This Master thesis is focused on ecological validity of a cognitive training in university students. Forty-five students participated in three months research during which 30 of them took regular personalized cognitive training using CogniFit programme on their computers. The study examines the impact of the cogntitive training on everyday cognitive functioning of students. The scientific methods used for the ecological validity research were the following self-reporting questionnaires: Cognititive Failure Questionnaire, Everyday Memory Questionnaire and Dysexecutive Questinnaire. Students also filled in Schwartz Outcome Scale - 10 and Self-image questionnaire for detailed exploration of more variables. For the research, we applied test-retest design and used control group of fifteen students for results comparison. Analysis of the gathered data proved little evidence of ecological validity of cognitive training, which can be attributed to considerable cognitive stress at students. An unexpected outcome of the study which proved to be very significant is relation between executive functions and well-being of a student. This relation was confirmed repeatedly. Possible improvements of methodology and also problem with randomization of students is discussed. Proposal for the further development of...

Die Kapazität des Arbeitsgedächtnisses (AG) sagt die Leistungsfähigkeit in diversen anderen kognitiven Funktionen voraus. Zusätzlich werden altersbedingte Beeinträchtigungen in AG mit Defiziten in anderen kognitiven Funktionen assoziiert, was sich im hohen Alter in der Minderung der Selbständigkeit und des Leistungsniveaus in alltäglichen Aufgaben widerspiegelt. Das AG kann durch Trainingsmaßnahmen verbessert werden, und auch andere kognitive Funktionen können von AG-Training profitieren. Die Befundlage bezüglich dieser Transfereffekte deutet darauf hin, dass AG-Training auch Mechanismen zur Verbesserung der allgemeinen kognitiven Leistungsfähigkeit umfasst. Obwohl es zunehmend Hinweise für die Möglichkeit gibt, kognitive Funktionen durch AG-Training zu verbessern, sind die genauen Mechanismen von Training und Transfer noch unklar. In der vorliegenden Dissertation präsentiere ich vier Studien, in denen ich die genauen Mechanismen von AG-Training untersucht habe. Ich konnte zeigen, dass Training die Leistung in verschiedenen Tests zu exekutiven Funktionen verbessert, und dass der Transfer von Trainingseffekten statt auf die Förderung einer allgemeinen kognitiven Fähigkeit auf die Verbesserung in einem spezifischen Prozess zurückzuführen ist. Weiterhin habe ich zum ersten Mal gezeigt, dass bereits 16 Sitzungen eines AG-Trainings zu strukturellen Veränderungen in der weißen Substanz führen. Diese ließen sich in den Nervenbahnen nachweisen, die die mit AG assoziierten Hirnareale verbinden. Ich zeigte erstmals auch, dass altersbedingte Unterschiede in AG zwischen jungen und älteren Erwachsenen bereits nach 16 Trainingssitzungen ausgeglichen werden können. Die Befunde der vorliegenden Arbeit werden in Bezug auf die Flexibilität der kognitiven Funktionen und auf die Plastizität des zugrunde liegenden neuronalen Substrats diskutiert. Zusätzlich werden neue Ansichten für Modelle von Training- und Transfermechanismen vorgestellt. / Working memory (WM) is a cognitive function that is engaged in several everyday tasks. WM performance predicts performance in diverse other cognitive functions. Additionally, WM decline at old age is associated with age-related impairments in others cognitive functions, thus affecting autonomous performance of everyday tasks. It has been shown that WM can be improved with training interventions, and evidence has accumulated showing that also other cognitive functions can profit from WM training. The transfer findings indicate that WM training might enclose a mechanism to improve cognitive functions in general. Even though there exists a growing body of evidence on the possibilities to improve cognitive functions with WM training in different populations, the exact mechanisms of training and transfer have remained unclear. In the current dissertation I examine the prospects and precise mechanisms of WM training with four studies using the bi-modal dual n-back paradigm. I showed that dual n-back training improved performance in various tests tapping executive functions. I could also demonstrate that the mechanisms underlying transfer result from an improvement in a specific process tapped by the training task rather than in the boosting of a general cognitive ability. Consequently, transfer can occur to tasks if they engage the same specific process. Additionally, I provided primary evidence that only 16 sessions of WM training produces microstructural changes in white matter pathways connecting brain regions that support WM functions. I also showed for the first time that age-related differences in WM performance between young and older adults can be compensated for after only 16 training sessions. The findings of the present dissertation are discussed in relation to the flexibility of cognitive functions and the plasticity of the underlying neuronal substrate; additionally, new conceptions to models of training and transfer mechanisms are presented.

