Global ETD Search

11	A new model for worm detection and response : development and evaluation of a new model based on knowledge discovery and data mining techniques to detect and respond to worm infection by integrating incident response, security metrics and apoptosis Mohd Saudi, Madihah January 2011 (has links) Worms have been improved and a range of sophisticated techniques have been integrated, which make the detection and response processes much harder and longer than in the past. Therefore, in this thesis, a STAKCERT (Starter Kit for Computer Emergency Response Team) model is built to detect worms attack in order to respond to worms more efficiently. The novelty and the strengths of the STAKCERT model lies in the method implemented which consists of STAKCERT KDD processes and the development of STAKCERT worm classification, STAKCERT relational model and STAKCERT worm apoptosis algorithm. The new concept introduced in this model which is named apoptosis, is borrowed from the human immunology system has been mapped in terms of a security perspective. Furthermore, the encouraging results achieved by this research are validated by applying the security metrics for assigning the weight and severity values to trigger the apoptosis. In order to optimise the performance result, the standard operating procedures (SOP) for worm incident response which involve static and dynamic analyses, the knowledge discovery techniques (KDD) in modeling the STAKCERT model and the data mining algorithms were used. This STAKCERT model has produced encouraging results and outperformed comparative existing work for worm detection. It produces an overall accuracy rate of 98.75% with 0.2% for false positive rate and 1.45% is false negative rate. Worm response has resulted in an accuracy rate of 98.08% which later can be used by other researchers as a comparison with their works in future. 621.382
12	Optimization and verification of changes made to US-EPA 1623 Method to analyse for the presence of Cryptosporidium and Giardia in water Khoza, M. N. L. (Mtetwa) 03 1900 (has links) Thesis. (M. Tech. (Dept. of Biosciences, Faculty of Applied and Computer Sciences))--Vaal University of Technology, 2010 / Methods for detecting the presence of Cryptosporidium oocysts and Giardia cysts have been developed and continuous improvement is being done to improve the recovery rate of the target protozoa. Rand Water has adopted their method for isolation and detection of Cryptosporidium oocysts and Giardia cysts in water from United State Environmental Protection Agency (US-EPA) Method 1623, 1999. In 2005 changes were made by US-EPA to the Method 1623. A study was done to improve the performance of the Rand Water Method 06 (2007) used for isolation and detection of Cryptosporidium oocysts and Giardia cysts. Three methods namely: Rand Water Method 06 (2007), US-EPA Method 1623 (2005) and Drinking Water Inspectorate standard operating procedures (2003) were compared and key different steps in the methods were identified (wrist action speed, centrifuge speed, immunomagnetic separation procedures and addition of pre-treatment steps). Different experiments were conducted to verify and evaluate the difference between two wrist action shaker speeds, three different centrifuge speeds, two slightly different immunomagnetic separation procedures and when a pre-treatment step was included in the method. Three different types of water matrices (reagent grade water, drinking water and raw water) were used for the experiments and secondary validation. Data obtained from the experiments and secondary validation was statistically analyzed to determine whether there was a significant difference in the recovery of Cryptosporidium oocysts and Giardia cysts. Secondary validation of the Rand Water Method 06 (2007) was performed by implementing the study experiments‟ findings into the method. The results indicated an increase in the recovery rate of Cryptosporidium oocysts and Giardia cysts when data was compared with the previous secondary validation report. The mean recovery of Cryptosporidium oocysts in reagent grade water samples increased from 31% to 55%, drinking water samples increased from 28% to 44% and raw water decreased from 42% to 29%. The mean recovery of Giardia cysts in reagent grade water samples increased from 31% to 41%, drinking water samples increased from 28% to 46% and raw water decreased from 42% to 32%. Furthermore, even though the recovery rate of raw water decreased the use of pre-treatment buffer reduced the number of IMS performed per sample by reducing the pellet size. Enumeration of microscope slides was also easier as there was less background interference. The optimization of the Rand Water Method 06 (2007) was successful as the recovery rate of Cryptosporidium oocysts and Giardia cysts from water increased. All the changes that were verified and that increased the recovery rate were incorporated into the improved Rand Water Method 06. US-EPA 1623 Cryptosporidium oocysts Giardia cysts Water analysis Protozoa in water Rand Water Method 06 (2007) Reagent grade water Raw water Drinking water 572.539 Water quality Biochemistry Water. Analysis Drinking water Water. Microbiology.
