Introdução - O peso mais baixo ao nascimento (PN<3 kg) pode estar relacionado a modificações na composição corporal na infância e vida adulta, pois a desnutrição intra-utero pode se associar a diminuição de massa magra e muitas vezes ao aumento de massa gorda. O peso mais alto ao nascimento (PN3 kg) e/ou ganho ponderal acima de 2DP em relação ao peso de nascimento nos primeiros dois anos de vida (catch-up growth) também podem se associar ao aumento de massa gorda, IMC, circunferência abdominal e circunferência do pescoço. Objetivos - Verificar a associação entre peso ao nascimento, ganho de peso nos primeiros dois anos de vida e alteração na composição corporal na idade escolar. Materiais e métodos - Estudo transversal avaliando-se 124 crianças escolares com cinco anos de idade, matriculadas no primeiro ano de quatro escolas municipais e uma particular de Capão Bonito, SP. Foram investigados fatores socioeconômicos e demográficos através de questionários e realizadas medidas antropométricas (peso, estatura, circunferências abdominal e do pescoço). A bioimpedanciometria foi utilizada para avaliação da composição corporal. O peso ao nascimento (PN) foi transcrito das fichas hospitalares dos recém-nascidos e o ganho de peso nos primeiros dois anos de vida, das carteiras de vacina ou prontuários médicos dos postos de saúde de Capão Bonito. Análise estatística - Para armazenamento e análise dos dados foi utilizado o software Stata versão 10. Foi estabelecido um nível de significância de 5 por cento . Para investigação das relações entre peso ao nascimento, ganho ponderal nos primeiros dois anos de vida e composição corporal aos 5 anos de idade, foi utilizada análise de regressão linear múltipla. Resultados O PN 3,0 kg, o catch-up growth (>2DP) e a obesidade materna se associaram a aumentos de média de massa gorda (p=0,036; p=0,007; p= 0,018, respectivamente); IMC (p=0,011; p=0,004; p=0,002, respectivamente) e circunferência abdominal (p= 0,002; p=0,001; p= 0,002, respectivamente). O PN 3 kg e catch-up growth se associaram (p=0,003 nos dois casos) ao aumento da média da circunferência do pescoço. Quando avaliados separadamente por sexo tanto o catch-up growth como a obesidade materna apresentaram associação com aumentos na média de massa gorda (p= 0,033 e p=0,014, respectivamente) e circunferência abdominal (0,048; 0,003, respectivamente) em meninos. A obesidade materna teve associação com maior media de IMC (p=0,001) no sexo masculino. O PN 3 kg esteve associado a aumentos de média de IMC (p=0,008), circunferência abdominal (p=0,001) e circunferência do pescoço em meninas (p=0,002). Conclusões Nesta pesquisa as maiores médias de massa gorda, IMC, circunferência abdominal estiveram associadas ao PN 3kg, catch-up growth e à obesidade materna. Maiores médias de circunferência de pescoço estiveram associadas ao PN 3kg e à ocorrência de catch-up. No sexo masculino as maiores médias de massa gorda e circunferência abdominal apresentaram associação positiva com a ocorrência de catch-up growth e obesidade materna. A maior média de IMC esteve associada à obesidade materna. Não houve associação entre a circunferência do pescoço e as variáveis independentes estudadas. No sexo feminino não foi observada associação de massa gorda com estas variáveis, contudo houve associação de maiores médias de IMC, circunferência abdominal e circunferência do pescoço com PN 3kg. Visando a prevenção e controle de sobrepeso e obesidade em crianças e adultos, é importante considerar PN, catch-up growth, historia de obesidade materna e o sexo do individuo / Introduction: Sub nutrition during intra-uterine life may be related to a decrease in lean mass and, quite often, to an increase in fat mass. Therefore, lower birth weight (BW<3kg) may bear a relationship with changes in body composition during childhood and adult life. Heavier birth weight (BW3kg) and/or weight gain during the first two years above 2 DP in relation to birth weight (catch-up growth) may also be associated to increased fat mass, BMI, abdominal and neck circumferences. Objectives: To determine the relationship between birth weight, weight gain during the first two years of life and changes in body composition at school age. Materials and methods: One hundred twenty four children aged five years were included in a cross-sectional study carried out in Capão Bonito, SP, Brazil. A survey was carried out by means of structured questionnaires in order to establish socioeconomic and demographic