Northern Iraq's Christians are a second-order minority. That is, they are a minority within a minority. They occupy a tenuous position between the Arab-dominated central government and the Kurdistan Regional Government. All Christians in northern Iraq desire to remain in their historic homelands. Yet efforts to advance a common political goal have been rare. Differences within the Iraqi Christian community center on three interrelated points: 1) the adoption and advancement of the Assyrian ethno-nationalist identity; 2) the struggle for leadership of the community between secular parties and church officials; and 3) the securing of group rights through either Baghdad or Erbil, which is typified by the debate over a province for minorities in the Nineveh Plain. The Islamic State's invasion in June 2014 made this dynamic even more complex. This dissertation explores how a second-order minority mobilized to protect its homelands during state breakdown and state recalibration. It examines how an Iraqi Christian political party, the Assyrian Democratic Movement (ADM), responded to the rise and spread of the Islamic State. More specifically, it analyzes the ADM's creation of a self-defense force, the Nineveh Plains Protection Units (NPU), and how the party positioned itself for the post-conflict state. Data generated through ethnographic fieldwork, combined with existing primary and secondary sources, reveals a detailed process whereby security threats shaped mobilization. Notions of historic homelands and distrust of both the central government and KRG were the central factors shaping this outcome. The ADM created the NPU to liberate occupied lands. More importantly, the NPU was created to ensure Christians retained a place in their historic homelands after the Islamic State was evicted. The use of the name "Nineveh Plains Protection Units" held strategic importance. The binding principle of the NPU was an indigenous-based attachment to the Nineveh Plain, including the right to defend it, and Christianity in Iraq. Both elements captured the common threads among all Iraqi Christians and the claim they make on the state. The ADM, therefore, was particularly attuned to Iraq's pre-Islamic ancient Mesopotamian heritage. This ironically echoed earlier efforts by the Ba'ath regime to instill a Mesopotamian identity among citizens by glorifying a common Assyrian and Babylonian heritage all could presumably share. Second-order minority status meant the ADM had to eventually align with either Baghdad or Erbil. The ADM chose Baghdad, effectively balancing against ISIS and the KRG in the Nineveh Plain. Baghdad proved a willing partner for a time. The ADM, however, was left alone to navigate the Nineveh Plain's position in the September 2017 Kurdistan referendum on independence. / PHD / This dissertation examines the Assyrian Democratic Movement’s response to the Islamic State. It analyzes the ADM’s creation of a self-defense force, the Nineveh Plains Protection Units, and how the party positioned itself for the post-conflict state. Data generated through ethnographic fieldwork conducted in northern Iraq combined with existing primary and secondary sources reveals a detailed process whereby security threats shaped mobilization. Homeland claims and distrust of both the central government and KRG were the central factors driving this process. Second-order minority status meant the ADM had no choice but to pick sides between Baghdad and Erbil. The party eventually aligned with Baghdad. However, it was left alone to navigate Nineveh Plain’s position within the Kurdistan independence referendum.

This thesis aims to investigate how the Russian PMSC the Wagner Group affects conflict severity in countries where they operate. To illustrate their impact two countries, The Central African Republic and Syria, will be compared to each other. PMSCs and their effect on conflict dynamics have been studied before, usually by using a quantitive method, and the Wagner Group since their debut to the daylight in 2014 have also received scholarly attention. However, these two fields have not been linked together before and thus will this thesis bring new knowledge to both scientific fields by presenting a qualitative comparative study. The study is based on the social movement theoretical framework of resource mobilization by John D. McCarthy and Mayer N. Zald and sets out to test the theory whitin this new context of conflict dynamics. The result from this thesis shows some correlation between the implementation of the Wagner Group and conflict severity and that resource mobilization can be used to explain changes in conflict dynamics. However, the results isnt´t conclusive, and more research is needed on the subject.

