Made available in DSpace on 2016-04-27T19:31:56Z (GMT). No. of bitstreams: 1 A GUARDA NACIONAL NA PROVINCIA PARAENSE.pdf: 1836307 bytes, checksum: 3926f2f0bda433321af2e60ab790d4c9 (MD5) Previous issue date: 2005-05-31 / The dissertation "the National Guard in the Paraense Province: representations of a paramilitary army (1831/1840)" intend to reflect some thematics that helped to promote tensions in the Paraense Province. The City the Genesis of the National Guard Legislation Constitution Insubordination and the Defection are thematics that made this dissertation and the object in question. The three chapters that are part of this work have as ultimate object to argue the axles above cited which had provoked debates and fidgets in the Paraense Province of the first half of century XIX.thus to stablish the creation and the development of the corporation in the Province.The National Guard - had turned into a desert and "joyed together" in the Cabano Movement? In compliance with this the present dissertation does not intend to trace a profile concerning the reasons of turning into a desert in this period much less to make a study on the Cabano Movement. The real intend was to perceive tensions and forces formed in the Paraense Province when it s placed in the main thematic ounce displayed. These subjects had been located in the core of an intense society that lived deeply a period of substructure transformations that the Regeny itself tried to put into work / A dissertação A Guarda Nacional na Província Paraense: representações de uma milícia para-militar (1831/1840) procurou refletir sobre algumas temáticas que ajudaram a revelar tensões na Província Paraense. A Cidade a Gênese da Guarda Nacional a Legislação a Constituição a Insubordinação e a Deserção são temáticas que compõem esta dissertação e o objeto em questão. Os três capítulos que fazem parte deste trabalho procuram discutir os eixos acima citados os quais provocaram debates e inquietações na Província Paraense da primeira metade do século XIX de forma a estabelece-se como foi percebida a criação e o desenvolvimento da corporação na Província. Deste modo a problematização se contém em compreender como determinados sujeitos sociais Guardas Nacionais desertaram e adentraram juntos no Movimento Cabano. Em conformidade com isso a presente dissertação não pretende traçar um perfil acerca dos porquês de se desertar neste período muito menos fazer um estudo sobre o Movimento Cabano. Procurou-se antes perceber tensões e relações de força que se formaram na Província Paraense quando se colocava em pauta as temáticas acima expostas. Estes assuntos não se pode esquecer estiveram localizados no seio de uma sociedade que vivenciou um período de intensas transformações infra-estruturais que a própria Regência tentou operacionalizar

Made available in DSpace on 2016-04-28T14:16:36Z (GMT). No. of bitstreams: 1 Enezio Eugenio de Almeida Filho.pdf: 4288341 bytes, checksum: 6d7c3e5e0f23728ac321058b96f617c8 (MD5) Previous issue date: 2008-10-17 / Discovery Institute - Center for Science and Culture / This research follows the line of History and Theory of Science that has as a goal to explain the construction of scientific thought by discussing the foundation of hypotheses and theories within their historical contexts. The goal of this thesis is to analyze Mivart´s critiques and Darwin´s answers, and to verify if they were scientifically well formulated and based considering the scientific context of that time. The reason for writing this work is an attempt to fill a gap in the History of Science about the scientific controversy between Mivart and Darwin on the role of natural selection in the origin of species. This work´s hypotheses are two: that Mivart´s critiques, despite being religiously motivated, were plausible scientifically, and that Darwin answered them fully. This research analyzes the primary sources of Mivart (Genesis of species) and Darwin's Origin of Species, and other secondary sources. The result reached was that Mivart´s critiques were indeed scientific, and that Darwin answered them according to the evidences and scientific knowledge then available / Esta pesquisa segue a linha de História e Teoria da Ciência que objetiva trazer esclarecimentos sobre a construção do pensamento científico através da discussão da fundamentação de hipóteses e teorias dentro do seu contexto histórico. O objetivo desta dissertação é analisar as críticas de Mivart e as respostas dadas por Darwin, e verificar se elas estavam bem formuladas e fundamentadas cientificamente considerando-se o contexto científico daquela época. A justificativa para a realização desta trabalho é tentar preencher uma lacuna em História da Ciência sobre a controvérsia científica entre Mivart e Darwin sobre o papel da seleção natural na origem das espécies. As hipóteses deste trabalho são duas: as críticas de Mivart, apesar de terem sido religiosamente fundamentadas, eram cientificamente plausíveis, e Darwin as respondeu satisfatoriamente. O aspecto teórico-metodológico foi a análise das fontes primárias de Mivart (Genesis of species) e de Darwin (Origin of species), e outras fontes secundárias. O resultado obtido foi que as críticas de Mivart eram científicas, e que Darwin respondeu-as conforme as evidências e o conhecimento científico da época