parameters. In addition, anthropometric data (weight, height, abdominal and neck circumferences) were recorded for each student. Body composition was determined by bioimpedance measurements. Birth weight (BW) was obtained from medical records on file at the local hospital, while weight gain during the first two years was transcribed from the childs vaccination card or from medical files available at public health stations in Capão Bonito. Statistical Analysis: Data storage and analysis was carried out using the Stata statistical package, Version 1.0, using 5 per cent as the significance level. A multiple regression analysis was used to determine the relationship between birth weight, weight gain during the first two years of life and changes in body composition at school age. Results: BW3.0 kg, catch-up growth (>2DP) and maternal obesity were related to increased fat mass (p=0,036; p=0,007; p= 0,018, respectively), BMI (p=0,011; p=0,004; p=0,002, respectively) and abdominal circumference (p=0,002; p=0,001; p=0,002, respectively). BW 3.0 kg, catch-up growth (>2DP) were associated (p=0,003 in both cases) with increased neck circumference. When the results were considered separately for boys and girls, for boys there was a relationship between the two variables: catch-up growth and maternal obesity with fat mass (p=0,033 and p=0,014, respectively) and abdominal circumference (p=0,048 and p=0,003, respectively). BW 3.0 kg was associated with increases in BMI (p=0,008), abdominal circumference (p=0,001) and neck circumference (p=0,002) in girls. Conclusions This research shows that high averages of fat mass, BMI and abdominal circumference were associated to three main factors: i) BW 3 kg; ii) catch-up growth and, iii) maternal obesity. It also shows that high averages of neck circumference were associated to BW 3 kg and to the occurrence of catch-up growth. For males, high averages of fat mass and high averages of abdominal circumference were positively associated to the occurrence of catch-up growth and maternal obesity; the highest average of BMI was associated to maternal obesity. There was no association between neck circumference and the independent variables studied. In contrast, for females this research did not show associations between fat mass and BW 3kg, catch-up growth or maternal obesity. However, there was a positive association between high averages of BMI, abdominal circumference and neck circumference with BW 3kg.These findings indicate that, in order to prevent and control overweight and obesity in children and adults, it is important to consider BW, catch-up growth, maternal obesity and gender

This study investigates the impacts of regional characteristics on the early-stage performance of New Technology-Based Firms (NTBFs) in catch-up regions where a mature industrial cluster has yet to be formed. It hypothesized that the average NTBF performance in a region is a function of its scientist job market conditions, cultural diversity, venture capital, academic research, industrial structure, and local entrepreneurial climate. Using the events of Initial Public Offerings (IPO) and Merger & Acquisitions (M&A) as an indicator of early-stage success of NTBFs, this study constructs a set of Zero-Inflated-Negative-Binomial (ZINB) models to predict the spatial distribution of such events in the U.S. biopharmaceutical and Information Technology (IT) service industries during the period from 1996 to 2005. Several empirical findings emerge from this study. First, the local entrepreneurial climate plays a significant and positive role on NTBF performance in both industries. Second, the positive impact of cultural diversity is more significant in the IT service industry than in the biopharmaceutical industry. Third, the scientist job market size and absolute salary level have positive impacts on NTBF performance, but the effect of relative salary level is negative. Fourth, proximity to venture capital firms has positive but non-linear effects, but the adverse effect of excess venture capital is stronger in the IT service industry. Fifth, there is little evidence of the direct effects of academic research in determining the NTBF performance in both industries. Finally, industrial specialization is significant and positive only in the IT service industry. The results suggest that promoting local entrepreneurial climate and cultural diversity are two effective policy instruments for catch-up regions to foster their NTBF growth.