13	Padronização dos procedimentos operacionais para a gestão da qualidade no Biotério de experimentação de Farmanguinhos - Fiocruz / Standardization of operating procedures for quality management in Farmanguinhos experimentation Vivarium - Fiocruz Sales, André Nunes de January 2013 (has links) Made available in DSpace on 2015-08-19T13:52:56Z (GMT). No. of bitstreams: 2 10.pdf: 4071879 bytes, checksum: e4995bcd224e527acb6bbb7591fa93b9 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2013 / Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos/Farmanguinhos. Rio de Janeiro, RJ, Brasil. / A presente dissertação sugere a padronização dos procedimentos operacionais e a elaboração do manual da qualidade para adoção de um sistema de gestão da qualidade no Biotério de Experimentação do Laboratório de Farmacologia Aplicada de Farmanguinhos. Os animais de laboratório contribuem há mais de 100 anos para as ciências biológicas no conhecimento, prevenção e tratamento de doenças, no desenvolvimento de medicamentos de uso humano e veterinário, além de proporcionar o aperfeiçoamento de técnicas clínicas e cirúrgicas. A Fundação Oswaldo Cruz (Fiocruz) tem um papel importante e histórico no cenário brasileiro em relação à promoção da saúde da população, sendo um dos principais centros de pesquisas científicas e tecnológicas no Brasil. Os camundongos e ratos utilizados nas pesquisas científicas do laboratório devem ser livres de agentes patogênicos específicos e sem dúvidas com relação à sua qualida de sanitária e genética, variáveis que possam gerar erros nos resultados exp erimentais. Para garantir este padrão de qualidade dos animais faz-se necessário o controle de parâmetros ambientais e operacionais na gestão do biotério. A verificação de conformidades ou não conformidades com as legislações nacionais vigentes e o levantamento das atividades operacionais exercidas no biotério determinaram a necessidade do estabelecimento de normas e propostas de ações corretivas para implantar o sistema de gestão da qualidade no biotério de experimentação do laboratório. A partir do relatório das atividades e processos executados no biotério foi elaborada a lista mestra de procedimentos a serem padronizados. Foram geradas também as ações corretivas para o cumprimento das exigências dos órgãos fiscalizadores, e o credenciamento e cadastro do biotério junto ao Conselho Regional de Medicina Veterinária (CRMV) e ao Conselho Nacional de Controle da Experimentação Animal (CONCEA). Com a padronização dos procedimentos operacionais e a elaboração do manual da qualidade do biotério será possível obter as orientações específicas e necessárias para garantir a boa manutenção dos animais no biotério de experimentação e, consequentemente, a maior confiabilidade dos resultados experimentais. A adoção do sistema de gestão da qualidade no biotério garante o uso ético e o bem-estar dos animais e cumpri as exigências legislativas nacionais. / This thesis suggests the standardization of operating procedures and the preparation of quality manual for the adoption of a system of quality management in the Laboratory Animal Facility of Experimentation of Applied Pharmacology in Farmaguinhos. The laboratory animals contribute for more than 100 years to the life sciences knowledge, prevention and treatment of diseases, the development of medicinal products for human and veterinary use, in addition to providing improvement of clinical and surgical techniques. The Oswaldo Cruz Foundation (Fiocruz) has an important role in the Brazilian scenario and history in relation to the promotion of health of the population, being one of the main centers of scientific and technological research in Brazil. The mice and rats are used in scientific research laboratory should be free of specific pathogens and no doubts about its continued health and genetic variables that can generate errors in the experimental results. To ensure this standard of quality of certain animals it is necessary to control environmental parameters and operational management of the biotherium. To check compliance or non-compliance with the national laws and the lifting of the operational activities carried on in the biotherium was possible to determine the need to establish standards and proposed corrective actions to implement the quality management system. From the report of the activities and processes on the biotherium was prepared master list of procedures to be standardized. Were also generated corrective actions to comply with the requirements of regulatory agencies, and accreditation and registration of the biotherium with the Regional Council of Veterinary Medicine (CRMV) and the National Council for the Control of Animal Experimentation (CONCEA). With the standardization of operating procedures and the preparation of quality manual from the facility will be possible to obtain specific guidelines and necessary to ensure the proper maintenance of animals in experimental animal facility and consequently the greater reliability of the experimental results. The adoption of the system of quality management in the vivarium ensures ethical use and welfare of animals and fulfill the national requirements. Biotério de Experimentação Experimentação Animal Gestão da Qualidade Procedimentos Operacionais Padrão Indústria Farmacêutica Laboratory Animal Facility Animal Experimentation Quality Management Standard Operating Procedures Pharmaceutical Industry Técnicos em Manejo de Animais Gestão da Qualidade Experimentação Animal
