INTRODUÇÃO: A osteoartrose de joelho (OAJ) é uma das patologias que mais afetam o aparelho locomotor e interferem de forma considerável nas atividades da vida diária, acometendo os indivíduos em faixa etária variável e em diversos graus e níveis de dor articular. As propostas terapêuticas são bastante diversificadas para a osteoartrose (OA), a terapia física, a TENS está para colaborar no tratamento dos pacientes com osteoartrose de joelho. OBJETIVOS: Devido à importância da articulação do joelho nas atividades locomotoras e sua relação com as atividades da vida diária. Os pacientes com osteoartrose de joelho sofrem não somente pelo problema localizado, existe uma alteração funcional global que pode levar a processos dolorosos em outras articulações. Para uma eficaz orientação e avaliação do paciente primeiro é necessário que este faça a descrição clara de sua dor para que o profissional perceba como que esse estímulo doloroso prejudica sua vida. O objetivo do presente estudo foi avaliar o efeito da estimulação elétrica nervosa transcutânea (sigla em inglês TENS) nível sensório para tratamento de dor em pacientes com diagnóstico de osteoartrose de joelho, utilizando escalas de avaliação de dor, escala de avaliação funcional. MÉTODOS: Foram estudados 10 pacientes com diagnóstico de osteoartrose de joelho, utilizando uma modalidade fisioterapêutica, a eletroterapia, especificamente a (TENS), com parâmetros de 80 Hz e 140s, com um total de 10 sessões, 30 minutos para cada sessão, o período total de tratamento compreendeu 4 semanas, nesse total de 10 sessões, cada paciente foi entrevistado com um questionário na 1ª sessão, na 5ª e na 10ª sessão. Os formulários utilizados foram Questionário da Dor McGill Melzack, escala Analógica visual da dor, escala numérica com expressão facial de sofrimento, escala de atividades da vida diária da knee Outcome Survey - RESULTADOS: O resultado com a TENS nível sensório para efeito de analgesia mostra que as diferenças foram estatisticamente significativas (p<0,05) para escala Analógica visual da dor e o Questionário da Dor McGill, em alguns itens da escala de atividades da vida diária da knee Outcome Survey houve significância estatística. CONCLUSÃO: Nossos resultados sugerem que a TENS nível sensório reduz a dor e melhora a funcionalidade do joelho em alguns pontos da escala de atividades da vida diária em pacientes com OAJ / INTRODUCTION: Knee osteoarthritis (KOA) is one of the diseases that most affect the locomotor system and interfere significantly in activities of daily life, affecting individuals at varying ages and in different degrees and levels of joint pain. The proposals are quite diverse therapies for osteoarthritis (OA), physical therapy, TENS is to collaborate in the treatment of patients with osteoarthritis of the knee. OBJECTIVES: Because of the importance of the knee joint in locomotor activity and its relation to the activities of daily living. Patients with osteoarthritis of the knee not only suffer the problem located, there is a change in overall functional processes that can lead to pain in other joints. To provide efficient guidance and evaluation of the patient first must make this clear description of their pain for the professional to realize how painful stimulus that affect their lives. The aim of this study was to evaluate the effect of transcutaneous electrical nerve stimulation (TENS acronym in English) to the sensory processing of pain in patients with osteoarthritis of the knee, using rating scales of pain, functional scale. METHODS: We studied 10 patients with osteoarthritis of the knee, using a modality physiotherapy, electrotherapy, specifically (TENS), with parameters of 80 Hz and 140s, with a total of 10 sessions, 30 minutes for each session, the period Total treatment included 4 weeks in total of 10 sessions, each patient was interviewed with a questionnaire in the first session, on the 5th and 10th session. The forms used were the McGill Pain Questionnaire - Melzack, visual analogue pain scale, numerical scale with facial expression of pain, range of activities of daily living of the Knee Outcome Survey - RESULTS: The result with TENS for the effect of sensory analgesia shows that the differences were statistically significant (p <0.05) for visual analogue pain scale and McGill Pain Questionnaire, in some items of the scale of activities of daily living knee Outcome Survey of statistical significance. CONCLUSION: Our results suggest that sensory TENS reduces pain and improves knee function in some points of the scale of activities of daily living in patients with KOA