The aim of this thesis is to gain improved understanding of the income convergence between Finland and Sweden 1950-2000 with a focus on catch-up growth, wage formation, productivity growth, migration and structural change in a setting of structural and institutional differences on the factor markets. Earlier studies of Finnish and Swedish convergence has overlooked the international perspective and therefore missed the general European – US convergence during the period. The results shows that Sweden converged to 80 percent of the US productivity level in the early 1970s and is following US productivity growth thereafter. The Finnish catch-up growth towards the US continues until the beginning of the 1990s. This corresponds well with the convergence of labour productivity between Finland and Sweden which took place around 1970 and the gap was closed in the beginning of the 1990s. The convergence between the countries can therefore be understood from the catch-up growth against the USA and if the countries growth rates are plotted against their income level 1950 one can see that the two countries are well in line with other West European countries. This means that either country is deviating in a positive or negative direction during the period. This is to some extent in contrast with the view that has been put forward in the countries national economic historical writing where Finland is often since as a growth miracle while Sweden especially since 1970s is seen as a case of falling behind.      In order to explain the convergence scenario structural and institutional differences on the countries factor markets is examined. One aspect concerns Barry Eichengreens hypothesis regarding wage moderation as cause of the Post-War European convergence. The wage setting system in Sweden has been put forward by Eichengreen as a raw model for the type of institutional setting that would promote wage moderation. One central finding in this thesis is that we can not find support for wage moderation for Sweden as the labour share of the national income rises during the phase of Swedish catch-up growth while the labour income share was constant and periodically falling in Finland. In contrast with the view of the Finnish low interest rate policy during the post- the actual real interest rate was lower in Sweden.      There has also been a significant migration flow from Finland to Sweden especially from the 1950s to mid 1970s.  In the thesis we find a positive and significant relationship between wage and productivity differences on industry level between the countries. This supports the conclusion that migration was leading towards factor price convergence between the countries.      The shift-share analysis shows that there were higher gains for the productivity growth in reallocating labour on the Finnish labour market than in Sweden. This could be explained by the higher share of the labour in the agricultural sector as predicted by Peter Temin.

Introdução - O peso mais baixo ao nascimento (PN<3 kg) pode estar relacionado a modificações na composição corporal na infância e vida adulta, pois a desnutrição intra-utero pode se associar a diminuição de massa magra e muitas vezes ao aumento de massa gorda. O peso mais alto ao nascimento (PN3 kg) e/ou ganho ponderal acima de 2DP em relação ao peso de nascimento nos primeiros dois anos de vida (catch-up growth) também podem se associar ao aumento de massa gorda, IMC, circunferência abdominal e circunferência do pescoço. Objetivos - Verificar a associação entre peso ao nascimento, ganho de peso nos primeiros dois anos de vida e alteração na composição corporal na idade escolar. Materiais e métodos - Estudo transversal avaliando-se 124 crianças escolares com cinco anos de idade, matriculadas no primeiro ano de quatro escolas municipais e uma particular de Capão Bonito, SP. Foram investigados fatores socioeconômicos e demográficos através de questionários e realizadas medidas antropométricas (peso, estatura, circunferências abdominal e do pescoço). A bioimpedanciometria foi utilizada para avaliação da composição corporal. O peso ao nascimento (PN) foi transcrito das fichas hospitalares dos recém-nascidos e o ganho de peso nos primeiros dois anos de vida, das carteiras de vacina ou prontuários médicos dos postos de saúde de Capão Bonito. Análise estatística - Para armazenamento e análise dos dados foi utilizado o software Stata versão 10. Foi estabelecido um nível de significância de 5 por cento . Para investigação das relações entre peso ao nascimento, ganho ponderal nos primeiros dois anos de vida e composição corporal aos 5 anos de idade, foi utilizada análise de regressão linear múltipla. Resultados O PN 3,0 kg, o catch-up growth (>2DP) e a obesidade materna se associaram a aumentos de média de massa gorda (p=0,036; p=0,007; p= 