Trötthet i trafiken är ett stort problem i samhället. Det är särskilt farligt att trött framföra tunga lastbilar i trafiken eftersom dessa fordon är stora och har ofta livsavgörande roller vid inblandning i trafikolyckor. För att angripa problemet har det i denna rapport studerats kring vilket sömnstadie som är lämpligast att vakna under, i syfte att vakna pigg och alert samt vilka typer av tekniker och metoder som är lämpliga för att portabelt kunna detektera Rapid-Eye-Movement. Tidigare arbeten och studier har gjorts som påvisar att uppväckning i REM-sömn är optimalt för att känna sig alert. De valda metoderna är baserade på varianter av väletablerade tekniker som används för identifiering av sömnsteg. Elektrookulografi används för att mäta ögonrörelser med hjälp av fyra elektroder som är placerade på huvudet. Kroppsrörelser upptäcks genom en accelerometer som fästs på armen. Pulsmätningar görs och används för att räkna ut pulsvariansen under sömnen. Målet är att skapa en prototyp som ska känna av när användaren är i REM-sömn och sedan väcka användaren. Detta arbete är uppdelat i två inbyggda system som görs mellan två olika examensarbeten. Resultatet blev tre sensorer som fungerar individuellt. På grund av tidsbrist och en längre felsökning blev prototypen inte färdigställd. Innan sensorerna kan tillämpas i en produkt krävs det att ytterligare tester genomförs under monitorering av en sömnspecialist. / Tiredness in traffic is a major problem in society. It is especially dangerous to drive heavy trucks when tired because these vehicles are large and often have vital roles when involved in traffic accidents. To address the problem, this degree project has studied which sleep stage is most appropriate to wake up during, in order to wake up sharp and alert, and what types of techniques and methods are suitable for portable detection of Rapid-Eye-Movement. Previous work and studies have been done which indicates that awakening during REM sleep is optimal for feeling alert. The chosen methods are based on variants of well-established techniques that are used to identify sleep stages. Electrooculography is used to measure eye movements using four electrodes placed on the head. Body movements are detected by an accelerometer attached to the arm. Pulse measurements are made and used to calculate the pulse variation during sleep. The goal is to create a prototype which will know when the user is in REM sleep and then wake the user up. This work is divided into two embedded systems that are made between two different degree projects. The result was three sensors that worked individually. Due to lack of time and a longer troubleshooting, the prototype was not completed. Before the sensors can be used in a product, additional tests are required under the supervision of a sleep specialist.

No / Language is more than a source of information for accessing higher-order conceptual knowledge. Indeed, language may determine how people perceive and interpret visual stimuli. Visual processing in linguistic contexts, for instance, mirrors language processing and happens incrementally, rather than through variously-oriented fixations over a particular scene. The consequences of this atypical visual processing are yet to be determined. Here, we investigated the integration of visual and linguistic input during a reasoning task. Participants listened to sentences containing conjunctions or disjunctions (Nancy examined an ant and/or a cloud) and looked at visual scenes containing two pictures that either matched or mismatched the nouns. Degree of match between nouns and pictures (referential anchoring) and between their expected and actual spatial positions (spatial anchoring) affected fixations as well as judgments. We conclude that language induces incremental processing of visual scenes, which in turn becomes susceptible to reasoning errors during the language-meaning verification process.