Made available in DSpace on 2016-04-27T16:58:55Z (GMT). No. of bitstreams: 1 Jesus Victoria Flores Salazar.pdf: 3824721 bytes, checksum: 90508afa3a224018db018f851b864a0e (MD5) Previous issue date: 2009-06-29 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / This thesis has the purpose of observing how students from the 2nd year of High School make use of geometric transformations of space when interacting with the environment of Dynamic Geometry Cabri 3D, as well as what kind of reasoning they use when developing activities concerning this content. Thereby, this work intends to answer the following questions: How do students make use of the tools and/or resources of Cabri 3D in order to learn the geometric transformations of space? How does the integration of Cabri 3D interfere in the process of learning these geometric transformations? The methodology adopted used aspects of Didactics Engineering, according to Artigue (1988). The theoretical foundation was the Instrumental Approach of Rabardel (1995) to enable the understanding of how students interact with Cabri 3D and which contents they make use of during the development of a sequence of activities. In addition, the theory of Register of Semiotics Representation of Duval (1995) was used, specifically the apprehensions of a figure. The analyses of the activities which involve notions of geometrical transformation of space helped us realize other possibilities that the instruments can give the subjects as well as different ways of organizing the actions. Moreover, the activities made the development of different strategies easier for students who used the Cabri 3D and students established relationships between the software and mathematical knowledge. We verified the occurrence of Instrumental Genesis, because the students actions showed pre-established schemes or the development of new schemes. At the same time, the use of Cabri 3D helped the perceptive apprehension of the figures and allowed to become dynamic. This way, Cabri 3D permitted the dynamic figural register, facilitated the positional modification and the other modifications of figures, and their visualization / Esta tese teve por objetivo observar como estudantes do segundo ano do Ensino Médio apropriam-se das transformações geométricas no espaço, quando interagem com o ambiente de Geometria Dinâmica Cabri 3D, bem como qual raciocínio mobilizam quando desenvolvem atividades que abrangem esse conteúdo. Assim, a pesquisa pretendeu responder às seguintes questões: de que maneira, os estudantes apropriam-se das ferramentas e/ou recursos do Cabri 3D na aprendizagem das transformações geométricas no espaço? Como a integração do Cabri 3D interfere no processo de aprendizagem dessas transformações geométricas? A metodologia do estudo apoiou-se nos pressupostos da Engenharia Didática de Artigue (1988). O referencial teórico baseou-se na Abordagem Instrumental de Rabardel (1995a) para compreender como os alunos interagem com o Cabri 3D e quais conteúdos mobilizam no desenvolvimento da sequência de atividades e na teoria dos Registros de Representação Semiótica de Duval (1995), especificamente, nas diferentes apreensões de uma figura. A análise das atividades ajudou a perceber outras possibilidades que os instrumentos podem oferecer aos sujeitos e as diferentes maneiras de organizar suas ações. Além disso, as atividades facilitaram o desenvolvimento de distintas estratégias no uso do Cabri 3D e o estabelecimento de relações entre o software e os conhecimentos matemáticos dos estudantes. Constatou-se a ocorrência do processo de Gênese Instrumental, visto que as ações dos alunos evidenciaram esquemas de utilização preestabelecidos ou o desenvolvimento de novos esquemas. Ao mesmo tempo, o uso do Cabri 3D facilitou a apreensão perceptiva das figuras e permitiu dinamizá-las. Nesse sentido, o Cabri 3D propiciou o registro figural dinâmico, facilitou a modificação posicional e as outras modificações das figuras, além de auxiliar em sua visualização

Ce mémoire en recherche création débute par un récit poétique rédigé par fragments et intitulé Ma mère est une porte. Ce texte met en abyme les ruines afin de démontrer leur lien de contiguïté avec l’absence, l’empreinte, la mémoire et la mort. D’ailleurs, leur aspect ruiniforme rappelle le fragment, ce qui permet d’appuyer l’esthétique formelle de l’œuvre. La deuxième partie intitulée Approche génétique : un monument à la mémoire des disparus emportés par le temps de l’écriture, propose une réflexion sur l’imaginaire des ruines en lien avec les archives littéraires et la mémoire. Divisé en trois sections, cet essai pose un regard inquiet sur l’avenir de l’objet d’étude de la critique génétique, soit le manuscrit moderne. Depuis l’avènement de l’informatique et du traitement de texte, que conserverons-nous de la mémoire scripturale et du processus d’écriture de l’écrivain de demain? / This M.A. Thesis combining research and creative writing is divided in two parts: a poetic narrative and an essay. Ma mère est une porte is structured in fragments and contains the mise en abyme of ruins in order to demonstrate that they closely relate to the ideas of absence, genetic footprint, memory and death. Ruins suggest fragments, thus the narrative’s esthetical form. The second part, Approche génétique : un monument à la mémoire des disparus emportés par le temps de l’écriture, is an essay reflecting on the metaphorical link between manuscript, ruins, archives and memory. Divided in three sections, it posits that new technology will cause modern manuscripts to disappear and the methodology behind genesis of text’s to evolve. Moreover, this will change how creative writing’s memory is preserved, hence affecting our cultural heritage.