0,018, respectivamente); IMC (p=0,011; p=0,004; p=0,002, respectivamente) e circunferência abdominal (p= 0,002; p=0,001; p= 0,002, respectivamente). O PN 3 kg e catch-up growth se associaram (p=0,003 nos dois casos) ao aumento da média da circunferência do pescoço. Quando avaliados separadamente por sexo tanto o catch-up growth como a obesidade materna apresentaram associação com aumentos na média de massa gorda (p= 0,033 e p=0,014, respectivamente) e circunferência abdominal (0,048; 0,003, respectivamente) em meninos. A obesidade materna teve associação com maior media de IMC (p=0,001) no sexo masculino. O PN 3 kg esteve associado a aumentos de média de IMC (p=0,008), circunferência abdominal (p=0,001) e circunferência do pescoço em meninas (p=0,002). Conclusões Nesta pesquisa as maiores médias de massa gorda, IMC, circunferência abdominal estiveram associadas ao PN 3kg, catch-up growth e à obesidade materna. Maiores médias de circunferência de pescoço estiveram associadas ao PN 3kg e à ocorrência de catch-up. No sexo masculino as maiores médias de massa gorda e circunferência abdominal apresentaram associação positiva com a ocorrência de catch-up growth e obesidade materna. A maior média de IMC esteve associada à obesidade materna. Não houve associação entre a circunferência do pescoço e as variáveis independentes estudadas. No sexo feminino não foi observada associação de massa gorda com estas variáveis, contudo houve associação de maiores médias de IMC, circunferência abdominal e circunferência do pescoço com PN 3kg. Visando a prevenção e controle de sobrepeso e obesidade em crianças e adultos, é importante considerar PN, catch-up growth, historia de obesidade materna e o sexo do individuo / Introduction: Sub nutrition during intra-uterine life may be related to a decrease in lean mass and, quite often, to an increase in fat mass. Therefore, lower birth weight (BW<3kg) may bear a relationship with changes in body composition during childhood and adult life. Heavier birth weight (BW3kg) and/or weight gain during the first two years above 2 DP in relation to birth weight (catch-up growth) may also be associated to increased fat mass, BMI, abdominal and neck circumferences. Objectives: To determine the relationship between birth weight, weight gain during the first two years of life and changes in body composition at school age. Materials and methods: One hundred twenty four children aged five years were included in a cross-sectional study carried out in Capão Bonito, SP, Brazil. A survey was carried out by means of structured questionnaires in order to establish socioeconomic and demographic parameters. In addition, anthropometric data (weight, height, abdominal and neck circumferences) were recorded for each student. Body composition was determined by bioimpedance measurements. Birth weight (BW) was obtained from medical records on file at the local hospital, while weight gain during the first two years was transcribed from the childs vaccination card or from medical files available at public health stations in Capão Bonito. Statistical Analysis: Data storage and analysis was carried out using the Stata statistical package, Version 1.0, using 5 per cent as the significance level. A multiple regression analysis was used to determine the relationship between birth weight, weight gain during the first two years of life and changes in body composition at school age. Results: BW3.0 kg, catch-up growth (>2DP) and maternal obesity were related to increased fat mass (p=0,036; p=0,007; p= 0,018, respectively), BMI (p=0,011; p=0,004; p=0,002, respectively) and abdominal circumference (p=0,002; p=0,001; p=0,002, respectively). BW 3.0 kg, catch-up growth (>2DP) were associated (p=0,003 in both cases) with increased neck circumference. When the results were considered separately for boys and girls, for boys there was a relationship between the two variables: catch-up growth and maternal obesity with fat mass (p=0,033 and p=0,014, respectively) and abdominal circumference (p=0,048 and p=0,003, respectively). BW 3.0 kg was associated with increases in BMI (p=0,008), abdominal circumference (p=0,001) and neck circumference (p=0,002) in girls. Conclusions This research shows that high averages of fat mass, BMI and abdominal circumference were associated to three main factors: i) BW 3 kg; ii) catch-up growth and, iii) maternal obesity. It also shows that high averages of neck circumference were associated to BW 3 kg and to the occurrence of catch-up growth. For males, high averages of fat mass and high averages of abdominal circumference were positively associated to the occurrence of catch-up growth and maternal obesity; the highest average of BMI was associated to maternal obesity. There was no association between neck circumference and the independent variables studied. In contrast, for females this research did not show associations between fat mass and BW 3kg, catch-up growth or maternal obesity. However, there was a positive association between high averages of BMI, abdominal circumference and neck circumference with BW 3kg.These findings indicate that, in order to prevent and control overweight and obesity in children and adults, it is important to consider BW, catch-up growth, maternal obesity and gender

