A oxidação anódica local utilizando o Microscópio de Força Atômica (AFM - Atomic Force Microscopy) foi investigada aplicando-se uma tensão negativa entre sonda de nitreto de silício e superfícies de Si. Todas as amostras foram limpas em uma solução de 1 NH4OH (30%): 1H2O2 (38%): 4H2O(DI) a 80ºC conhecida na literatura como SC1 (Standard Cleaning 1) ou, alternativamente, uma imersão em solução diluída de ácido hidrofluorídrico seguido de SC1 ou fervura em álcool isopropílico. As nano-oxidações consistiram de padrões quadrados localizados de óxido com área de 0,25 µm² e foram obtidos através do crescimento de linhas paralelas com espaço e comprimento interlinear constante (<2 nm) e várias varreduras dos quadrados em uma mesma área. Das análises de AFM, foram obtidos perfis transversais e 3D, os quais foram empregados na obtenção da espessura do óxido como função da tensão aplicada, número de varreduras e intervalo de tempo após a limpeza SC1. Foi observado que a espessura aumenta com a tensão negativa aplicada e com o número de varreduras. Também foram realizadas simulações para levantar as distribuições de tensão e de campo elétrico no sistema sonda-ar-silício ou sonda-ar-óxido-silício(substrato). Observou-se uma oxidação local assistida por um alto campo elétrico capaz de induzir difusão iônica local finita na extremidade da sonda. Foi simulado também o efeito das diferentes terminações de sonda do AFM, circular ou pontiaguda, no campo elétrico e na queda de tensão. Foram também realizadas oxidações com sondas recobertas com ouro em superfícies de Si precedidas de imersão simples em solução de ácido hidrofluorídrico seguido ou não do procedimento de limpeza SC1. Por fim, análises de absorção por infravermelho (FTIR) foram realizadas em superfícies de Si oxidadas por AFM para analisar a estrutura dos óxidos anódicos obtidos. A oxidação anódica utilizando sondas de nitreto de silício ocorre apenas após pré-limpeza terminada com SC1, sendo catalisada pelos altos campos elétricos (_ 106 V/cm), tendo como elementos reagentes, as espécies H2O adsorvidas e o óxido nativo hidrolisado na superfície após a etapa de limpeza SC1. / Local anodic oxidation of silicon using Atomic Force Microscopy (AFM) was investigated by applying a negative voltage between silicon nitride tip and Si surfaces. All samples were cleaned with an ammonium-based solution known in literature as standard cleaning 1 (SC1) or a dip in a diluted hydrofluoric acid solution followed by SC1 or, also, boiling in isopropyl alcohol. Localized squares patterns of oxide, 0.25 µm² in area, were formed by growing parallel lines with constant interlinear spacing and length and several scans in the same area. From AFM analysis with non-biased tip, it was obtained 3D and section profiles, which were used to obtain the oxide thickness as a function of the applied voltage, number of scans and interval of time after SC1 cleaning. It was noteworthy that thickness increases with the applied negative voltage and with the number of scans. Simulations were performed in order to model voltage and electric field distributions of the system tip-air-silicon or tip-air-oxide-silicon(substrate) indicating a local oxidation assisted by high electrical field and local ionic diffusion of species. It was simulated the effect of tip termination, circular or sharpen, on the electric field and voltage distributions. In addition, oxidations were performed using Au coated tips onto Si surfaces previously dipped in diluted hydrofluoric acid solution followed or not by SC1 cleaning process. Finally, infrared absorption analysis (FTIR) were performed in order to analise the structure of the obtained anodic oxides. The anodic oxidation using silicon nitride tips has occurred only after SC1 precleaning step, being catalized by high electric field (_ 106 V/cm), having as reagents, the adsorbed water species and hydrolized native oxide on the surface after the SC1 cleaning step.

