Bakgrund: CVK-relaterade infektioner i blodbanan är förenat med förlängd sjukhusvistelse, ökad mortalitet, ökade ekonomiska kostnader samt ökat lidande för patienten. Användningen av centrala venösa katetrar ökar och därmed är risken att drabbas av infektion större. Det finns en bristande kunskap hos sjuksköterskan gällande förebyggandet av dessa infektioner och en bristande följsamhet till riktlinjer. Syfte: Beskriva hur sjuksköterskan kan förebygga CVK-relaterade infektioner i blodbanan. Metod: Allmän litteraturstudie av kvantitativa artiklar. Resultat: En kombination av utbildning, praktiska åtgärder såsom skötsel, hygienrutiner och checklistor samt feedback minskade antalet CVK-relaterade infektioner i blodbanan. Slutsatser: Utbildning, olika typer av praktiska åtgärder samt feedback minskar antalet CVK-relaterade infektioner i blodbanan och är viktigt för sjuksköterskans förebyggande vård. En stor del av vad som framkom i resultat stämmer överens med riktlinjerna för förebyggandet av CVK-relaterade infektioner, dock bör utbildning och feedback prioriteras i högre utsträckning. Det är känt sedan tidigare att följsamhet till riktlinjer bland sjuksköterskor skulle underlätta utförandet av evidensbaserad omvårdnad. Mer fokus bör därför ligga på att få sjuksköterskor att följa riktlinjer. Klinisk betydelse: Studien kan bidra med ökad kunskap hos sjuksköterskor om hur CVK-relaterade infektioner i blodbanan kan förebyggas vilket i sin tur skulle kunna generera bättre vård, minskat lidande för patienten, minskad mortalitet samt ekonomiska besparingar. / Background: CVC-related bloodstream infections often lead to prolonged hospitalization, increased mortality, higher economical cost and more suffering for the patient. The usage of central venous catheters increases and therefore the risk of infection is also higher. When it comes to prevention of these infections there is a lack of knowledge amongst nurses and compliance with the guidelines. Aim: Describe how the nurse can prevent CVC-related bloodstream infections. Method: General literature review of quantitative studies. Results: A combination of education, hands-on initiatives such as management, hygieneroutines and checklists as well as feedback turned out to reduce CVC-related bloodstream infections. Conclusions: Education, different hands-on initiatives and feedback decreases the number of CVC-related bloodstream infection and is essential for the nurse’s preventive care. Most of the results correlate with the guidelines for the prevention of CVC-related bloodsteam infections, nevertheless education and feedback should be prioritized in higher extent. It is known that adherence to guidelines among nurses would facilitate the execution of evidence-based nursing. Therefore more focus should be on having nurses follow the guidelines. Clinical importance: This study would contribute with increased knowledge amongst nurses regarding prevention of CVC-related bloodstream infections which would give better care, diminish the suffering of the patient, decrease mortality and lead to economical benefits.

