京都大学 / 新制・課程博士 / 博士(医学) / 甲第24281号 / 医博第4897号 / 新制||医||1061(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 森田 智視, 教授 妹尾 浩, 教授 波多野 悦朗 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

京都大学 / 新制・課程博士 / 博士(医学) / 甲第24831号 / 医博第4999号 / 新制||医||1067(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 山本, 洋介, 教授 武藤, 学, 教授 永井, 純正 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

Alors que le traitement standard du cancer du rectum (traitement néoadjuvant avec chirurgie d’exérèse et stomie temporaire) n’épargne ni la psyché ni le corps, peu d’études se sont intéressées à l’ajustement psycho-social des patients qui y sont confrontés. Le corps est bien souvent perçu, à la suite des traitements, comme dérivant de la norme et générant un sentiment de honte. Ainsi le premier travail de cette thèse a été de valider un outil, en population française, permettant de mesurer la honte liée à l’image du corps. Dans un deuxième travail, nous avons pu comparer la honte liée à l’image du corps ainsi que la qualité de vie, l’image du corps, et la détresse psychologique des patients ayant reçu un traitement standard à ceux traités par excision locale (nouvelle approche proposée aux patients présentant une bonne réponse clinique aux traitements néoadjuvants). Le traitement standard entraînant des difficultés psycho-sociales plus marquées, nous avons évalué plus spécifiquement ses conséquences sur la détresse psychologique et l’image du corps dans un troisième travail. La période avec la stomie temporaire représente un temps spécifique durant lequel les patients semblent mettre leur vie entre parenthèses. Ainsi, dans un quatrième travail, nous avons investigué le rôle du temps comme un déterminant possible de la qualité de vie de ces sujets. Nos résultats ont montré qu’il conviendrait de considérer, dans le parcours de soin du patient, la façon dont celui-ci perçoit le temps, en vue de prévenir une altération de sa qualité de vie. Cette altération persiste plusieurs mois après la fin des traitements mais peu d’études s’y sont, à ce jour, intéressées. Ainsi, dans un cinquième travail, nous avons exploré la qualité de vie, deux ans après le diagnostic de cancer, chez des survivants du cancer du côlon-rectum traités par chirurgie avec ou sans stomie temporaire. Nous avons alors constaté que la qualité de vie physique était significativement plus altérée chez les patients qui ont eu une stomie. Face à ces difficultés, il convenait de proposer une intervention psycho-sociale répondant aux besoins émotionnels de ces patients. Peu d’interventions ont été développées en ce sens. Dans un sixième travail, nous avons développé et mis à l’épreuve une intervention psycho-sociale qui semble s’inscrire davantage dans une approche préventive. L’ensemble de ces travaux pourrait contribuer à améliorer l’accompagnement proposé à ces patients, même s’il est nécessaire de souligner l’importance de promouvoir la recherche dans ce domaine pour mieux comprendre encore les enjeux psycho-sociaux de ce traitement. / While the standard treatment for rectal cancer (neoadjuvant treatment with rectal excision) has spared neither the psyche nor the body, few studies have focused on psychosocial adjustment of patients who have received this treatment. Following treatment, the body is often perceived as deviating from the norm, generating feelings of shame. The first objective of this thesis was to adapt, and validate, for the French population, a body image shame scale. The second step consisted in comparing body image shame, quality of life, body image, and psychological distress between rectal cancer patients treated by surgery with temporary stoma or local excision (a new treatment approach proposed for patients with rectal cancer after a good clinical response to neoadjuvant therapy). Since standard treatment leads to more psychosocial problems, in a third study, we examined the effects of standard treatment on psychological distress and body image. The temporary stoma period represents a specific time during which patients seem to temporarily suspend their lives. Thus, the fourth study of this thesis investigated how the role of time perspective might act as a determinant of quality of life for rectal cancer patients. The time perspective construct provides keys in order to improve quality of life of rectal cancer patients. Quality of life alterations persist several months after the end of treatments but, to date, few studies have focused on this topic. The fifth goal was to assess colorectal cancer survivors’ quality of life two years after diagnosis of colorectal cancer according to their stoma status (reversed or never formed). Participants with a reversed stoma score lower on the physical quality of life scale than participants without stoma. Patients with rectal cancer experience psychosocial challenges. To deal with these challenges, psychosocial interventions focused on emotional needs of rectal cancer patients treated by standard treatment should be proposed. There is a lack of this type of intervention for this population. The sixth purpose was to develop and test a psychosocial intervention which seems to be more in line with a preventive approach. Taken together, these works may contribute to improve the support offered to these patients, even though the importance of promoting research to deal with the psychosocial challenges of this treatment must be underlined.

CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior / SÃndrome de DefecaÃÃo ObstruÃda (SDO) pode ser produzida por alteraÃÃo funcional (anismus) ou por alteraÃÃes anatÃmicas, especialmente retocele e prolapso mucoso retal. VÃrias tÃcnicas cirÃrgicas vÃm sendo utilizadas no tratamento da retocele, com vias de acesso transvaginal, perineal ou transanal, aquelas mais utilizadas por ginecologistas e a transanal por coloproctologistas, isto em funÃÃo das pacientes recorrerem a especialistas diferentes, dependendo da predominÃncia dos sintomas, sendo apresentados resultados semelhantes. O objetivo deste estudo foi avaliar os resultados do tratamento cirÃrgico de pacientes portadoras de SDO por retocele e prolapso mucoso retal, submetidas à ressecÃÃo transanal da retocele e mucosectomia com um grampeador (procedimento âTRREMSâ. Foram avaliadas 35 pacientes, sendo uma nulÃpara e as demais multÃparas, com idade mÃdia de 47,5 Â10,83 anos (31 â 67), portadoras de retocele e prolapso mucoso retal interno, sendo 13 (37,10%) com grau II e 22 (62,90%) com grau III. Os parÃmetros avaliados foram os escores de defecaÃÃo obstruÃda e de constipaÃÃo, o Ãndice funcional para continÃncia assim como a avaliaÃÃo da dor, satisfaÃÃo com o resultado e com a funÃÃo sexual e realizaÃÃo de defecografia no prà e no pÃs-operatÃrio. O escore mÃdio de SDO de 10,63 no prÃ-operatÃrio reduziu significativamente para 2,91 no pÃs-operatÃrio (p = 0,000). O escore mÃdio de constipaÃÃo de 15,23 no prÃ-operatÃrio reduziu significativamente para 4,46 no pÃs-operatÃrio (p = 0,000). O Ãndice funcional mÃdio para continÃncia, de 2,77 no prÃ-operatÃrio reduziu significativamente para 1,71 no pÃs-operatÃrio (p = 0,000). A dor no primeiro dia pÃs-operatÃrio, avaliada atravÃs da escala visual analÃgica (EVA) apresentou valor mÃdio de 5,23 reduzindo para 1,20 no oitavo dia (p = 0,000). A satisfaÃÃo com o resultado do tratamento, avaliada tambÃm atravÃs da EVA, ao final do primeiro mÃs foi 79,97, no terceiro 86,54, no sexto 87,65 e no dÃcimo segundo 88,06. TambÃm se obteve elevaÃÃo significativa, entre os valores mÃdios de 42,91 no prÃ-operatÃrio e 70,41 no sexto mÃs de pÃs-operatÃrio, para a satisfaÃÃo sexual avaliada atravÃs da EVA (p = 0,000). A defecografia demonstrou reduÃÃo significativa do tamanho mÃdio da retocele de 19,23 mm  8,84 (3 â 42) para 6,68 mm  3,65 (0 â 17) na fase de repouso e de 34,89 mm  12,30 (20 â 70) para 10,94 mm  5,97 (0 â 25) na fase evacuatÃria quando comparado o prà com o pÃs-operatÃrio (p = 0,000) (P=0,000) respectivamente. Procedimento âTRREMSâ à uma tÃcnica segura, eficiente e produziu resultados anatÃmicos e funcionais satisfatÃrios e nÃveis reduzidos de complicaÃÃes pÃs-operatÃrias / Obstructed defecation syndrome (ODS) can be induced by functional changes (anismus) or anatomical abnormalities, especially rectocele and rectal mucosal prolapse (RMP). Several surgical techniques with transvaginal, perineal or transanal access have been used in the treatment of rectocele. The first two are more commonly used by gynecologists, the last one is favored by proctologists. Depending on the prevalence of symptoms, patients may go to either specialist with the same result. The objective of the present study was to make a clinical and functional evaluation of patients submitted to the TRREMS procedure (transanal repair of rectocele and rectal mucosectomy with a single circular stapler) as treatment for ODS caused by rectocele and RMP. The study included 35 female patients (34 of whom multiparous) aged 47.5Â10.83 years (31â67) diagnosed with ODS caused by RMP-associated rectocele grade II (n=13; 37.1%) or grade III (n=22; 62.9%). The study parameters included SDO and constipation scores, functional continence index, sexual function and treatment outcome satisfaction and pre- and postoperative defecographic measures. The average preoperative ODS score (10.63) was significantly reduced after surgery (2.91) (p=0.000). The average constipation score fell from 15.23 to 4.46 (p=0.000). The average functional continence score decreased from 2.77 to 1.71 (p=0.000). Between the first and the eighth postoperative day, the average visual analog scale pain score fell from 5.23 to 1.20 (p=0.000). Using the same scale, satisfaction with the treatment outcome was 79.97, 86.54, 87.65 and 88.06 at 1, 3, 6 and 12 months, respectively, and the average sexual function satisfaction was 42.91 (19â70) and 70.41 (39â97) before and after surgery, respectively (p=0.000). On defecography, average reductions in rectocele size were from 19.23Â8.84 mm (3â42) to 6.68Â3.65 mm (0â17) at rest and from 34.89Â12.30 mm (20â70) to 10.94Â5.97 mm (0â25) during evacuation (both p=0.000). The TRREMS procedure is a safe, efficient technique associated with satisfactory anatomical and functional results and reduced levels of postoperative pain and complications.

