as having presided over the development of the French state and facilitated the rise of absolutism. Yet his court has received comparatively little attention. Traditionally understood as the reflection of its master, Louis XIII's court has been assumed to be backwards and inconsequential. On the contrary, this thesis contends that Louis's court experienced substantial institutional development and expansion over the course of his rule. Neither Louis nor Richelieu was the principal instigator of this growth. The main drivers were the courtiers themselves who sought to expand their prerogatives and to find new ways of profiting from their offices. The changes that were initiated from the top down were not determined by a broad, sweeping agenda held by Louis or his minister-favourites but rather by immediate needs and contingencies. Cardinal Richelieu, nonetheless, recognised that Louis's court really mattered for high politics in this period: the royal households produced key players for the governance of the realm, either gravitating from court office to broader governmental office, or holding both simultaneously. Furthermore, Louis's court helped to bind the realm together, not just because it acted as a hub attracting people from the provinces but also because of the time it spent in the provinces. Richelieu, however, struggled to control this court — so vital to the direction of the French monarchy in this period — because its members were so active and vibrant. They shaped the cultural and social environment surrounding and associated with the court because they were heavily invested in the court as an institution. Indeed, the court did not only serve the needs of the monarch: courts could only operate because a large group of people had a stake in ensuring that they functioned. By establishing the importance of Louis XIII's court for the direction of the French monarchy, and his courtiers' role in moulding it, this thesis seeks to throw light on humans' fundamental relationship with power.
43

The role of collagen XIII in B-cell lymphoma development, and characterization of its biosynthesis and tissue distribution

Tuomisto, A. (Anne) 25 November 2008 (has links)
Abstract Collagen XIII belongs to the subgroup of collagenous transmembrane proteins. It has a wide tissue distribution and has been localized to many sites of cell-matrix and cell-cell interaction in tissues. Biochemical and in silico analyses of collagen XIII and other collagenous transmembrane proteins revealed that the biosynthesis of this structurally varied group is characterized by a coiled-coil motif following the transmembrane domain, and these trimerization domains appear to be associated with each of the collagenous domains. The collagen XIII trimer was shown to have an interchain disulfide bond at the junction of the NC1 and COL1 domains, and several other collagenous transmembrane proteins have a pair of cysteines in the same location. Furthermore, furin cleavage at the NC1 domain can be expected in most of the proteins. Mice heterozygous for the Col13a1del transgene, encoding a mutant collagen XIII, developed clonal mature B-cell lineage lymphomas originating in the mesenteric lymph node (MLN). The incidence of disease in conventionally reared mice was 2-fold higher than for mice raised in a specific pathogen-free facility. The lymphomas often associated with large populations of macrophages and T cells. Lymphomas expressed little if any collagen XIII, suggesting that the effect of the mutation was B-cell extrinsic and likely to be associated with collagen XIII-positive tissues drained by the MLN. Studies of the small intestines of transgenic mice showed highly abnormal subepithelial basement membranes (BM), associated with heightened expression of genes involved in immune responses. These findings suggest that collagen XIII-dependent maintenance of the intestinal BM is a critical determinant of cancer susceptibility. Collagen XIII exhibited a wide tissue distribution at the protein level, and the most intense expression was found in lung. Tissues contained 1-4 collagen XIII polypeptides, their size ranging between 78 and 102 kDa. Collagen XIII staining was detected in a restricted set of blood vessels in the liver, pancreas, adrenal gland, epididymis and brain. Moreover, Col13a1del transgene expression in the absence of endogenous collagen XIII proved to be deleterious for mouse embryonal development, leading to early fetal mortality.
44