Les chutes sont la deuxième cause de décès accidentels par traumatisme involontaire dans le monde. Les conséquences physiques et psychologiques représentent aussi un frein important à la mobilité des personnes âgées. Prévenir ces chutes apparait donc comme un enjeu majeur. Une première étape nécessaire est d'identifier les situations présentant un risque de chute important. L'objectif de cette thèse est de proposer des outils permettant de faire le lien entre une perturbation et le risque de chute associé. Dans une première partie, un modèle simple permet d'estimer les états à partir desquels il est possible de retourner dans une situation d'équilibre. Nous nous intéressons ensuite aux perturbations externes continues. Les résultats de la littérature étant limités sur cet aspect, une campagne expérimentale a été mise en place pour identifier les effets de certains paramètres de la perturbation sur le seuil de rattrapage. Le modèle est alors étendu pour traiter le cas de perturbations de l'équilibre ayant un profil temporel variable. Pour finir, nous proposons une modélisation utilisant un contrôleur basé sur la commande prédictive mettant en avant la régulation des stratégies de rattrapage. L'ensemble de ces travaux mettent en avant l'influence des paramètres liés au rattrapage qu'il est difficile d'appréhender lors d'expérimentations. Ils montrent également l'importance de la caractérisation de l'élément déclencheur de la perte d'équilibre dont la description est souvent incomplète dans la littérature. Certaines améliorations peuvent être apportées comme la représentation d'appuis non-coplanaires ou une intégration plus détaillée des aspects sensoriels / Falling is the second most important cause of accidental deaths in the world. These falls lead to physical injuries and psychological consequences which limit mobility especially for the elderly. Being able to prevent these events appears to be crucial and a first mandatory step is to identify the risk of fall depending on the situation (slipping, hazardous environment …). The objective of this thesis is to propose numerical tools in order to link the risk of fall to the balance perturbation. In a first part, a simple numerical model estimates if initial unbalanced states can be recovered using one recovery step. Then a focus was made on external perturbations with a specific temporal profile close to public transportation perturbations. An experimental protocol was set up due to the lack of knowledge about these perturbations. The experiment investigated the effect of the perturbation parameters on the Balance Recovery (BR) threshold. An adjustment of the previous model was made to evaluate continuous perturbations and to compare its results against our experimental findings. The final chapter developed a complementary approach based on previous work using a model predictive control scheme which aims to regulate BR strategies. This whole work contributes to highlight the BR parameters which are difficult to assess during experimental procedures. It also points out the perturbation definition which is frequently incomplete in the literature although it is the phenomenon responsible for the BR process. In order to represent more realistic human behaviors some improvements can be done such as adding noncoplanar contacts or as integrating more detailed sensorimotor aspects

The purpose of this thesis is to understand how social workers, working for social services in Sweden, reach out, catch up and offer co-dependent relatives to individuals with alcohol- and/or substance abuse help. Scientific research show that co-dependent people often develop a dependent relationship to their relatives with addiction, which cause feelings of shame and stigmatization. To decrease the codependency and negative emotions the relative need professional help. This paper will focus on how social workers work with reaching out to co-dependent relatives and how they offer them help. For this reason, the paper will also giveperspective on how organisations can help to improve the work with relatives to people with alcohol- and substance abuse, as well as how the social workers can use their own discretion to reach out and catch up the relatives in need of emotional support. This study is based on seven social workers experiences (in six different municipalities) of including relatives to individuals with addictions to either alcohol, substances, or gambling problems in their work and offer them help.