Submitted by Maicon Juliano Schmidt (maicons) on 2015-06-12T18:55:04Z No. of bitstreams: 1 Juciana Isabel da Silva.pdf: 852716 bytes, checksum: 135012f0748a1ec48c4adcff75e9ea92 (MD5) / Made available in DSpace on 2015-06-12T18:55:04Z (GMT). No. of bitstreams: 1 Juciana Isabel da Silva.pdf: 852716 bytes, checksum: 135012f0748a1ec48c4adcff75e9ea92 (MD5) Previous issue date: 2015-03-27 / Nenhuma / O uso indiscriminado de Cateter Venoso Central (CVC) na Unidade de Terapia Intensiva (UTI) pode causar infecções na corrente sanguínea (ICS), acarretando na busca de estratégias para qualificar a assistência. O objetivo deste estudo é analisar as etapas do processo de Cuidado ao Paciente com Cateter Venoso Central (CPCVC), buscando identificar falhas potenciais e elaborar ações de cuidados em saúde, a fim de prevenir a ICS nas UTIs em estudo. Utilizou-se o Método de Análise de Falhas e Efeitos (FMEA) como estratégia para qualificar o processo de CPCVC na prevenção de ICS nas UTIs de um hospital de grande porte localizado na cidade de Caxias do Sul. O Grupo de Avaliação (GA) foi constituído por onze profissionais de enfermagem que atuam nessas UTIs. A coleta de dados ocorreu em duas etapas: a) pela elaboração do Fluxo de Inserção e Manutenção do Cateter Venoso Central segundo as diretrizes que nortearam este estudo; e b) pela análise do risco das inconformidades com o GA, seguindo o Fluxo de Inserção e Manutenção do Cateter Venoso Central e as etapas do processo de CPCVC. Para o cálculo de risco foram definidas a gravidade (G), a probabilidade de ocorrência (O) e a possibilidade de detecção (D) em cada item avaliado. Esta pesquisa foi aprovada pelo Comitê de Ética e Pesquisa da Universidade do Vale do Rio dos Sinos (Unisinos) e pela Instituição em estudo. As principais inconformidades foram a falta de critério de indicação do CVC e os riscos relacionados a proteção de barreira, inserção e manutenção do CVC. Para a resolução das inconformidades, avaliadas como médio e alto risco, foram elaboradas as seguintes propostas de intervenção: a elaboração de três checklists para prevenção de infecção na corrente sanguínea; dois procedimentos operacionais padrão (POP) para a utilização e a manutenção do CVC; e um Programa de Práticas Educativas em Saúde. Os resultados apontaram que é necessário implementar estratégias para promover ações que possam impedir a ocorrência de falhas potenciais no processo de CPCVC, visando, principalmente, a prevenção de infecção na corrente sanguínea na UTI. / The indiscriminate use of Central Venous Catheter (CVC) in Intensive Care Units (ICU) may cause bloodstream infections, resulting in a search for strategies to qualify the assistance. The main point of this work is to analyse the steps taken in the process of Care of Pacient with Central Venous Catheter, willing to indetify potential failures and to propose actions of caring and permanent health education in order to prevent bloodstream infections in ICUs. The Failures and Effects Mode Analysis was used as a strategy to qualify the process of Care of Pacient with Central Venous Catheter and as a prevention to bloodstream infections in an ICU located in Caxias do Sul. The Evaluation Group (EG) was composed of nine nursing professionals that work at Caxias do Sul-RS ICUs. Data were collected in two parts: a) by the elaboration of a Central Venous Catheter Insertion and Maintenance Flux, according to this work guidelines; and b) by the EG analysis of the risk of all nonconformities, according to the Central Venous Catheter Insertion and Maintenance Flux and to the steps taken in the process of Care of the Pacient with Central Venous Catheter. To calculate the risk, it was necessary to identify the gravity (G), the occurrence probability (O) and the possibility of detection (D) for each evaluated item. This research was approved by the Ethics and Research Committee of Vale do Rio dos Sinos University (UNISINOS) and by the Institution observed in this work. The main nonconformities pointed in this work were the lack of criteria when indicating CVC and the risks related to CVC’s barrier protection, insertion and maintenance. To solve these nonconformities, evaluated as of medium and high risk, proposals of intervention were created: the elaboration of three checklists; two standard operational procedures for the utilization and maintenance of the CVC; and a Permanent Health Education Program. The results show that it is necessary to use strategies promoting actions that may prevent the occurrence of potential failures on the process of Care of Patient with Central Venous Catheter, aiming for the prevention of bloodstream infection in ICUs.