O sagrado, a morte e o dom : o martírio mendicante no século XIII

Boenavides, Dionathas Moreno January 2018 (has links)
Esta dissertação tem como tema o martírio cristão em escritos mendicantes no século XIII. Busca aprofundar reflexões sobre a temática martirológica da seguinte maneira: primeiramente, posiciona o martírio em relação a outros tipos de morte, destaca os fatores de aproximação e distanciamento entre o morto comum e o mártir e levanta, a partir da análise dos conceitos de “sagrado” e “violência”, duas hipóteses explicativas para a diminuição de canonizações oficias de mártires no século XIII. Uma trata dos problemas em torno do sujeito que executa o papel ativo na cena do martírio, ou seja, o assassino. Outra reflete sobre dispositivos de controle da violência e a possibilidade de terem diminuído o status oficial do mártir. Após, visa analisar como os conceitos de martírio e mártir eram trabalhados nos escritos das ordens franciscana e dominicana e como se distanciavam de alguns conceitos que antecederam essas ordens. A partir da história intelectual, percebe-se que em alguns momentos após as perseguições aos cristãos no âmbito do Império Romano, a morte deixou de ser exigida, sendo enfatizado o sofrimento para a configuração do mártir. Os mendicantes efetuam um retorno à exigência da morte. Por último, centra a atenção sobre Pedro de Verona, mártir dominicano morto em 1252 e canonizado em 1253. Propõe-se, por um viés de antropologia histórica, analisar as relações de intercâmbio em que o frade foi visto como participante pelos produtores dominicanos de textos sobre sua vida, morte e culto. / This paper works with the Christian martyrdom in the mendicant writings of the thirteenth century. In three chapters, it seeks to deepen reflections on the subject of martyrology as follows: in the first one, it positions martyrdom in relation to other types of death, highlights the factors of approximation and distance between the common dead and the martyr and raises, from the analysis of the concepts of “sacred” and “violence”, two explanatory hypotheses for the reduction of official canonizations of martyrs in the thirteenth century. One deals with the problems surrounding the subject who performs the active role in the scene of martyrdom, that is, the killer. Another reflects on the mechanisms to control violence and the possibility of it having diminished the official status of the martyr. The second chapter aims at analyzing how the concepts of martyrdom and martyr were worked out in the writings of the Franciscan and Dominican orders and how they deviated from some concepts that preceded these Orders. Through intellectual history, it can be seen that at some moments after the persecution of Christians under the Roman Empire, death was no longer required, and the suffering was emphasized for the configuration of the martyr. The mendicants make a return to the requirement of death. The third chapter focuses on Peter of Verona, a Dominican martyr who died in 1252 and was canonized in 1253. It is proposed, through a bias of historical anthropology, to analyze the relations of exchange in which the friar was seen as a participant by the Dominican producers of texts about his life, death and cult.
45

Le commandement nouveau en Jean 13,34-35 dans le cadre du premier discours d'adieu (13,33-14,31)

Boulet, Sylvie 06 March 2022 (has links)
Le présent mémoire étudie le commandement nouveau (Jn 13,34-35) en le situant dans le contexte du premier discours d'adieu (Jn 13,33-14,31). L'analyse structurelle montre que ce discours est composé d'une introduction (13,33-38) comportant deux thèmes: le retour de Jésus vers son Père et l'amour. Ces deux thèmes sont ensuite développés dans un corps central (14,1-24), lui-même subdivisé en deux sous-unités qui traitent l'une du retour (14,1-14) et l'autre de l'amour (14,15-24). Une conclusion (14,25-31) reprend ces deux thèmes. Ce contexte permet de préciser le sens du commandement nouveau en l'inscrivant dans une mission bien particulière: les disciples poursuivent la mission de Jésus pour rendre présente au monde la communauté eschatologique, communauté fondée sur la communauté de vie qui unit le Père, le Fils et les disciples.
46

Cataluña y el Rey. Representaciones y prácticas de la Majestad durante el cambio de soberanía (1640-1655) / Catalonia and the King. Representations and practicing of Majesty between tow sovereignties (1640-1655) / Catalogne et le roi. Représentations et pratiques de la majesté entre deux souverainetés (1640-1655)