14	An investigation into the elements influencing stock control and their relation to health care delivery in the public setting: Development of a stock control assessment tool Kagee, Halima January 2000 (has links) Masters of Science / The aim of this study was to develop a Stock Control Assessment Tool for use in the public health care sector and then to apply it to identify problems in the stock control system. This would help authorities to optimize the system. The advantages experienced with such a dynamic Assessment Tool were many: The Tool was quick and easy to apply; it was user friendly; it provided an immediate SWOT analysis of a particular facility; it is in line with the SA NDP directives and it provides an indication of which structures are in place and whether they are functioning properly. Furthermore; it could determine the increase or decrease in performance of a facility (therefore identify trends within the functional status of a system) when data is collected over a period of time; and finally, it could also be used to prioritize drug policy directives. The following steps were established in the development of the Tool: A literature review of pharmaceutical stock control and Drug Supply Management was addressed to provide the background information for the motivation of this study and to identify the various elements that could influence stock control at a facility level. Observational studies were applied at selected private and public facilities to observe the impact of these identified stock control elements. An 'ideal' stock control system was then generated from the literature review and observational assessment. A structured questionnaire was developed and surveyed at these facilities to generate key areas of concern of a stock control system. A study and adaptation of the indicator methods used by the World Health Organization (WHO) to monitor drug use in health facilities resulted in the formulation of a practical Stock Control Assessment Tool based on 11 key indicators and a number of sub-indicators, all of which were objectively defined. The Tool was then applied at selected public facilities and the results were analyzed quantitatively, qualitatively and subjectively. Each of the indicators was then applied and results examined closely with a view to possible refinements of the indicator. The refinements were made and the Tool was re-applied at two selected facilities. These two facilities were randomly selected from the original six facilities included for the testing of the Tool. Final conclusions and specific recommendations were generated to improve the stock control systems at the selected public health care facilities. ABC value analysis Good Manufacturing Practices (GMP) Central Medical Depot (CMD) Standard Operating Procedures (SOP) World Health Organization (WHO)
15	A new model for worm detection and response. Development and evaluation of a new model based on knowledge discovery and data mining techniques to detect and respond to worm infection by integrating incident response, security metrics and apoptosis. Mohd Saudi, Madihah January 2011 (has links) Worms have been improved and a range of sophisticated techniques have been integrated, which make the detection and response processes much harder and longer than in the past. Therefore, in this thesis, a STAKCERT (Starter Kit for Computer Emergency Response Team) model is built to detect worms attack in order to respond to worms more efficiently. The novelty and the strengths of the STAKCERT model lies in the method implemented which consists of STAKCERT KDD processes and the development of STAKCERT worm classification, STAKCERT relational model and STAKCERT worm apoptosis algorithm. The new concept introduced in this model which is named apoptosis, is borrowed from the human immunology system has been mapped in terms of a security perspective. Furthermore, the encouraging results achieved by this research are validated by applying the security metrics for assigning the weight and severity values to trigger the apoptosis. In order to optimise the performance result, the standard operating procedures (SOP) for worm incident response which involve static and dynamic analyses, the knowledge discovery techniques (KDD) in modeling the STAKCERT model and the data mining algorithms were used. This STAKCERT model has produced encouraging results and outperformed comparative existing work for worm detection. It produces an overall accuracy rate of 98.75% with 0.2% for false positive rate and 1.45% is false negative rate. Worm response has resulted in an accuracy rate of 98.08% which later can be used by other researchers as a comparison with their works in future. / Ministry of Higher Education, Malaysia and Universiti Sains Islam Malaysia (USIM) Apoptosis Data mining Security metrics Knowledge discovery technique (KDD) Standard Operating Procedures (SOP) Worm incident response Static analysis Dynamic analysis Worm rules Worm classification STAKCERT model Worm detection Internet security