Bakgrunn: Sentralvenøse katetre (SVK) er et tilbud til mange pasientgrupper når det foreligger indikasjoner. Dette medfører at SVK håndteres av helsepersonell på alle enheter i helsetjenesten. Samtidig som SVK er livgivende, kan anvendelse av katetre i blodbanen resultere i alvorlige blodbaneinfeksjoner (SVK-BBI). Blodbaneinfeksjoner assosiert med innleggelse og håndtering av SVK, er en av de alvorligste komplikasjonene som kan oppstå. Fokus på forebygging av SVK-BBI har spredd seg fra å gjelde intensivavdelinger tilå gjelde hele helsetjenesten. Hensikten med denne studien erå se på etterlevelse av infeksjonsforebyggende retningslinjer for å forebygge SVK-BBI utenom intensivavdelinger. Fokuseropplæring, aseptisk teknikk, håndhygiene ogdesinfeksjon av koblingene. Metode: Studien er en tverrsnittsstudie hvor det gjennomføres observasjoner av etterlevelse av håndtering og stell av SVK,samten spørreundersøkelse som kartlegger opplæringav helsepersonelli forhold tildette. 40 sykepleiere deltar i observasjonsstudien og 112 helsepersonelldeltar i spørreundersøkelsen. Hovedresultat: Etterlevelse av aseptisk teknikk under prosedyre var 72,5 %.Etterlevelse av håndhygiene før SVK-prosedyre var 42%. Etterlevelse av desinfeksjon før tilgang/ skifte av koblinger var 89,6 %. 96 % av desom håndterte SVK,har fått opplæring. 68 % er opplært med multimodale metoder. Konklusjon: Studien viser at defleste som håndterteSVK har hatt opplæring. Kommentarene til spørreundersøkelsen viser likevel at det etterlyses bedre opplæring hvor praktisk trening og oppdatering av kunnskap er vektlagt. Til tross for stort fokus på opplæring viser observasjonene av etterlevelse av SVK-prosedyren at vesentlige infekjsonsforebyggende tiltak svikter. / Background:Central venous catheters (CVCs) are usedfor a wide range of indications and handled by health care professionals throughout the hospital. While CVCsare life-giving, their use may result in serious bloodstream infections. Catheter-related bloodstream infections (CRBSIs) are among the most serious complications in health care. Consequently, hospitals now focus on CRBSIs prevention throughout the entire hospital. Aim. The purpose of this study is to look at adherence to infection control guidelines for preventing CRBSIs outside intensive care units. Studied issues are education/ training of health care workers, aseptic technique, hand hygiene and disinfection of the hubs/ connections prior to use. Method.This cross-sectional study aimed to observe guideline compliance by 40 nurses during handling procedures and care of CVCs. We also conducted a sample survey of healthcare workers (n=112) to map the training of healthcare workers handling CVCs. Main results. Adherence to aseptic technique during the procedure was 72.5%, and compliance with hand hygiene before CVCs procedure was 42%. Compliance with use of disinfectant prior to access/change of hubs/connections was 89.6%. The survey revealed that 96% of respondents had been trained in properly handling CVCs; 68 % were trained with multimodal methods. Conclusion. Most healthcare workers were trained to handle CVCs. Some workers requested better training that emphasizes practical issues and updated knowledge. Despite a strong focus on education/training, our observations show that many healthcare workersremain noncompliant in CVC procedure / <p>ISBN 978-91-86739-76-8</p>

Orientador: Carlos Magno Castelo Branco Fortaleza / Resumo: Seasonality of healthcare-associated infections (HCAIs) has been recently reported, especially involving Gram-negative bacilli (GNB). Factors underlying this phenomenon were not elucidated. It is theoretically conceivable it reflects seasonal variations in traditional risk factors for those infections. With this in mind, we conducted a study to analyze the interplay of season, weather and usual predictors of healthcare-associated bloodstream infections caused by Gram-negative bacilli (GNB-BSI). The study had a retrospective, case-only desing. It was conducted in the teaching hospital from Botucatu School of Medicine (450 beds). The study enrolled 446 patients with GNB-BSI caused by Escherichia coli, Enterobacter spp., Klebsiella spp., Pseudomonas aeruginosa or Acinetobacter baumannii, diagnosed from July 2012 through June 2016. Demographic data, comorbidities, invasive procedures and use of antimicrobials were reviewed in medical charts. The season in which GNB-BSI occurred, as well as weather parameters of the day of diagnosis, were recorded. We analyzed factors associated with occurrence of GNB-BSI in different seasons (with winter as reference category) and caused by different GNB (reference category, E. coli). Univariate and multivariable models of polytomous (multinomial) logistic regressions were used for analysis. In multivariable analysis, GNB-BSI diagnosed in summer were more likely to be caused by Klebsiella spp. (OR, 5.33; 95%CI, 2.04-13.96) or A. baumannii (OR, 2.... