No description available.

In light of the extirpation of a number of elasmobranch species commonly encountered in fresh and estuarine waters elsewhere in the world, 39 river systems were sampled throughout northern Australia to determine the species present. A total of 502 elasmobranchs representing 36 species, in addition to 1531 teleosts representing 46 species, were captured. In regard to elasmobranch species known to frequent riverine habitats, the bull shark Carcharhinus leucas was captured in the highest number, followed by the freshwater sawfish Pristis microdon, the freshwater whipray Himantura chaophraya and the dwarf sawfish Pristis clavata. Although these species were generally captured in low numbers, all were widely distributed throughout the region. Furthermore, the waters of King Sound, Western Australia, and the rivers entering it, i.e. the Fitzroy, May and Robinson rivers, were found to contain far higher numbers of P. microdon and P. clavata than any of the other rivers sampled, as well as the northern river shark Glyphis sp. C, and which subsequently provided an ideal locality to study the biology of these species. The Fitzroy River was shown to act as a nursery for P. microdon and P. clavata, where immature individuals remain for a maximum of four or five years before migrating to marine waters. Investigations of the rostra and rostral tooth morphology of P. microdon indicated their usefulness as a diagnostic tool in differentiating this species from other members of the genus, including P. clavata, and for differentiating between the sexes, i.e. female P. microdon generally possess 17-21 teeth cf. 19-23 teeth in males. However, no significant difference in the number of rostral teeth was found between female and male P. clavata, with both sexes possessing an average of 42. Furthermore, the facts that P. clavata was captured up to 2332 mm in total length and all of the individuals were immature, indicates that the description of this species as a ‘dwarf’ sawfish is erroneous. The use of rivers of northern Australia as nurseries was also apparent for C. leucas, with none of the 111 individuals dissected (ranging in length from 681 to 1365 mm TL) being mature. Furthermore, this species appeared to remain within the rivers for approximately four years. Stomach content analysis and field observations confirmed an opportunistic, and often aggressive, feeding nature, and thus the species may pose some risk to bathers utilising inland waters far upstream (i.e. over 300 km). Morphometrics and radiographs of 10 Glyphis sp. C captured from the macrotidal waters of King Sound (the first capture of this species in Western Australia) indicated that these specimens possessed both a wider range in total vertebral count (i.e. 140-151 cf. 147-148) and number of diplospondylous caudal centra (i.e. 64-70 cf. 65-68) than that previously reported and lent support for its synonymisation with Glyphis gangeticus. Radiographs also revealed the spinal deformation and fusing of vertebrae in three of the ten individuals, which may be attributable to a genetic abnormality indicative of inbreeding within a small gene pool. Analyses of stomach content and stable carbon (ä13C) and nitrogen (ä15N) isotope ratios of fishes occurring in the Fitzroy River indicated that the diets of a majority of the species present are broad, and greatly influenced by the seasonal availability of different prey types. While stomach content analysis suggested that aquatic insects, and to a lesser extent filamentous algae, represent vitally important food sources for many of the species present, stable isotope analysis strongly suggested that this latter food source may not be an important direct energy source, and that prey types which persist throughout the year (e.g. fish, molluscs and Macrobrachium rosenbergii) may in fact be more important sources of the energy than dietary data revealed. Dietary overlap was found to be the highest during the wet season when prey availability was high, decreased in the early dry season as fishes became more specialised in their feeding, before increasing again in the late wet when food became very limited. These analyses also supported the views that juvenile fishes may target high energy food items to attain higher growth rates and a large size rapidly, in order to achieve competitive feeding advantages and reduce the risk of predation, and that many species will maximise their energy intake in response to changes in resource availability.

No description available.

<p>An <em>isotype heterojunction</em> is a junction between two layers of dissimilar semiconductors both of which are doped either n-type or p-type. These semiconductor structures are found in a variety of optoelectronic devices, such as solar cells, semiconductor lasers, and detectors. Motivated by the structure of third generation inorganic solar cells, this thesis concentrates on the analytical modelling of isotype heterojunctions and its application to the design optimization of these devices. The main development of this work is the introduction of an analytical expression for the current density across an isotype heterojunction valid for arbitrary doping concentration ratios. This result generalizes the standard expression found in the literature, which is limited by the assumption that the doping concentration ratio between the two sides of the heterojunction is equal to one. The generalization is developed by employing the Lambert W function in the solution of the electrostatic boundary condition associated with the heterojunction interface. As done in the derivation of the standard expression found in the literature, the generalization only considers thermionic emission, but the same method can readily be applied for other transport mechanisms. A key feature of this generalized result is that it mathematically contains the expression for the current density across a metal-semiconductor Schottky contact as a limiting case, thereby unifying the treatment of these two heterointerfaces into a single general analytical description. This latter find is particularly significant from a theoretical perspective, considering that the two heterointerfaces are traditionally described as separate topics in the presentation of semiconductor device theory.</p> / Master of Applied Science (MASc)