近年來隨著電腦科技的進步，發展出了各種人機介面的應用。不同於傳統的滑鼠與鍵盤，新的人機介面往往在其他不同的領域能夠得到更好的發揮，眼動（eye movement）即是一個例子，利用眼球移動在螢幕上的眼動軌跡來操控電腦。另一方面，螢幕所呈現的內容也會影響使用者的眼動行為，例如閱讀文章時不同的文章內容就會影響使用者在看文章時的眼動行為，因此我們就可以從眼動軌跡去推測出使用者對於螢幕的內容（如文章或圖片）的反應。本論文的目的就是要找出閱讀文章時的眼動軌跡和閱讀者對該文章的理解程度之間的關連性，最後發展出一個系統，利用閱讀文章時的眼動軌跡就能去推測閱讀者對於文章的理解程度，而無需後續的閱讀測驗。 / 一般人通常對自身的眼動軌跡的進行方式不甚了解，認為閱讀文章的眼動應該是順著字句的進行而移動。其實仔細觀察細小的眼動軌跡會發現比想像中複雜的多，例如當我們閱讀到文意較為困難的片段時，通常都會放慢速度，或是反覆閱讀，又例如看到自己有興趣的主題時會凝視在某些區塊較久的時間等等行為，這些都是在各種不同的情境之下做出相對的反應。本論文提出了資料探勘的方法來分析複雜的眼動軌跡，能針對每個人不同的閱讀模式找出不同的眼動規則。此方法能適應各種使用者的閱讀習性，對閱讀理解程度的預測能達到更精確的效果。 / With the advance of the computer technology, there are many kinds of HCI (Human Computer interface) applications been developed in recent years. Different from mouse and keyboard, new interface will bring more benefits in different area, and eye-movement is an example. It extracts the trace of eye movement to control the computer. Furthermore, the screen content will also affect the eye-movement. For example, when the user reads the articles, the content will affect the eye-movement, so we can speculate the reaction of the user after seen the screen content (such as article or picture) by eye-movement. The goal of the paper is to find out the relationship between eye-movement and the degree of comprehension, and develop a system which can automatically measure reading comprehension without any follow-up comprehension test. / Most people don’t realize how there eye move. They think eye movements should be carried out along the words. In fact, eye movement will find more complex than imagined, for example, when we read the context of the article is more difficult, we often slow down or read over and over again. In another example, people will gaze at some of the subjects that they are interest in for a longer period of time. These reactions correspond to a variety of different situations. This paper presents a data mining approach to analyze complex eye movement. It can find out the different rules of eye movement for users who have different reading strategy. This method will be able to adapt to a variety of users reading habits, and make more accurate prediction with the degree of the comprehension.

在人類溝通及語言使用行為中，口語和場景是構成人類跨感官理解歷程的兩項重要成分。究竟兩類資訊如何共同改變理解歷程仍待檢驗。本論文旨在探問四項研究問題：一，過去文獻對理解期間的視覺注意力運作提出兩類觀點。階層取徑主張口語優先並決定視覺表徵的處理，互動取徑則認為口語和視覺表徵可獨立影響視覺注意力。二，口語可促進指涉物體的凝視行為，然口語指涉效果是否受作業目標影響的本質仍不清楚。三，以複雜場景作為視覺情境，探討視覺複雜性和語義一致性表徵如何影響理解歷程。四，檢驗視覺刺激的預覽時間如何改變口語和場景表徵因素對理解歷程的影響。 　　本論文透過一系列視覺情境典範實驗探討以上研究問題。在每ㄧ項嘗試次中，參與者在聆聽中文語句期間同時觀看包含包含兩項物體的圖片：一為鑲嵌在一致（例如：原野）、不一致（例如：天空）和空白背景的口語指涉目標物體（例如：老虎），另一項則為口語未指涉且與背景一致的非目標物體（例如：禿鷹）。其次，四項實驗直交地操弄「作業目標」（「口語理解作業」或「場景理解作業」）和「預覽時間」（「一秒預覽」或「無預覽」）因素。 　　實驗結果發現：一，無論作業目標為何，所有實驗皆出現穩定的口語指涉效果。二，場景的視覺複雜性和語義一致性表徵不僅可獨立引導物體凝視行為，也可和口語共同決定理解期間的視覺注意力運作。三，作業目標對口語指涉效果及場景一致性效果產生差異化的調節作用。四，預覽時間有效促進口語理解作業的口語指涉效果，場景理解作業則不受影響。 　　整體而言，本論文的實驗證據支持互動取徑觀點。換言之，在跨感官理解的過程中，人類認知運作可透過協調語言、視覺和記憶等次系統，快速整合口語和場景所提供的物理和語義表徵，並依據當下情境動態地改變人類對外在世界的感官經驗。 / In human communication and language use, both speech and scene constitute the　cross-modal comprehension process. However, how these two elements combine to　affect human comprehension process has not yet been fully resolved. Four　research　questions will be examined. First, two approaches can account for the comprehension process: the hierarchical approach asserts speech plays the main part whereas the visual feature has only a supporting role, while the interactive approach states that both speech and visual feature combine to determine the comprehension process. Second, despite the speech can cause the spoken reference effect on having more fixations on its visual referent, the nature of this effect is still unclear. Third, most past studies adopted simple object array as visual context, little is known about the impact of real world scenes on the comprehension process. Fourth, whether the preview time could alter the influence of speech and scene on comprehension will be tested. A series of visual world paradigm experiments were conducted. Factors of task demand (speech comprehension vs. scene comprehension) and preview time (1-second vs. none) were orthogonally manipulated in four experiments. In each trial, participants listened to a spoken