Aznar, Daniel 09 September 2016 (has links)
L’intégration de la Catalogne dans la monarchie française en 1641, ouvre une période de coexistence de deux univers politiques différents. Pour la France, l’incorporation de cette nouvelle province intervient dans une société marquée par une culture de l’héroïsme. Le règne de Louis XIII coïncide avec son âge d’or, puisqu’il sert de fondement au pouvoir royal et de référence pour l’ethos nobiliaire. La guerre qui s’ensuit, porte la culture de l’héroïsme à son paroxysme. La proclamation du roi comme souverain de Catalogne ouvre de nouveaux horizons à cet imaginaire politique revitalisant un messianisme qui substitue un prince français au souverain espagnol. Le récit de l’entreprise catalane produit par l’entourage royal offre une nouvelle perspective à la construction de l’image de Louis XIII. L’horizon catalan «achève» la fabrication de son profil héroïque et lui sert d’apothéose, valorisant à posteriori la mort «sacrificielle» du roi conséquence de sa présence au siège de Perpignan. Les vice-rois se retrouvent également au centre d’un discours héroïque, protagonistes d’une véritable épopée catalane. Les lumières et les zones d’ombres de ces expériences de l’héroïsme apparaissent dans le devenir, parfois tragique, de ces représentants du roi. Outre les défis militaires et politiques relevant de leur charge, ils doivent faire face aux équilibres de pouvoir relevant de la cour. Côté catalan, l’avènement de Louis XIII s’inscrit dans la dynamique «révolutionnaire» entamée en 1640. Le meneurs de la révolte, qui protestent néanmoins de leur fidélité à Philippe IV, formulent un récit capable de donner une cohérence aux tumultes et à l’instabilité permanente de la situation. L’horizon d’une «restauration» providentielle de Catalogne apparaît alors. L’issue républicaine semble ici introuvable entre l’interruption formelle de la juridiction de Philippe IV et l’acclamation de Louis XIII. Dès lors un discours providentielle de restauration de la Principauté se développe à travers une royauté messianique incarnée par un nouveau prince. L’image du roi devient un idéal sur lequel les dirigeants catalans projettent leurs attentes politiques et se justifient. La visite à Barcelone, annulée in extremis, précède de peu sa mort. Les funérailles royales servent alors à magnifier ce récit, et offrent par l’image du roi «sacrifié» et à canoniser, un emblème pour la Catalogne française. / The integration of Catalonia into the French Monarchy in 1641 opens a period of coexistence of two political universes. In France, the incorporation of the new province arrives in a social context under the influence of a strong culture of heroism. Under Louis XIII’s reign culminates a process of reformulation of the heroic paradigm: a political model of government and an ethical referent for the French nobility. The heroic culture is taken to its paroxysm when the Spanish war begins. The proclamation of the king as sovereign of Catalonia opens new horizons for this imagery, mobilizing also old messianic referents. The narrative of the Catalan enterprise developed by the royal entourage offers a new perspective of Louis XIII’s image making process. This Catalan enterprise completes the build of the king’s heroic profile, and serves to make his apotheosis, emphasizing the fact of a sacrificial death as a consequence of the royal presence in the Perpignan’s siege.The viceroys become the center of a heroic narrative also. They are protagonists of a true «Catalan epic». The light and darkness of this heroic experience of politics appear through the destiny, sometimes tragic, of these king’s agents (and images). They have to face, besides the military and political challenges, the power struggles in court. On the Catalan side, the accession of king Louis XIII has to be considered in the «revolutionary» context of 1640. The leaders of the revolt, who claim to be loyal to their king, Philip IV, build a narrative able to tame serious adverse events that sometimes escape their control. The horizon of a providential «restoration» of Catalonia appears in this narrative. Republican time seems here «unfound», between the broken of one king’s jurisdiction and the other king proclamation. Since then a providential propaganda speech about the restoration of the Principality through a Messianic Royalty incarnated by the new prince. The new king’s figure becomes one idealized image where Catalans look to project their political expectations, as well as a way for the Catalan leaders to justify themselves. The failed royal visit to Barcelona shortly precedes the king’s death. The royal funerals serve to the crystallization of these narratives: they offer the image of a «sacrificed» king, who is also a saint. He becomes the real emblem of the Franco-Catalan regime.
47

Desenvolvimento de um sistema para a gestão de desempenho dos centros de atenção psicossocial (CAPS) em um departamento regional de saúde / not available