La thèse aborde le « trou noir de la genèse » dans l’étude des organisations, c’est-àdire comment une organisation en vient à exister pour la première fois. Elle montre comment la genèse s’accomplit à travers l’agencement de multiples composantes (humaines, symboliques, matérielles), articulées à travers les interactions. S’appuyant sur une analyse détaillée des interactions performées durant le congrès fondateur d’un parti politique au Québec tenu durant l’année 2006, elle identifie et discute les diverses stratégies et tactiques employés par les artisanes et artisans de cette fondation pour mettre en acte l’existence de ce nouvel agent collectif. Autrement dit, la thèse mène à une recension des manières de « communiquer la genèse ». Cela inclut l’usage de narratifs unificateurs, la gestion des identités, la mise en place de principes à travers des documents fondateurs, et la création d’une voix collective, à la fois partagée et négociée par les divers agents impliqués dans ce processus. Ces accomplissements mettent en lumière la dimension résolument rhétorique de l’organisation, conçus en tant que « stratégies pour rendre compte d’une situation », pour nommer sa structure et ses composantes primordiales à travers « l’usage du langage comme moyen symbolique d’induire la coopération ». La configuration rhétorique de discours, d’objets, de corps, de dispositifs spatiaux et physiques, et d’impératifs économiques, politiques et institutionnels à l’oeuvre dans les organisations procure un nouvel éclairage sur les modes d’existence de l’organisation. Par le fait de recenser les composantes « essentielles » ou « fondatrices » du parti politique investigué, et par l’analyse de celle-ci à l’aide des concepts de la théorie rhétorique du dramatisme, la thèse développe une perspective novatrice pour l’étude de la constitution communicative des organisations. / The dissertation addresses the “black hole of genesis” in organizational studies: how an organization gets constructed in the first place, and for the first time. It shows that an organization is founded through the interplay of various agencies (human, symbolic, material) articulated by communicative interactions. Based on the in-depth analysis of interactions performed during the founding convention of a political party in the Canadian province of Québec in 2006, it identifies and discusses the various strategies and tactics employed by members to enact the existence of a new collective agent, i.e., their ways of “communicating genesis.” Those include unification narratives, management of identities, institution of principles through founding documents, and the establishment of a collective voice, simultaneously shared and disputed by various agents. Such accomplishments are inherently rhetorical to the extent that they are “strategies for encompassing a situation,” for naming its structure and outstanding ingredients through “the use of language as a symbolic means of inducing cooperation.” This rhetorical configuration of discourses, objects, bodies, physical and spatial designs, economical, political, and institutional imperatives, that represents the heterogeneous agencies at work in organizations, bears new lights on what organizations come into being. By identifying the “foundational” or “essential” components of this political party, and by inscribing them in the concepts of the dramatist rhetorical theory, the dissertation develops an innovative perspective for the study of the communicative constitution of organizations.

No description available.

