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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
61

Mathematical modelling of HTLV-I infection: a study of viral persistence in vivo

Lim, Aaron Guanliang 11 1900 (has links)
Human T-lymphotropic virus type I (HTLV-I) is a persistent human retrovirus characterized by life-long infection and risk of developing HAM/TSP, a progressive neurological and inflammatory disease. Despite extensive studies of HTLV-I, a complete understanding of the viral dynamics has been elusive. Previous mathematical models are unable to fully explain experimental observations. Motivated by a new hypothesis for the mechanism of HTLV-I infection, a three dimensional compartmental model of ordinary differential equations is constructed that focusses on the highly dynamic interactions among populations of healthy, latently infected, and actively infected target cells. Results from mathematical and numerical investigations give rise to relevant biological interpretations. Comparisons of these results with experimental observations allow us to assess the validity of the original hypothesis. Our findings provide valuable insights to the infection and persistence of HTLV-I in vivo and motivate future mathematical and experimental work. / Applied Mathematics
62

Detekce fibrilace síní v EKG / ECG based atrial fibrillation detection

Plch, Vít January 2019 (has links)
This diploma thesis deals with detection of atrial fibrillation from HRV, classification of Poincare map and in the end the divide into two groups, one with detected atrial fibrillation and one not. The result is the decision on which variables are statistically significant for the identification of atrial fibrillations and which are not, and classification of the ECG signals with Bayes and Lavenberg-Marquardt neural networks. Bayes neural network with 23 neurons in hidden layer is best with F1 measure = 83,6 %, Sensitivity = 88,1 % and Specificity 94,5 %.
63

Sledování trendů elektrické aktivity srdce časově-frekvenčním rozkladem / Monitoring Trends of Electrical Activity of the Heart Using Time-Frequency Decomposition

Čáp, Martin January 2009 (has links)
Work is aimed at the time-frequency decomposition of a signal application for monitoring the EKG trend progression. Goal is to create algorithm which would watch changes in the ST segment in EKG recording and its realization in the Matlab program. Analyzed is substance of the origin of EKG and its measuring. For trend calculations after reading the signal is necessary to preprocess the signal, it consists of filtration and detection of necessary points of EKG signal. For taking apart, also filtration and measuring the signal is used wavelet transformation. Source of the data is biomedicine database Physionet. As an outcome of the algorithm are drawn ST segment trends for three recordings from three different patients and its comparison with reference method of ST qualification. For qualification of the heart stability, as a system, where designed methods watching differences in position of the maximal value in two-zone spectrum and the Poincare mapping method. Realized method is attached to this thesis.
64

Cislunar Trajectory Design Methodologies Incorporating Quasi-Periodic Structures With Applications

Brian P. McCarthy (5930747) 29 April 2022 (has links)
<p> </p> <p>In the coming decades, numerous missions plan to exploit multi-body orbits for operations. Given the complex nature of multi-body systems, trajectory designers must possess effective tools that leverage aspects of the dynamical environment to streamline the design process and enable these missions. In this investigation, a particular class of dynamical structures, quasi-periodic orbits, are examined. This work summarizes a computational framework to construct quasi-periodic orbits and a design framework to leverage quasi-periodic motion within the path planning process. First, quasi-periodic orbit computation in the Circular Restricted Three-Body Problem (CR3BP) and the Bicircular Restricted Four-Body Problem (BCR4BP) is summarized. The CR3BP and BCR4BP serve as preliminary models to capture fundamental motion that is leveraged for end-to-end designs. Additionally, the relationship between the Earth-Moon CR3BP and the BCR4BP is explored to provide insight into the effect of solar acceleration on multi-body structures in the lunar vicinity. Characterization of families of quasi-periodic orbits in the CR3BP and BCR4BP is also summarized. Families of quasi-periodic orbits prove to be particularly insightful in the BCR4BP, where periodic orbits only exist as isolated solutions. Computation of three-dimensional quasi-periodic tori is also summarized to demonstrate the extensibility of the computational framework to higher-dimensional quasi-periodic orbits. Lastly, a design framework to incorporate quasi-periodic orbits into the trajectory design process is demonstrated through a series of applications. First, several applications were examined for transfer design in the vicinity of the Moon. The first application leverages a single quasi-periodic trajectory arc as an initial guess to transfer between two periodic orbits. Next, several quasi-periodic arcs are leveraged to construct transfer between a planar periodic orbit and a spatial periodic orbit. Lastly, transfers between two quasi-periodic orbits are demonstrated by leveraging heteroclinic connections between orbits at the same energy. These transfer applications are all constructed in the CR3BP and validated in a higher-fidelity ephemeris model to ensure the geometry persists. Applications to ballistic lunar transfers are also constructed by leveraging quasi-periodic motion in the BCR4BP. Stable manifold trajectories of four-body quasi-periodic orbits supply an initial guess to generate families of ballistic lunar transfers to a single quasi-periodic orbit. Poincare mapping techniques are used to isolate transfer solutions that possess a low time of flight or an outbound lunar flyby. Additionally, impulsive maneuvers are introduced to expand the solution space. This strategy is extended to additional orbits in a single family to demonstrate "corridors" of transfers exist to reach a type of destination motion. To ensure these transfers exist in a higher fidelity model, several solutions are transitioned to a Sun-Earth-Moon ephemeris model using a differential corrections process to show that the geometries persist.</p>
65

Non-euclidean geometry and its possible role in the secondary school mathematics syllabus

