Det råder frågetecken om hur följsamhet till behandlingens metoder inom internetbaserad kognitiv beteendeterapi (IKBT) för depression påverkar symtomreduktion. Syfte: undersöka sambandet mellan följsamhet till behandlingsmetoder inom IKBT och symtomreduktion, för depressionspatienter. Frågeställning: föreligger samband mellan följsamhet till behandlingens metoder och symtomreduktion. Metod: deltagarna var 90 patienter, vilka behandlats för depression vid Internetpsykiatrin i Stockholm. Antal moduler deltagarna genomfört registrerades, och mängd och kvalité utförande hemuppgifter skattades enligt en behandlingsspecifik följsamhetsskala. Symtomreduktion mättes genom förändring i depressionsnivå, från förmätning till eftermätning. Resultat: samband påvisades mellan antal genomförda moduler och symtomreduktion, men inte mellan mängd och kvalité utförande hemuppgifter och symtomreduktion. Mängd och kvalité tillförde ingen ytterligare förklaring av variansen för symtomreduktion än antal genomförda moduler. Slutsats: det förefaller viktigare att patienter kommer framåt i behandlingen, än hur behandlingsmetoderna utförs. / There are questions about how adherence to treatment methods in Internet-based cognitive behavioral therapy (ICBT) for depression affects symptom reduction. Purpose: explore the relationship between adherence to treatment methods within internet-based cognitive behavioral therapy (ICBT) and symptom reduction, for depressed patients. Research question: is there a relationship between adherence to treatment methods and symptom reduction. Method: the participants were 90 patients treated for depression at the Internetpsykiatri in Stockholm. The number of modules completed was registered, the amount and quality of homework was estimated by a treatment-specific adherence scale. Symptom reduction was measured by changes in level of depression, from pre-measurement to post-measurement. Results: correlation was demonstrated between number of completed modules and symptom reduction, but not between amount and quality of homework and symptom reduction. Amount and quality did not add more explanation of the variance in symptom reduction than the number of completed modules. Conclusions: it is more important that patients advance in the treatment, than how the treatment methods are performed.

Tools for measuring competence in delivering Cognitive Behavioural Therapy (CBT) provide a means of assessing the training of new CBT therapists and ensuring the quality of treatment provision within routine practice, provide a framework for delivering formative feedback, promote ongoing self-reflection, and are essential to establishing treatment integrity in research trials. As such, identifying an optimal strategy for assessing the competence with which CBT is delivered is crucial to the continued progression of the field. However, research in this area has been somewhat limited to date. Thus, there are at present no evidence-based best practice guidelines outlining the way CBT competence should be assessed. Furthermore, many of the assessment measures currently available have been widely criticised, indicating a need for improved tools for assessing CBT competence. To begin addressing this issue, the first two chapters of this thesis focus on reviewing and evaluating current assessment methods. Chapter one provides a systematic review of current methods of assessing CBT competence and chapter two outlines a qualitative exploration of experts’ understandings and experiences of assessing CBT competence. Findings from these studies provide tentative recommendations for practitioners and researchers assessing CBT competence. These initial studies also highlight ways in which the assessment of CBT competence could be improved and therefore provide a platform for guiding subsequent thesis chapters which focus on further developing existing assessment measures. Specifically, chapters three to six focus on the development and evaluation of a novel CBT competence rating scale: the Assessment of Core CBT Skills (ACCS). The ACCS builds upon currently available scales (especially the Cognitive Therapy Scale- Revised: CTS-R) to provide an assessment framework for assessors to deliver formative and summative feedback regarding therapists’ performance within observed CBT treatment sessions and for therapists to rate and reflect on their own performance. Development of the ACCS involved three key stages: 1- theory-driven scale development (chapter three), 2- an ‘expert’ review of the content validity, face validity, and usability of the scale (chapter four), and 3- an evaluation of the scale involving a pilot study examining its psychometric properties (chapter five) and a focus group examining its usability and utility (chapter six). Results from these studies indicate that the ACCS is a useful learning tool, is easy to use, has good psychometric properties, and offers an acceptable alternative to the CTS-R. Finally, chapter seven examines whether assessors require training in how to use the ACCS, concluding that simply reading the ACCS manual may be sufficient to achieve acceptable levels of reliability and usability. The results from the thesis are then drawn together in the final concluding comments in chapter eight, which discusses the findings within the broader context of the assessment of CBT competence.