sentence in Chinese while viewing a picture with two critical objects: one is the mentioned target object (e.g., tiger), which was embedded in either a consistent, inconsistent or blank background; the other is an unmentioned non-target object (e.g., eagle) that was always consistent with its background. Several findings were found. First, the reliable spoken reference effect were shown regardless of the task demand was given. Second, the visual complexity and scene consistency not only can individually guide fixations on objects, but can work together with the speech to determine the visual attention during comprehension. Third, task demand could differently modulate the spoken reference and scene consistency effect, respectively. Fourth, preview time significantly enhances the spoken reference effect in the speech comprehension task, whereas no impact was observed in the scene comprehension task. These evidence supported the view of interactive approach. In conclusion, human’s different cognitive systems, including language, vision and memory, can interact with each other and cause the moment to moment experience of how we understand the complex world around us.

The aim of this PhD thesis was to investigate traffic safety and mobility for individuals with hearing loss (HL). Three studies were conducted: 1. a questionnaire survey aimed to evaluate differences in choice of transportation that might be related to HL, 2. a driving simulator study that looked into compensatory strategies and evaluated the efficiency of a tactile signal to alert the driver, and 3. a field study to evaluate these effects in real traffic and to evaluate a navigation system with a supportive tactile signal. The effects of HL discovered in this thesis add to the knowledge and understanding of the influence of HL on traffic safety and mobility. Differences found consistently point to a generally more cautious behavior. Compensatory and coping strategies associated with HL are bound to driving complexity and appear when complexity increases. These strategies include driving at lower speeds, using a more comprehensive visual search behavior and being less engaged in distracting activities. Evaluation of a tactile signal showed that by adding a tactile modality, some driver assistance systems can also be made accessible to drivers with HL. At the same time, the systems might be more effective for all users, since the driver can be more focused on the road. Based on the results in this thesis, drivers with HL cannot be considered an increased traffic safety risk, and there should be no need for adjustments of the requirements of hearing for a license to drive a car. / Syftet med den här doktorsavhandlingen var att undersöka trafiksäkerhet och mobilitet för individer med hörselnedsättning (HN). Tre studier har genomförts: 1. en enkätstudie för att undersöka skillnader i transportvanor relaterade till HN, 2. en körsimulatorstudie for att titta på kompensatoriska strategier och utvärdera effektiviteten i en taktil signal för att påkalla förarens uppmärksamhet och 3. en fältstudie för att undersöka effekterna i riktig trafik samt utvärdera ett navigationssystem med en taktil signal som stöd för navigering. Effekterna av HN som kom fram i denna avhandling bidrar till kunskapen och förståelsen för hur HN påverkar trafiksäkerhet och mobilitet. De funna skillnaderna pekar konsistent mot ett generelltmera försiktigt beteende. Kompensatoriska - och copingstrategier förknippade med HN beror på körkomplexitet och observeras när komplexiteten ökar. Dessa strategier innebär körning med lägre hastighet, mera heltäckande visuell avsökning och mindre engagemang i distraherande uppgifter. Utvärdering av en taktil signal visade att genom att lägga till en taktil modalitet kan vissa förarstödsystem bli tillgängliga även för förare med HN. Samtidigt kan systemen bli mera effektiva för alla användare eftersom föraren då kan fokusera mera på vägen. Baserat på resultaten i den här avhandlingen kan inte förare med HN betraktas som någon förhöjd risk och det bör därmed inte finnas något behov av att justera hörselkraven när det gäller körkortsinnehav.