16	Development and validation of the marine benthic copepod Robertsonia propinqua as a bioindicator to monitor estuarine environmental health Hack, L. A. January 2008 (has links) Studies in the USA have reported that species of meiobenthic copepods can be used as bioindicators of sediment-associated contaminants. The main objective of this research project was to develop and validate methods to assess the effects of estuarine pollution, using the marine benthic copepod Robertsonia propinqua as a bioindicator of environmental health in New Zealand intertidal / estuarine areas. Cultures of R. propinqua were set up and maintained in the laboratory and individuals used in 96h acute and full life-cycle chronic bioassays using the pre-selected contaminants atrazine and zinc sulphate. From the 96h acute experiments it was found that the lethal doses at which 50% mortality occurred (LC50) for exposed nauplii and adult individuals were 7.5 mg/L and 31.8 mg/L, respectively for atrazine and 1.7 mg/L and 2.7 mg/L, respectively for zinc sulphate. This indicated that the nauplii life stage was more sensitive than were the adult life stages for exposure to both contaminants. Based on the 'trigger' values reported (atrazine = 0.013 mg/L, zinc = 0.015 mg/L) in the Australian and New Zealand guidelines for fresh and marine water quality, which provide values at which concentrations of contaminants can occur in the environment before they begin causing effects on aquatic fauna, it is unlikely that the calculated LC50s in the current research will induce biological effects in exposed copepods in the short-term. The calculated LC50 results were then used to further investigate the effects of chronic exposure of sediment-associated contaminants on the complete life-cycle (egg-reproductive adult) of R. propinqua. In a laboratory-based full life-cycle toxicity test, field-collected sediments from polluted sites in the Auckland and Bay of Plenty regions reduced reproductive output (nauplii and copepodite production) of R. propinqua individuals, but the number of males and females, gravid females, clutch size per female and the number of eggs produced were not affected by either the polluted or non-polluted (reference) sediment samples from both field regions. Field investigations of meiofauna community composition in polluted and non-polluted field sites were carried out in 2004 in the Auckland and Bay of Plenty field regions in New Zealand. Greater sediment organic content and a correspondingly deeper redox potential discontinuity layer occurred in all polluted field sites compared with the non-polluted sites. However, species composition could not be used to characterise polluted and non-polluted sites, as there were no dominant taxa which were representative of these sites. The results presented in this thesis indicate that R. propinqua has strong potential to be a good candidate species as a bioindicator of environmental contamination. Furthermore, the full life-cycle toxicity test could be used as a rapid test to detect immediate changes in individual reproduction and development as well as long-term population effects. The technologies developed as part of this research may eventually provide additional tools for commercial environmental consultancies and may compliment existing standard operating procedures for environmental assessments involving pollution of estuarine ecosystems. Robertsonia propinqua bioindicator environmental health assessment ecological risk assessment atrazine zinc sulphate water quality guideline values copepod life-cycle copepod culture standard operating procedures
17	The development and implementation of methods and procedures of issuing drivers licences in the Madibeng Municipality Alers, Corlia 01 1900 (has links) This study investigated the development and implementation of methods and procedures as generic administrative function, with specific reference to issuing drivers licences in the Driving Licence Testing Centre of the Madibeng Municipality. The contribution of the study to the discipline, Public Administration, is found in the basic framework for the development of standard operating procedures. Furthermore, a set of standard operating procedures to issue drivers licences was developed. In essence, the systems theory inspired the design of the basic framework for the development of standard operating procedures, while the phases of the ADDIE instructional design model simplified the drafting of the standardised procedures to issue drivers licences. Although the empirical data collection commenced with a quantitative research methodology, a qualitative dimension was required to fully understand the problem why the Driving Licence Testing Centre at the Madibeng Municipality lacks contemporary and relevant standard operating procedures to issue drivers licences. A mixed methods research design was eventually adopted to explore the phenomenon because a second research method was needed to strengthen the primary research method. Data was initially collected through a questionnaire, and follow-up personal interviews were conducted to clarify issues that were not responded to or unclear from the self-administered questionnaires. This conforms to pragmatism - the research philosophy adopted for this study because predetermined research questions dictated the path towards realising the research objectives. Since this study utilised a mixture of qualitative and quantitative research designs, the research methodology was shaped by various strategies, techniques and data collection instruments, such as literature reviews, document analyses to draft the standardised procedures, case study (Driving Licence Testing Centre of the Madibeng Municipality), a structured questionnaire and semi-structured personal interviews. In this