Cette thèse présente l’apport d’une analyse fractale de la texture de l’os trabéculaire sur des clichés de radiographie du genou pour la caractérisation de la gonarthrose. Dans un premier temps cette analyse de texture a été confrontée aux méthodes actuelles de suivi de la pathologie afin de valider leur intérêt dans le suivi clinique des patients. Un second temps a été consacré à la prédiction de l’initiation de la pathologie où aucun marqueur ne fait référence. L’analyse de texture a été menée en utilisant des approches fractales permettant de s’affranchir des problèmes de variation d’acquisition entre différents centres cliniques tout en comparant différentes méthodes de calcul. La texture osseuse trabéculaire a été analysée à différentes plages d’échelle afin de caractériser les mécanismes sous-jacents de modification de la microarchitecture osseuse induits par la gonarthrose. Nous avons pu mettre en évidence l’intérêt prédictif de cette analyse peu coûteuse et largement accessible dans le cadre aussi bien de l’initiation que de la progression de l’arthrose du genou. / This thesis presents the contribution of the trabecluar bone texture fractal analysis on knee radiographs for the knee osteoarthritis characterization. Firstly, this texture analysis was confronted to the actual methods of the pathology clinical monitoring in order to validate their interest in the patients monitoring. Secondly, the prediction of the knee osteoarthritis initiation was investigated, domain in which there are still no markers defined. The texture analysis was performed using fractal approaches avoiding the problems of the variations in the acquisition among different clinical centers and comparing different computing methods. Trabecular bone texture was analyzed at different ranges of scale in order to characterize the underlying mechanisms of the microarchitecture modification induced by the knee osteoarthritis. Thus, we highligthed the predictive interest of this cheap and largely available analysis for both the initiation and the progression of the knee osteoarthritis.

Made available in DSpace on 2016-01-26T12:51:43Z (GMT). No. of bitstreams: 1 rassen_dissert.pdf: 1247464 bytes, checksum: 68e143195fe25c1bd50b6681db4d40e7 (MD5) Previous issue date: 2001-09-28 / The aim of the present study is to evaluate the result of the knee pain treatment using The Opposite Side Technique from the Traditional Chinese Medicine. Thirty-six patients with unilateral gonalgia were studied. 44.44% (16) with osteoarthrosis, 30.55% (11) with patella femural osteoarthrosis, 11.11% (4) with severe osteoarthrosis, 11.11% (4) with patella chrondomalacy and 2.77% (1) with synovial plica. The patients were divided in two groups: Group I (Acupuncture) were eighteen, who submitted to 20 acupuncture sessions, where it was used points of counter to lateral acupuncture to the affected knee and acupuncture points to the distance according to the Traditional Chinese Medicine and to the acupuncture neurophisiologic action standard to select these points for the treatment, and Group II (Phisiotherapy) also eighteen, who submitted to 20 physiotherapeutic sessions and antiinflamatory non steroid (AINS) medicines. According to the results from the statistical analysis, non-parametric, of the subjective data (the intensity of the described pain, difficulty in walking, in crouching, in going upstairs and downstairs, in running, in jumping, in claudicant motion, in making use of some walking support) as the objective parameters ( the restriction of the flexional moviment and also the one of the knee extension moviment, and the arc moviment) showed good results in all the studied parameters. The most refractory parameters were the objective ones above mentioned. The Jue Yin (Liver) energetic channel of the foot showed to be the most affected (22.22%), followed by the associations of the Jue Yin (Liver) and the Tae Yang (Bladder) energetic channel of the foot (22.22%), the Jue Yin (Liver) and the Yang Ming (Stomach) of the foot (16.66%), and the Jue Yin (Liver) and the Shao Yang (Gall Bladder) of the foot (11.11%), and another associations (16.66%). The false-Yang (52.77%) characteristics of disorders were the predominant in relation to the energetic ones followed by the Yin (33.33%) and the Yang (13.88%) disorders of the patients. / O presente estudo teve a finalidade de avaliar a eficácia da acunputura no pós-operatório das cirurgias artroscópicas no joelho utilizando - se a técnica "ao oposto" da medicina tradicional chinesa. As 36 gonalgias estudadas foram distribuídas conforme a patologia encontrada nas artroscópicas cirúrgicas: 50,0% tinham lesão do menisco medial isolada, 19,44% tinham lesão meniscal associada à artrose de joelho, 11,11% tinham lesão meniscal lateral associada à artrose de joelho, 8,33% tinham lesão meniscal lateral isolada de joelho, 2,77% apresentavam lesão em ambos os menisco associados à artrose de joelho, 2,77% apresentavam condromalácea de patela e 2,77% eram portador de corpo livre. Os pacientes foram dividos em dois grupos. Todos os pacientes do grupo i (acunputura) 18 foram submetidos a 20 sessões de acunputura, utilizando-se pontos de acunputura, utilizando-se pontos de acunputura contra-lateral ao joelho afetado, e os pacientes do grupo ii (fisioterapia), 18, foram submetidos a 20 sessões de fisioterapia, associadas a anti-inflamatórios não esteroídes (aine). Nota de Resumo A análise estatística não paramétrica dos resultados obtidos nos dados subjetivos (intensidade da dor relatada, dificuldade de andar, de agachar, de subir e descer degraus, de correr, de uso de apoio a marcha), como os parâmetros objetivos (limitação do movimento de flexão, extensão, arco de movimento, edema, derrame e trofismo de joelho) evidenciaram bons resultados na maioria dos parâmetros estudados. Embora os resultados fossem semelhantes, a acunputura apresentou melhores resultados do tratamento mais precocemente, enquanto a fisioterapia mais tardiamente.