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Seasonality of healthcare-associated infections (HCAIs) has been recently reported, especially involving Gram-negative bacilli (GNB). Factors underlying this phenomenon were not elucidated. It is theoretically conceivable it reflects seasonal variations in traditional risk factors for those infections. With this in mind, we conducted a study to analyze the interplay of season, weather and usual predictors of healthcare-associated bloodstream infections caused by Gram-negative bacilli (GNB-BSI). The study had a retrospective, case-only desing. It was conducted in the teaching hospital from Botucatu School of Medicine (450 beds). The study enrolled 446 patients with GNB-BSI caused by Escherichia coli, Enterobacter spp., Klebsiella spp., Pseudomonas aeruginosa or Acinetobacter baumannii, diagnosed from July 2012 through June 2016. Demographic data, comorbidities, invasive procedures and use of antimicrobials were reviewed in medical charts. The season in which GNB-BSI occurred, as well as weather parameters of the day of diagnosis, were recorded. We analyzed factors associated with occurrence of GNB-BSI in different seasons (with winter as reference category) and caused by different GNB (reference category, E. coli). Univariate and multivariable models of polytomous (multinomial) logistic regressions were used for analysis. In multivariable analysis, GNB-BSI diagnosed in summer were more likely to be caused by Klebsiella spp. (OR, 5.33; 95%CI, 2.04-13.96) or A. baumannii (OR, 2.... (Complete abstract click electronic access below) / Mestre

Background: Critically ill patients are at particular risk of developing bloodstream infection. Such infections are associated with the development of sepsis, leading to a marked increase in mortality rate. Early detection of the causative organism and appropriate antibiotic treatment are therefore critical for optimum outcome of patients with nosocomial infection. Current infection diagnosis is based on standard blood culture techniques. However, microbiological culture has a number of limitations, not least that it takes several days to confirm infection and is therefore not useful in directing the early treatment with antibiotics. New techniques based on the detection of pathogen DNA using real-time polymerase chain reaction (PCR) technology have the potential to address these limitations but their clinical utility is still to be proved. Objectives: Develop and evaluate novel PCR-based approaches to bloodstream infection diagnosis in critical illness based on detection and identification of bacterial and fungal DNA in blood. Methods: A range of commercial and 'in-house' PCR-based assays for detection of bacterial and fungal DNA were developed and/or optimised for use in clinical blood samples. These included LightCycler SeptiFast, a CE-marked multi-pathogen assay for common bloodstream pathogens, BactScreen and GramScreen, broad spectrum bacterial assays based on 16S rRNA gene and real-time PCR assays developed to detect a range of clinically important fungal pathogens. Novel approaches to speciation of pathogen DNA using melting temperature (Tm) profiling and high resolution melting analysis (HRMA) were developed. Clinical evaluation of assays was either on blinded clinical isolates or blood samples from critically ill patients with clinical suspicion of bloodstream infection against conventional microbiological culture. Several techniques aimed at improving extraction of pathogen DNA from blood were also investigated. Results: The CE-marked commercial assay SeptiFast showed analytical sensitivity and specificity of 79% and 83% respectively. Concordance with positive culture results was good but high levels of 'false positives' were detected possibly attributed to detection of free pathogen DNA not associated with viable pathogens. The predictive value of a negative SeptiFast test was 98% suggesting that absence of pathogen DNA is a strong indicator of absence of infection. Further studies were aimed at detailed optimisation and validation of 16S rRNA gene real-time PCR assays for bacterial DNA. BactScreen and GramScreen were able to detect a broad range of clinically important bacteria down to <50 CFU/ml blood. A preliminary comparative evaluation against SeptiFast showed BactScreen gave excellent concordance with blood culture results with minimal false positive results compared to SeptiFast. Efficient extraction of pathogen DNA was shown to be a key factor in determining analytical sensitivity and several protocols were evaluated. Low cost approaches to speciation of bacterial DNA were developed by combining broad range real-time PCR with HRMA. A novel HRMA method based on Tm profiling was shown to identify 89% and 96% of blinded clinical isolates at species or genus level respectively. Real-time PCR/HRMA approaches were also successfully