La télévision traditionnelle, « voix de la France » est un média de masse. Avec un taux d’équipement des foyers de plus de 98%, un taux d’écoute de plus de 3h50 par jour, un chiffre d’affaires publicitaires de plus de 4 Mrd EUR , et des « contenus rendez-vous » assurant des audiences record, cette télévision trône dans le salon et réunit la famille. Jusque dans les années 1980, elle reste placée sous le contrôle du pouvoir politique.Sous la Présidence de François Mitterrand, la télévision se libéralise. De nouvelles chaînes privées et commerciales financées par l’audience et la publicité apparaissent, tandis que le secteur public reste principalement financé par la redevance audiovisuelle. Dans les années 90, l’arrivée du câble et du satellite, puis de la TNT en 2005, permettent l’accroissement considérable du nombre de nouvelles chaînes et des offres de télévision (abonnements au câble, au satellite, et à Canal + en 1984). Le numérique révolutionne le secteur de la télévision, les technologies et les usages. Le nombre de chaînes continue de s’accroître de façon exponentielle. On voit se développer la production de contenus générés par les consommateurs (UGC), et l’interactivité est favorisée grâce aux réseaux sociaux. L’évolution des équipements changent les habitudes de consommation du petit écran, notamment pour les plus jeunes. L’ordinateur, la tablette, le Smartphone et la télévision connectée permettent de visionner « la télévision comme je veux, où je veux, quand je veux. ». Ainsi la télévision traditionnelle considérée comme un média de masse, tend à s’individualiser, et s’adapte aux goûts et aux envies de chacun. L’écosystème jusqu’à présent hexagonal est littéralement en train d’exploser pour faire face à l’internationalisation des contenus et à des acteurs audiovisuels majoritairement nord-américains. La réglementation devenue obsolète peine à trouver un nouveau cadre juridique à l’échelle française et européenne. Face à l’offre mondialisée, et les nouveaux usages de consommation notamment les usages délinéarisés (télévision de rattrapage, et Vidéo à la demande), la télévision continue néanmoins à fédérer le public autour de grands évènements d’actualité (évènements sportifs, politiques, journal télévisé du 20h…). Les profondes mutations et les changements rapides qui s’opèrent actuellement laissent planer une grande incertitude sur l’avenir de la télévision traditionnelle et faute de pouvoir s’adapter, celle-ci pourrait à plus ou moins long terme disparaitre… / Traditional TV, "Voice of France" is a mass medium. With a home ownership rate of over 98%, a viewing rate of l more than 3.50 hours, advertising revenue of over 4 billion euros , and “contenus Rendez-vous” bringing in record audiences, television rules over the living room, bringing the family together up into the 1980s. It is, however, controlled by the ruling political powers.Under the presidency of François Mitterrand, television was liberalized with the appearance of new private and commercial channels, financed by audiences and advertising, while the public sector continued to be funded by a license fee. In the 90s, the arrival of cable and satellite, followed by TNT in 2005, allowed the amazing increase of a number of new channels and TV services (« subscriptions to cable, satellite and finally Canal + in 1984 )But this evolution continues with the arrival of digital TV, revolutionizing the industry. It increases the number of channels exponentially, expands the production of content generated by consumers, and promotes interactivity through social networks. Technological advances are changing consumer habits with regard to the small screen, especially for young people. The computer, tablet, smartphone and the connected TV let you watch "television as I want, where I want, when I want”. Traditional TV, once considered as a mass media, is now a media that is individualized and that adapts to the tastes and desires of each viewer.The current financial system in France is literally exploding to deal with the internationalization of audiovisual content and players, with most of the content produced in North America.. Obsolete regulations can no longer keep pace with consumer demand in Europe and France. Faced with global supply and new viewing habits (delinearised viewing: replayand video on demand), television still continues to unite the public around major news events (sporting events, political events, the evening news …). The important, rapid changes now occurring in TV content and distribution lead to considerable uncertainty with regard to the future of traditional television, and unless it can adapt, it could more or less disappear in the long term.