A cartilagem articular, por sua natureza avascular, apresenta uma capacidade limitada de regeneração. Uma abordagem terapêutica para o tratamento de defeitos da cartilagem consiste na utilização de células ou tecidos aplicados ao local da lesão. O objetivo deste estudo foi avaliar o efeito da aplicação de centrifugado de medula óssea autóloga em lesões osteocondrais no joelho de coelhos, em comparação com um grupo controle de lesões osteocondrais sem preenchimento, analisando o comportamento histológico destes grupos em função do tempo. Foram utilizados doze coelhos da raça Nova Zelândia, albinos, machos, adultos, submetidos a uma lesão osteocondral, de 4 mm de diâmetro e 3 mm de profundidade, em ambos os joelhos, na região da tróclea femoral. Nos joelhos direitos, que constituíram o Grupo Estudo, o defeito osteocondral foi preenchido por um coágulo de células mesenquimais, obtidas por centrifugação de um aspirado da medula óssea e selado com cola de fibrina. Nos joelhos esquerdos, que constituíram o Grupo Controle, o defeito osteocondral não recebeu qualquer preenchimento. Os animais foram divididos em três grupos de quatro coelhos, estudados após oito, 16 e 24 semanas. Os resultados foram descritos com base em uma escala de pontuação histológica que avaliou a morfologia celular, a reconstrução do osso subcondral, o aspecto da matriz, o preenchimento do defeito, a regularidade da superfície e a conexão das margens. A análise estatística foi realizada pelo Teste t-student para dados pareados na comparação entre Grupo Estudo e Grupo Controle. Para as comparações através do fator temporal, utilizou-se o Teste ANOVA one way. Com 5% de confiança, rejeitou-se a hipótese de igualdade entre os Grupos Estudo e Controle. Notou-se uma distância decrescente entre os escores dos Grupos Estudo e Controle com o aumento do tempo, bem como uma tendência crescente do valor da escala para o Grupo Controle. Concluiu-se que a aplicação de centrifugado de medula óssea em defeitos osteocondrais no joelho de coelhos mostrou melhor resultado na avaliação histológica, em comparação ao Grupo Controle. Analisando a evolução dos grupos através do tempo, houve uma aproximação de seus escores histológicos, sobretudo pelo aumento observado no Grupo Controle / The articular cartilage, due to its avascular nature, presents a limited regeneration capacity. A therapeutical approach to the treatment of cartilage defects consists of the utilization of cells or tissues applied to the lesion site. The aim of this study was to evaluate the effect of applying autologous bone marrow centrifuged in osteochondral lesions in the knees of rabbits, compared to a control group of osteochondral lesions without any filling, analyzing the behavior of these groups in terms of time. Twelve adult albino male New Zealand rabbits were used being submitted to an osteochondral lesion of 4 mm in diameter and 3 mm deep in both knees, at the femoral trochlea area. On the right knees, which comprised the Study Group, the osteochondral defect was filled by a clot of mesenchymal cells, obtained by centrifugation of an aspirate from bone marrow and sealed with fibrin glue. On the left knees, which comprised the Control Group, the osteochondral defect did not get any filling. The animals were divided into 3 groups of 4 rabbits, and studied after eight, 16 and 24 weeks. The results were described based on a histological grading scale which took into account the cell morphology, the subchondral bone reconstruction, the matrix staining, the filling of the defect, the surface regularity and the bonding of the edges. The statistical analysis was made by the t-student Test for paired data in the comparison between the Study Group and the Control Group. For the comparisons made by the time factor, it was used the ANOVA Test one way. With 5% level of confidence, the hypothesis of equality between the Study and Control Groups was rejected. It was observed a decreasing distance between scores of the Study and Control Groups as time increased, as well as an increasing tendency of the scale value for the Control Group. It was concluded that the application of autologous bone marrow centrifuged in osteochondral defects in the knees of rabbits showed better result in histological evaluation, in comparison to the Control Group. By analyzing the evolution of the groups through time, there was an approach of their histological scores, especially by the increase observed in the Control Group