This thesis examines the trajectory and role of development within the context of transition from a command to market economy, in a northern region of the Lao PDR. It looks at how the long-term effects of development interventions have contributed to a context of regional integration where the role of foreign investment and the private sector are increasing. In particular, it examines the role of development interventions in the processes of diversification and differentiation that accompany market integration. The village of Ban Jai illustrates this process as a site where despite the failures of development projects a diversification of livelihoods have developed. The implementation of UNDP projects in Ban Jai raises questions regarding the role of international projects and suggests that rather than alleviating poverty they produce a chain of effects that contribute to the tensions that result from structural changes to the village household economy. My analysis examines the tensions produced by such shifts and how villagers negotiate their engagement with the market economy. The experience of women traders illustrates how relations of solidarity are reworked in an attempt to negotiate tensions produced through processes of market integration. As structural shifts take place with increasing economic integration, international agencies also respond in particular ways by shifting strategies. I also ask what changes shifts in strategy introduce at the local level and how this intersects with the way policies are rationalized by local officials and the UNDP. An examination of this trajectory over a period of two decades, suggests that changing strategies in development have involved a shifting role between international development organizations and the private sector. I ask what kind of context this intersection of structural shifts, policy shifts and institutional shifts produces on the ground and how such shifts are negotiated locally.

Chinese calligraphy and Western typography have been evolving for around five thousands years. During this time, they have developed quite different characteristics. Compared with the geometrical form and precision of Western printing types, Chinese calligraphy features abstract shapes and spontaneous strokes. These differences result in a gap that prevents a harmonious and organic relationship between them. This project explores the possibilities of combining these two historical visual systems, demonstrates specific methods and approaches for creating compelling formal relationships, and endeavors to establish a friendly, organic and harmonious dialogue between Chinese calligraphy and Western typography. The outcome of this project is a handmade book and a series of posters. The content of them comes from the writings of Lao-Tzu.