No / Lysophosphatidic acid (LPA) enhances cell migration and promotes wound healing in vivo, but the intracellular signaling pathways regulating these processes remain incompletely understood. Here we investigated the involvement of agonist-induced Ca2+ entry and STIM1 and Orai1 proteins in regulating nuclear factor of activated T cell (NFAT) signaling and LPA-induced keratinocyte cell motility. As monitored by Fluo-4 imaging, stimulation with 10 μM LPA in 60 μM Ca2+o evoked Ca2+i transients owing to store release, whereas addition of LPA in physiological 1.2 mM Ca2+o triggered store release coupled to extracellular Ca2+ entry. Store-operated Ca2+ entry (SOCE) was blocked by the SOCE inhibitor diethylstilbestrol (DES), STIM1 silencing using RNA interference (RNAi), and expression of dominant/negative Orai1R91W. LPA induced significant NFAT activation as monitored by nuclear translocation of green fluorescent protein-tagged NFAT2 and a luciferase reporter assay, which was impaired by DES, expression of Orai1R91W, and inhibition of calcineurin using cyclosporin A (CsA). By using chemotactic migration assays, LPA-induced cell motility was significantly impaired by STIM1, CsA, and NFAT2 knockdown using RNAi. These data indicate that in conditions relevant to epidermal wound healing, LPA induces SOCE and NFAT activation through Orai1 channels and promotes cell migration through a calcineurin/NFAT2-dependent pathway.

The indigenous of the Amazon region of Ecuador unite against the petroleum industry and destructive resource extraction practices in order to preserve environment and indigenous cultures. Since the 1990s, the indigenous movement of Ecuador has played out in the international arena and become a transnational movement, which includes social actors from the international legal, human rights, and environmental communities. This transnational movement exemplifies identity politics through the projection of ethnicity and essentialized signifiers of indigenousness. Indigenous actors, Ecuadoran nongovernmental organizations, international filmmakers, and US nongovernmental organizations all use ethnic identity and signifiers via documentaries and cyberspace as symbolic resources to represent the movement. This thesis explores the intersection of external actors (international community of filmmakers and NGOs) and internal actors' (the indigenous themselves and Ecuadoran NGOs) projection of ethnicity as symbolic resource. Utilizing resource mobilization theory and new social movement theory as a syncretic to understand the movement and theoretical contributions of identity and representation to explore the process of mobilization, the study explores the question of ethnic identity as symbolic resource in four documentaries and on fifteen websites. The discourse analysis of the four documentaries and content analysis of the fifteen websites illustrate that there is consistency in the message within the transnational social movement community of actors who strive to work for and on behalf of the indigenous of the Ecuadoran Amazon. / Master of Arts

Syftet med denna studie var att öka kunskapen om motiv som leder till att medborgare organiserar sig mot vapenvåld och för en tryggare ort, efter att en ung man i området skjutits till döds på öppen gata. Vidare var syftet att få en förståelse för hur de mobiliserande processerna tar sig uttryck i Skarpnäck. Studiens frågeställningar har besvarats genom kvalitativa intervjuer med sju medborgare som deltar i mobiliseringen, samt ostrukturerade observationer av mobiliseringens skeende. Studiens data har analyserats med teorin om sociala rörelser, samt Bourdieus kapitalformer i kombination med begreppen fält och habitus. Resultaten visar på att motiven till deltagandet grundar sig i en kombination av faktorer, som exempelvis sociala relationer, platsidentitet och gemenskap. Vidare framkommer det av resultatet att området präglas av bland annat boendesegregation och resursbrister i den kommunala skolan, som på olika sätt bidrar med en distans mellan medborgarna och aktörer inom den offentliga sektorn. Mobiliseringen i Skarpnäck utgörs av ett kritiskt och kollektivt handlade som fokuserar på att kartlägga behov i området, vilket sedermera framförts till Stadsdelsnämnden i form av ett medborgarförslag. / The aim of this paper is to increase knowledge on the motives that lead to citizens organizing against gun violence and for a safer neighborhood, after a young man in the community was shot to death on an open street. Furthermore, the aim of this paper is to gain an understanding of how the process of mobilisation took place in Skarpnäck. The study’s questions have been answered through two research methods; qualitative interviews with seven citizens who took part in the mobilization, as well as by unstructured observations of mobilising events. Theories applied whilst analysing the collected data were social movement theoryand Bourdieu’s theory of capital as well as the terms field and habitus. Results show that citizen participation is motivated by several factors, such as social ties,  place identity and  community. Results also show that the neighborhood, amongst other things, is affected by segregation and lack of resources in the local public school, which in different ways  contribute to a distance between citizens and civil servants in the public sector. Mobilisation in Skarpnäck takes form through critical and collective action that focuses on mapping needs in the neighborhood, which are then presented to the districts committee as citizen proposals.