Sasso, Ariane Morassi 28 September 2015 (has links)
Nos últimos 40 anos, o modelo de atenção em saúde mental sofreu profundas modificações, sendo que desde a década de 70 diversos movimentos sociais e profissionais impulsionaram a Reforma Psiquiátrica e o processo de desinstitucionalização. Este, pregava o fim do modelo asilar vigente, responsável pela exclusão e cronificação de doentes, para dar lugar a criação de um novo modelo guiado por serviços extra-hospitalares e mais humanitários, tendo como principal representante os Centros de Atenção Psicossocial (CAPS). Esses serviços foram considerados a porta de entrada da rede de atenção à saúde mental e tem como responsabilidade estabelecer iniciativas conjuntas de levantamento de dados relevantes sobre os principais problemas e necessidades de saúde mental no território. Para tanto, necessitam de uma forma de coletar, armazenar e disponibilizar esses dados, de modo a gerar informações que possam auxiliar no processo de gestão e tomada de decisão, para garantir a qualidade do cuidado prestado. A entrada de dados e obtenção dessas informações poderiam ser feitas por meio de um sistema eletrônico, no entanto, percebe-se a ausência de sistema de armazenamento e manipulação de dados com informações técnicas e gerenciais acerca da saúde mental no Sistema Único de Saúde (SUS) e a carência de instrumentos de avaliação e de indicadores para aferir a efetividade do serviço prestado, inclusive no Departamento Regional de Saúde XIII do Estado de São Paulo (DRS XIII), que é o foco desse projeto. Dessa maneira, torna-se necessário o desenvolvimento de um sistema informatizado, que auxilie os CAPS dessa região nessa coleta e armazenamento de dados e na geração de indicadores e relatórios que se mostrem eficazes para a melhoria do serviço como um todo. Dessa forma, no presente projeto, como resultados foram descritos os fluxos de atendimento pelo qual é submetido o paciente em cada CAPS do DRS XIII, foram analisados alguns instrumentos de coleta de dados utilizados pelos mesmos, como o projeto terapêutico e a entrevista psicossocial e ainda, visando melhorar futuramente o armazenamento de dados no sistema, foram feitas sugestões para representação de conceitos na área de saúde mental por meio de arquétipos no padrão openEHR. Além disso, o sistema web foi desenvolvido e está em fase de testes. / In the last 40 years, the mental health care system has undergone profound changes, and since the 70s, various social and professional movements boosted the psychiatric reform and the deinstitutionalization process. This, preached the end of the current asylum model, responsible for the exclusion and chronicity of patients, and made way for a new model driven by more humanitarian outpatient services, wherein the main representatives were the Community Mental Health Services (Centros de Atenção Psicossocial, CAPS). These services are considered the entrance to the mental health network and they have the responsibility for establishing joint initiatives for data collection on key issues and on mental health needs in the territory. To achieve this, they need a way to collect, store and make this data available in order to generate information that can assist in the management and in the decision making process, ensuring the quality of care provided. The data entry and the obtainment of this information could be made through an electronic system, however, we can notice the absence of a system to store and manipulate technical and managerial information about mental health in the Unified Health System (Sistema Único de Saúde, SUS). In addition, there is a lack of assessment tools and indicators to measure the effectiveness of the services, including in the XIII Regional Health Department of the São Paulo State (Departamento Regional de Saúde XIII, DRS XIII), which is the focus of this project. In this way, it becomes necessary to develop a computerized system, which would help CAPS from that region in the data collection and storage of relevant information and in the generation of indicators and reports that may be effective to improve the network as a whole. In this dissertation, as an initial process for the creation of the system, the study of the flow of care a patient is subjected in each CAPS from the DRS XIII is described. Besides that, is also described the study of data collection instruments used by them, such as the therapeutic project and psychosocial interview. Finally, aiming to improve future data storage in the system, suggestions are made for the representation of concepts in the mental health area through archetypes in the openEHR standard.
48

Desenvolvimento de um sistema para a gestão de desempenho dos centros de atenção psicossocial (CAPS) em um departamento regional de saúde / not available