Contexte : Environ 257 millions de personnes dans le monde sont infectées de manière chronique par le virus de l'hépatite B (VHB). La transmission mère-enfant représente la majorité des nouveaux porteurs chroniques du VHB, en particulier en Asie. Le VHB peut être transmis in utero, lors de l'accouchement ou pendant la petite enfance voire plus tard. Environ 80 à 90% des nourrissons infectés à la naissance développent une infection chronique par le VHB avec le risque élevé de développer de graves complications, notamment une fibrose du foie, une cirrhose, un carcinome hépatocellulaire jusqu’à un décès lié au foie à l’âge adulte. Nous avons évalué la proportion des enfants immunisés avec succès dans deux grands hôpitaux de Vientiane, en République démocratique populaire lao, où l’immunoglobuline HB (HBIg) n’est pas disponible. Méthodes : Nous avons étudié une cohorte prospective de femmes enceintes infectées par le VHB et de leurs enfants jusqu'à six mois après la naissance de janvier 2015 à mars 2017. Tous les nourrissons ont reçu le vaccin anti-HB à la naissance et six, 10 et 14 semaines après la naissance. Le statut d’infection par le VHB chez l’enfant a été évalué à l’âge de 6 mois. Le séquençage du gène de surface du VHB a été effectué chez des couples mère-enfant infectés. Résultats : Sur 153 mères ayant été dépistées positives pour l'antigène de surface HB (AgHBs), 60 (39%) avaient l'antigène HBe (AgHBe) positif. Les femmes enceintes ayant AgHBe-positif étaient plus jeunes que les femmes ayant d’AgHBe négatif ((âge médian 26 versus 28 ans; p = 0,02). et avaient une charge virale du VHB significativement plus élevée à l'accouchement (médiane 8,0 versus 4,0 log10 UI / mL, p <0,001). Au total, 141 nouveau-nés, dont une paire de jumeaux, sont nés pendant l'étude. Parmi les 112 nouveau-nés pour lesquels l’information concernant le délai entre la naissance et l’heure d’administration du vaccin contre le VHB était disponible, 110 (98%) ont reçu le vaccin dans les 24 heures suivant la naissance. Le délai médian entre la naissance et l'administration du vaccin était de 6 heures (EI 3 à 13), avec 95 (72%) dans les 12 heures suivant la naissance. Un nouveau-né a reçu le vaccin 26 heures après la naissance car le vaccin n'était pas disponible dans la salle d'accouchement et un autre nouveau-né a reçu le vaccin 3 jours après la naissance car, en raison d'une détresse respiratoire sévère à la naissance, le vaccin a été considéré comme contre-indiqué. Parmi les 120 enfants évalués à l'âge de 6 mois, 5 (4%) étaient positifs pour AgHBs et présentaient une charge virale détectable pour le VHB par réaction en chaîne avec une polymérase. Tous sont nés de mères ayant l’AgHBe positif et une charge virale> 8,5 log10 UI / mL. Cependant, seulement quatre enfants (3,3%, IC à 95%, 0,5% à 7,0%) avaient une souche virale étroitement apparentée à celle de leur mère. Des mutations du gène de surface du VHB (G145G/R, G145G/A, M133T, M133I) ont été détectées chez 4 des 5 enfants infectés. Le taux d'anticorps anti-HBs était supérieur à 10 UI / L chez 105 nourrissons (88%) à l'âge de 6 mois. Conclusions : La transmission de la mère à l'enfant s'est produite moins souvent que ce que nous avions prévu en absence de l'utilisation de HBIg. L’ajout d’une prophylaxie par HBIg et / ou antivirale maternelle aurait pu prévenir certaines de ces infections. L'observation du taux d'anticorps anti-HBs non satisfait chez 9% des enfants non infectés à 6 mois souligne la nécessité d'améliorer les procédures d'immunisation universelles / Background: An estimated 257 million people are chronically infected with the hepatitis B virus (HBV) worldwide. Mother-to-child transmission accounts for the majority of new chronic HBV carriers, especially in Asia. HBV can be transmitted in utero, during delivery or during infancy and later. About 80–90% of infants infected at birth will develop a chronic HBV infection, and will have a high risk of developing serious complications including liver fibrosis, cirrhosis, hepatocellular carcinoma (HCC) and liver-related death during adult age. We aimed at assessing the percentage of infants successfully immunized in two major hospitals in Vientiane, Lao People's Democratic Republic (Lao PDR) where HB immune globulin (HBIg) is not available. Methods: We studied a prospective cohort of chronically HBV infected pregnant women and their infants until 6 months post-partum from January 2015 to March 2017. All infants received the HB vaccine at birth and 6, 10 and 14 weeks thereafter, and their HBV status was assessed at 6 months of age. HBV surface gene sequencing was performed in infected mother-infant pairs.Results: Of 153 mothers with HB surface antigen (HBsAg), 60 (39%) had detectable serum HBe antigen (HBeAg). HBeAg positive pregnant women were younger than those negative (median age 26 versus 28 years; p=0.02) and had a significantly higher HBV viral load at delivery (median 8.0 versus 4.0 log10 IU/mL, p <0.001). A total of 141 infants including a pair of twins were included in the study and information at the time of vaccine administration after birth was available for 112 newborns. Of these, 110 (98%) received the HepB-BD within 24 hours after birth. One newborn received the vaccine 26 hours after birth because the vaccine was not available at the delivery room, and another newborn 3 days after birth due to fetal distress, which was erroneously considered to be a vaccine contra-indication. Among the 120 infants assessed at 6 months of age, 5 (4%) were positive for HBsAg and had a detectable HBV viral load by polymerase chain reaction. All were born to mothers with HBeAg and a viral load >8.5 log10 IU/mL. However, only four (3.3%, 95% CI 0.5% to 7.0 %) had a virus strain closely related to their mother’s strain. HBV surface gene mutations were detected in 4 of the 5 infected infants (G145G/R, G145G/A, M133T, M133I). Anti-HBs antibody level was above 10 IU/L in 105 (88%) infants at 6 months of age. Conclusions: Mother-to-child transmission occurred less frequently than expected without the use of HBIg. Adding HBIg and/or maternal antiviral prophylaxis may have prevented some of these infections. The observation of unsatisfactory levels of anti-HBs antibodies in 9% of the uninfected infants at 6 months highlights the need for improvement of the universal immunization procedures

This thesis reaches across multiple disciplines, including music psychology, performing arts, and philosophy, to propose using Lao Tzu’s philosophical thoughts in his book Tao Te Ching (also Dao De Jing, daodejing) to cultivate a classical performing musician’s “professional mindset.” “Professional mindset” is defined as the performer’s attitude in dealing with people including himself, and philosophical perspectives in making music. Part I evaluates the recurring traits of classical performing musicians (CPMs) as key for later arguing that Tao Te Ching helps enhance and transform the associated behaviors of a CPM’s recurring traits. These traits include being aloof, intelligent, emotionally unstable, dominant, sensitive, imaginative, self-sufficient, having high ergic tension, along with the associated second-order factors introversion, anxiety, independence, and being unrestrained. Part II introduces Tao Te Ching by building its thinking system map, with each of the book’s components explained and the underlying concepts hidden in the map uncovered via my English translations of the text as found in Chen Guying’s commentary. Part III presents three perspectives that collectively argue how Tao Te Ching cultivates a CPM’s professional mindset. The first analyzes anecdotes from the biographies of flutist Marcel Moyse using the recurring traits of CPMs in order to show how Lao Tzu’s thoughts can enhance or transform the associated behaviors of the recurring traits of CPMs. The second philosophically applies the duality of Lao Tzu to a CPM’s main musical activities and defines his daily performing cycle. The third explains how Tao Te Ching creatively deals with musical matters.