no / This thesis paper tracks the development of the draft in Taiwan leading up to the Second World War and through its conclusion. In the mobilization of Taiwan as part of the Greater East Asia Co-Prosperity Sphere, many factors played a role in first encouraging and then pressing the Taiwanese population into service, including the propagation of mass paranoia labeled spy fever, Japanifized education policies, assimilation projects, general media stresses, social organization allowing for a police state, economics and the weight of Taiwan’s own unique frontier history. All of the routes created a certain frenzied (for lack of a better word) atmosphere and deserve attention in understanding the processes that led young Taiwanese males, and females, to first volunteer in the Imperial Japanese Army, Navy and Air Force and then comply to institutionalized conscription. The story of these individuals remains overlooked in the current reconstruction of Taiwan’s history. The era has been overshadowed by the turbulent events following the Second World War and the landing of half a million Chinese immigrants in Taiwan upon defeat in China. This corner of Taiwan’s history is still inappropriately relegated to the sidelines. With the Second World War generation and in particular the 200,000 who served both in Taiwan and overseas as volunteers and conscripts beginning to die off, the need to get their first-hand accounts recorded and preserved for posterity is pressing. In maintaining their information and stories, the interested historian can do service by adding to the historical record. Knowing this, “From Volunteerism to Conscription: The Mobilization of Taiwan for the Second World War” does not seek to score political points in plotting such a course. The thesis paper simply attempts to better comprehend the mechanisms that worked to pit Taiwan against her ancestral China and to comment on the plight of the survivors, bringing up their influence on Taiwan today. So, this paper will delve into 13 years of history, from 1932 to 1945, when Taiwan sat at the side of Japan as a colonial possession, and did its part in an unprecedented modern territorial expansion. The thesis paper wants to explain more about those who served, and why their service and its outcome might remain relevant in shaping Taiwan’s story at this very moment.

Diese Arbeit umfasst die Präparation sowie Charakterisierung von neuartigen Uran(IV)-Kolloiden, die in nahneutralen pH-Bereichen und unter umweltrelevanten Bedingungen stabilisiert vorliegen. Rückschlüsse auf Stabilitätsverhalten und Partikelgrößenverteilungen wurden durch dynamische Lichtstreuung, Zetapotentialmessungen sowie Ultrafiltration und Ultrazentrifugation in Kombination mit Elementanalysen getroffen. UV-Vis- und Laserfluoreszenzspektroskopie bestätigten den tetravalenten Zustand des Urans bei den Experimenten. Anders als bisherige Untersuchungen vermuten lassen, ist es möglich langzeitstabile Uran(IV)-Kolloide in höheren Konzentrationen zu erzeugen. Durch Zusatz von geochemischen Komponenten, wie Carbonat und Silikat sind diese sedimentationsstabil und im nahneutralen bis basischen pH-Bereich über längere Zeiträume beständig. Dabei zeigte sich, dass gelöstes Silikat bei der Herstellung der Kolloide eine wesentliche Rolle spielt und Uran(IV) bis zu einer Konzentration von 10-3 mol/L, entsprechend 0,238 g/L in Lösungen stabilisieren kann. Diese Urankonzentration ist dabei ca. drei Potenzen höher als für bisher bekannte silikatfreie, wässrige Uran(IV)-Kolloide. Durch die Verwendung unterschiedlicher analytischer Methoden konnte gezeigt werden, dass die Durchmesser der entstandenen Uran(IV)-Kolloide im nanoskaligen Bereich von teilweise unter 20 nm liegen. Durch diesen kolloidalen Zustand kann eine hohe Mobilität in aquatischen Systemen unterstellt werden. Zusätzlich weisen Langzeituntersuchungen darauf hin, dass diese Kolloide in einem abgeschlossenen System über Jahre stabilisiert werden. Je höher dabei das Verhältnis zwischen Silikat- und Uran(IV)-Gehalt und je höher der pH-Wert der Lösung ist, desto kleiner und stabiler sind diese Partikel. Es ist anzumerken, dass sich keine Kolloide in Abwesenheit von Uran(IV) bilden. Silikat ist in der Lage, die negative Oberflächenladung der Uran(IV)-Kolloide im nahneutralen pH-Bereich zu erhöhen. Dies führt zu einer stärkeren elektrostatischen Abstoßung bzw. repulsiven Wechselwirkungen, womit eine bessere Stabilisierung gewährleistet wird. Der isoelektrische Punkt der erzeugten Partikel wird zu niedrigeren pH-Werten verschoben. Extended-X-ray-absorption-fine-structure-Untersuchungen zeigen, dass die innere Struktur der Kolloide durch den steigenden Silikatgehalt bei deren Bildung von U-O-U-Bindungen (entsprechend Uran(IV)oxyhydroxiden) zu U-O-Si-Bindungen verändert wird. Die Koordination