developed for detection and identification of fungal pathogens including a range of Candida and Aspergillus species associated with bloodstream fungal infection. Conclusions: These studies have highlighted some of the key factors that need to be considered when developing and validating PCR based assays for pathogen DNA detection in blood. A set of novel tools have been developed for rapid detection and identification of bacterial and fungal pathogens that could address the challenges of infection diagnosis based on pathogen DNA detection. Further work is required, not least in development of more efficient pathogen DNA extraction and detailed clinical validation but the tools described here have the potential to provide cost effective solutions to aid infection diagnosis that would be complementary to current culture-based methods. The provision of time critical information could have a positive impact on clinical decision-making leading to more effective management and treatment of patients with suspected bloodstream infection.

Ensuring the bloodstream is one of the most frequently indicated invasive procedures, especially in the pre-hospital emergency and intensive care. All invasive inputs are nowadays an integral part of intensive care. Despite careful daily care, vascular accesses are at risk of complications, which annually effects many patients institutionalized at intensive care units. Catheter sepsis is undoubtedly one of the most serious. Although a significant proportion of these infections are considered highly preventable, they still contribute to high morbidity and mortality among these patients. The aim of this diploma thesis is to analyse nursing care for vascular inputs. One of the partial goals is to evaluate and compare the relevance of the nursing standard of a medical facility with scientific knowledge and current recommendations of professional societies. The research method is a quantitative questionnaire survey focused on nursing staff working in the Department of Anesthesiology and Reanimation. The analysis of the vascular inputs re-dressings was performed in patients hospitalized in the same ward, where the research itself took place. The results of the research survey show a discrepancy between the given procedure in the nursing standard and common practice in the ward. In view of the...

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Sepsis characterized by severe bloodstream bacterial infection that results in high mortality rates and medical expenses has become a global healthcare challenge. The current clinical sepsis diagnosis is based on blood culture and requires a long waiting time, delaying effective treatments. The emerging sepsis diagnosis shortens the turn-around of time but requires an efficient bacteria separation from the blood beforehand. In this master’s degree project, a new filter-based method of separating bacteria from the blood is investigated to meet the clinical need for future sepsis diagnosis. The separation device is controlled within the size of a centrifuge falcon tube and integrated with a slanted filter inside. Through a centrifuge, blood cells and bacteria are maneuvered toward the filter and separated by it. Using the optimal design, at concentrations as low as 100 CFU/mL, the device can recover around 30% of bacteria of E. coli, K. pneumoniae, and S. aureus from 1 mL of whole blood within 60 minutes, and reject 99.4% RBCs from going through the filter. Bacteria recovery at 10 CFU/mL concentration demonstrated all-positive results, making this new separation method a promising candidate for future clinic needs in sepsis diagnosis. / Sepsis, som kännetecknas av svår bakterieinfektion i blodomloppet och leder till hög dödlighet och medicinska kostnader, har blivit en global utmaning inom hälso- och sjukvården. Den nuvarande kliniska diagnosen av sepsis baseras på blododling och kräver lång väntetid, vilket försenar effektiva behandlingar. Den framväxande diagnosmetoden för sepsis förkortar väntetiden men kräver effektiv separation av bakterier från blodet. I detta masterprojekt undersöks en ny filterbaserad metod för att separera bakterier från blodet för att möta den kliniska efterfrågan inom framtida sepsisdiagnostik. Separationsenheten kontrolleras inom storleken av en falcon-rör och är integrerad med en lutande filterinsats. Genom en centrifug manövreras blodceller och bakterier mot filtret och separeras av det. Genom att använda den optimala designen kan enheten återhämta cirka 30% av bakterierna E. coli, K. pneumoniae och S. aureus från 1 ml helblod med koncentrationer så låga som 100 CFU/ml inom 60 minuter, och avvisa 99,4% av de röda blodkropparna från att passera genom filtret. Återhämtningen av bakterier vid en koncentration av 10 CFU/ml visade helt positiva resultat, vilket gör denna nya separationsmetod till en lovande kandidat för framtida kliniska behov inom sepsisdiagnostik.