Background: Difficulties with anxiety among children and young people are common and can impact upon their developmental trajectory leading to adverse outcomes in later life. There is, therefore, a need to increase access to early intervention services. Existing research has indicated that school-based cognitive behavioural interventions are effective for children and young people experiencing difficulties with anxiety, yet there remains a proportion of the population for whom they are not effective. In addition, there is a lack of research on how these may be implemented in real world settings as opposed to a research trial. The present research focuses on the provision of cognitive behavioural school-based interventions in two parts: a systematic review of psychological, interpersonal and social variables as predictors, mediators and moderators of mental health outcomes following a school-based intervention and an empirical mixed methods evaluation of the facilitators and barriers to the implementation of a school-based intervention. Method: A systematic search of electronic databases for studies examining interpersonal, psychological and social predictors, moderators and mediators of mental health outcome following school-based cognitive behavioural interventions was conducted. Effect sizes for these analyses were calculated and the quality of eligible studies was assessed using a standardised rating tool. Within the empirical project, the implementation of a school-based cognitive behavioural intervention was evaluated through a mixed methods approach. Semi-structured interviews with stakeholders in the intervention were analysed using grounded theory integrated with framework analysis. Quantitative data on the reach of the intervention, practitioner evaluation of training and coaching as well as routine outcome measures from children and young people receiving the intervention was collected. Results: Within the systematic review, twenty-two studies (N=22) met the predefined eligibility criteria. There was heterogeneity in the variables explored, effect size of these on treatment outcome and the quality of the literature within the included studies. Cognitive style was found to mediate treatment outcome, but there was limited evidence for other predictors, mediators and moderators of treatment outcome within the review. Quantitative results of the empirical project indicated that the model of the intervention was acceptable to both practitioners and children and young people, and preliminary data indicated a significant improvement in mental health outcomes. Facilitators that emerged from qualitative data included an enabling context, therapeutic engagement, motivation and congruence, self-efficacy and containment and encouragement. The exclusivity of the intervention, a lack of systemic understanding and transparency as well as demands and pressure on resources were barriers to implementation. Conclusions: Although preliminary evidence for potential predictors, mediators and moderators is presented, further research with improvements in the design and reporting of explanatory variables on treatment outcome is required prior to informing clinical decision-making. The successful implementation of school-based interventions requires multi-agency integration and collaboration as well as on-going support in managing systemic pressures and skill development.

The studies presented in this thesis sought to investigate a number of developmental factors that influence the efficacy of preventive intervention for child anxiety disorders. Preventive intervention has emerged as a vital step forward in clinical research following data indicating anxiety disorders are among the most common forms of psychopathology in youngsters (Kashani & Orvaschel, 1990; Mattison, 1992). Several risk and protective factors associated with childhood anxiety disorders have been identified, along with effective treatment protocols (Kendall, 1994; Howard & Kendall, 1996; Barrett, 1998, 1999; Silverman et al., 1999a, 1999b), as prerequisites to the development of preventive programs for child anxiety problems (Spence, 2001). The first objective of this research was to add to the literature on risk and protective factors by investigating the role of peer interaction in the development of child anxiety problems. Study one examined developmental differences in the influence of peer interaction on children's anxiety-related cognition and behaviour. One hundred and sixty two children enrolled in grade 6 (n = 96) aged between 9 and 10 years, and grade 9 (n = 66) aged between 14 and 16 years participated in the study. Participants were stratified into either an at risk group or to a healthy group, based on their anxiety scores on the Spence Child Anxiety Scale (SCAS; Spence, 1997), and further allocated to a peer group comprising of 3 'healthy' (non-anxious) and 3 'at risk' (high anxious) children. Prior to and following a peer discussion, participants completed a standardised self-report measure of threat interpretation and response plans to two ambiguous vignettes (Barrett, Rapee, Dadds, & Ryan, 1996; Dadds, Barrett, Rapee, & Ryan, 1996). Results showed all participants evidenced changes in threat interpretation and response plans following the discussion with peers (p < .001). Overall, findings highlight the potential importance of peer interaction in the development of anxiety-related cognition and behaviour. The findings of study one have important implications for