INTRODUÇÃO: O fortalecimento do quadríceps em pacientes com osteoartrite (OA) de joelho está associado à redução da dor, independência para caminhar e melhora funcional, salientando o papel dos exercícios físicos no tratamento dessa doença. Portanto, procedimentos capazes de aumentar os efeitos do exercício sobre força e função muscular podem ser potencialmente terapêuticos nesses pacientes. OBJETIVOS: Demonstrar a eficácia da suplementação de creatina associada ao treinamento de força (TF) no tratamento da OA de joelho. MÉTODOS: Mulheres entre 50 e 65 anos de idade com OA de joelho foram suplementadas com CR (20 g/d por 7 dias e depois 5 g/d até o fim do estudo) ou placebo (PL) e submetidas a um programa de TF por 12 semanas. Antes e após esse período, foram realizadas avaliações de capacidade física funcional (desfecho primário), dor, qualidade de vida, força muscular, composição corporal e função renal. RESULTADOS: Houve significante melhora da capacidade física funcional aferida pelo teste de levantar e sentar em 30 segundos (desfecho primário) apenas no grupo CR (P = 0,006). Além disso, foi observado efeito de interação entre grupos (CR PRÉ: 15,7 ± 1,4, CR PÓS: 18,1 ± 1,8; PL PRÉ: 15,0 ± 1,8, PL PÓS: 15,2 ± 1,2; P = 0,004). O grupo CR também apresentou melhora nos domínios de capacidade física funcional (P = 0,005) e de rigidez (P = 0,024) do Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), no índice algofuncional de Lequesne (P = 0,01) e na massa magra de membros inferiores mensurada pela densitometria de dupla emissão com fonte de raios X (P = 0,04). Em ambos os grupos houve redução da dor, tanto pela escala visual numérica quanto pelo domínio de dor do WOMAC (P < 0,05). De forma similar, houve aumento da força muscular pelo teste de 1 repetição máxima (P = 0,005), sem diferença entre grupos (P = 0,81). Não houve alteração na depuração de 51Cr-EDTA (CR PRÉ: 86,16 ± 14,36, PÓS: 87,25 ± 17,60 mL/min/1,73 m2; PL PRÉ: 85,15 ± 8,54, PÓS: 87,18 ± 9.64 mL/min/1,73 m2; P = 0,81), bem como em qualquer outro parâmetro de função renal avaliado (dosagem sérica de creatinina e ureia, depuração estimada de creatinina, dosagem de creatinina, ureia, albumina e proteína na urina de 24 horas e cálculo da razão albumina/creatinina na urina de 24 horas). CONCLUSÃO: A suplementação de CR melhora capacidade física funcional, qualidade de vida e massa magra de membros inferiores em mulheres com OA de joelho submetidas ao treinamento de força sem afetar a função renal / INTRODUCTION: Strengthening of the quadriceps muscle in patients with knee osteoarthritis (OA) is related to walking self-efficacy, reduced pain, and improved function, stressing the role of strengthening exercises in the treatment of this disease. Therefore, procedures capable of enhancing the exercise effects on muscle strength and function may be potentially therapeutic for knee OA patients. OBJECTIVES: To demonstrate the efficacy of creatine (CR) supplementation associated with strengthening exercises in knee OA. METHODS: Women aged 50 to 65 years with knee OA were allocated to receive either CR (20 g/d for one week and 5 g/d thereafter) or placebo (PL) and were enrolled in a lower limb resistance training program. They were assessed at baseline (PRE) and after 12 weeks (POST). The primary outcome was the physical function as measured by the timed-stands test. Secondary outcomes included pain, quality of life, muscle strength, body composition and renal function. RESULTS: Physical function was significantly improved only in the CR group (P = 0.006). Additionally, a significant betweengroup difference was observed (CR PRE: 15.7 ± 1.4, POST: 18.1 ± 1.8; PL PRE: 15.0 ± 1.8, POST: 15.2 ± 1.2; P = 0.004). The CR group also presented improvements in the subscales of physical function (P = 0.005) and stiffness (P = 0.024) of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Additionally, only the CR group presented a significant improvement in quality of life assessed by the Lequesne Index (P = 0.01) and in lower limb lean mass measured by dual X-ray absorptiometry (P = 0.04). Both CR and PL groups demonstrated significant reductions in pain assessed by the visual numeric scale and by the WOMAC subscale of pain (P < 0.05). Similarly, a main effect for time revealed an increase in muscle strength by the leg press 1 