« - Comment apprécions-nous la complexité du monde qui nous entoure ?- En bougeant nos yeux !- Pourquoi ?- Parce qu’une perception visuelle efficace (avec une acuité maximale !) nécessite de placer l’image des éléments pertinents du champ visuel au niveau d’une petite partie de notre rétine : la fovéa. » Les saccades oculaires sont les mouvements les plus rapides que peut produire notre organisme et sont malgré tout très précises. Le contrôle de ces mouvements représente un défi pour notre cerveau. En effet, ces saccades sont tellement rapides qu’aucune information visuelle ne peut modifier leur trajectoire en cours d’exécution. Mais alors, de quels moyens dispose notre cerveau pour maintenir ces performances tout au long de notre vie? En cas d’imprécision répétée, des mécanismes vont progressivement modifier l’amplitude de nos saccades oculaires afin d’en rétablir la précision. Cette adaptation saccadique repose sur des modifications centrales plastiques. Ce travail de thèse a comme vocation d’élucider les caractéristiques de l’adaptation saccadique chez l’homme. Des approches complémentaires ont permis d’étudier d’une part, l’adaptation des deux grandes catégories de saccades, réactives et volontaires, et d’autre part, l’adaptation en diminution et en augmentation d’amplitude. Nos données permettent de disséquer les mécanismes d’adaptation saccadique dans leur complexité et de mettre en évidence des structures neuronales indispensables à leur mise en place. Notre travail constitue également le support pour le développement de nouvelles procédures de rééducation, basées sur la plasticité oculomotrice. / “- How can we appreciate the complexity of the surrounding word? - By moving our eyes! - Why? - Because an efficient visual perception (with a maximal acuity!) necessitates placing the image of pertinent element from the visual scene at the level of a small part of our retina: the fovea.” Ocular saccades are the fastest movements our organism can produce and they are also highly precise. The control of these movements is a challenge for our brain. Indeed, these saccades are so fast that no visual information can be used during their execution to modify their trajectory. But then, what means does our brain have to maintain these performances all life long? In case of repeated inaccuracies, some mechanisms will progressively modify the amplitude of our ocular saccades in order to restore accuracy. This saccadic adaptation relies on central plastic modifications. The work of this doctorate has the vocation to elucidate the characteristics of saccadic adaptation in Human. Complimentary approaches allowed to study on one side, the adaptation of the two main saccade categories, reactive saccades and voluntary saccades, and on another side, the adaptation decreasing and increasing saccade amplitude. Our data dissects the complexity of mechanisms underlying saccadic adaptation and highlights the neural substrates necessary for these adaptive changes to take place. Our work constitutes also the basis for the development of new rehabilitation procedures, usingoculomotor plasticity.

A busca visual é uma habilidade crítica para várias tarefas da vida diária e pode estar prejudicada em pacientes com deficiência visual. O objetivo deste estudo foi comparar a busca visual exploratória entre pacientes com glaucoma primário de ângulo aberto (GPAA) e controles saudáveis, avaliando a correlação espacial entre áreas com perdas localizadas na busca visual exploratória e os defeitos perimétricos, em pacientes com GPAA e com visão normal. Cinquenta e sete indivíduos com visão normal (acuidade visual corrigida melhor que 0.2 logMAR) diagnosticados (grupo GPAA, n = 29) ou não (grupo CONTROL, n = 28) com GPAA, realizaram um exame oftalmológico completo, incluindo perimetria visual (Humphrey -Fast 24.2) e uma tarefa exploratória de busca visual baseada em uma tela com dígitos. Um software personalizado quantificou o (s) tempo (s) gasto (s) até o encontro do número \"4\" em uma matriz aleatória de dígitos distribuídos em cinco áreas, em nove telas sequenciais do programa. Cinco áreas da tela de busca visual foram espacialmente correlacionadas com cinco setores