Ariane Morassi Sasso 28 September 2015 (has links)
Nos últimos 40 anos, o modelo de atenção em saúde mental sofreu profundas modificações, sendo que desde a década de 70 diversos movimentos sociais e profissionais impulsionaram a Reforma Psiquiátrica e o processo de desinstitucionalização. Este, pregava o fim do modelo asilar vigente, responsável pela exclusão e cronificação de doentes, para dar lugar a criação de um novo modelo guiado por serviços extra-hospitalares e mais humanitários, tendo como principal representante os Centros de Atenção Psicossocial (CAPS). Esses serviços foram considerados a porta de entrada da rede de atenção à saúde mental e tem como responsabilidade estabelecer iniciativas conjuntas de levantamento de dados relevantes sobre os principais problemas e necessidades de saúde mental no território. Para tanto, necessitam de uma forma de coletar, armazenar e disponibilizar esses dados, de modo a gerar informações que possam auxiliar no processo de gestão e tomada de decisão, para garantir a qualidade do cuidado prestado. A entrada de dados e obtenção dessas informações poderiam ser feitas por meio de um sistema eletrônico, no entanto, percebe-se a ausência de sistema de armazenamento e manipulação de dados com informações técnicas e gerenciais acerca da saúde mental no Sistema Único de Saúde (SUS) e a carência de instrumentos de avaliação e de indicadores para aferir a efetividade do serviço prestado, inclusive no Departamento Regional de Saúde XIII do Estado de São Paulo (DRS XIII), que é o foco desse projeto. Dessa maneira, torna-se necessário o desenvolvimento de um sistema informatizado, que auxilie os CAPS dessa região nessa coleta e armazenamento de dados e na geração de indicadores e relatórios que se mostrem eficazes para a melhoria do serviço como um todo. Dessa forma, no presente projeto, como resultados foram descritos os fluxos de atendimento pelo qual é submetido o paciente em cada CAPS do DRS XIII, foram analisados alguns instrumentos de coleta de dados utilizados pelos mesmos, como o projeto terapêutico e a entrevista psicossocial e ainda, visando melhorar futuramente o armazenamento de dados no sistema, foram feitas sugestões para representação de conceitos na área de saúde mental por meio de arquétipos no padrão openEHR. Além disso, o sistema web foi desenvolvido e está em fase de testes. / In the last 40 years, the mental health care system has undergone profound changes, and since the 70s, various social and professional movements boosted the psychiatric reform and the deinstitutionalization process. This, preached the end of the current asylum model, responsible for the exclusion and chronicity of patients, and made way for a new model driven by more humanitarian outpatient services, wherein the main representatives were the Community Mental Health Services (Centros de Atenção Psicossocial, CAPS). These services are considered the entrance to the mental health network and they have the responsibility for establishing joint initiatives for data collection on key issues and on mental health needs in the territory. To achieve this, they need a way to collect, store and make this data available in order to generate information that can assist in the management and in the decision making process, ensuring the quality of care provided. The data entry and the obtainment of this information could be made through an electronic system, however, we can notice the absence of a system to store and manipulate technical and managerial information about mental health in the Unified Health System (Sistema Único de Saúde, SUS). In addition, there is a lack of assessment tools and indicators to measure the effectiveness of the services, including in the XIII Regional Health Department of the São Paulo State (Departamento Regional de Saúde XIII, DRS XIII), which is the focus of this project. In this way, it becomes necessary to develop a computerized system, which would help CAPS from that region in the data collection and storage of relevant information and in the generation of indicators and reports that may be effective to improve the network as a whole. In this dissertation, as an initial process for the creation of the system, the study of the flow of care a patient is subjected in each CAPS from the DRS XIII is described. Besides that, is also described the study of data collection instruments used by them, such as the therapeutic project and psychosocial interview. Finally, aiming to improve future data storage in the system, suggestions are made for the representation of concepts in the mental health area through archetypes in the openEHR standard.
49

Étude des facteurs de l'hémostase après thrombolyse par le rT-PA dans l'infractus cérébral aigu : corrélations cliniques et étiologiques / Haemostasis factors after rt-PA thrombolysis in acute cerebral infarct