the future development of school-based intervention programs; specifically those conducted in the classroom. Study two sought to advance the current research on preventive intervention for child anxiety by establishing the age at which youngsters benefit the most from the FRIENDS program as a classroom-based universal intervention. Study two presents the results of a longitudinal study evaluating the effects of a universal school-based intervention for child anxiety at two developmental stages. The study involved a cohort of 733 children enrolled in grade 6 (n = 336, 45.6%) aged between 9 and 10 years, and grade 9 (n = 401, 54.4%) aged between 14 and 16 years, Participants were allocated to either a school-based cognitive behavioural intervention or to a monitoring group. Participants completed standardised measures of anxiety, depression and coping style. Participants identified as 'at risk' of an anxiety disorder were assessed for a clinical diagnosis with a structured diagnostic interview. Results indicated the universal intervention effective in significantly reducing anxiety (p < .001), depression (p < .001) and behaviour avoidance in children at post- intervention and 12-month follow-up intervals. Grade 6 children reported significantly higher anxiety at pre-intervention and greater reductions in anxiety at post intervention compared with the grade 9 (p < .001), although both primary and secondary school participants showed equal reductions in anxiety at 12-month follow up. Overall, findings suggest universal intervention potentially successful in reducing symptoms of anxiety and increasing coping skills in children. Primary school children reported the greatest changes in anxiety symptoms, suggesting earlier preventive intervention potentially more advantageous than later intervention. Developmental differences in anxiety, depression and coping strategies are discussed in addition to the implications and limitations of this study and directions for future research.

Research shows that anxiety disorders are common and problematic in children. Treatment studies demonstrate that cognitive-behavioural interventions for children can successfully minimise these problems. Further, when implemented as early intervention or prevention programs, these interventions can prevent the onset of anxiety problems in 7 to 14 year olds and reduce existing levels of anxiety. This type of preventive approach has enormous potential for improving community mental health in a low cost model of service delivery. Yet, to develop this as a viable service model, these programs need to be evaluated under 'real world' conditions as opposed to specialist university clinical teams. In this research, the long-term effectiveness of an ecological model of the prevention of anxiety disorders for children was conducted. In the first study, teachers (N = 17) were trained intensively in the principles of anxiety and the FRIENDS anxiety prevention program (Barrett, Lowry-Webster & Holmes, 1999). Measures were taken of the PROXIMAL effects of training on the knowledge and self-efficacy of participating teachers at two points in time. Compared to teachers in a control group (N= 17) and a group comprised of psychologists regarded as experts in the FRIENDS anxiety program (N= 22), trained teachers demonstrated significant increases in the levels of knowledge and self-efficacy at time two. These increases approached levels exhibited by experts in terms of knowledge, and were not significantly different from experts in their levels of self-efficacy to implement the FRIENDS program following training. This study also explored the quality or fidelity of program implementation by these trained teachers (INTERMEDIATE EFFECTS). Results demonstrated that trained teachers implemented the program with high levels of integrity in accordance with the FRIENDS intervention manual. The second study sought to investigate the outcomes for participating children in terms of actually preventing and reducing existing levels of anxiety. Also of interest was the impact this intervention had on levels of depression. Participants were 594 children aged 10-13 years from 7 schools in Brisbane Australia. Children, and parents reported on children's social, emotional and behavioural characteristics at three-assessment points over 12 months. Results were examined universally (for all children) and for children who scored above the clinical cut-off for anxiety at pre-test. Results revealed that children in the FRIENDS intervention group reported fewer anxiety symptoms regardless of their risk status at posttest. In terms of reported levels of depression, only the high anxiety group who completed the FRIENDS intervention evidenced significant improvements at posttest. The results indicated that intervention gains were maintained over a period of 12 months, as measured by self-reports and diagnostic interviews. Moreover, evidence of a prevention effect was also demonstrated, with a significantly greater percentage of children in the control group progressed to "at risk" or "remained at risk" compared to children in the intervention group. Additionally, 85% of children in the intervention group who were scoring above the clinical cut-off for anxiety and depression were diagnosis free in the intervention condition at 12-month follow-up, compared to only 31.2% of children in the control group. Implications of these findings are examined, alongside limitations of the study and directions for future research.