do mapa total deviation (TD) da perimetria visual, após ajustes de ângulo e distância. A análise de covariância (ANCOVA) e testes de correlação foram utilizados para correlacionar parâmetros perimétricos e da busca visual exploratória, por meio de avaliação do tempo individual (gasto para encontrar cada dígito) e tempo total (gasto para completar a tarefa). Os pacientes com GPAA apresentaram pior sensibilidade perimétrica (MD) e de busca visual exploratória do que os controles (MD: -8,02 ± 7,88 dB vs -1,43 ± 1,50 dB; p <0,0001 e tempo total: 106,42 ± 59,64 s vs 52,75 ± 19,07 s; p < 0.0001). A sensibilidade do MD de ambos os grupos correlacionou-se significativamente com o tempo total (GPAA: r = -0.45; p = 0,01 e CONTROL: r = 0,37; p = 0,049). Os testes de ANCOVA mostraram uma correlação significativa entre a busca visual exploratória (tempo individual) e a acuidade visual (P = 0,006) e o diagnóstico de glaucoma (p = 0,005). A sensibilidade média das áreas perimétricas periféricas do grupo GPAA mostrou correlação significativa com o tempo de busca individual nas áreas espaciais correspondentes, exceto na área periférica temporal superior (r = -0,35, p = 0,06). Os controles não mostraram correlação significativa para nenhuma dessas áreas perimétricas, exceto a área periférica temporal superior (r = 0,43, p = 0,02). Com base em nossos resultados, regiões com pior desempenho na busca visual exploratória puderam ser correlacionadas às perdas periféricas localizadas dos pacientes com GPAA. Uma vez que foram estudados pacientes com acuidade visual normal, estes achados destacam a importância do uso de ferramentas de busca visual na avaliação do impacto das perdas perimétricas periféricas em atividades diárias de pacientes com glaucoma. / Visual search is a critical skill for several daily tasks and may be declined in patients with impaired vision. The objectives of this study were to compare the exploratory visual search performance (EVSP) between patients with primary open-angle glaucoma (POAG) and healthy controls, and evaluate the spatial correlation between localized decreases in the EVSP and areas of visual field (VF) loss in normally-sighted patients POAG. Fifty-seven normal vision subjects (best corrected visual acuity better than 0.2 logMAR) diagnosed (POAG group; n= 29) or not (CONTROL group; n= 28) with POAG yielded a complete comprehensive ophthalmological examination, including Humphrey VF tests (SITA-Fast 24.2), and an exploratory visual search digit-based task. A custom software quantified the time (s) spent until patients found the number \"4\" on a random array of digits distributed in five areas on nine sequential screens. Each area was spatially matched with five sectors of the total deviation map from VF, after angle and distance adjustments. Covariance (ANCOVA) and correlation tests were used for correlating VF parameters and EVSP, evaluated through individual time (spent for finding each digit) and total time (spent for completing the task). POAG patients presented worse VF mean deviation (MD) sensitivity and EVSP than controls (MD: -8.02±7.88 dB vs -1.43±1.50 dB; p<0.0001, and total time: 106.42±59.64 s vs 52.75±19.07 s; p<0.0001). MD sensitivity of both groups significantly correlated with total time (POAG: r = -0.45; p = 0.01 and CONTROL: r = 0.37; p = 0.049). ANCOVA tests showed a significant correlation between EVSP (individual time) and both visual acuity (p = 0.006) and glaucoma diagnosis (p = 0.005). The mean sensitivity of the peripheral VF areas of the POAG group showed significant correlation with the individual search time in the corresponding spatial areas, except in the peripheral temporal superior area (r = -0.35, p =0.06). Controls did not show a significant correlation for any of those VF areas, except the peripheral temporal superior area (r =0.43, p =0.02). Based on our results, worse EVSP can be attributable to localized losses in the peripheral VF areas in patients with POAG. Since only normally sighted patients were studied, these findings highlight the importance of using visual search tools to evaluate the impact of peripheral VF loss in daily activities of glaucoma patients, such as driving.