The NeuroTracker (NT), a computerized three-dimensional multiple object tracking (3D-MOT) training device, has potential benefits for concussion assessment and management, as well as maintenance of cognitive function. Accessing 3D technology is a limiting factor for 3D-MOT, so we assessed the performance of MOT training in 2D and 3D environments in both healthy and concussed individuals (8-91 years of age). The participants (n=86) who completed all ten training sessions over the three-month period, were assigned to one of three different studies: (1) an environment comparison (2D versus 3D), (2) an age comparison (youth, young adult, and older adult), or (3) a concussed population comparison (non-concussed, recently concussed, and prolonged concussed). In all studies, performance increased with training, indicating all individuals could increase perceptual cognitive function in all environments. Significant differences were apparent when 2D and 3D environments were compared, with participants in the 3D environment out performing participants in the 2D environment. Furthermore, switching from the 3D to the 2D environment was detrimental to learning performance. When comparing learning performance between different aged individuals, a linear regression demonstrated learning performance increased at a lesser rate with age(p<0.05). Concussed populations also demonstrated correlative trends when comparing learning performance, as well as initial NT scores. The longer an individual was suffering from concussion symptoms, the lower the initial NT score was, but the higher the rate of learning performance was through out training. Further investigation into attention, memory, and visual processing speeds in each population may help to better resolve the relationship between these domains and clarify if NT can serve as a means for concussion assessment and rehabilitation for individuals at any age in the future. / Graduate

<p><em><p>Depression är en vida utbredd sjukdom. Kognitiv träning skulle kunna</p><p>vara en kostnadseffektiv och lättillgänglig intervention att bemöta</p><p>sjukdomen i ett tidigt skede. Tidigare forskning tyder på att kognitiv</p><p>träning har effekt på depression och kognitiva nedsättningar. Denna</p><p>studie ämnade undersöka om träning hemma skulle leda till</p><p>förbättringar av depression, och om dessa berodde på träningen i sig.</p><p>Fyra deltagare med depressionssjukdomar genomförde träning med</p><p>Paced Auditory Serial Addition Task (PASAT). Studien hade en n=1-</p><p>design med för- och eftermätningar, och kontroll genom</p><p>pseudointervention. Dagliga och veckovisa mätningar visade</p><p>förbättring för endast en deltagare. Träningen visade sig därmed inte</p><p>effektiv. Tre deltagare upplevde nytta med interventionen. Det kan</p><p>vara skäl för fortsatta studier av kognitiva interventioner vid</p><p>depression.</p></em></p><p> </p> / <p>Depression is a widely spread disorder. Cognitive training could be a</p><p>cost effective and easily accessible intervention to treat the disorder in</p><p>an early stage. Previous research indicates that cognitive training is</p><p>effective in alleviating depression and cognitive deficits. The aim of</p><p>this study was to investigate whether cognitive training at home would</p><p>lead to improvements in depression, and whether improvements were</p><p>due to the training per se. Four subjects with depression participated</p><p>in training with the Paced Audity Serial Addition Task (PASAT). The</p><p>study had an n=1-design with pre- and post-measures, and control by</p><p>a pseudo-intervention. Daily and weekly measures showed effects</p><p>only for one participant. Thus the training was not shown to be</p><p>effective. Three participants experienced benefits from the</p><p>intervention. That could be a reason for further studies of cognitive</p><p>interventions of depression.</p>

Depression är en vida utbredd sjukdom. Kognitiv träning skulle kunna vara en kostnadseffektiv och lättillgänglig intervention att bemöta sjukdomen i ett tidigt skede. Tidigare forskning tyder på att kognitiv träning har effekt på depression och kognitiva nedsättningar. Denna studie ämnade undersöka om träning hemma skulle leda till förbättringar av depression, och om dessa berodde på träningen i sig. Fyra deltagare med depressionssjukdomar genomförde träning med Paced Auditory Serial Addition Task (PASAT). Studien hade en n=1- design med för- och eftermätningar, och kontroll genom pseudointervention. Dagliga och veckovisa mätningar visade förbättring för endast en deltagare. Träningen visade sig därmed inte effektiv. Tre deltagare upplevde nytta med interventionen. Det kan vara skäl för fortsatta studier av kognitiva interventioner vid depression. / Depression is a widely spread disorder. Cognitive training could be a cost effective and easily accessible intervention to treat the disorder in an early stage. Previous research indicates that cognitive training is effective in alleviating depression and cognitive deficits. The aim of this study was to investigate whether cognitive training at home would lead to improvements in depression, and whether improvements were due to the training per se. Four subjects with depression participated in training with the Paced Audity Serial Addition Task (PASAT). The study had an n=1-design with pre- and post-measures, and control by a pseudo-intervention. Daily and weekly measures showed effects only for one participant. Thus the training was not shown to be effective. Three participants experienced benefits from the intervention. That could be a reason for further studies of cognitive interventions of depression.