Despite receiving large quantities of aid, many developing countries, especially the Least Developed Countries, have remained stagnant and became more aid-dependent. This grim reality provokes vigorous debate on the effectiveness of aid. This study re-examines the effectiveness of aid, focusing on the ongoing debate on the interactive effect of aid and policy conditionality on sustainable economic growth. A theoretical model of the aid-growth nexus was developed to explain why policy conditionality attached to aid may not always promote sustainable economic growth. Noticeable methodological weaknesses in the aid fungibility and aid-growth models have led to the construction of two macroeconometric models to tackle and reduce these weaknesses. The Lao People's Democratic Republic's economy for the 1978-2001 period has been used for a case study.It is argued that the quality of policy conditionality and the recipient country's ability to complete specified policy conditions are the main factors determining the effectiveness of aid. Completing the policy prescriptions contributes to a stable aid inflow. The aid-growth nexus model developed in this study shows that stable and moderate aid inflow boosts economic growth even when aid is fungible. However, failure to complete the policy conditionality owing to inadequate policy design and problems of policy mismanagement caused by lack of state and institutional capability in the recipient country triggers an unstable aid inflow. The model shows that unstable aid flows reduce capital accumulation and economic growth in the recipient country. These empirical findings reveal that policy conditionality propagated through the "adjustment programmes" has mitigated the side effects of aid fungibility and "Dutch disease" in the case of the Lao PDR. Preliminary success in implementing the policy conditions in the pre-1997 period led to a stable aid inflow and contributed to higher economic growth. This favourable circumstance, however, was impaired by unstable aid flow in the post-1997 period. The lack of state and institutional capacity in the Lao PDR and the inadequate policy design to deal with external shocks triggered the instability of aid inflow, which in turn exacerbated the negative effects of the Asian financial crisis on the Lao PDR's economy.

Master of Science / The objective of this research is to employ Geographical Information Systems to fisheries management in the Mekong River Basin. The study uses artisanal fisheries practices in Khong district, Champasack province Lao PDR as a case study. The research focuses on integrating indigenous and scientific knowledge in fisheries management; how local communities use indigenous knowledge to access and manage their fish conservation zones; and the contribution of scientific knowledge to fishery co-management practices at village level. Specific attention is paid to how GIS can aid the integration of these two knowledge systems into a sustainable management system for fisheries resources. Fieldwork was conducted in three villages in the Khong district, Champasack province and Catch per Unit of Effort / hydro-acoustic data collected by the Living Aquatic Resources Research Centre was used to analyse and look at the differences and/or similarities between indigenous and scientific knowledge which can supplement each other and be used for small scale fisheries management. The results show that GIS has the potential not only for data storage and visualisation, but also as a tool to combine scientific and indigenous knowledge in digital maps. Integrating indigenous knowledge into a GIS framework can strengthen indigenous nowledge, from un processed data to information that scientists and decision-makers can easily access and use as a supplement to scientific knowledge in aquatic resource decision-making and planning across different levels. The results show that when scientific and indigenous knowledge are both stored digitally in GIS databases, a variety of analysis can be done. Multiple layers or visualising functions in ArcGIS are an example of ways in which indigenous and scientific knowledge can be combined in GIS. Maps of deep pools and important fishing grounds gathered using GPS and indigenous knowledge provide base maps of aquatic resources in the study area. The attribute table associated with the map links characteristics of each point, including fishing gear and species found in each pool as well as spawning grounds and migration periods. This information is useful for management and planning purposes. This research illustrates that mental maps and GIS digital maps can be used for fisheries management at different levels. Where mental maps are suitable for communicating with the local community and have the potential for use in fisheries co-management in small-scale fisheries; GIS may be appropriated for data storage and analysis at provincial and national levels, it can be used as a communication tool amongst stakeholders to monitor and understand the aquatic environment.