Malgré sa condamnation post-positiviste et sa réception négative par la gauche, l’empirisme logique regagne en intérêt. Cette thèse est une contribution à la littérature émergente du «Cercle de Vienne de gauche» (CVG). Autour de Neurath et quelques autres personnalités de l’aile gauche du Cercle (Carnap, Frank, Hahn, Zilsel), nous proposons de repenser la relation de l’empirisme logique avec le marxisme. Ces deux courants se rejoignent dans leur défense d’une «conception scientifique du monde» et leur sécularisme radical. Les critiques communistes et néo-marxistes (l’École de Francfort, l’épistémologie féministe) adressées à l’empirisme logique sont recensées et leur pertinence questionnée à travers les données de l’historiographie du CVG. La politique de l’empirisme logique est examinée à travers les textes économiques de Neurath et son œuvre d’infographiste. Son engagement pour l’économie socialiste planifiée et ses efforts en graphisme pour la popularisation des méthodes quantitatives (la méthode Isotype pour la visualisation des statistiques sociales) sont présentés en vue d’une évaluation politique du CVG, ainsi que les connexions de l’empirisme logique avec le mouvement pour une langue auxiliaire internationale. / Despite logical empiricism’s dismissal by ambient postpositivism in academia as well as by the Far Left, a growing interest in its previously unknown socialist origins has resulted in a new topic in the history of philosophy of science : «Left Vienna Circle» (LVC). This thesis dedicated to LVC studies aims to clarify the politics of European logical empiricism. A presentation of its major critics from the Left (from communist parties to neo-Marxist trends like Frankfurt School and feminist epistemology) is followed by more recent arguments about its socialist politics. The «scientific world conceptions» of logical empiricism and Marxism will be compared through the work of Neurath and some other representatives of LVC (Carnap, Frank, Zilsel, Hahn). Alongside the connections of logical empiricism to the movement for an international auxiliary language, Neurath’s economical writings and his efforts to popularize quantitative methods in social sciences (the Isotype method of visual statistics) will be presented in an attempt to evaluate the politics of logical empiricism.

Diseases that affect dairy cattle have serious economic and animal welfare implications. The inclusion of immune response (IR) traits in breeding indices has been suggested to improve inherent animal health, and decrease the use of antimicrobials. The objectives of this research were to (1) evaluate cell-mediated (CMIR) and antibody-mediated immune responses (AMIR) on 680 Holstein cows from 58 herds across Canada, (2) estimate genetic parameters of these traits (3) examine the associations with routinely evaluated traits as well as the incidence of mastitis, (4) evaluate the correlation of natural and specific antibody and (5) perform a genome-wide association study (GWAS) to determine genetic markers associated with high or low IR. In collaboration with the Canadian Bovine Mastitis Research Network cows were immunized with both a type 1 and type 2 test antigen to stimulate CMIR and AMIR, respectively. A cutaneous delayed-type hypersensitivity test to the type 1 test antigen was used as an indicator of CMIR, and serum antibody (IgG1 and IgG2) to the type 2 test antigen as an indicator of AMIR. IR phenotypes varied significantly by cow, herd and region in Canada. Heritability estimates were moderate, 0.19 for CMIR and 0.16-0.43 for AMIR depending on time in the immunization protocol and antibody isotype. Beneficial associations between AMIR and some reproductive traits were found. Using estimated breeding values, cows were classified as high, average or low responders. High AMIR cows had significantly lower incidence rates of clinical mastitis compared to average and low cows. No difference was found when cows were classified based on CMIR. Natural antibody was not genetically correlated with specific antibody nor was it associated with mastitis. The GWAS found 198 genetic markers significantly associated with AMIR, with the majority on chromosome 23 where the major histocompatability complex is located. Other significant genes involved in IR include those associated with the complement system, interleukin 17 and tumor necrosis factor. This research confirms the benefit of identifying high IR cows and gives a glimpse of current IR profiles in Canadian Holsteins. This was the first GWAS for IR traits in dairy cattle and suggests it may be possible to include IR traits in genomic selection indices. / This research was financed by grants to B.A. Mallard from National Sciences and Engineering Research Council of Canada, Alberta Milk, Dairy Farmers of New Brunswick, Nova Scotia, Ontario and Prince Edward Island, Novalait Inc., Dairy Farmers of Canada, DairyGen council of Canadian Dairy Network, Agriculture and Agri-Food Canada, Public Health Agency of Canada, Technology PEI Inc., Université de Montréal and University of Prince Edward Island through the Canadian Bovine Mastitis Research Network. Kathleen Adele Thompson Crispi was funded by the Dairy Farmers of Ontario Doctoral Research Assistantship.