Plasticity is a central concept within the life-span approach of development and is defined as the ability of an individual to change and reorganize in response to environmental challenges (e.g., Baltes & Singer, 20019. Such intraindividual changes can be induced by systematic cognitive training. Recent studies suggest that substantial amounts of plasticity can be induced in executive control functions with a process-based training approach. These newer studies show that repeated practice on executive control tasks not only improved performance on these trained tasks, but also led to improvements in nontrained tasks (i.e., transfer; e.g., Jaeggi, Buschkuehl, Jonides, & Perrig, 2008; Karbach & Kray, 2009). Executive control processes are especially relevant from a developmental perspective because executive control is involved in a wide range of complex cognitive activities (e.g., van der Sluis, de Jong, & van der Leij, 2007) and is one of the most central areas of cognitive development (e.g., Craik & Bialystok, 2006). The current thesis aimed at elucidating several important questions concerning the plasticity of executive control functions induced by systematic cognitive training. Firstly, the amount, range, and stability of plasticity in adolescents and older adults were investigated. Secondly, studies explored if training design, age, and interindividual differences moderate the amount and range of plasticity. Furthermore, the current thesis aimed at exploring how process-based training specifically leads to transfer effects. To explore these questions, all studies employed a pretest-posttest-design comparing a group of participants that was trained with a process-based training approach to a group of control partici-pants that did not receive the training. Pretraining and posttraining sessions incorporated systematic assessment of transfer measures in different cognitive domains. The first study set out to investigate if executive control can be trained in adolescents with a task switching training. Additionally, the study explored what particular domains of executive control may underlie training and transfer effects, and if acute bouts of exercise directly prior to cognitive training enhance training effects. Analyses indicated substantial training effects for both training groups (with or without acute exercise) and near transfer to a similar switching task. Other findings of transfer were limited to a speed task and a tendency for faster reaction times in an updating task. Thus, findings indicate, for the first time, that executive control can be enhanced in adolescents through a short training. Furthermore, analyses suggest that updating may be of particular relevance for the effects of the task switching training. Analyses revealed no additional effects of the exercise intervention. The second study set out to explore, for the first time, the effects of a process-based training ap-proach in old-old age (above 80 years). After ten sessions of practice on working memory tasks, the training group improved in four of the five trained tasks, emphasizing the potential for plasticity even in old-old age. The gains in the training group were largely driven by individuals who started out with a low capacity in the training tasks. Thus, findings suggest that working memory can be improved with a short executive control training even in old-old age, particularly for low-capacity individuals. The absence of transfer effects in this study may point to the limits of plasticity in this age group. The third study aimed at further elucidating the mixed findings regarding the amounts of training and transfer effects induced by executive control training in older adults. For that purpose, a sample of older adults covering a wide range from young-old to old-old age (65 to 95 years) was either trained for nine sessions on a visuospatial and a verbal working memory as well as an executive control task; or served as controls. Analyses revealed significant training effects in all three trained tasks, as well as near transfer to verbal working memory and far transfer to a nonverbal reasoning task. Remarkably, all training effects and the transfer effect to verbal working memory were even stable at a nine-month follow-up. These findings suggest that cognitive plasticity is preserved over a large range of old age and that even a rather short training regimen can lead to (partly specific) training and transfer effects. However, analyses also revealed that there are a range of factors that may moderate the amount of plasticity, e.g., age and baseline performance in the training domain. To summarize, the current thesis explored effects of short executive control trainings on cognitive functions in adolescents and older adults. The findings suggest a high potential for intraindividual variability across the whole life-span. Plasticity was shown on the level of training and transfer tasks, as well as on the level of stability of effects. Furthermore, results support the notion that process-based training improves executive control processes that in turn lead to improvements in tasks that rely on these processes. The current thesis makes important contributions to the conceptual debate about the potentials and limits of training-induced plasticity across the life-span. It benefits the debate in that it specifically delineates factors that moderate the obtained effects.