A busca visual é uma habilidade crítica para várias tarefas da vida diária e pode estar prejudicada em pacientes com deficiência visual. O objetivo deste estudo foi comparar a busca visual exploratória entre pacientes com glaucoma primário de ângulo aberto (GPAA) e controles saudáveis, avaliando a correlação espacial entre áreas com perdas localizadas na busca visual exploratória e os defeitos perimétricos, em pacientes com GPAA e com visão normal. Cinquenta e sete indivíduos com visão normal (acuidade visual corrigida melhor que 0.2 logMAR) diagnosticados (grupo GPAA, n = 29) ou não (grupo CONTROL, n = 28) com GPAA, realizaram um exame oftalmológico completo, incluindo perimetria visual (Humphrey -Fast 24.2) e uma tarefa exploratória de busca visual baseada em uma tela com dígitos. Um software personalizado quantificou o (s) tempo (s) gasto (s) até o encontro do número \"4\" em uma matriz aleatória de dígitos distribuídos em cinco áreas, em nove telas sequenciais do programa. Cinco áreas da tela de busca visual foram espacialmente correlacionadas com cinco setores do mapa total deviation (TD) da perimetria visual, após ajustes de ângulo e distância. A análise de covariância (ANCOVA) e testes de correlação foram utilizados para correlacionar parâmetros perimétricos e da busca visual exploratória, por meio de avaliação do tempo individual (gasto para encontrar cada dígito) e tempo total (gasto para completar a tarefa). Os pacientes com GPAA apresentaram pior sensibilidade perimétrica (MD) e de busca visual exploratória do que os controles (MD: -8,02 ± 7,88 dB vs -1,43 ± 1,50 dB; p <0,0001 e tempo total: 106,42 ± 59,64 s vs 52,75 ± 19,07 s; p < 0.0001). A sensibilidade do MD de ambos os grupos correlacionou-se significativamente com o tempo total (GPAA: r = -0.45; p = 0,01 e CONTROL: r = 0,37; p = 0,049). Os testes de ANCOVA mostraram uma correlação significativa entre a busca visual exploratória (tempo individual) e a acuidade visual (P = 0,006) e o diagnóstico de glaucoma (p = 0,005). A sensibilidade média das áreas perimétricas periféricas do grupo GPAA mostrou correlação significativa com o tempo de busca individual nas áreas espaciais correspondentes, exceto na área periférica temporal superior (r = -0,35, p = 0,06). Os controles não mostraram correlação significativa para nenhuma dessas áreas perimétricas, exceto a área periférica temporal superior (r = 0,43, p = 0,02). Com base em nossos resultados, regiões com pior desempenho na busca visual exploratória puderam ser correlacionadas às perdas periféricas localizadas dos pacientes com GPAA. Uma vez que foram estudados pacientes com acuidade visual normal, estes achados destacam a importância do uso de ferramentas de busca visual na avaliação do impacto das perdas perimétricas periféricas em atividades diárias de pacientes com glaucoma. / Visual search is a critical skill for several daily tasks and may be declined in patients with impaired vision. The objectives of this study were to compare the exploratory visual search performance (EVSP) between patients with primary open-angle glaucoma (POAG) and healthy controls, and evaluate the spatial correlation between localized decreases in the EVSP and areas of visual field (VF) loss in normally-sighted patients POAG. Fifty-seven normal vision subjects (best corrected visual acuity better than 0.2 logMAR) diagnosed (POAG group; n= 29) or not (CONTROL group; n= 28) with POAG yielded a complete comprehensive ophthalmological examination, including Humphrey VF tests (SITA-Fast 24.2), and an exploratory visual search digit-based task. A custom software quantified the time (s) spent until patients found the number \"4\" on a random array of digits distributed in five areas on nine sequential screens. Each area was spatially matched with five sectors of the total deviation map from VF, after angle and distance adjustments. Covariance (ANCOVA) and correlation tests were used for correlating VF parameters and EVSP, evaluated through individual time (spent for finding each digit) and total time (spent for completing the task). POAG patients presented worse VF mean deviation (MD) sensitivity and EVSP than controls (MD: -8.02±7.88 dB vs -1.43±1.50 dB; p<0.0001, and total time: 106.42±59.64 s vs 52.75±19.07 s; p<0.0001). MD sensitivity of both groups significantly correlated with total time (POAG: r = -0.45; p = 0.01 and CONTROL: r = 0.37; p = 0.049). ANCOVA tests showed a significant correlation between EVSP (individual time) and both visual acuity (p = 0.006) and glaucoma diagnosis (p = 0.005). The mean sensitivity of the peripheral VF areas of the POAG group showed significant correlation with the individual search time in the corresponding spatial areas, except in the peripheral temporal superior area (r = -0.35, p =0.06). Controls did not show a significant correlation for any of those VF areas, except the peripheral temporal superior area (r =0.43, p =0.02). Based on our results, worse EVSP can be attributable to localized losses in the peripheral VF areas in patients with POAG. Since only normally sighted patients were studied, these findings highlight the importance of using visual search tools to evaluate the impact of peripheral VF loss in daily activities of glaucoma patients, such as driving.