Introdução: Descrita em 1983 e de sólida aplicação clínica, o impacto da microcirurgia endoscópica transanal (TEM) sobre a função anorretal permanece pouco conhecido. Os objetivos do presente estudo foram avaliar o impacto da TEM na função anorretal conforme avaliações clínicas (Wexner score) e funcional (manometria anorretal) antes e após a cirurgia. Método: Prospectivamente, 23 pacientes consecutivos com lesões retais foram operados com o uso do equipamento TEO® (Karl Storz, Tuttlingen, Alemanha). Para todos os pacientes, o valor do escore de Wexner foi obtido antes e após a cirurgia (7, 30 e 90 dias), e a eletromanometria anorretal foi realizada antes da cirurgia e também no pós-operatório (30 e 90 dias). Resultados: Quatorze pacientes eram homens. A idade média foi 53,7 (24-81) anos. A distância média da lesão à linha pectínea foi de 7 (2-15) cm. A histopatologia revelou adenoma em 14 (61%), tumor neuroendócrino em 5 (21,7%), carcinoma invasivo em 3 (13%) e pólipo hiperplásico em 1 (4,3%) caso. A duração média do seguimento pós-operatório foi de 5 (3-7) meses. O escore de Wexner foi significativamente menor aos 30 dias em comparação com 7 dias (Wilcoxon, p = 0,03). A capacidade retal foi significativamente menor aos 30 dias após a cirurgia e recuperada aos 90 dias após a cirurgia (ANOVA, p = 0,04). Conclusões: Após TEM, um impacto modesto na função anorretal pode ser observado. O comprometimento transitório resulta de perda de capacidade retal e não por comprometimento dos esfíncteres anais cessando completamente 90 dias após a cirurgia. Em última análise, não conseguimos detectar um impacto na qualidade de vida após TEM / Background: The impact of transanal endoscopic microsurgery (TEM) on anorectal function remains poorly available, particularly when considering that the technique involves undertaking full- or partial-thickness excision of the rectal wall. Moreover, in spite of wide adoption of TEM, its impact on quality of life remains unknown since most evidence derives from retrospective studies. Objective: The objectives of the present study were to evaluate the impact of TEM on sphincter function determined by clinical (Wexner score), functional (anorectal manometry), and quality of life (FIQL) evaluations conducted before and after surgery. Design: prospective, observational, single-center, 23 consecutive patients with rectal lesions underwent were operated on using the TEO® equipment (Karl Storz, Tuttlingen, Germany). Wexner and FIQL scores were obtained before and after surgery (7 days, 30 days and 90 days postoperatively). Anorectal manometry was obtained before surgery, and postoperatively after 30 and 90 days. Main Outcome Measures: Wexner and FIQL scores; anorectal manometry results. Results: Fourteen patients were men. Mean age was 53.7 (24-81) yrs. Mean distance from the lesion to the dentate line was 7 (2-15) cm. A full- thickness resection was undertaken in 18 (78.3%) cases. Histopathology revealed adenoma in 14 (61%), neuroendocrine tumor in 5 (21.7%), invasive carcinoma in 3 (13%), and hyperplastic polyp in 1 (4.3%) case. Postoperative rectal wound separation occurred in 2 patients and 1 patient developed atrial fibrillation. The mean duration of postoperative follow-up was 5 (3-7) months. Overall, Wexner score significantly declined between postoperative days 7 and 30 (Wilcoxon, p = 0.03). Rectal compliance exhibited significant decline 30 days after surgery and recovery at 90 days after surgery (ANOVA, p = 0.04). It was not possible to measure any difference in the FIQL results before and after surgery. Limitations: small sample size; limited follow-up. Conclusions: Following TEM, a modest impact on anorectal function could be confirmed. Interestingly, anorectal function impairment after surgery was not due to sphincter dysfunction, but resulted from loss of rectal compliance. Ultimately, we could not detect a significant impact on quality of life after TEM