Background: With age, older adults experience declines in both short- and long-term memory. One way to counter these age-related declines is through memory interventions which include computerized cognitive training and non-computerized cognitive stimulation. This dissertation examined whether a cognitive training program, Dakim BrainFitness (Dakim Inc., 2002) and a program of cognitive stimulation, Mind Your Mind (Seagull & Seagull, 2007), enhance memory performance among cognitively-intact older adults residing in independent-living retirement communities. Specifically, the following research questions were proposed: (a) How effective is the computerized cognitive training program in improving memory performance relative to the cognitive stimulation program or a no-contact control condition? (b) How effective is the non-computerized cognitive stimulation program, Mind Your Mind, at improving memory performance relative to a control condition? and (c) Will memory training gains endure 3-months post-training for those who participate in cognitive training? Method: Fifty-three older adults were randomized to cognitive training (n = 19), cognitive stimulation (n = 17), or a no-contact control (n = 17) condition. Participants in the cognitive training and cognitive stimulation conditions were asked to complete five 25-minute sessions per week for a 10-week period. Memory outcome measures included the Auditory Verbal Learning Test (AVLT), the Hopkins Verbal Learning Test (HVLT), and the Wechsler Memory Scale-Third Edition (WMS-III) Family Pictures subtest. Outcome measures were administered at baseline, immediately post-training (or equivalent delay), and again at 3-months post-training. Results: Multivariate Analysis of Variance indicated no significant differences between the three training conditions on baseline characteristics and memory outcome scores (p = .660). To test hypotheses one and two, memory outcome measures were compared across training conditions and testing occasions. A repeated measures MANOVA indicated a significant group x time interaction, Wilks' Λ =.585, F(10,92) = 2.83, p = .004, partial η2 = .235. Follow-up analyses for each memory outcome measure from baseline to immediately post-training were conducted with training condition as the independent variable. Significant group x time interactions were found between conditions for AVLT delayed recall, F(2,50) = 3.683, p = .032, partial η2 = .128, and the HVLT immediate recall, F(2,50) = 5.059, p = .010, partial η2 = .168. No significant group x time interaction was indicated on the AVLT immediate recall, F(2,50) = 2.544, p = .089, partial η2 = .092. There was a marginally significant group x time interaction on the WMS-III Family Pictures delayed recall F(2,50) = 2.975, p = .060, partial η2 = .106. Post-hoc comparisons for significant outcome measures were conducted using Fisher's LSD test, while controlling for baseline performance. Results indicated that the cognitive training condition performed significantly better than the cognitive stimulation condition from baseline to immediately post-training on the AVLT delayed recall (p = .012), as well as on HVLT immediate recall (p < .001). The cognitive training condition also performed significantly better from baseline to immediately post-training as compared to the no-contact control condition (p = .011). A significant difference between the cognitive training condition and the no-contact control condition was also found on the WMS-III delayed recall measure (p = .030) immediately post-training. No significant differences between any of the conditions were found on either AVLT immediate or WMS-III Family Pictures immediate recall (ps > .05). There were no differences between the cognitive stimulation and control conditions across all memory outcomes (ps > .05). For hypothesis three, a repeated measures MANOVA indicated no main effect of time within the cognitive training condition for the memory outcome measures, Wilks' Λ = .047, F(6,11) = 2.11, p = .135, partial η2 = .535. Discussion: These findings provide evidence that the adaptive computerized cognitive training program, Dakim BrainFitness, significantly improved memory abilities as measured by the AVLT delayed recall, HVLT, and WMS-III Family Pictures delayed recall relative to cognitive stimulation. In contrast, there were no significant improvements for participants in the non-adaptive, non-computerized program of cognitive stimulation relative to controls. These findings coincide with the Model of Adult Cognitive Plasticity that in order to improve cognitive performance, there needs to be a mismatch between the individual's capacities and the demands of the task. Adaptive cognitive training may be more likely to provide a mismatch and produce positive plasticity changes in the brain. Future research pertains to exploring the cognitive benefits that these programs have on other types of cognitive domains.