repetition maximum (P = 0.005) with no significant differences between groups (P = 0.81). Renal function measured by 51Cr-EDTA clearance was not different between groups (CR PRE: 86.16 ± 14.36, POST: 87.25 ± 17.60 mL/min/1.73 m2; PL PRE: 85.15 ± 8.54, POST: 87.18 ± 9.64 mL/min/1.73 m2; P = 0.81). Other kidney function parameters (serum creatinine and urea, estimated creatinine clearance and 24h-urinary creatinine, urea, albumine, protein and albumin:creatinine ratio) were also unchanged. CONCLUSION: CR supplementation improves physical function, quality of life, and lower limb lean mass in postmenopausal women with knee OA undergoing strengthening exercises and this supplementation does not affect renal function

Introdução: Os corticosteroides intra-articulares (IA) são amplamente utilizados no tratamento da osteoartrite (OA) de joelho, porém é desconhecido qual dentre estes agentes é o mais eficaz. Objetivo: O objetivo do presente estudo foi comparar a eficácia das infiltrações IA de triancinolona hexacetonida (TH) e de acetato de metilprednisolona (AM) na OA de joelho. Pacientes e Métodos: Pacientes com OA sintomática de joelho, graus II ou III de Kellgren-Lawrence, foram randomizados para receber uma única infiltração IA com 40mg de TH ou AM. As avaliações clínicas foram realizadas nas semanas 4, 12 e 24. O desfecho primário do estudo foi a melhora da dor do joelho pelo paciente por escala visual analógica (EVA) da visita basal à semana 4. Os desfechos secundários incluíram a avaliação global da doença pelo paciente e pelo médico, o questionário de osteoartrite Western Ontario and McMaster Universities (WOMAC), o índice de Lequesne e o critério de resposta Outcome Measures in Rheumatology and Osteoarthritis Research Society International (OMERACT-OARSI). Na análise estatística, foram empregadas equações de estimativa generalizada, com estatística de Wald para contrastes do tipo 3 e ajustes de Tukey-Kramer para comparações múltiplas. Resultados: Cem pacientes foram incluídos na população com intenção de tratar, 50 em cada braço do estudo. Uma melhora significativa na dor pela EVA foi observada na semana 4 para ambos os grupos (P < 0,0001), não havendo diferença entre eles (P=0,352). Esta melhora foi sustentada até a semana 24. Uma melhora significativa em relação à avaliação basal foi observada na avaliação global da doença pelo paciente e pelo médico, no questionário WOMAC e no índice de Lequesne, não havendo diferença entre os grupos. A melhora nos desfechos secundários de avaliação foi sustentada durante o estudo, exceto para a avaliação global da doença pelo paciente. O critério de resposta OMERACT-OARSI foi alcançado por 74% e 72% dos pacientes dos grupos TH e AM, respectivamente. Conclusão: TH e AM são igualmente eficazes na OA de joelho, e a melhora na dor e na função física pode ser sustentada por até 24 semanas / Introduction: Intra-articular (IA) corticosteroid injections are broadly used in the treatment of knee osteoarthritis (OA), but it is unknown which of these agents is the most effective. Objective: The aim of the present study was to compare the efficacy of triamcinolone hexacetonide (TH) and methylprednisolone acetate (MA) IA injections in knee OA. Patients and Methods: Patients with symptomatic knee OA, Kellgren-Lawrence grades II or III, were randomized to receive a single IA injection with 40mg of TH or MA. Evaluations were performed at 4, 12 and 24 weeks. The primary outcome of the study was to evaluate the improvement in the patient\'s knee pain by visual analogue scale (VAS) from baseline to week 4. Secondary outcomes included the global assessment of the disease by the patient and the physician, the Western Ontario and McMaster Universities osteoarthritis questionnaire (WOMAC), the Lequesne index and the Outcome Measures in Rheumatology and Osteoarthritis Research Society International (OMERACT-OARSI) criteria of response. Generalized estimating equations with Wald statistics for type 3 contrasts and Tukey-Kramer multiple comparison adjustment were employed in statistical analysis. Results: The intention-to-treat population included one hundred patients; 50 in each study arm. A significant improvement in pain by VAS was observed at week 4 for both groups (P<0.0001), with no difference between them (P=0.352). This improvement was sustained up to week 24. A significant improvement from the baseline was observed for the patients\' and the physicians\' global assessments, WOMAC questionnaire, and Lequesne index, with no differences between the groups. Improvements in the secondary outcomes were sustained during the study, except for the patients\' global assessment of disease. OMERACT-OARSI criteria of response was achieved by 74% and 72% of patients in the TH and the MA groups, respectively. Conclusion: TH and MA are equally effective in knee OA and improvement in pain and physical function can be sustained for up to 24 week