La myopathie myotubulaire (XLMTM, OMIM 310400) est causée par des mutations dans le gêne MTM1 situé sur le chromosome X et apparaît à une fréquence de 1/50 000 naissances mâles. Les patients présentent une hypotonie et une faiblesse musculaire généralisées et de graves problèmes respiratoires à la naissance. En absence de traitement, les patients sont nombreux à décéder durant la première année de vie. Mon travail de thèse consiste à développer un traitement de thérapie génique pour la myopathie myotubulaire. L'injection intraveineuse du vecteur thérapeutique rAAV9-DES-Mtm1 chez le modèle murin de la myopathie myotubulaire permet d'obtenir de la protéine transgénique dans l'ensemble des muscles squelettiques de l'organisme. Un an après le traitement, les muscles malades retrouvent une morphologie normale et les souris sont en vie. La seconde partie porte sur l'évaluation des effets de la protéine MTMR2, un homologue de la myotubularine (MTM1), sur le muscle déficient en myotubularine, comme alternative à la thérapie génique avec MTM1. L'administration d'un vecteur AAV comportant le transgène MTMR2 dans le muscle malade améliore, partiellement, le phénotype musculaire. Ces résultats suggèrent que l'augmentation du niveau d'expression de MTMR2 dans le muscle malade pourrait être un traitement efficace. Enfin j'ai étudié le rôle de l'activité phosphatase de la myotubularine dans son action thérapeutique. J'ai comparé l'effet d'une forme inactive de myotubularine (MTMIC375S) à celui du transgène thérapeutique sur le muscle atteint de myopathie myotubulaire. Les résultats montrent que l'activité phosphatase de la myotubularine est nécessaire pour son activité thérapeutique. / Myotubular myopathy (XLMTM, OMlM 310400) is caused by mutations in the MTM1 gene located on the X chromosome and appeared at a frequency of 1/50 000 male births. Most of the patients arc affected by hypotonia and generalized muscular weakness as weIl as grave respiratory problems in the birth. In absence of an effective therapeutic treatment they are many to die during the first year of their life. My thesis work consists in developing a treatment of gene therapy for myotubular myopathy. The intravenous injection of the therapeutic vector rAAV9-DES-MTM1 into the murin model of the myotubular myopathy allows transgenic protein in the whole skeletal muscle of the body. The therapeutic protein cures the muscular phenotype rapidly after injection. At one year after treatment, the thick muscles still be cured, mice are alive and recovered a normal development. Then, I estimated the effects of the protein MTMR2, a counterpart of the myotubularine (MTM1), on muscles from mice devoid of myotubularin, as alternative at the gene therapy with MTM1. The administration of a vector AAV containing the transgene MTMR2 in the thick muscles improves, partially, the muscular phenotype. These results suggest that the increase of MTMR2 protein level MTMR2 thick muscle could be an effective treatment. Finally, I studied the role of myotubularin phosphatase activity on its therapeutic action, I compared the effect of an inactive shape of myotubularin (MTM1C375S) on muscle affected by myotubular myopathy as the effect of therapeutic transgene on the same muscle. The results show that the phosphatase activity of the myotubularin is necessary for its therapeutic activity.

O presente trabalho tem como finalidade principal demonstrar que não existem maiores divergências entre o criacionismo bíblico e a teoria da evolução, quando olhamos o fato à luz do transformismo do Pe. Teilhard de Chardin, isto é, sem desprezar a ciência, mas com um profundo conhecimento bíblico, no qual seja possível detectar a verdade científica e, ao mesmo tempo, ter uma visão da verdade bíblica revelando-se a ponto de ver e sentir a união entre matéria e espírito. Quanto ao criacionismo bíblico, fizemos questão de apresentar as duas narrativas da criação descrita nos Gênesis e algumas interpretações hermenêuticas sobre elas, bem como a aceitação da segunda narrativa no Antigo e no Novo Testamento. No que se refere à teoria da evolução, preocupamo-nos em apresentar os pontos de vista científicos, com as naturais divergências entre eles, para que se possa entender melhor o conteúdo de tal teoria, que se empenha em mostrar como surgiu o ser humano na terra, através de uma enorme cadeia de ocorrências até a aparição inexplicável do homo sapiens. Após colocarmos as bases do criacionismo e do evolucionismo é que tratamos dessa possibilidade de equilíbrio entre os dois temas através do transformismo teilhardiano, que nos deixa ver bem claro que o elo perdido da evolução é o sopro de Deus, que promove aquele salto, inexplicável pela ciência, através do fenômeno complexidade-consciência, promovendo o equilíbrio tão almejado / This Work aims meanly at demonstrating that there are not so great divergences between biblical Creationism and Evolution Theory, as we look onto the fact on its whole, in view of Fr. Teilhard de Chardins Transformism, i. e. without disregarding Science, but with a biblical deep knowledge in which it could be possible detecting up scientific truth, revealing itself in a such way that turns possible seeing and feeling deep unity, fusion between matter and spirit. Regarding to biblical Creationism, we have assumed, we have undertaken presenting the two narratives in reference to Creation, described in Genesis and some hermeneutic interpretations about them the two narrations as weel as our adoption, acceptance with regards to second narration in Old and New Testament. As for Evolution Theory, we have been concerned focusing the scientifical viewpoints, with natural divergences among them, in order to make possible a better comprehension, understanding regarding to such a theory content that strives showing up the way human being arose in earth, through a large events, accurences chain, series until Homo Sapiens inexplicable appearance. Since we have delt with we have discussed this equilibrium possibility between these two themes, through Teilhardian transformism, that enables us seeing very clearly that Evolutions missing link is Gods Breath that moves on, through complexity consciousness, that leap, jump, inexplicable for Science, moving on the so longed for equilibrium