Despite increasing prevalence, significant negative biopsychosocial consequences, and few treatment options, overweight and obesity in adolescence has received very little attention in the scientific literature. The major objective of this research program was to evaluate the efficacy of a cognitive behavioural (CBT) program in the treatment of adolescent overweight and obesity. Sixty three overweight or obese adolescents (28M, 35F) aged 11.5 to 18.9 years (M = 14.41, SD = 1.85) participated in a randomized controlled trial evaluating the efficacy of a CBT weight loss intervention. This comprehensive intervention program incorporated a range of CBT techniques aimed at assisting adolescents to establish and maintain healthy eating and physical activity habits. Treatment resulted in improved body composition post treatment and sustained or improved body composition following maintenance. Participation in a motivational interview (MI) prior to this CBT intervention did not influence treatment outcomes. Despite reductions in weight and body fat, lean body mass was not affected by the intervention, thus, treatment did not detrimentally effect linear growth and lean body tissue. Poor compliance with measurement protocols limits conclusions that can be drawn regarding the impact of treatment on eating and activity habits. However, results suggest that treatment resulted in a reduction in fat consumption, reduced saturated fat intake, and reduced time spent in sedentary activities. Increases in physical activity were not evident. The treatment seeking sample did not report elevated psychopathology levels and treatment did not impact on adolescent depression, anxiety, or stress. Adolescents receiving treatment reported improvements in disordered eating relative to those in the control condition. A secondary aim of this research program was to redress the limited information available on the behavioural and psychosocial factors associated with adolescent overweight and obesit y. These factors were explored in community samples of adolescents (n = 161, M = 16.3, SD = I .8) and their parents, and young adults (n = 292, M = 19.7, SD = 2.0). In comparison to both normal and overweight adolescents, treatment seeking adolescents reported greater body dissatisfaction and weight. discontent. Body weight was not associated with psychopathology in the community samples and treatment seeking adolescents did not differ from normal or overweight adolescents from the community sample in terms of psychopathology. However, young adults who reported being overweight during childhood reported greater psychopathology as young adults. These findings suggest that excess weight in adolescence may have longer term rather than immediate effects on psychopathology. A number of family factors were associated with body weight in both adolescents and young adults. Combined, results indicated that CBT is efficacious in the treatment of overweight and obesity in adolescents and MI does not improve the efficac y of CBT. The current findings suggest that the impact of excess weight on psychosocial functioning is limited to body discontent and dissatisfaction in adolescence but is associated with increased psychopathology in early adulthood. Results also highlighted the importance of parents and family in the treatment of overweight and obesity in adolescents.

The aims of the present thesis were: * To investigate how women patients with borderline personality disorder (BPD) perceive their suffering, quality of life and encounter with psychiatric care (paper 11 and III). * To describe BPD patients' and psychiatric professionals' perceptions of receiving and giving dialectical behavioural therapy, DBT (paper I). * To investigate how starting treatment of BPD patients with DBT affected the psychiatric professionals' experience of occupational stress and professional burnout (paper IV) Due to the different types of research questions the thesis deal with, it uses a mix of qualitative and quantitative research methods. In two of the studies (11 and 111) the main methods were qualitative. Data from free format questionnaires, individual- as well as group interviews and biographical texts, were analysed with content analysis or a hermeneutic approach. In study Ill the methods were quantitative. A summated rating scale measuring healthrelated quality-of-life (HRQOL) was analysed with descriptive and inferential statistics. In study IV quantitative and qualitative methods were combined. Two burnout inventories were analysed with descriptive and inferential statistics, and data from free format questionnaires and group interviews were analysed with qualitative content