Dans le monde globalisé contemporain, les hommes sont de plus en plus mobiles pour des motifs aussi divers que la recherche d'un emploi, la poursuite des études ou encore la quête d'exotisme. La santé n'échappe pas à cette tendance et ainsi certains malades n'hésitent pas à traverser les frontières et à parcourir parfois des milliers de kilomètres pour consulter tel médecin renommé, bénéficier d'une prise en charge rapide, de qualité ou à bas coût. Notre étude s'intéresse à ces questions, les flux de patients, appréhendés à l'échelle régionale et plus précisément au sein de l'espace frontalier lao-thaïlandais où apparaissent des dynamiques thérapeutiques transfrontalières : le recours aux soins des Laotiens dans des hôpitaux thaïlandais limitrophes. Cette pratique engagée par une partie de la population vivant dans les bordures frontalières accompagne l'ouverture récente du Laos et souligne l'écart de développement existant entre les deux pays. La discontinuité géographique entre le Laos et la Thaïlande se double d'une discontinuité sanitaire, propice à la mobilité des patients et facilitée en outre par la proximité et les liens historiques entretenus par les populations riveraines du Mékong. Que révèlent ces mobilités de patients sur le fonctionnement de l'espace lao-thaïlandais et sur les relations entre les deux pays ? Comment participent-elles à une recomposition du territoire transfrontalier ? En utilisant les recours aux soins transfrontaliers comme révélateur, notre objectif, en tant que géographe est d'analyser les processus socio-territoriaux en présence actuellement au sein de l'espace lao-thaïlandais. L'entrée par la santé constitue un point de vue original pour renouveler la réflexion sur la notion de frontière.

Depuis 1975, Vientiane est la capitale de la République Démocratique Populaire Lao, un régime autoritaire qui, bien qu'ouvert à l'économie de marché depuis 1986, maintient un parti unique et une ligne socialiste affichée. Le système de soins étant un appareil d'Etat à l'usage de la population, il constitue de fait un objet d'analyse traduisant l'action des dirigeants et leur projet de société. Or, compte tenu du contexte politique laotien, entre autoritarisme et libéralisation économique, quelle géographie du système de soins peut-on dresser à Vientiane ? Est-elle l'expression d'un interventionnisme d'Etat ? L'étude des différentes inscriptions spatiales du système de soins - localisation de l'offre, aire d'attraction des structures publiques, recours aux soins -, qui correspond à la trame de notre développement, rendra compte de l'attitude des dirigeants en ce qui concerne le contrôle social et territorial, la couverture sanitaire ou encore l'assistance publique. Ces trois marqueurs spatiaux formant chacun un territoire - entendu ici comme un espace pratiqué par un acteur -, ce concept, vu son intérêt analytique, fonde notre démonstration. La démarche privilégiée, qui met au centre du système explicatif les acteurs concernés, montre les capacités d'action des institutions sanitaires, des soignants, publics comme privés, des patients, et donc, en définitive, l'implication de l'Etat dans le secteur des soins. La géographie du système de soins ainsi appréhendée à Vientiane révèle les motivations du pôle dirigeant laotien et, en somme, sa manière de contribuer à la production de l'espace vientianais.

The aim of this study is to examine socio-economic transformation and gender relations in Lao PDR after the adoption of economic liberalization by the Lao government in the late 1980s. Against a background of general socio-economic transformation in Laos the main focus of the study is on the local level, with emphasis on how people in their everyday lives have engaged with and handled the changes. The application of economic liberalization shaped new conditions for people in local communities, and various livelihoods strategies were adopted under the new circumstances. The study examines gender relations, livelihoods and actors of change in two different contexts of globalization. The first context is the case of foreign direct investment in the Sepone mine, the largest gold-copper mine in the country located in Vilabury district, Savannakhet province. Five villages located close to the mine and directly affected by the operation were chosen as research site. The second case is the context of international tourism development in the small town of Vang Vieng, situated halfway between Vientiane Capital and the world heritage town of Luangprabang. The purpose with the two case studies is to examine how changes take place in different places of the same country under the same political direction and development policy. The study is inspired by theories of space and place and the view that phenomena are place-based and different places are constituted by different socio-spatial relations. The findings show that profound changes took place both in the economic and social-cultural spheres, including in gender relations. The two contexts experienced different processes of changes: in the context of Vilabury district, the transformation was produced through top-down development and created a dependency pattern where new social inequalities and social stratification emerged through unequal access to the new resources of the villagers. In the context of Vang Vieng and the expansion of international tourism, the development process proceeded more through a bottom-up pattern; the villagers perceived they were important actors of development, had more equal access to resources and could define livelihood strategies by themselves.