No description available.

This work describes advanced fabrication of custom orthopaedic implants using unconventional additive manufacturing technology - Selective Laser Melting (SLM). There was a main focus on custom knee replacement and certainly on its femoral component. The study investigated three general issues within the domain of the usage of additive manufacturing technology in medical application. First, there was an evaluation of process parameters influences of SLM fabrication method on surface and mechanical properties of titanium Ti6Al4V ELI specimens. This material was used because of its biocompatibility and its wide use within implant fabrication. Then, a proposal of the manufacturing strategy was carried out and the fabrication of customized knee femoral component prototype by SLM technology was done. The elaboration of the numerical chain prior the SLM implant fabrication, from patient's CT knee scan to final femoral replacement model, was also done. Then, a proposal of different 3-axis and 5-axis strategies of machining of the fitting femoral surface of bone prototype (3D printed from the powder) using CNC machines FV 25 CNC and TAJMAC ZPS MCV 1210 was projected and also, the 3-axis spiral machining was realised. The individual machining tool paths were generated by software Power Mill from Delcam group. Finally, these machining strategies were generated as a prior step before a machining of real patient’s bone, therefore the machining tests of cartilage and bone were done.

Orientador: Aparecido Augusto de Carvalho / Abstract: In the last few years, several studies have been carried out showing that neuromuscular electrical stimulation (NMES) can produce good therapeutic results in patients with spinal cord injury (SCI). This research introduces a new robust and intelligent control-based methodology for human lower limb rehabilitation via NMES using a continuous-time control technique named robust integral of the sign of the error (RISE). Although in the literature the RISE controller has shown good results without any fine-tuning method, a trial and error approach would quickly lead to muscle fatigue in SCI patients. Therefore, it was shown in this study that the control performance for robustly tracking a reference signal can be improved through the proposed approach by providing an intelligent tuning for each voluntary. Simulation results with a mathematical model and eight identified subjects from the literature are provided, and real experiments are performed with seven healthy and two paraplegic subjects. Besides, this research introduces the application of deep and dynamic neural networks namely the multilayer perceptron, a simple recurrent neural network, and the Long Short-Term memory architecture, to identify the nonlinear and time-varying relationship between the supplied NMES and achieved angular position. Identification results indicate good fitting to data and very low mean square error using few data for training, proving to be very prospective methods for proposing control-oriented ... (Complete abstract click electronic access below) / Resumo: Nos últimos anos, vários estudos foram realizados mostrando que a estimulação elétrica neuromuscular (EENM) pode produzir bons resultados terapêuticos em pacientes com lesão medular (LM). Esta pesquisa introduz uma nova metodologia robusta e inteligente baseada em controle para a reabilitação de membros inferiores humanos via EENM usando uma técnica de controle de tempo contínuo chamada robust integral of the sign of the error (RISE). Embora na literatura o controlador RISE tem demonstrado bons resultados sem qualquer método de ajuste fino, uma abordagem de tentativa e erro poderia levar rapidamente à fadiga muscular em pacientes com LM. Portanto, foi mostrado nesse estudo que o desempenho do controle para rastrear com robustez um sinal de referência