A deficiência de imunoglobulina A (DIgA) é a imunodeficiência primária mais comum com prevalência de 1: 223 a 1:1000 em estudos epidemiológcos, sendo menos freqüente em populações asiáticas. As manifestações clínicas variam desde indivíduos assintomáticos até aqueles com manifestações atópicas, auto-imunes ou infecciosas. Entre estas últimas destacam-se os acometimentos dos tratos respiratório e digestório. Associação com outras imunodeficiências primárias tem sido reportada, em especial a imunodeficiência comum variável e a deficiência de subclasses de imunoglobulina G. Os objetivos deste estudo foram a avaliação dos pacientes com DIgA, diagnosticados na infância, após a segunda década da vida e a avaliação diagnóstica de seus familiares quanto aos aspectos clínicos e laboratoriais. A metodologia utilizou, para o diagnóstico de DIgA, o critério adotado pelo ESID/PAGID (1999). Foi realizada a avaliação das concentrações de imunoglobulina A(IgA) e imunoglobulina M (IgM), na saliva e a pesquisa de auto-anticorpos séricos (Anti-tireóide, FR,FAN) nos pacientes e familiares com DIgA. Realizou-se uma curva de distribuição de IgM salivar em indivíduos normais para comparação com os pacientes DIgA. Os resultados mostraram a avaliação dos 34 pacientes (19 do sexo feminino) com deficiência de imunoglobulina A (DIgA) com idade superior a 10 anos (variação: 10 à 52 anos), sendo 27 deles diagnosticados na infância e 7 familiares dos 62, que responderam à convocação. Considerando-se todos os indivíduos com DIgA, processos infecciosos (de repetição ou graves) ocorreram em 91,2%, manifestações atópicas em 58,8% e auto-imunidade em 52,9%. Manifestações clínicas de auto-imunidade foram observadas em 14/18 indivíduos, sendo que sete foram diagnosticados após 10 anos de idade, por ocasião da realização da pesquisa. Auto-anticorpos foram observados em 10 pacientes, sendo quatro pacientes assintomáticos. Fator reumatóide não foi detectado nesta casuística. Tireoidopatias (seis casos) e artropatias (quatro casos) foram as manifestações clínicas auto-imunes mais observadas. As concentrações de IgM salivar mostraramse elevadas em todos, exceto cinco casos. A comparação dessas concentrações nos grupos com e sem auto-imunidade não mostrou diferença significante (p= 0,48). As conclusões desta pesquisa mostraram os processos infecciosos como as manifestações clínicas mais freqüentes nos pacientes com DIgA, observando-se, porém, uma relevante presença de auto-imunidade nestes pacientes quando reavaliados após a segunda década de vida. Este fato alerta para a necessidade de avaliação rotineira de fenômenos auto- imunes nestes pacientes, durante seguimento. As concentrações de IgM salivar foram semelhantes em pacientes com DIgA com e sem auto-imunidade. Auto-anticorpos foram detectados independentemente da presença de sintomatologia clínica, sendo os mais encontrados aqueles relacionados à tireóide. Os familiares de primeiro grau dos pacientes com DIgA devem ser avaliados, tanto para diagnóstico de imunodeficiências como para detecção de fenômenos auto-imunes, permitindo assim o diagnóstico e abordagens precoces de ambas condições. / IgA deficiency (IgAD) is the most frequent primary immunodeficiency. Its prevalence varies from 1:223 to 1:1000 in epidemiological studies, but in asiatic populations it is uncommon. The clinical manifestations of IgAD are spectral, ranging from asymptomatic patients to recurrent infections, allergic symptoms and/or autoimmunity conditions. The most common infections frequently associated to IgAD involve respiratory and gastrointestinal tracts. The association with other primary immunodeficiency such as common variable immunodeficiency and immunoglobulin G subclasses deficiency has been reported. The aim of this study is to describe clinical and laboratorial evolution regarding autoimmune manifestations in IgAD patients diagnosed during the first years of life and after the second decade and their relatives diagnosed during this study. Laboratorial data included immunoglobulins A and M levels in saliva and auto-antibody screening in immunoglobulin A deficient relatives and patient. The criterion adopted for IgAD diagnosis was defined by Pan-American Group for Immunodeficiency and European Society for Immunodeficiency. The results showed 34 (19 female) immunoglobulin A deficient patients (IgAD) over 10 years of age (range: 10-52 years), 27 of them diagnosed during their childhood, and seven adults detected among 62 screened relatives. Recurrent infections were diagnosed in 91.2% of cases, atopic manifestations in 58.8% and autoimmune clinical manifestation in 52.9%. Autoimmune clinical manifestations were observed in 14 of our 18 IgA deficient patients and relatives with autoimmunity phenomena and seven of them diagnosed only over 10 years old during the study. Auto-antibodies were observed in (10/18) of patients and relatives, with four of them (asymptomatic) showing only the presence of auto-antibodies. Thyroid and osteo-articular involvement (six and four cases, respectively) were the most frequent clinical autoimmune manifestations. The rheumatoid factor was not detected in this casuistic. Auto-antibodies had no statistical difference among patients with or without autoimmunity phenomena. High salivary IgM concentrations were detected in all IgA deficient patients and relatives, except five cases. The comparison of these concentrations in the groups with and without autoimmunity did not show significant difference (p=.0, 48). In conclusion, recurrent infections were the most frequent clinical manifestations of IgA deficient patients and also autoimmune diseases, after the second decade of life. This fact at this series reinforced the necessity of active search for autoimmune conditions diagnosis in these patients. IgM levels showed no statistical difference among IgA deficient patients and relatives with or without autoimmunity. Auto-antibodies, mainly anti-thyroid antibodies, were detected in patients independently of autoimmunity clinical manifestation presence. This study showed the importance of the first degree relatives of IgA deficient patients evaluation, focusing as immunodeficiency as autoimmune disease, permiting an earlier diagnosis of both conditions and an adequate approach to optimize the clinical management and improvement of quality of life of IgAD patients.