in der benachbarten Region von U(IV) in den U(IV)-Silikat-Kolloiden ist vergleichbar mit der des Coffinits, USiO4. Dieses, für tetravalentes Uran noch nicht beschriebene Phänomen, wurde bereits bei silikatstabilisierten Eisen(III)- oder Mangan(III,IV)-Kolloiden beobachtet und als „Sequestrierung“ bezeichnet. Die silikatstabilisierten U(IV)-Kolloide sind in Laborexperimenten unter kontrollierten Bedingungen erzeugt worden, d.h. es ist noch nicht bekannt, ob diese Phasen in der Natur frei auftreten können. Die qualitative Zusammensetzung der Matrix der experimentellen Lösungen (H+, OH-, Na+, HCO3-/CO32-, Silikat) wurde ähnlich der geochemischen Natur von Grund- bzw. Porenwässern gewählt. Dadurch kann prinzipiell von einem Vorhandensein solcher Kolloide in Wässern natürlichen Ursprungs ausgegangen werden. Die Existenz solcher Partikel würde eine Erklärung für das beobachtete Auftreten von Uran(IV)-Kolloiden in anoxischen Porenwässern oder anoxischen Grundwässern liefern. Es ist jedoch zu beachten, dass experimentell die Reduktion von Uran(VI)-Phasen vorausgesetzt wurde und eine anschließende Verdünnung in Anwesenheit von Silikat erfolgt. Umweltbezogene Untersuchungen zur Mobilität und Stabilität in aquatischen Systemen dieser Kolloide waren nicht Gegenstand der Arbeit und so kann eine umweltrelevante Beurteilung dieser neuartigen Uran(IV)-Kolloide in Bezug auf den Eintrag in die Biossphäre noch nicht getroffen werden. Die hier präsentierten Ergebnisse bieten aber die Grundlage für weitere, intensive Untersuchungen zu Möglichkeiten der Mobilisierung und Stabilisierung verwandter Actinide und Schwermetalle und sollten Bestandteil der Sicherheitsanalyse bei der Lagerung radioaktiven Abfälle in tiefen geologischen Formationen sein. / This work includes the preparation and characterization of new uranium(IV) colloids which are formed and stabilized in the near neutral pH range and under environmentally relevant conditions. Conclusions on stability behavior and particle size distributions were drawn based on results obtained by dynamic light scattering, zeta potential measurements, as well as ultrafiltration and ultracentrifugation in combination with element analyzes. Spectroscopic methodes confirmed the tetravalent state of uranium in the experiments. Unlike empirical data, it is possible to generate long-term stable uranium(IV) colloids at higher concentrations. By addition of geochemical components such as carbonate and silicate, they are stable and resistant in the near neutral pH range over a long period. It was found that dissolved silica plays an essential role in the preparation of colloids. Colloid-borne uranium(IV) up to a concentration of 10-3 mol/L, corresponding to 0,238 g/L, is stabilized in solutions. This concentration is about three orders of magnitude higher than so far known silicate-free aqueous uranium(IV) colloids. Through the use of different analytical methods (invasive and non-invasive) it could be shown that the resulting uranium(IV) colloids are in the nanoscalar range. A high mobility can be assumed in aquatic systems. Evidence is provided by photon correlation spectroscopy, ultrafiltration, and ultracentrifugation that uranium(IV) can form silicate-containing colloids of a size lower than 20 nm. The particles are generated in near neutral to slightly alkaline solutions containing geochemical relevant components (carbonate, silicate, sodium ions). They remain stable in aqueous suspension over years. Electrostatic repulsion due to a negative zeta potential in the near-neutral to alkaline pH range caused by the silicate stabilizes the uranium(IV) colloids. The isoelectric point of the nanoparticles is shifted towards lower pH values by the silicate. The higher the silicate to uranium(IV) content ratio and the higher the pH of the solution are, the smaller and more stable (in terms of pH-changes) are the particles. It should be noted that no colloids were formed in absence of uranium(IV). The mechanism of the colloidal stabilization can be regarded as “sequestration” by silicate, a phenomenon well known from heavy metal ions of high ion potential such as iron(III) or manganese(III,IV), but never reported for uranium(IV) so far. Extended X-ray absorption fine structure (EXAFS) spectroscopy showed that U–O–Si bonds, which increasingly replace the U–O–U bonds of the amorphous uranium(IV) oxyhydroxide with increasing silicate concentration, make up the internal structure of the colloids. The next-neighbor coordination of uranium(IV) in the uranium(IV)-silica colloids is comparable with that of coffinite, USiO4. The assessment of uranium behavior in the aquatic environment should take the possible existence of uranium(IV)-silica colloids into consideration. Their occurrence might influence uranium migration in anoxic waters. The