Pre-clinical evaluation of novel antimicrobial coatings for blood-contacting devices commonly relies on the performance of animal studies since alternative in vitro models do not adequately represent the interactions between blood, bacteria, and material surfaces as they occur in vivo. To reduce the need of these cost-intensive and controversial animal tests, this project was dedicated to the development of a new model setup that overcomes this limitation and allows in vitro evaluation under in vivo-like conditions. This newly developed model was intended to be directly applied to evaluate recently in-house developed antimicrobial coatings, so-called anchor polymers. Therefore, the project was divided into two parts. The first part of the project focused on the evaluation of the anchor polymer coatings concerning their applicability in blood-contacting devices. For this purpose, the PEGylated styrene-maleic acid copolymers were intensively studied using established laboratory tests. These examinations showed very promising results regarding adsorption and stability on relevant polymer substrates, antimicrobial efficacy, and biological safety of the coatings, thus revealing their great potential for future applications in medical devices. Moreover, this basic characterization was meant to allow a subsequent comparison of the new in vitro model with state-of-the-art in vitro tests. The second part of the thesis focused on the development of the realistic in vitro model. Here, a single-pass flow system realized the implementation of adjustable flow conditions. Furthermore, incubation with freshly drawn human blood provided a physiological nutrient environment and included the influence of an immune response. Staphylococcus aureus were chosen as representative microorganisms, as they are responsible for a majority of device-related blood stream infections. The resulting blood flow model was validated with one anti-adhesive and one contact-killing anchor polymer coating, confirming the model’s ability to differentiate the investigated surfaces. Inflammatory and coagulant blood activation correlated slightly with bacterial coverage, which in turn was strongly dependent on the investigated material surface. Incubation with varying flow conditions demonstrated the model’s capability to reflect the well-documented dependence of bacterial colonization and occurring flow conditions. In contrast to the state-of-the-art in vitro tests, the simultaneous incubation of test surface, bacteria and whole blood allowed the analysis of mutual interactions of the three parameters. Thus, the model represents an excellent method for pre-clinical evaluation of novel antimicrobial coatings for blood-contacting devices.