Dentre os vários campos de interesse das Ciências da Religião, o sagrado e seu impacto nas culturas dos diversos povos e épocas, tem sido objeto de estudo para muitos que enveredam nesse campo tão vasto. Através de pesquisa bibliográfica, o presente trabalho, à luz das Ciências da Religião, se presta a fazer uma análise hermenêutica comparativa sobre a relação entre o poema babilônico da criação, Enuma Elish, e o relato bíblico da criação em Gênesis 1,12,4a. Esse estudo, que tem como base a Teologia Comparada, busca fazer uma análise sobre a influência que uma cultura exerce quando interage com outra. Pretende sinalizar algumas semelhanças e diferenças entre esses dois textos de culturas e épocas diferentes. Procura ainda ajudar o leitor a perceber de que maneira o mito pode ser entendido e de que forma ele pode ser empregado no campo científico. Após a análise do levantamento de dados, percebemos que há alguns elementos em comum entre os dois poemas. Dentre eles destacamos: a criação do universo, do firmamento, dos astros e do homem. Percebemos, portanto, que de fato, quando um povo interage com outro de cultura diferente da sua, acaba havendo uma influência mútua de um povo em relação ao outro. / Among the various fields of interest of the Religion Sciences, the sacred and its impact over the cultures of different peoples and ages, has been studied by many who go through that vast field. Through bibliographic studies, this project, under the lights of the Religion Sciences, intends to make an hermeneutics comparative analysis about the relationship between the Babylonian poem of Creation, Enuma Elish, and the biblical account of creation in Genesis 1. This study, which is based on Comparative Theology, seeks to analyze the influence that a culture has when interacting with others. It aims to identify some similarities and differences between these two texts from different cultures and times. It also seeks to help the reader to understand how the myth can be understood and how it can be employed in the scientific field. After analyzing the survey data, we realize that there are some elements in common between the two poems. Among them we highlight: the creation of the universe, the firmament, the stars and man. We see, therefore, that in fact, when people interact with another culture than theirs, it comes to happen a mutual influence of one people over the other.

Dans « En songeant à un art poétique », Jules Supervielle définit sa poésie comme une entreprise d’humanisation. Quelle acception convient-Il de donner à ce terme, et en quoi se révèle-T-Il pertinent pour aborder l’œuvre de l’écrivain ? C’est à cette question que tente de répondre cette thèse, en cherchant à déterminer le sens qu’il convient de donner à l’humanisation à partir du double héritage de l’humanisme de la Renaissance et de l’humanitarisme romantique, et en s’appuyant sur des manuscrits et des correspondances en partie inédits. Dans une première partie, l’étude de la théorisation de l’humanisation chez Supervielle nous amène à mener une réflexion ressortissant de l’histoire des idées et de l’histoire littéraire, en nous penchant sur l’idée de la littérature développée par l’écrivain, et en analysant le rôle joué par Jean Paulhan et par René Étiemble dans l’apparition de cette idée. La seconde partie analyse la genèse diachronique de l’humanisation, au sein d’un essai de géographie poétique qui se focalise sur le tournant que constituent les années 1920 et 1930. La troisième partie est consacrée à l’étude de la genèse synchronique, considérant l’apparition de l’humanisation dans les divers états d’un texte, en poésie, en prose et au théâtre. L’étude de l’humanisation dans l’œuvre de Jules Supervielle permet ainsi de préciser le paysage littéraire et l’interpénétration des idées de la littérature qui se développent dans la première moitié du XXe siècle, en marge du surréalisme. / In « En songeant à un art poétique », Jules Supervielle defines his poetry as an attempt at humanization. How should this term be understood, and how does it enlighten Supervielle’s work ? In order to answer this question, this dissertation sets out to define the meaning of humanization through the lens of the double legacy of the humanism of the Renaissance and the humanitarianism of Romanticism, and in the light of partly unpublished manuscripts and letters. In the first part, this dissertation studies how Supervielle theorizes humanization. It leads to an analysis of a history of ideas and of literature, in order to define Supervielle’s conception of literature and in order to assess Jean Paulhan’s and René Étiemble’s roles in this theorization. The second part is a chronological study of humanization that takes the form of an essay of poetic geography. It focuses particularly on the work of the 1920’s and 1930’s. The third part is a genetic one : we study how humanization appears in the different states of a poem, a prose and a drama. The Study of humanization in Supervielle’s works enables us to have a better understanding of the literary landscape and of the entanglement of literary ideas in the first half of the twentieth century, in the margins of Surrealism.