silicate-stabilized colloids have been generated in laboratory experiments under controlled conditions; i.e., it is not known yet whether these phases can occur in natural water. The qualitative composition of the matrix of the experimental solutions (H+, OH-, Na+, HCO3-/CO32-, silicate) was chosen similar to the geochemical nature of groundwater. Thereby, it can be assumed that such colloids are present in natural waters. The existence of such particles would provide an ex-planation for the occurrence of uranium(IV) colloids in anoxic pore waters or groundwaters. However, it should be noted that these results were observed by the reduction of uranium(VI) carbonate and dilution in the presence of silicate. Studies on the mobility and stability of these colloids in aquatic systems were not subject of this work and an environmental assessment of these novel uranium(IV) colloids with respect to the entry in the biosphere cannot be taken into account. But the possibilities of mobilization and stabilization can be applied to surrogate actinides and heavy metals, and point to the need for more intensive research in this area.

No description available.

This research incorporates streambank erosion and failure processes into a distributed watershed model and evaluates the impacts of climate change on the processes driving streambank sediment mobilization at a watershed scale. Excess sediment and nutrient loading are major water quality concerns for streams and receiving waters. Previous work has established that in addition to surface and road erosion, streambank erosion and failure are primary mechanisms that mobilize sediment and nutrients from the landscape. This mechanism and other hydrological processes driving sediment and nutrient transport are likely to be highly influenced by anticipated changes in climate, particularly extreme precipitation and flow events. This research has two primary goals: to develop a physics-based watershed model with more inclusive representation of sediment by including simulation of streambank erosion and geotechnical failure; and to investigate the impacts of climate change on unstable streams and suspended sediment mobilization by overland erosion, erosion of roads, and the erosion as well as failure of streambanks. This advances mechanistic simulation of suspended sediment mobilization and transport from watersheds, which is particularly valuable for investigating the impacts of climate and land use changes, as well as extreme events. Model development involved coupling two existing physics-based models: the Bank Stability and Toe Erosion Model (BSTEM) and the Distributed Hydrology Soil Vegetation Model (DHSVM). This approach simulates streambank erosion and failure in a spatially explicit environment. The coupled model is applied to the Mad River watershed in central Vermont as a test case. I then use the calibrated Mad River model to predict the response in watershed sediment loading to future climate scenarios that specifically represent local temperature and precipitation trends for the northeastern US, particularly changing trends in the frequency and magnitude of extreme precipitation. Overall the streambank erosion and failure processes are captured in the coupled model approach. Although the presented calibration of the model underestimates suspended sediment concentrations resulting from relatively small storm/flow events, it still improves prediction of cumulative loads and in some cases suspended sediment concentrations during elevated flow events in comparison to model results without including BSTEM. Increases in temperature affect the timing and magnitude of snow melt and spring flows, as well as associated sediment mobilization, in the watershed. Increases in annual precipitation and in extreme precipitation events produce increases in annual as well as peak discharge and sediment loads in the watershed. This research adds to the body of evidence indicating that streambank erosion and failure can be a major source of suspended sediment, and thereby a major source of phosphorus as well. It also shows that local climate trends in the Northeast are likely to result in higher peak discharges and sediment yields from meso-scale, high-gradient watersheds that encompass headwater forested streams and agricultural floodplains. One limitation was that we could not drive the model with meteorological data that represented changes in both temperature and precipitation, highlighting the need for improved climate predictions. This coupled model approach could be parameterized for alternative watersheds and be re-applied to answer various questions related to erosion processes and sediment transport in a watershed. These findings have important implications for resource allocation and targeted watershed management strategies.