analysis. The main findings were that BPD patients suffer to an extent that is often unendurable, leading to deliberate self-harm (DSH) and suicide attempts to relieve suffering or just try to get away from it all (paper 11). In study Ill the BPD patients showed significantly poorer quality-of-life (even physical) than normal population controls of comparable age. The suffering, suicide attempts, DSH and poor quality-of-life (paper 11 and 111) put the patients in a position of voluntarily or involuntarily getting involved with psychiatric care. Study II revealed a double role of the psychiatric care in relation to BPD patients. On one hand, psychiatric professionals can add to the suffering by not being understanding and being disrespectful, on the other hand they can be helpful and relieve suffering by being respectful, understanding and validating. There was a clear relationship between the patients' experience of validation and the experience of being helped. DBT seems (both from the patients' and psychiatric professionals' perspective) to be a treatment with a philosophy, content and structure being able to relieve BPD patients suffering and helping them to independence and a bearable life-situation (paper I). Study IV confirms previous findings that psychiatric professionals experience treatment of self-harming patients as profoundly stressful. DBT was seen as stressful in terms of learning demands, but decreased the experience of stress in the actual treatment of the patients due to its high degree of structure and specific techniques. The DBT team-work and supervision were felt to be supportive, as was one particular facet of DBT, namely mindfulness training which some professionals felt also improved their handling of other work stressors not related to DBT. This finding also corresponds to BPD patients' perceptions of the mindfulness component in DBT, which they reported as particularly helpful (paper 1). It should be noted that the patient samples in the thesis may be considered as a "worse off" subgroup among BPD patients, as they usually entered special treatment programs after a period of escalating symptoms, which standard psychiatric services had had difficulties handling. The rather small number of participants and the lack of equivalent andlor concurrent control groups in the quantitative studies limit the generalization of the results.

Syftet med föreliggande studie var att vidareutveckla en behandlingsspecifik följsamhetsskala för paniksyndrom vid internetförmedlad kognitiv beteendeterapi (IKBT). Studiens frågeställningar var 1) uppnår skalan tillräcklig interbedömarreliabilitet, 2) finns det ett samband mellan skalan och det tidigare använda följsamhetsmåttet antalet genomförda moduler, och 3) finns det ett samband mellan skalan och behandlingsutfallet. Interbedömarreliabiliteten mellan två bedömare testades genom två omgångar samskattning. 80 deltagare som behandlades med IKBT för paniksyndrom vid enheten för internetpsykiatri i Stockholm skattades sedan enligt den behandlingsspecifika följsamhetsskalan. Även antalet moduler deltagarna genomförde registrerades. Resultaten visade att skalan sammantaget hade en god interbedömarreliabilitet. Vidare korrelerade följsamhetsskalan positivt med både antalet genomförda moduler och behandlingsutfallet. Slutsats: Skattningsskalan vidareutvecklad i föreliggande studie visade indikationer på att vara ett tillförlitligt och användbart instrument för att mäta följsamheten till IKBT vid paniksyndrom. / The purpose of this study was to further develop a treatment-specific rating scale for adherence to internet-based cognitive behavioural therapy (ICBT) for panic disorder. The research questions for this study were 1) does the rating scale show satisfying inter-rater reliability, 2) is there an association between the rating scale and the commonly used measurement of adherence, module completion, and 3) is there an association between the rating scale and treatment outcome. The inter-rater reliability between two raters was assessed twice. 80 participants treated with ICBT for panic disorder at Internetpsykiatrin (the unit for internet-based cognitive behavioural therapy in Stockholm) were then assessed using the treatment-specific rating scale for adherence. Module completion was also registered. Results show that the rating scale had an overall satisfying inter-rater reliability. Furthermore, the rating scale correlated positively with both module completion and treatment outcome. Conclusion: The rating scale further developed in the present study showed indications of being a reliable and useful instrument for measuring adherence to ICBT for panic disorder.