Ce travail de thèse porte essentiellement sur le cervelet. Nous y suivons deux axes majeurs : en termes de fonctions cérébelleuses, nous nous intéressons à l’apprentissage et l’adaptation du contrôle moteur ; en termes de dysfonctions cérébelleuses, nous nous intéressons à la dyslexie développementale.Nous nous orientons vers l’apprentissage du contrôle moteur afin d’en proposer un modèle computationnel fonctionnel appliqué aux mouvements oculaires volontaires. Pour ce faire, la Logique Floue est un de nos outils précieux. Nous avons proposé deux modèles. Le premier, AFCMAC (Auto-adaptive Fuzzy Cerebellar Model Articulation Controller), le résultat de l’intégration de la Logique Floue dans l’architecture de CMAC (Cerebellar Model Articulation Controller), est pourvu d’améliorer la vitesse/durée d’apprentissage et le besoin en termes de mémoire par rapport à CMAC. Le second modèle est CMORG (fuzzy logiC based Modeling for Oculomotor contRol LearninG), dont sa structure est également basée sur la Logique Floue, et dans lequel, le réseau de neurones est utilisé comme la mémoire pour gérer les règles Floues. Les résultats des évaluations des modèles proposés (AFCMAC et CMORG) et étudiés (CMAC et FCMAC – Fuzzy Cerebellar Model Articulation Controller), via les données oculomotrices des groupes d’enfants dyslexiques et contrôles lors de la lecture, montrent que CMORG est le plus performant à la fois, en termes de vitesse/durée d’apprentissage et également, de consommation de mémoire. Un autre avantage principal de CMORG par rapport aux autres modèles, est son interprétabilité par les experts.Concernant la dyslexie développementale, nous avons mené une étude expérimentale sur les déficits du contrôle moteur binoculaire lors des saccades des six enfants dyslexiques pendant les deux tâches différentes (la lecture d’un texte et la visualisation des chaînes de caractères) et dans les deux distances de vision (40 cm et 100 cm). Nous corroborons et adhérons à l’idée que la (mauvaise) qualité de la coordination binoculaire des saccades chez les enfants dyslexiques est indépendante des difficultés en lecture, associée peut-être aux hypothèses du déficit du magnosystème et du dysfonctionnement cérébelleux. / This thesis focuses on the cerebellum. We follow two main lines: in terms of cerebellar functions, we are interested in learning and adaptation motor control ; in terms of cerebellar dysfunctions, we are interested in developmental dyslexia.We focus on learning motor control in order to provide a functional computational model applied to voluntary eye movements. To this end, Fuzzy Logic is one of our valuable tools. We proposed two models. The former is AFCMAC (Auto-adaptive Fuzzy Cerebellar Model Articulation Controller), the result of the integration of Fuzzy Logic in CMAC (Cerebellar Model Articulation Controller) architecture, in order to improve learning speed/time and memory requirements compared to the CMAC. The latter is CMORG (fuzzy logiC based Modeling for Oculomotor contRol LearninG), whose structure is also based on Fuzzy Logic, and in which, the neural network is used as the memory to handle Fuzzy rules. The evaluation results of the proposed (AFCMAC and CMORG) and studied (CMAC and FCMAC – Fuzzy Cerebellar Model Articulation Controller) models via oculomotor data of dyslexic and control groups while reading show that CMORG is the most efficient both in terms of learning speed/time and also memory consumption. Another main advantage of CMORG over the other models is its interpretability by experts. Regarding the developmental dyslexia, we conducted an experimental study on binocular motor control deficits during saccades in six dyslexic children while two different tasks (text reading and character string scanning) and in two viewing distances (40 cm and 100 cm). We corroborate and adhere to the idea that the (bad) quality of binocular coordination of saccades in dyslexic children is independent of reading difficulties, maybe associated with magnosystem and cerebellar deficit hypothesis.