L'objectif de notre travail est de comprendre la contribution relative des voies de signalisation précoces du TCR et de CD28 dans l'activation des lymphocytes T naïfs. Notre étude a d'abord montré que dans les cellules T CD4+ naïves, la stimulation du TCR augmente de manière significative la liaison en deux dimensions (2D) de CD28 avec ses ligands B7, et ceci dépend à la fois du domaine cytoplasmique de CD28 et de l'activité des src kinases. Par la suite, notre analyse biochimique a démontré que l'engagement du TCR par son ligand (CMHp) potentialise la phosphorylation de CD28 stimulée par son ligand B7. En outre, la stimulation conjointe du TCR et de CD28 augmente fortement la phosphorylation des protéines de signalisation proximales telles que les molécules Vav-1 et PLCγ-1. Nous avons également examiné la mobilisation des ions calcique (Ca++). Nous avons trouvé que l'engagement du TCR ou de CD28 seul est capable de déclencher une élévation de la concentration intracellulaire d'ions Ca++ dans des cellules T naïves. Cette élévation qui se caractérise par de fortes fluctuations de la concentration calcique impliquerait principalement 2 types de canaux calciques de la membrane plasmique. De façon attendue, une stimulation conjointe des lymphocytes par le TCR et CD28 augmente l'amplitude moyenne de la réponse calcique. Nos données ont révélé que seule une stimulation conjointe, et non individuelle, du TCR et de CD28 augmente significativement le temps de résidence du Ca++ libres fluctuants par rapport aux cellules non stimulées. Par conséquent, cette augmentation du temps de résidence caractérise spécifiquement la réponse calcique induite par TCR et CD28. / In this work, we aimed at determining the relationship between and specific contribution of TCR and CD28 early signaling pathways in naïve CD4+ T cell activation. Our data showed that in naïve CD4+ T cells, TCR stimulation significantly increased the 2D binding of CD28 to its B7 ligands and this increase depended on both cytoplasmic tail of CD28 and activity of src kinases. Our biochemical analysis then demonstrated that TCR engagement with its ligand pMHC strongly enhanced the CD28 tyrosine phosphorylation triggered by B7. Moreover, the conjoint stimulation of TCR and CD28 markedly augmented activation of proximal signaling molecules such like Vav-1 and PLCγ-1 compared to the stimulation with each receptor alone. We next went to examine the calcium ion (Ca2+) mobilization. We found that in naïve CD4+ T cells, engagement with ligand of TCR or CD28 alone was able to trigger rise of the fluctuating cytosolic-free Ca2+ level. Unexpectedly, such rises implicated predominantly the involvements of two different types of calcium channels: Cav and CRAC channels. The conjoint stimulation with both TCR and CD28 enabled the augment of average amplitude of the calcium response. Through the time series analysis, our data unveiled that the conjoint, but not separate, TCR and CD28 stimulation in naïve CD4+ T cells significantly increased the fluctuating cytosolic-free Ca2+ dwell time relative to that found in unstimulated cells. The increase of the cytosolic-free Ca2+ dwell time therefore uniquely characterized the calcium response triggered by TCR and CD28 and presumably corresponded to a fundamental feature for the high efficiency of T cell activation induction.