study, the administrative generic function of determining and revision of methods and procedures was referred to as ‘methods and procedures’. Within the context of Public Administration, the study revealed that methods and procedures specify the sequence, processes and techniques necessary to execute certain actions and operations during service delivery. Moreover, it states how tasks must be exercised within the public sector, as well as indicate who must take action. Consequently, methods and procedures are built into all public service activities, regardless whether these are administrative, functional or auxiliary activities. It was concluded that methods and procedures form an indispensable part of any public institution’s activities. However, the study focused on methods and procedures to issue drivers licences at the Driving Licence Testing Centre of the Madibeng Municipality. The study realised its overall aim when recommendations were made to the Driving Licence Testing Centre of the Madibeng Municipality of how to develop and implement standard operating procedures to issue drivers licences. In essence, it was recommended that the basic framework for the development of standard operating procedures be applied when updating and/or developing methods and procedures. Moreover, it was recommended that the set of newly developed standard operating procedures be adopted and implemented. It was also suggested, amongst other proposals, that the management and the staff at the Centre engage from the initial stages in the procedure development process, that clear steps and instructions of how to reach organisational short-term objectives, be specified, and caution be taken by the Madibeng Municipality against the implementation of an overly multifaceted internal control system at its Driving Licence Testing Centre. / Department of Public Administration and Management / D.Admin. (Public Administration) Driver fitness Drivers licence Driving Licence Testing Centre Internal control Internal control mechanisms Madibeng Municipality Methods National Road Traffic Act Procedure Policy formulation Public policy Standard operating procedures Standardised procedures 352.29096824
18	Low Intensity Conflict: Contemporary Approaches and Strategic Thinking Searle, Deane January 2007 (has links) Low Intensity Conflict (LIC) is a significant feature of the contemporary world and it is a particular challenge to the armed forces of many states which are involved is such conflict, or are likely to become so. This thesis is not concerned with how such difficult conflict situations arise. Rather it is concerned with how, from the point of view of the state, they may be contained and ultimately brought to a satisfactory resolution. The work is thus concerned with the practicalities of ending LIC. More specifically, the purpose of this research is to establish a framework of doctrinal and military principles applicable to the prevention and resolution of LIC. The principles of this thesis are based in numerous historical examples of LIC and six in depth case studies. These distilled principles are analysed in two central chapters, and are then applied in two latter defence force chapters so as to ensure there practicality and resilience. Numerous defence academics and military practitioners have been consulted in the production of this thesis; their contribution has further reinforced the functionality of the principles examined in this research. The research illustrates the criticality of a holistic approach to LIC. The function of this approach is to guarantee the stability of the sovereign state, by unifying civil, police, intelligence and military services. The effectiveness of the military elements must also be ensured, as military force is central to the suppression of LIC. Consequently, the research makes strategic and operational prescriptions, so as to improve the capability of defence forces that are concerned with preventing or resolving LIC. low intensity conflict counterinsurgent counterinsurgency insurgent insurgency guerrilla small wars conflict combat urban conflict new zealand defence force australian defence force afghanistan iraq somalia chechnya east timor bougainville bosnia defence policy doctrine soviet russia red army airpower combined arms intelligence command control communications surveillance intervention peacekeeping peacebuilding peace enforcement strategy tactics infantry armour aviation non-urban terrain psychological war small scale operations combat service support civil military affairs urban dominance rapid dominance manoeuvre warfare nationalism restraint civil resolve operation enduring freedom operation anaconda suppressing fire joint warfare synergy strike target acquisition civil affairs public affairs operation iraqi freedom operation telic professionalism asymmetric warfare power projection sea power precision strike C4ISTAR C4ISR HUMINT logistics coalition post war environment internal security population security civil support unitary command expeditionary civil service personnel techniques standard operating procedures artillery protection manoeuvrability firepower visibility helicopters aircraft friendly fire initiative policy training light armoured vehicle light operational vehicle aviation navy air force army counter communications sea control maritime power projection rules of engagement engineers

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