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Hook-Proteine spielen eine wichtige Rolle im intrazellulären Transport. Sie binden n-terminal Mikrotubuli, haben eine coiled-coil-Domäne und binden c-terminal Organellen. Da aus humanen Hirnschnitten eine Kolokalisation mit den bei Alzheimerscher Erkrankung auftretenden neurofibrillären Tangles bekannt war, erscheint eine weitere Untersuchung der Expression und Lokalisation von Hook-Proteinen im zentralen Nervensystem interessant. Hierzu wurde die Expression der humanen Hook-Proteine mittels real-time RT-PCR quantifiziert und die Lokalisation der Hook-Proteine in verschiedenen transgenen Mausmodellen der Tauopathie mittels Immunhistochemie dargestellt. Außerdem wurde die cDNA der Hook-Proteine mittels PCR auf alternatives Spleißen untersucht.

James Hook was employed as organist, composer and music director at Vauxhall Gardens in London for forty-six years, from 1774-1820. He was preceded in that position by Thomas Arne, a composer better known to musicians of the twentieth century. Hook had an enormous output including over 2000 songs, most of which were intended for performance at the gardens. Many of these songs were popular enough to be published in New York, Baltimore, and Philadelphia, as well as London. These songs are generally in the lightly textured gallant style popularized in England most notably by J.C. Bach.

I vår studie har vi undersökt hur journalister gestaltar tre amerikanska skolskjutningar i svensk och amerikansk press. Skolskjutningarna ägde rum på Columbine High School, Virginia Tech och Sandy Hook Elementary School. Vi har analyserat sammanlagt 91 texter publicerade i Aftonbladet, Dagens Nyheter och New York Times. Teorierna vi har valt till vår studie är gestaltningsteori, media events och moralpanik. Kvantitativt har vi undersökt hur journalisterna valt att gestalta gärningsmännen och vilka som fått komma till tals i artiklarna. Kvalitativt har vi närstuderat 12 texter med fokus på skillnaderna mellan de svenska och amerikanska journalisternas gestaltning. Slutsatserna vi kan dra från vår studie är att rapporteringen skiljer sig åt mellan svenska Dagens Nyheter och amerikanska New York Times. De amerikanska journalisterna har större benägenhet att gestalta överlevande i skolskjutningar som “hjältar” och gärningsmännen som “onda personer”. De svenska journalisterna dramatiserar händelserna med fokus på sorg och tragedi. Både de svenska och amerikanska journalisterna väljer att gestalta gärningsmännen som unika individer.

This thesis is comprised of a collection of stories concerning big-shot morticians and their futile quest for a perfect flute made from a pelican bone.

Jag har undersökt hur användandet av två olika metoder i låtskrivning och musikproduktion som beskrivs i Seabrooks bok The Song Machine påverkar det slutliga klingande resultatet av en färdig produktion. Detta gjordes genom att producera fyra stycken låtar varav två metoder använts som kallas Melody & Hook och Track & Hook som innebär att melodin och till viss del text skrivs antingen först eller sist i arbetsflödet. När det klingande resultatet var färdigt jämfördes låtarna i deras sound i form av instrumentering, genretillhörighet och eventuella övriga effekter där min slutsats var att det inte var av större betydelse, men det som var av större betydelse var inspirationen som befann sig i stunden vid skrivandet av låten och mina val av instrument.

More guns-less violence? A qualitative and comparative analysis between the swedish and the american daily news-press.

This thesis deals with the design of a crane hook block with a capacity of 20 tons with two guiding and one equalizing roller for handling sheet metal coils. The work includes the calculation and design of the elements and strength calculations of individual parts. Part of the work is the drawings of the given assemblies.