Le faible poids de naissance et/ou une accélération de la croissance pondérale durant l’enfance sont reconnus actuellement comme facteur de risque de maladies cardiovasculaires (hypertension artérielle, en particulier). Leur rôle dans la progression des maladies rénales chroniques de l’adulte est moins évident. Cette association entre un faible poids de naissance et un risque accru d’hypertension artérielle (HTA) à l’âge adulte ferait intervenir une réduction du nombre de néphrons. Ce déficit néphronique, associé au faible poids de naissance, est responsable d’une hyperfiltration glomérulaire au sein de chaque néphron. Ce mécanisme adaptatif entraîne au fil du temps des lésions rénales, une protéinurie, une insuffisance rénale chronique et une véritable hypertension artérielle. Mais l’hypothèse pathogénique du déficit néphronique reste discutable. De plus peu l’influence de la nutrition postnatale précoce a été très peu étudiée chez l’animal. A travers 2 modèles de restriction de croissance intra-utérine (RCIU) chez le rat, nous avons montré que, plus que la RCIU elle-même, le devenir vasculaire et rénal chez le rat RCIU dépend de la sévérité du déficit néphronique. Un déficit néphronique modéré n’est pas suffisant pour affecter à long terme les fonctions/structures vasculaires et rénales chez le rat RCIU obtenu par une restriction protéique maternelle modérée (caséine 9 %)Nous avons également validé un modèle de rattrapage pondéral précoce, chez le rat. Nous avons montré qu’un rattrapage pondéral et/ou une croissance exagérée durant la période néonatale jouent un rôle primordial sur la pression artérielle, les fonctions et la structure rénale à l’âge adulte. Ces paramètres étaient d’autant plus affectés que la suralimentation néonatale était associé à une RCIU. Les maladies vasculaires et rénales résulteraient, en grande partie, d’une inadéquation entre le nombre de néphrons, réduit lors d’un faible poids de naissance, et la nutrition néonatale/postnatale, surabondante.Chez l’homme, la mise en place de nouvelles cohortes est nécessaire afin de mieux comprendre le rôle de la nutrition durant différentes phases de croissance (fœtale, néonatale, enfance et adolescence) dans le développement des maladies chroniques de l’adulte. Ces études devraient évaluer la pertinence de marqueurs précoces, et permettre la mise en œuvre de stratégies préventives précoces nutritionnelles ou médicamenteuses chez les personnes les plus à risques. / Evidence suggest that low birth weight and/or postnatal catch-up growth increase the risk for long term cardiovascular diseases (hypertension especially). Their role on the progression of chronic kidney disease is less evident. The mechanism is incompletely known. Nephron number deficit, associated with low birth weight, may play an important role. In such a condition, an adaptative single nephron glomerular hyperfiltration to meet excretory demands may lead overtime to renal damages. However this hypothesis is still questionable.In the rat, through two experimental models of intrauterine growth restriction (IUGR), we have shown that adverse long term vascular and renal functions are highly dependent on the severity of nephron number deficit. Moreover, we have demonstrated that a rapid neonatal catch-up growth plays a determinant role. Neonatal overfeeding and a high protein diet following IUGR accelerate the expression of hypertension and the progression of chronic kidney disease. Long term vascular and renal diseases may thus result from a mismatch between adverse fetal environment and postnatal beneficial environment. In human prospective epidemiological studies are needed with the aim to evaluate the effect of postnatal nutrition and to determine early markers for future preventive studies.

本文嘗試在傳統的R&D模型中，引入技術引進的概念，並從技術發展型態的角度來探討其與經濟成長之關係。理論的結果告訴我們各個國家會採取何種技術發展的型態決定於其本身的技術水準。技術水準愈低的國家，基於成本的誘因，會採取較具優勢的技術引進的發展策略；相反地，技術水準較高的國家，則會利用本身較佳的技術優勢而自行研發。 採取不同技術發展型態的國家，其經濟成長的型態也跟著不同。採取技術引進策略的國家其成長的速度取決於本身和世界的技術差距，當差距愈大時，成長的速度就愈快；相反地，隨著差距的縮小，成長的速度也就會跟著緩慢下來。採取研發的國家，如同大部分R&D模型的結論，其均衡的成長路徑是維持一固定的成長率。 不同於以往內生成長模型只專注於長期的成長，我們的模型中，除了具有長期持續成長的特色外，更強調各個國家由於初始條件的差異及其成長的速度和世界成長的速度的不同，致使成長的路徑也會不同，而且每個國家收歛的恆定狀態也不相同，這也說明了為什麼世界各國之間會存在廣泛的所得差異性的現象。 另外，我們的理論也強調技術落後的國家不見得會永遠處於落後的地位，只要其成長的速度足夠支持其發生技術發展型態的結構性改變，就有可能追趕上先進國家，甚至超越。而原先處於領先地位的先進國家，也有可能因本身研發的效率退步，致使成長速度落後於世界的平均水準，結果反倒是由領先的地位退到落後國家之林。 而成長的另一個普遍獲得實證支持的現象，也就是在Solow模型中預測的條件性收歛，在我們的模型中的解釋是當一個國家的成長路徑一直高於世界的平均水準的話，換言之，該國家是一直在不斷進步的過程中，則也會發生所謂條件性收歛的現象。而我們的理論更預測了另一種現象是，當一個國家的成長路徑是處於世界平均水準之下的話，也就是說是由原本的領先退步到落後的過程中，其成長的速度反倒是開始時會較慢，而在接近收歛時開始加快速度，然後達到恆定狀態，這種現象和所謂的條件性收歛恰好反其道而行，我們稱之為逆條件性收歛現象。 除了理論之外，我們更藉由數值模擬的方式進行了政策上的分析。我們發現在成長速度上處於領先地位的國家，若要保持其領先的優勢，必定要採取研發的策略。而處於成長速度較緩慢的國家，若想要擺脫落後並追趕上領先國家的話，就得靠技術引進的方式來加快其成長的速度。 同時我們亦分析了幾種改變成長速度的政策手段，發現每一種政策的效果對不同的國家而言也不盡相同，所以各個國家所應採取的手段應視其條件而定。另外，當外生的世界成長率加快時，我們發現這個現象對成長速度落後的國家是很有幫助的，因為可以使得其速度加快趕上世界的水準。