Submitted by Onia Arantes Albuquerque (onia.ufg@gmail.com) on 2018-10-11T15:04:28Z No. of bitstreams: 2 Dissertação - Alexsandra Gomes Resende de Souza da Silva - 2018.pdf: 3027265 bytes, checksum: 4c70a842bfa34b413b177bde613f5ba1 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2018-10-15T11:04:15Z (GMT) No. of bitstreams: 2 Dissertação - Alexsandra Gomes Resende de Souza da Silva - 2018.pdf: 3027265 bytes, checksum: 4c70a842bfa34b413b177bde613f5ba1 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Made available in DSpace on 2018-10-15T11:04:15Z (GMT). No. of bitstreams: 2 Dissertação - Alexsandra Gomes Resende de Souza da Silva - 2018.pdf: 3027265 bytes, checksum: 4c70a842bfa34b413b177bde613f5ba1 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2018-08-29 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES / Introduction: Central-line associated bloodstream infections (CLABSIs) are common in Intensive care units (ICUs), leading to longer hospital stays, high hospital costs and death. As such, surveillance, prevention and control are indispensable.Objective: Analyze the epidemiological and microbiological profile of central-line associated bloodstream infections in adult ICUs in the municipality of Goiânia, Brazil. Method: Analytical ecological study conducted using secondary data from reports of all clinical and laboratory central-line associated bloodstream infections in adult ICUs in Goiânia, between 2012 and 2016. SPSS-17.0 and Stata software (version 14.0) were used. Data were expressed as temporal trend, descriptive statistics and percentiles. Data analysis considered a 95% confidence interval and significance level of p<0.05. Results: We analyzed 1988 healthcare-associated infection (HAI) notifications from 42 adult ICUs. The temporal trend of central-line associated bloodstream infections incidence density was stationary. The incidence density of laboratory central-line associated bloodstream infections varied from 3.32 to 4.34 infections per 1000 catheters/day. The rate of central venous catheter use in the period was 55.36%. In relation to percentile, increase was observed in the study period, particularly in 2016 in the 90th percentile. There was no statistical association between the variables analyzed. With respect to the microbiological and antimicrobial susceptibility profile, SCon and S. aureus showed 91.8% and 71.4% resistance to oxacillin, respectively, in 2016. K. pneumoniae and Acinectobacter spp. Were resistant to 3rd and 4th generation cephalosporins and carbapenems. Conclusion: It was concluded that the temporal trend of central-line associated bloodstream infections was stationary, and incidence density and percentiles increased over the years. The primary causative agents were SCon and K. pneumoniae, with broad spectrum antimicrobial resistance. Measures should be implemented to monitor health services and provide continuing education for health workers regarding the prevention and control of these infections. / Introdução: As infecções primárias de corrente sanguínea são frequentes, em Unidade de Terapia Intensiva (UTI) ocasionando prolongamento no tempo de internação, elevados custos hospitalares e óbitos. Mediante essa situação a vigilância, prevenção e controle são imprescindíveis. Objetivo: Analisar o perfil epidemiológico e microbiológico das infecções primárias de corrente sanguínea de UTI adulto do Município de Goiânia. Método: Estudo analítico ecológico, realizado a partir de dados secundários de notificações de infecções primárias de corrente sanguínea clínicas e laboratoriais das UTI adulto no Município de Goiânia-GO, no período de 2012-2016. Utilizou-se os Softwares SPSS-17.0 e Stata, versão 14.0. Os dados foram apresentados por meio da tendência temporal, estatística descritiva e percentis. Considerou-se IC: 95% e p<0,05.de significância de p<0,05. Resultados: Analisou-se 1988 fichas de notificações de IRAS dos referentes a 42 UTI adulto. A tendência temporal da densidade de incidência das infecções primárias de corrente sanguínea foi estacionária. A densidade de incidência das infecções primárias de corrente sanguínea laboratoriais variou de 3,32 a 4,34 infecções por 1000 cateteres-dia. A taxa de utilização de cateter venoso central no período foi de 55,36%. Em relação aos percentis houve elevação no período de estudo com destaque no ano de 2016 no percentil 90. Não houve associação estatística entre as variáveis analisadas. Quanto ao perfil microbiológico e de sensibilidade antimicrobiana identificou-se: SCon e S. aureus resistentes à oxacilina em 91,8% e 71,4% respectivamente em 2016. K. pneumoniae e Acinectobacter spp. resistentes às cefalosporinas de 3ª e 4ª gerações e aos carbapenêmicos. Conclusão: Conclui-se que a tendência temporal das infecções primárias de corrente sanguínea se manteve estacionária; a densidade de incidência e os percentis apresentaram elevação no decorrer dos anos. Os principais patógenos foram os SCon e K. pneumoniae com resistência a antimicrobianos de amplo espectro. Medidas de monitoramento dos serviços de saúde e de educação permanente dos trabalhadores da área da saúde, quanto a prevenção e controle dessas infecções, devem ser instituídas.