Le système visuel humain est complexe par son organisation anatomique et par son fonctionnement incomplètement élucidé. Il est fonctionnellement divisé en deux systèmes. Le premier système est destiné à la vision consciente communément appelée voie visuelle principale ou en anglais « image forming visual pathways ». Le second, appelé système secondaire ou accessoire, n’apporte pas d’information visuelle consciente, il est dit « non image forming visual pathway ». Ce dernier apporte à notre cerveau une information sur l’environnement telle que la sensation jour/nuit. Ses fonctions sont sous-tendues par l’afflux d’informations rétiniennes non visuelles sur des structures de l’hypothalamus comme le noyau supra-chiasmatique. Les deux systèmes visuels ont un substratum anatomique complexe faisant intervenir de nombreuses structures anatomiques au sein des différents étages du cerveau cortical et sous-cortical comme les noyaux gris centraux dits « Basal Ganglias » (BG). Le système visuel secondaire intervient aussi comme une structure de contrôle des mouvements oculomoteurs tels que la poursuite ou les saccades nécessaires pour explorer notre environnement. Ainsi les saccades oculomotrices sont sous le contrôle modulateur des BG. De ce fait l’étude des saccades apparait comme un très bon modèle pour explorer le fonctionnement du système extrapyramidal au cours des maladies neuro-dégénératives. Les connaissances actuelles sur ce système de contrôle des saccades proviennent essentiellement des études sur le primate non humain et sur des observations cliniques chez l’homme au cours de pathologies dégénératives ou toxiques des BG. L’observation des structures anatomiques, en particulier du réseau de la substance blanche cérébrale qui supporte les connections axonales, n’est pas accessible à l’imagerie clinique de routine. Pour décrire et étudier ces réseaux de connections, la notion de connectomique a été introduite il y a un dizaine d’années. Dans ce travail, nous nous sommes donné l’objectif de décrire le connectome des saccades oculomotrices sur un plan structurel. Nous avons exploré les structures sous-corticales intervenant dans le contrôle des saccades comme les BG, le colliculus supérieur et le pulvinar. Pour ce faire, nous avons utilisé l’imagerie IRM structurelle en diffuseur de tension (DTI) chez deux groupes de patients présentant une maladie neuro-dégénérative : un groupe souffrant de maladie de Parkinson chez qui une atteinte des BG et une dysfonction des saccades sont reconnues, et un groupe de trembleurs essentiels reconnu pour ne pas présenter de dysfonction des saccades et chez qui les BG sont épargnés. Le résultat de ce travail a permis pour la première fois une description in vivo du connectome des saccades chez l’Homme. Il a de plus montré des différences dans la structure du connectome dans les deux groupes de patients. Une meilleure connaissance de ce connectome pourrait permettre de mieux comprendre certains troubles oculomoteurs et aussi de suivre l’évolution de certaines maladies neurodegeneratives. / Visual system is complex by its anatomy and its function. Neuro-anatomists have been interested in understanding the link between the visual pathways and the brain for centuries. Classical brain fixation and dissection methods were used to describe the visual pathways identifiable macroscopically. Non–image visual pathway, particularly the part involves in saccadic eye movements network in human is still not mastered. Our current knowledge in SCM is based on animal studies, anatomic dissection and brain histopathology examination of specimens from patients with clinical basal ganglia (BG) disorders. Saccadic eye movements (SCM) are under the control of the basal ganglia (BG) and SCM circuitry within the BG represents a good model for studying pathology in the extra-pyramidal system. The diagnosis of Parkinson’s disease (PD), which affects SEM and its distinction from non-dopaminergic, essential tremor (ET) where SEM are not impaired can be challenging and still relies on clinical observations. Diffusion tensor imaging and fiber tractography (DTI-FT), a new MRI technology, can be used to evaluate the presence and integrity of white matter tracts using directional diffusion patterns of water. The purpose of this study is to use DTI-FT to analyse SEM networks within BG and compare the SEM neural pathways or connectome of patients clinically diagnosed with PD and ET. To date, there are no studies, using DTI-FT for the extensive exploration of non-image visual pathways and SCM circuits, notably the deep brain connections. For this goal, we introduced the concept of SCM connectomes, derived from the general concept of connectome. Our study used structural MRI to identify nuclei and fascicles of the SCM connectome in PD and ET patients; imageries were acquired in routine clinical conditions fitted for DBS surgery. We found a reduction of the fiber number in two fascicles of the connectome in PDcompared to ET group.