Purpose: The aim of the systematic review was to address whether psychological interventions were able to reduce fatigue severity or the impact of fatigue in individuals with Multiple Sclerosis. The empirical study aimed to evaluate the effectiveness of a CBT based self-help workbook at reducing perceived impact of fatigue in a clinical sample of MS patients. Methods: A systematic search of the literature was carried out between the years 1980 and February 2015 to review whether psychological interventions were effective for fatigue management in Multiple Sclerosis. A randomised controlled trial examined the effectiveness of a CBT-based self-help workbook for the reduction of fatigue impact in MS. Participants were randomly allocated to one of three groups treatment as usual (TAU), pure self-help (PSH) or guided self-help (GSH). Results: Eleven studies were included in the systematic review, which indicated that CBT based interventions aiming to reduce fatigue or depression were most effective at reducing the severity of fatigue. Impact of fatigue can be reduced through mindfulness, CBT, motivational interviewing and to a lesser extent acceptance and commitment therapy. The empirical study did not find any significant differences between groups, however satisfaction with the workbook was high. Conclusions: The review suggests that there is a clear role for psychological interventions in fatigue management in MS, although further robust research into different therapeutic modalities is needed. From the empirical study it appears that the low level CBT-based intervention for fatigue in MS was not effective at reducing the perceived impact of fatigue. This study reflects an inclusive, clinical sample, recruited from a specialist rehabilitation unit, with high levels of multidisciplinary input which may have diluted any potential effect of the workbook. Objectives: The aim of the systematic review was to address whether psychological interventions are able to reduce fatigue severity or the impact of fatigue in individuals with Multiple Sclerosis Data sources: A search was conducted of: Psychinfo, Medline, Embase, CINAHL between 1980 and February 2015. Review methods: All studies were evaluated against a set of quality criteria by author (KG) with a proportion of studies being independently reviewed by author (DP) to ensure reliability of ratings. Results: Eleven studies were included in the review. CBT based interventions with a focus on fatigue management and depression appear to significantly reduce fatigue severity with medium to large effect. Significant reductions in fatigue impact can be found from mindfulness groups, motivational interviewing and CBT. Effect sizes for CBT interventions ranged from negligible to medium. For the mindfulness and motivational interviewing interventions effect sizes were not able to be calculated. The acceptance and commitment therapy intervention did not find a significant reduction in fatigue but found a medium effect for the intervention. Conclusions: There is a clear role for psychological interventions in the reduction of fatigue management but more high quality research needs to be carried out.

Background: Group CBT approaches have been shown to be equally as effective as individual CBT for reducing depressive symptoms and preventing relapse; however, the predictors of response are poorly understood. The primary objective of the studies presented in this thesis was to further examine the formal and process factors within group CBT for depression that contribute to various treatment outcomes. The first study investigated the relationship between group CBT for depression and changes in interpersonal distress, as well as the process mechanisms that might influence this relationship. The second study assessed whether formal feedback provided to therapists and clients derived from the Outcome Questionnaire (OQ-45), a robust measure of client functioning, would enhance group processes and treatment outcomes. Method: Study 1: Secondary data from clients having received individual CBT for depression at a community-based mental health training centre constituted one condition (18 clients). Data for the group condition (12 clients) were collected from clients attending group CBT for depression at a tertiary care facility. Relationship distress, as measured by the OQ-45 relationship distress subscale score, was assessed at intake and termination. Group participants also completed process measures at the start and end of treatment. In study 2, participants were recruited from a tertiary care facility to participate in a CBT group for depression. Participation involved completing brief questionnaires assessing psychological and process variables before and after treatment, as well as the OQ-45 at every session. Three groups (21 clients) received standard CBT and two groups (12 clients) received enhanced CBT, which included feedback about their progress from the OQ-45. Results: Results of study 1 suggest that clients who participated in group CBT experienced a significantly greater reduction in relationship distress across time than clients who participated in individual CBT. Results also indicate that therapeutic alliance, and not group cohesion, mediates the relationship between pretreatment relationship distress on posttreatment relationship distress in group CBT. Results of study 2 indicate that participants in the enhanced condition experienced greater improvements in quality of life, dysfunctional beliefs, and therapeutic bond at termination, relative to participants in the standard condition. Trends also suggest a greater reduction in depressive symptoms. Conclusions: Group CBT for depression may be more effective than the individual modality for reducing interpersonal distress. Furthermore, therapeutic alliance plays a significant role in improving interpersonal distress within a structured group CBT protocol. Feedback from the OQ-45 may help improve client outcomes and enhance therapeutic bonding with facilitators in group CBT for depression.