Older adults who stay physically and mentally active appear to have better cognitive function compared to their less active counterparts. In fact, those who perform either regular exercise or cognitive training (CT) can maintain and improve their cognitive functioning, even in their later years. Resistance training (RT) causes an increase in specific hormones that are responsible for improved brain functioning; however, many questions about how these hormones respond to RT are unanswered. Understanding how these hormones respond to RT can help researchers and clinicians create optimal training programs for older adults. Research shows that combining exercise and CT may be better for the brain compared to either activity performed alone; however, nobody has looked at RT combined with CT. We believe that combining RT and CT where CT is performed when an individual’s hormones are highest (right after RT) could have a big effect on brain function in a short period of time. This work represents a two-part study looked at: 1) how these hormones respond to a session of RT, and 2) the effect of combined RT and CT on cognitive function in older adults. Our participants performed CT immediately after RT, 3 times per week for 8 weeks. Specific hormones which are important for brain function were measured immediately before and for 2 hours after an acute bout of RT before and after 8-weeks of RT. Cognitive function was measured before and after the RT training period. Our primary findings were: 1) significant increases in brain derived neurotrophic factor immediately after RT and 2) participants cognitive function improved after 8 weeks of training. This is important because short-term combined RT and CT can lead to significant improvements in cognitive functioning. Also, this work will allow researchers to begin designing exercise programs that can maximize the brain’s ability to change, even at an old age. / Thesis (Master, Kinesiology & Health Studies) -- Queen's University, 2012-09-21 15:29:35.509

Mindfulness-based meditation practices involve various attentional skills including the ability to sustain and focus ones attention. During a simple mindfulness based breath awareness meditation, sustained attention is required to maintain focus on the breath while meta-cognitive awareness and executive control are required to detect and correct mind wandering. The purpose of this thesis was to investigate whether a simple, mindfulness based breath awareness meditation, administered over a short period to meditation naïve individuals could modulate core attentional functions and associated task related neural activity. Two longitudinal randomised control studies were conducted. The aim of the first study was to establish if said modulations were possible in a sample of healthy adults, meeting a current research need for longitudinal evidence in this field and providing important information regarding a potential mechanism for the salutary effects widely observed from the use of mindfulness based interventions. It was found that short term engagement with a mindfulness based breath awareness meditation can modulate core attentional functions and task related neural activity, with specific modulations found in electrophysiological markers of sustained attention to the goal/task at hand and perceptual stimulus discrimination. In line with current theoretical models it is argued that modulations to such core attentional processes following short term training may provide a platform upon which mindfulness related salutary effects are built. The second study was designed to establish if such modulations were possible in older adults. It is argued that mindfulness training may have utility for increasing cognitive reserve, a potential mechanism by which age related declines in cognitive functions may be mitigated. It was found that both behavioural and electrophysiological markers of core attentional functions were modulated following 8 weeks mindfulness training but not following a matched active control group condition (simple brain training exercises). The reviewed extant evidence and findings of this study suggest that mindfulness meditation may enhance cognitive reserve through the repeated activation of attentional functions and associated neural activity during practice and are consistent with recent theoretical models of cognitive reserve. The potential for mindfulness training to positively modulate core attentional functions in older adults and to potentially impact cognitive ageing demands further investigation.