pode ser melhorado através da abordagem proposta, fornecendo um ajuste inteligente para cada voluntário. Resultados de simulação com um modelo matemático e oito sujeitos identificados da literatura são fornecidos, e experimentos reais são feitos com sete indivíduos saudáveis ​​e dois paraplégicos. Além disso, esta pesquisa introduz a aplicação de redes neurais profundas e dinâmicas, especificamente o perceptron multicamadas, uma rede neural recorrente simples e a arquitetura Long Short-Term Memory, para identificar a relação não-linear e variante no tempo entre a EENM fornecida e a posição angular alcançada. Os resultados de identificação indicam boa adaptação aos dados e erro quadrático médio muito baixo usando poucos dados para... (Resumo completo, clicar acesso eletrônico abaixo) / Mestre

Les troubles musculo-squelettiques (TMS) sont la principale cause d’absentéisme au travail. Ils représentent un coût économique important, mais ils ont aussi de graves conséquences au niveau individuel – douleurs persistantes, limitations fonctionnelles ou perte d’emploi. De nombreuses expositions professionnelles ont déjà été mises en évidence pour expliquer la présence de ces symptômes, mais certaines relations restent encore à confirmer.L’objectif de ce travail de thèse était d’étudier l’association entre les facteurs professionnels, en particulier les facteurs physiques, et les TMS au niveau des coudes et des genoux. Les TMS au niveau des coudes ont été étudiés à travers la prévalence des symptômes aux coudes et des épicondylites, et l’incidence des épicondylites. Les douleurs aux genoux ont été étudiées à travers l’incidence des douleurs de courte ou de longue durée. Ce travail a nécessité l’utilisation de méthodologies spécifiques, en particulier les diagrammes causaux et les méthodes de gestion des données manquantes qui seront explicitées dans une partie théorique. La population dans ce travail de thèse était une cohorte de 3 710 sujets représentatifs des actifs des Pays de la Loire. Ils ont été recrutés entre 2002 et 2005 et ont été suivis entre 2007 et 2010. A chaque phase, un questionnaire sur les conditions de travail a été rempli par les participants et un examen clinique qui évaluait la présence de troubles musculo-squelettiques a été réalisé par des médecins du travail volontaires. En conclusion, les facteurs professionnels mis en évidence étaient globalement des facteurs de mouvements répétitifs impliquant les articulations étudiées (torsion des poignets et flexion/extension des coudes ou le fait de s’agenouiller). Le travail en force (manipulation de charges, efforts physiques importants) et les tâches répétitives ont également été mis en évidence comme prédicteurs de TMS ultérieurs / Musculoskeletal disorders (MSDs) are a leading cause of absenteeism from work. In addition to their major economic impact, musculoskeletal disorders have important consequences on individuals with the persistence of pain, disability and potential job loss. Many occupational exposures were highlighted to explain these symptoms, but certain relationships between occupational exposures and MSDs should be examined further.The aim of this thesis is to investigate the association between occupational exposures, especially biomechanical exposures, and elbow or knee MSDs. The elbow MSDs are studied with the prevalence of symptoms and lateral epicondylitis, and the incidence of lateral epicondylitis. The incidence of knee pain is examined according to its duration.The methodologies and theories appropriate to this type of work is briefly presented - a section focuses on the causal diagrams and methods of handling missing data.The population used is a cohort of 3710 subjects representative of the French workforce. Subjects were selected from workers undergoing a mandatory annual health examination between 2002 and 2005 and were followed between 2007 and 2010. For each phase of the study, a self-administered questionnaire on working conditions was completed and a clinical examination was performed in order to evaluate the presence of musculoskeletal disorders. In conclusion, repetitive movements involving the joints studied such as wrist-twisting, flexion/extension of the elbows or kneeling are associated with MSDs. The notion of force, such as load handling and physical exertion, and the notion of repetitive tasks are also identified as predictors of subsequent MSDs