Sun, Xuhong 15 September 2015 (has links)
L'étude systématique de l'hémostase post-thrombolytique a été peu étudiée. Chez 80 malades thrombolysés consécutifs, une étude prospective a comporté l'étude – aux heures 0, 2 et 24 – des facteurs de l'hémostase suivants: fibrinogène, plasminogène, PDF (produits de dégradation de la fibrine et du fibrinogène), D-dimères, alpha2-antiplasmine et facteur XIII, ainsi que l'hématocrite et la numération plaquettaire. Des calculs statistiques approfondis ont exploré les corrélations des variations des facteurs hémostatiques entre eux et avec 37 paramètres cliniques et étiologiques. Processus moléculaires post-thrombolytiques. Le rt-PA induit deux processus, indépendants statistiquement à la 2ème heure: d'une part une élévation des PDF et des D-dimères; d'autre part, une baisse du fibrinogène, corrélée à une baisse du plasminogène (r=0,48, p=0.01), de l'alpha2-antiplasmine (r=0.48, p =0.004) et du facteur XIII (r=0.44, p=0.01). La baisse du plasminogène est corrélée significativement avec celle de l'alpha2-antiplasmine (r=0.77, p<0.001), et du facteur XIII (r=0.47, p=0.02). La mise en jeu de facteurs anti-fibrinolytiques, qui n'avait jamais été décrite précédemment, peut jouer un rôle dans une limitation de la fibrinolyse et dans la rethrombose. Des corrélations sont notées entre la baisse précoce du plasminogène et l'étiologie cardioembolique (p=0.04), et un mauvais pronostic final (p=0.03), possiblement en rapport la thrombolyse intense de gros caillots. Les hématomes intra-cérébraux parenchymateux (HP) sont liés significativement à la baisse du fibrinogène (p=0.01) et à l'augmentation des PDF (p=0.01). Une baisse du fibrinogène au-dessous de 2g/L multiplie la probabilité de HP précoce par un facteur 12,82. Ainsi est confirmé le modèle d'une “coagulopathie précoce avec dégradation du fibrinogène”», prédictive de l'hématome, proposé par l'équipe lyonnaise de thrombolyse en 2004 / A systematic study of post-thrombolytic haemostasis has rarely been performed. In 80 consecutive patients, we have prospectively studied at hours 0, 2 and 24 the following parameters: fibrinogen, plasminogen, alpha2-antiplasmin, factor XIII, fibrin(ogen) Degradation Products (FDP), D-dimers, haematocrit and platelet count. Comprehensive statistical studies calculated correlations of the haemostatic values betwen themselves and with 38 etiological and clinical parameters. Molecular dynamics. Two changes between h0 and h2 were statistically independent: an increase in FDP and D-Dimers; a decrease in fibrinogen, plasminogen, alpha2-antiplasmin and factor XIII. At h2, the decrease in fibrinogen was significantly correlated with that of plasminogen (0.48, p = 0.01), alpha2-antiplasmin (0.48, p = 0.004), and factor XIII (0.44, p = 0.01). The decrease in plasminogen was significantly correlated with those of antifibrinolytic components, alpha2-antiplasmin (r=0.77, p<0.001) and factor XIII (0.47, p=0.02). To our knowledge, such an activation of antifibrinolytic components had not hitherto been mentioned. The h2 decrease of plasminogen was correlated with cardioembolic etiology (p=0.04) and final poor oucome (p=0.03), a fact possibly due to intense thrombolysis of large clots. Patients having early parenchymal hematomas (PH) showed h2 haemostasis disturbances: high FDP (p=0.01), and low fibrinogen (p=0.01). The decrease in fibrinogen less than 2g/L multiplies the odds of early PH by a factor 12.82. Thus, we confirm the model of an “early fibrinogen degradation coagulopathy” predictive of hematomas, which had been coined by the Lyon thrombolysis team in 2004
50

Collective meaning and specific, prophetic reference in the parables of Matthew 13