Made available in DSpace on 2016-03-15T19:40:17Z (GMT). No. of bitstreams: 1 Carla Nunes Cantiere.pdf: 1519984 bytes, checksum: 41cacc5c24655360da688012eeb9606f (MD5) Previous issue date: 2014-08-05 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / According to the literature, neuropsychological intervention has demonstrated efficacy in improving cognitive functions, in the performance of daily activities and in increasing the quality of life of patients with diseases that affect the nervous system. This work aims to face an exploratory study to implement and evaluate indicators of improvement for a program of intervention for neuropsychological skills training attention and cognitive flexibility in children with signs of inattention and hyperactivity. The study included four individuals aged between 8 and 12, without intellectual deficits, and behavioral indicators of inattention and or hyperactivity, referred by their parents and teachers. The participants underwent a pre-intervention assessment, with the use of inventories of behavioral profiles, tests of voluntary, automatic and temporal attention, executive function and resistance to distraction, and speed of cognitive processing. After the initial assessment, 15 meetings were held with each participant, one a week, with an average duration of 60 minutes each day, in which activities directed to attention and cognitive flexibility were held. At the end of the intervention, participants were reassessed by the same behavioral and neuropsychological instruments and the data was compared with the pre-assessment ones. All the sessions were attended by an observer, in order to register and evaluate the intervention. For this aim, an observation protocol, to categorize targets behaviors in ADHD, was used. It was found that, in most of the studied cases, different kind of behavioral and cognitive indicators were improved, as the reduction of inattention and hyperactivity behavior and the presence of a higher number of correct answers, fewer omissions, decrease of the reaction time and continuous decline due to the interval in applied neuropsychological and computerized tests. In other words, there are important indicators of the improvement of children after the intervention, which may reflect in terms of educational development and social inclusion of the participants. / De acordo com a literatura a intervenção neuropsicológica tem demonstrado eficácia na melhora das funções cognitivas, no desempenho das atividades cotidianas e no aumento da qualidade de vida de pacientes com diferentes tipos de doenças que afetam o sistema nervoso. Este trabalho tem por objetivo, como um estudo exploratório, desenvolver, implementar e avaliar indicadores de melhora de um programa de intervenção neuropsicológica para treino de habilidades de atenção e flexibilidade cognitiva em crianças com sinais de desatenção e hiperatividade. Participaram deste estudo 4 indivíduos com idade entre 8 e 12 anos, sem déficit intelectual e com indicadores comportamentais de desatenção e/ou hiperatividade referidos por seus pais e professores. Os participantes foram submetidos a uma avaliação pré-intervenção, utilizando inventários de perfis comportamentais, testes de atenção voluntária, automática e temporal, função executiva e resistência à distração e velocidade de processamento cognitivo. Após a avaliação inicial, foram realizados 15 encontros com cada participante, um por semana, com duração média de 60 minutos cada, nos quais foram feitas atividades lúdicas direcionadas à atenção e à flexibilidade cognitiva. Ao final das intervenções, os participantes foram reavaliados pelos mesmos instrumentos comportamentais e neuropsicológicos e os dados comparados aos da pré-avaliação. Em todas as sessões houve a participação de um observador, com o intuito de registrar a intervenção. Para tanto, utilizou-se um protocolo de observação para categorizar comportamentos alvos no TDAH. Verificou-se que na maioria dos casos estudados foi possível observar melhora de diferentes tipos de indicadores comportamentais e cognitivos como a redução dos comportamentos de desatenção e hiperatividade e a presença de uma quantidade maior de acertos, menor número de omissões, redução de ensaios administrados, diminuição do tempo de reação e declínio contínuo em função do intervalo nos testes neuropsicológicos e computadorizados aplicados. Ou seja, há indicadores importantes sobre a melhora das crianças após a intervenção o que pode refletir em termos do desenvolvimento quanto a inserção educacional e social dos participantes.