A deficiência de imunoglobulina A (DIgA) é a imunodeficiência primária mais comum com prevalência de 1: 223 a 1:1000 em estudos epidemiológcos, sendo menos freqüente em populações asiáticas. As manifestações clínicas variam desde indivíduos assintomáticos até aqueles com manifestações atópicas, auto-imunes ou infecciosas. Entre estas últimas destacam-se os acometimentos dos tratos respiratório e digestório. Associação com outras imunodeficiências primárias tem sido reportada, em especial a imunodeficiência comum variável e a deficiência de subclasses de imunoglobulina G. Os objetivos deste estudo foram a avaliação dos pacientes com DIgA, diagnosticados na infância, após a segunda década da vida e a avaliação diagnóstica de seus familiares quanto aos aspectos clínicos e laboratoriais. A metodologia utilizou, para o diagnóstico de DIgA, o critério adotado pelo ESID/PAGID (1999). Foi realizada a avaliação das concentrações de imunoglobulina A(IgA) e imunoglobulina M (IgM), na saliva e a pesquisa de auto-anticorpos séricos (Anti-tireóide, FR,FAN) nos pacientes e familiares com DIgA. Realizou-se uma curva de distribuição de IgM salivar em indivíduos normais para comparação com os pacientes DIgA. Os resultados mostraram a avaliação dos 34 pacientes (19 do sexo feminino) com deficiência de imunoglobulina A (DIgA) com idade superior a 10 anos (variação: 10 à 52 anos), sendo 27 deles diagnosticados na infância e 7 familiares dos 62, que responderam à convocação. Considerando-se todos os indivíduos com DIgA, processos infecciosos (de repetição ou graves) ocorreram em 91,2%, manifestações atópicas em 58,8% e auto-imunidade em 52,9%. Manifestações clínicas de auto-imunidade foram observadas em 14/18 indivíduos, sendo que sete foram diagnosticados após 10 anos de idade, por ocasião da realização da pesquisa. Auto-anticorpos foram observados em 10 pacientes, sendo quatro pacientes assintomáticos. Fator reumatóide não foi detectado nesta casuística. Tireoidopatias (seis casos) e artropatias (quatro casos) foram as manifestações clínicas auto-imunes mais observadas. As concentrações de IgM salivar mostraramse elevadas em todos, exceto cinco casos. A comparação dessas concentrações nos grupos com e sem auto-imunidade não mostrou diferença significante (p= 0,48). As conclusões desta pesquisa mostraram os processos infecciosos como as manifestações clínicas mais freqüentes nos pacientes com DIgA, observando-se, porém, uma relevante presença de auto-imunidade nestes pacientes quando reavaliados após a segunda década de vida. Este fato alerta para a necessidade de avaliação rotineira de fenômenos auto- imunes nestes pacientes, durante seguimento. As concentrações de IgM salivar foram semelhantes em pacientes com DIgA com e sem auto-imunidade. Auto-anticorpos foram detectados independentemente da presença de sintomatologia clínica, sendo os mais encontrados aqueles relacionados à tireóide. Os familiares de primeiro grau dos pacientes com DIgA devem ser avaliados, tanto para diagnóstico de imunodeficiências como para detecção de fenômenos auto-imunes, permitindo assim o diagnóstico e abordagens precoces de ambas condições. / IgA deficiency (IgAD) is the most frequent primary immunodeficiency. Its prevalence varies from 1:223 to 1:1000 in epidemiological studies, but in asiatic populations it is uncommon. The clinical manifestations of IgAD are spectral, ranging from asymptomatic patients to recurrent infections, allergic symptoms and/or autoimmunity conditions. The most common infections frequently associated to IgAD involve respiratory and gastrointestinal tracts. The association with other primary immunodeficiency such as common variable immunodeficiency and immunoglobulin G subclasses deficiency has been reported. The aim of this study is to describe clinical and laboratorial evolution regarding autoimmune manifestations in IgAD patients diagnosed during the first years of life and after the second decade and their relatives diagnosed during this study. Laboratorial data included immunoglobulins A and M levels in saliva and auto-antibody screening in immunoglobulin A deficient relatives and patient. The criterion adopted for IgAD diagnosis was defined by Pan-American Group for Immunodeficiency and European Society for Immunodeficiency. The results showed 34 (19 female) immunoglobulin A deficient patients (IgAD) over 10 years of age (range: 10-52 years), 27 of them diagnosed during their childhood, and seven adults detected among 62 screened relatives. Recurrent infections were diagnosed in 91.2% of cases, atopic manifestations in 58.8% and autoimmune clinical manifestation in 52.9%. Autoimmune clinical manifestations were observed in 14 of our 18 IgA deficient patients and relatives with autoimmunity phenomena and seven of them diagnosed only over 10 years old during the study. Auto-antibodies were observed in (10/18) of patients and relatives, with four of them (asymptomatic) showing only the presence of auto-antibodies. Thyroid and osteo-articular involvement (six and four cases, respectively) were the most frequent clinical autoimmune manifestations. The rheumatoid factor was not detected in this casuistic. Auto-antibodies had no statistical difference among patients with or without autoimmunity phenomena. High salivary IgM concentrations were detected in all IgA deficient patients and relatives, except five cases. The comparison of these concentrations in the groups with and without autoimmunity did not show significant difference (p=.0, 48). In conclusion, recurrent infections were the most frequent clinical manifestations of IgA deficient patients and also autoimmune diseases, after the second decade of life. This fact at this series reinforced the necessity of active search for autoimmune conditions diagnosis in these patients. IgM levels showed no statistical difference among IgA deficient patients and relatives with or without autoimmunity. Auto-antibodies, mainly anti-thyroid antibodies, were detected in patients independently of autoimmunity clinical manifestation presence. This study showed the importance of the first degree relatives of IgA deficient patients evaluation, focusing as immunodeficiency as autoimmune disease, permiting an earlier diagnosis of both conditions and an adequate approach to optimize the clinical management and improvement of quality of life of IgAD patients.