Fish, Washiela 01 1900 (has links)
There are numerous problems associated with the teaching of Euclidean geometry at secondary schools today. Students do not see the necessity of proving results which have been obtained intuitively. They do not comprehend that the validity of a deduction is independent of the 'truth' of the initial assumptions. They do not realise that they cannot reason from diagrams, because these may be misleading or inaccurate. Most importantly, they do not understand that Euclidean geometry is a particular interpretation of physical space and that there are alternative, equally valid interpretations. A possible means of addressing the above problems is tbe introduction of nonEuclidean geometry at school level. It is imperative to identify those students who have the pre-requisite knowledge and skills. A number of interesting teaching strategies, such as debates, discussions, investigations, and oral and written presentations, can be used to introduce and develop the content matter. / Mathematics Education / M. Sc. (Mathematics)
66

Histoire du théorème de Jordan de la décomposition matricielle (1870-1930).<br />Formes de représentation et méthodes de décomposition.

Brechenmacher, Frederic 09 March 2006 (has links) (PDF)
L'histoire du théorème de Jordan est abordée sous l'angle d'une question d'identité posée sur la période qui sépare la date de 1870 et l'énoncé par Camille Jordan d'une forme canonique des substitutions linéaires des années trente du vingtième siècle au cours desquelles le théorème de Jordan de la décomposition matricielle acquiert une place centrale dans la théorie des matrices canoniques. A partir d'un moment historique de référence, la controverse entre Jordan et Kronecker de 1874, le théorème de Jordan permet de jeter un regard original sur l'histoire de la période 1870-1930 en suivant le rôle joué par des savoirs tacites, des idéaux et des pratiques propres à des réseaux et des communautés. Ce regard permet notamment de mettre en évidence la dynamique d'une tension entre formes canoniques et invariants dans l'évolution de la signification de la notion de forme en mathématiques et contribue à l'histoire de l'algèbre linéaire en décrivant le rôle joué par une méthode de décomposition indissociable d'un mode particulier de représentation : la décomposition matricielle.
67

Non-euclidean geometry and its possible role in the secondary school mathematics syllabus

Fish, Washiela 01 1900 (has links)
There are numerous problems associated with the teaching of Euclidean geometry at secondary schools today. Students do not see the necessity of proving results which have been obtained intuitively. They do not comprehend that the validity of a deduction is independent of the 'truth' of the initial assumptions. They do not realise that they cannot reason from diagrams, because these may be misleading or inaccurate. Most importantly, they do not understand that Euclidean geometry is a particular interpretation of physical space and that there are alternative, equally valid interpretations. A possible means of addressing the above problems is tbe introduction of nonEuclidean geometry at school level. It is imperative to identify those students who have the pre-requisite knowledge and skills. A number of interesting teaching strategies, such as debates, discussions, investigations, and oral and written presentations, can be used to introduce and develop the content matter. / Mathematics Education / M. Sc. (Mathematics)
68

Field Theoretic Lagrangian From Off-shell Supermultiplet Gauge Quotients

Katona, Gregory 01 January 2013 (has links)
Recent efforts to classify off-shell representations of supersymmetry without a central charge have focused upon directed, supermultiplet graphs of hypercubic topology known as Adinkras. These encodings of Super Poincare algebras, depict every generator of a chosen supersymmetry as a node-pair transformtion between fermionic bosonic component fields. This research thesis is a culmination of investigating novel diagrammatic sums of gauge-quotients by supersymmetric images of other Adinkras, and the correlated building of field theoretic worldline Lagrangians to accommodate both classical and quantum venues. We find Ref [40], that such gauge quotients do not yield other stand alone or "proper" Adinkras as afore sighted, nor can they be decomposed into supermultiplet sums, but are rather a connected "Adinkraic network". Their iteration, analogous to Weyl's construction for producing all finite-dimensional unitary representations in Lie algebras, sets off chains of algebraic paradigms in discrete-graph and continuous-field variables, the links of which feature distinct, supersymmetric Lagrangian templates. Collectively, these Adiankraic series air new symbolic genera for equation to phase moments in Feynman path integrals. Guided in this light, we proceed by constructing Lagrangians actions for the N = 3 supermultiplet YI /(iDI X) for I = 1, 2, 3, where YI and X are standard, Salam-Strathdee superfields: YI fermionic and X bosonic. The system, bilinear in the component fields exhibits a total of thirteen free parameters, seven of which specify Zeeman-like coupling to external background (magnetic) fluxes. All but special subsets of this parameter space describe aperiodic oscillatory responses, some of which are found to be surprisingly controlled by the golden ratio, [phi] = 1.61803, Ref [52]. It is further determined that these Lagrangians allow an N = 3 - > 4 supersymmetric extension to the Chiral-Chiral and Chiral-twistedChiral multiplet, while a subset admits two inequivalent such extensions. In a natural proiii gression, a continuum of observably and usefully inequivalent, finite-dimensional off-shell representations of worldline N = 4 extended supersymmetry are explored, that are variate from one another but in the value of a tuning parameter, Ref [53]. Their dynamics turns out to be nontrivial already when restricting to just bilinear Lagrangians. In particular, we find a 34-parameter family of bilinear Lagrangians that couple two differently tuned supermultiplets to each other and to external magnetic fluxes, where the explicit parameter dependence is unremovable by any field redefinition and is therefore observable. This offers the evaluation of X-phase sensitive, off-shell path integrals with promising correlations to group product decompositions and to deriving source emergences of higher-order background flux-forms on 2-dimensional manifolds, the stacks of which comprise space-time volumes. Application to nonlinear sigma models would naturally follow, having potential use in M- and F- string theories.

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