Scholtz, Jacob Jan 12 1900 (has links)
Thesis (MTh)--Stellenbosch University, 2013. / ENGLISH ABSTRACT: This thesis investigates whether the parables of Matthew 13 can be understood, both individually and collectively, when they are connected to specific, prophetic referents. After a review of parable research, hermeneutical guidelines are identified in order to interpret the parables of Matthew 13 (chapter 2). Novel guidelines identified include the identification of specific, prophetic referents, the possibility of using details already explained in Matthew 13 in a contextually consistent manner, focusing on the collective meaning of this parabolic discourse and identifying what is new and old in each parable. After considering the structure of Matthew 13 (in chapter 3), these hermeneutical guidelines are applied, focusing on the contextual background (chapter 4) before analysing the parables individually (chapter 5) and collectively (chapter 6). The time period covered by the parables of Matthew 13 as a group is from the days of John the Baptist until the second coming of Jesus Christ. The kingdom of heaven is understood to exist from Pentecost onwards but will only be established when Christ returns, that is, the kingdom of heaven “exists-but-is-not-yet-established”. In Matthew’s presentation, the parable of the sower covers the time period during which Jesus presents the word (or gospel) of the kingdom to Israel only. During that time, Jesus authenticates his Messianic claims to Israel and, by doing so, displays the authority and power bestowed on the Christ to them. But when Jesus is rejected, the treasure is hidden and he goes to the cross to provide the sign of Jonah. After purchasing the field, having received all authority in heaven and on earth, the Son of Man sends good seed not only to Israel, but to all the nations of the world. The sons of the kingdom first sent must include Peter and the other ten disciples who are commanded to go and make disciples. The surprising growth of the Church after the great commission includes, perhaps unexpectedly, also Gentiles, for the Son of Man commences his pearl ministry by baptising not only Jewish and Samaritan but also Gentile believers with the Holy Spirit. At the end of this age, the gospel of the kingdom will again be preached. This time, however, it will be preached not only to Israel, but as a witness to all the nations — and then the present age will end. After the tribulation and judgment of those days, the King returns to unveil the treasure in order to establish the Messianic kingdom on earth. It is submitted that, regardless of one’s eschatological view (this thesis is presented from a dispensational, premillennial perspective), by focusing on specific, prophetic referents and by considering this series of parables in a collective and contextually consistent manner, the parables of Matthew 13 (and perhaps the Gospel of Matthew as a whole) can be understood differently. And it is about understanding all these things that Jesus questions his disciples. / AFRIKAANSE OPSOMMING: Hierdie tesis ondersoek of die gelykenisse van Matteus 13, sowel individueel as kollektief beskou, verstaan kan word wanneer dit met spesifieke, profetiese referente in verband gebring word. Ná ’n oorsig van navorsing oor gelykenisse word hermeneutiese riglyne ontwikkel waarmee die gelykenisse van Matteus 13 geïnterpreteer kan word (hoofstuk 2). Nuwe riglyne wat aangebied word, sluit in die identifisering van spesifieke, profetiese referente, die moontlike gebruik van referente wat reeds in Matteus 13 verklaar is op ’n kontekstueel konsekwente wyse, ’n fokus op die kollektiewe betekenis van hierdie paraboliese diskoers en om wat in elke gelykenis nuut en oud is, te identifiseer. Nadat oorweging aan die struktuur van Matteus 13 geskenk is (hoofstuk 3), word die hermeneutiese riglyne toegepas, eers op die kontekstuele agtergrond (hoofstuk 4), en daarna word elke gelykenis individueel ontleed (hoofstuk 5) voordat dit kollektief beskou word (hoofstuk 6). Daar is bevind dat die tydperk wat hierdie gelykenisse as ’n kollektiewe eenheid dek van die dae van Johannes die Doper af tot by Jesus Christus se wederkoms strek. Die koninkryk van die hemele word begryp as dat dit bestaan vanaf Pinkster maar sal eers opgerig word as Christus terugkeer, dit is, die koninkryk van die hemele “bestaan-maar-is-nog-nie-opgerig-nie”. In Matteus se aanbieding dek die gelykenis van die saaier die tydperk waartydens Jesus die woord (of evangelie) van die koninkryk alleen aan Israel aanbied. Gedurende hierdie tydperk bekragtig Jesus sy Messiaanse aansprake aan Israel en daardeur vertoon Hy aan Israel die mag en krag waarmee die Christus bedeel is. Maar wanneer Jesus verwerp word, word die skat verberg, en Hy gaan na die kruis toe om die teken van Jona te verskaf. Nadat die saailand gekoop is, nadat Hy alle mag in die hemel en op aarde ontvang het, stuur die Seun van die Mens goeie saad, nie net na Israel toe nie, maar na al die nasies van die wêreld. Die seuns van die koninkryk wat eerste gestuur is, moet Petrus en die ander tien dissipels wat beveel is om dissipels te gaan maak, insluit. Die verrassende groei van die Kerk ná die groot opdrag sluit, miskien onverwags, ook heidene in, want die Seun van die Mens begin sy pêrel bediening deur Joodse, Samaritaanse en ook heidense gelowiges met die Heilige Gees te doop. Aan die einde van hierdie eeu sal die evangelie van die koninkryk weer verkondig word, dan egter nie net aan Israel nie maar tot ‘n getuienis aan alle nasies — en dan sal hierdie eeu eindig. Ná die verdrukking en oordeel van daardie dae sal die Koning terugkeer om die skat te openbaar en om die Messiaanse koninkryk op aarde te vestig. Daar word voorgestel dat, ongeag die eskatologiese siening wat gehuldig mag word — en hierdie tesis word aangebied vanuit ’n dispensasionele, premillennialistiese perspektief — die gelykenisse van Matteus 13 (en miskien ook die Evangelie van Matteus as ’n geheel) anders verstaan kan word as daar op spesifieke, profetiese referente gefokus word en hierdie reeks gelykenisse op ’n kollektiewe en kontekstueel konsekwente manier benader word. En juis oor ’n begrip van al hierdie dinge is waaroor Jesus sy dissipels uitvra.

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