No description available.

Ce mémoire accompagne l’oeuvre Picto-Moi, qui est le fruit de mon cursus universitaire au sein de la maitrise en arts visuels. L’oeuvre Picto-Moi dont il est question dans ce mémoire se présentera sous forme d’une série de pictogrammes, autrement dit, un langage visuel graphique et symbolique.Celui-ci reflète une étape figée de l’enfance d’une Canadienne d’origine marocaine, « Moi », partagée entre son pays natal et son pays d’origine pour ainsi dévoiler par ce langage symbolique un ensemble d’évènements, de moeurs et de particularités en toute subtilité. Il s’agira d’abord de percevoir tous ces éléments bruts, responsables de l’émergence de cette oeuvre, viennent en priorité les archives de mon enfance. Dans ce mémoire, je tenterai de révéler au grand jour mon ordinaire et mon extraordinaire, dans une approche singulière et très symbolique.D’autre part, il s’agira d’appuyer mon oeuvre par la notion de monde et plus précisément, la version de Nelson Goodman dans Manières de faire des mondes. Ceci concerne le cadre théorique. Sur le plan pratique, il s’agira d’introduire le système international d’éducation par les images sous le nom d’isotype, et ce en mettant en avant les créations d’Otto Neurath et son alliance avec l’artiste graphiste Gerd Arntz. De là, mon inspiration pour la création de mon langage visuel.