Submitted by (edna.saturno@ufrpe.br) on 2017-02-09T15:04:24Z No. of bitstreams: 1 Diogo Martins Nunes.pdf: 540969 bytes, checksum: 969307884f3ced0bc71b0426a1a8882d (MD5) / Made available in DSpace on 2017-02-09T15:04:24Z (GMT). No. of bitstreams: 1 Diogo Martins Nunes.pdf: 540969 bytes, checksum: 969307884f3ced0bc71b0426a1a8882d (MD5) Previous issue date: 2011-02-11 / Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq / Circle hooks (15/0 and 17/0) were compared with traditional hooks (type "J" 10/0) and used "hook timers (HT)” to identify the time capture and time in which the fish remained in line until haulback. Survival rates ranged considerably between species and species groups, and between the types of hooks and hooking location. As example, mortality rates showed billfishes significantly lower in circle hooks in compared to the traditional. The swordfish, in turn, reported higher mortality regardless the type of hook and hooking location, unlike the blue shark, which showed high levels of survival. By moreover, species of tunas and billfihes analyzed showed a significant trend toward reduction in mortality of individuals captured externally, resulting in an association between hooking location and the condition of the animal (χ2 = 13:54, p = 0.00023; χ2 = 27.35, p = 1.697e-07, respectively). For target species had a trend of increased survival with increased length of individual fish, although the group of sharks that trend was only observed for the blue shark, with a marginally significant difference, while other shark species showed a pattern otherwise, although the difference was statistically significant only for the crocodile shark. A total of 431 HT were activated and retrieved with fish on the line, represented by 20 species, of which 13 were captured more frequently at night. Some species demonstrated endure long periods of capture surviving until the time of haulback. Results suggest that knowledge of factors affecting survival of pelagic fish caught in fishing longline can develop/adopt fishing methods that reduce mortality primarily by members of the bycatch and animals caught incidentally. / Durante os experimentos anzóis circulares (15/0 e 17/0) foram comparados com anzóis tipo “J” 10/0 e utilizados “hook timers” (HT) para identificação da hora de captura e do tempo em que o peixe permaneceu na linha até seu embarque. O espadarte apresentou altos índices de mortalidade, ao contrário do tubarão azul, que obteve altos índices de sobrevivência a despeito do tipo e local em que o anzol foi fisgado. Por outro lado, as espécies de albacoras e agulhões analisados apresentaram uma tendência significativa de redução da mortalidade em indivíduos capturados externamente, resultando em uma associação entre o local de fisga e a condição do animal (χ2=13.54 e p=0.00023; χ2=27.35 e p=1.697e-07, respectivamente). Houve uma tendência de elevação da sobrevivência com aumento do comprimento individual dos peixes, embora no grupo dos tubarões essa elevação apenas foi observada para o tubarão azul, com uma diferença marginalmente significativa, enquanto que outras espécies de tubarão apresentaram um padrão contrário, embora a diferença tenha sido estatisticamente significante apenas para o tubarão cachorro. Um total de 431 HT foram ativados, havendo um claro crescimento da taxa de mortalidade dos peixes capturados com o aumento do tempo decorrido entre a captura e o seu embarque, porém, algumas espécies demonstraram suportar longos períodos de captura sobrevivendo até o momento do embarque. Os resultados sugerem que através do conhecimento dos fatores que afetam a sobrevivência de peixes pelágicos capturados na pesca com espinhel pode-se desenvolver/adotar métodos de pesca que reduzam a mortalidade principalmente dos integrantes da fauna acompanhante e animais capturados incidentalmente.

I den här uppsatsen undersöks vad som motiverar studenter vid Uppsala universitet att använda och stanna kvar på det sociala nätverket Facebook. Med hjälp av intervjuer samlas data in om hur målgruppen använder tjänsten, vad som motiverar dem, och vad de tycker om sitt eget användande. Intervjusvaren analyseras utifrån ett enkelt ramverk som baserats på The Hook Model och Fogg Behavior Model, vilka beskriver hur vaneanvändande kan skapas. Vi kommer fram till att det finns starka tendenser till vaneanvändande av Facebook hos målgruppen, och att detta är något de är missnöjda med. Vidare har målgruppens användande förändrats över tid, och vanorna som nu motiverar användandet verkar ha bildats då tjänsten uppskattades mer och användandet var mer aktivt. Vanan att använda Facebook förstärks nu inte längre, men lever kvar i högsta grad. Målgruppen vill även sluta använda Facebook, men lyckas inte göra detta. Vi kommer fram till att detta troligen beror på att en alltför stor social investering har gjorts i tjänsten, och att vanan som bildats är svår att bryta. / In this paper the motivation for using the social media platform Facebook is studied among students at Uppsala University. Interviews are used to collect data about how the demographic is using the platform, what motivates them and what they think about their own user behavior. The data is analysed with a framework based on The Hook Model and Fogg Behavior Model, that describes how platforms can be designed to create habitual use. We find that there are strong tendencies towards habitual use of Facebook among the demographic, and that this is something they are displeased with. The demographic Facebook use has changed over time, and the habits that now acts as motivation was formed when their appreciation for the platform was greater and they used it more actively. The habit to use Facebook is no longer enforced but is still present. The demographic wants to stop using Facebook, but are not able to do so. We conclude that this most likely is caused by a significant social investment in the platform, and that the habitual use is hard to end.