Introdução: Descrita em 1983 e de sólida aplicação clínica, o impacto da microcirurgia endoscópica transanal (TEM) sobre a função anorretal permanece pouco conhecido. Os objetivos do presente estudo foram avaliar o impacto da TEM na função anorretal conforme avaliações clínicas (Wexner score) e funcional (manometria anorretal) antes e após a cirurgia. Método: Prospectivamente, 23 pacientes consecutivos com lesões retais foram operados com o uso do equipamento TEO® (Karl Storz, Tuttlingen, Alemanha). Para todos os pacientes, o valor do escore de Wexner foi obtido antes e após a cirurgia (7, 30 e 90 dias), e a eletromanometria anorretal foi realizada antes da cirurgia e também no pós-operatório (30 e 90 dias). Resultados: Quatorze pacientes eram homens. A idade média foi 53,7 (24-81) anos. A distância média da lesão à linha pectínea foi de 7 (2-15) cm. A histopatologia revelou adenoma em 14 (61%), tumor neuroendócrino em 5 (21,7%), carcinoma invasivo em 3 (13%) e pólipo hiperplásico em 1 (4,3%) caso. A duração média do seguimento pós-operatório foi de 5 (3-7) meses. O escore de Wexner foi significativamente menor aos 30 dias em comparação com 7 dias (Wilcoxon, p = 0,03). A capacidade retal foi significativamente menor aos 30 dias após a cirurgia e recuperada aos 90 dias após a cirurgia (ANOVA, p = 0,04). Conclusões: Após TEM, um impacto modesto na função anorretal pode ser observado. O comprometimento transitório resulta de perda de capacidade retal e não por comprometimento dos esfíncteres anais cessando completamente 90 dias após a cirurgia. Em última análise, não conseguimos detectar um impacto na qualidade de vida após TEM / Background: The impact of transanal endoscopic microsurgery (TEM) on anorectal function remains poorly available, particularly when considering that the technique involves undertaking full- or partial-thickness excision of the rectal wall. Moreover, in spite of wide adoption of TEM, its impact on quality of life remains unknown since most evidence derives from retrospective studies. Objective: The objectives of the present study were to evaluate the impact of TEM on sphincter function determined by clinical (Wexner score), functional (anorectal manometry), and quality of life (FIQL) evaluations conducted before and after surgery. Design: prospective, observational, single-center, 23 consecutive patients with rectal lesions underwent were operated on using the TEO® equipment (Karl Storz, Tuttlingen, Germany). Wexner and FIQL scores were obtained before and after surgery (7 days, 30 days and 90 days postoperatively). Anorectal manometry was obtained before surgery, and postoperatively after 30 and 90 days. Main Outcome Measures: Wexner and FIQL scores; anorectal manometry results. Results: Fourteen patients were men. Mean age was 53.7 (24-81) yrs. Mean distance from the lesion to the dentate line was 7 (2-15) cm. A full- thickness resection was undertaken in 18 (78.3%) cases. Histopathology revealed adenoma in 14 (61%), neuroendocrine tumor in 5 (21.7%), invasive carcinoma in 3 (13%), and hyperplastic polyp in 1 (4.3%) case. Postoperative rectal wound separation occurred in 2 patients and 1 patient developed atrial fibrillation. The mean duration of postoperative follow-up was 5 (3-7) months. Overall, Wexner score significantly declined between postoperative days 7 and 30 (Wilcoxon, p = 0.03). Rectal compliance exhibited significant decline 30 days after surgery and recovery at 90 days after surgery (ANOVA, p = 0.04). It was not possible to measure any difference in the FIQL results before and after surgery. Limitations: small sample size; limited follow-up. Conclusions: Following TEM, a modest impact on anorectal function could be confirmed. Interestingly, anorectal function impairment after surgery was not due to sphincter dysfunction, but resulted from loss of rectal compliance. Ultimately, we could not detect a significant impact on quality of life after TEM

Background: Colorectal adenocarcinoma is the third commonest cancer in Sweden, with 6100 new cases every year. Several factors have been identified as contributors in the development of colorectal adenocarcinoma, amongst them is inflammation inducing angiogenesis, cell migration and mutations. C-reactive protein (CRP) is an acute phase protein that is produced by the liver in response to inflammation. Method: CRP was measured at diagnosis and six weeks after surgery in 271 patients with stage II and III colorectal adenocarcinoma. The concentration of CRP in plasma was compared to parameters and outcomes as registered in the Swedish Colorectal Cancer Registry. Results: Age over 70, co-morbidities, acute operation and mortality were significantly correlated with CRP concentrations over 5 mg/l. Using Cox-regressions univariate hazard ratios (HR) were calculated. CRP (HR 1.19-7.22, p<0.05), age (HR 6.02 p=0.0001), ASA-classification (HR 5.47, p=0.000), acute operation (HR 3.25, p=0.004), positive lymph nodes (HR 4.45-5.71, p=0.006), postoperative complications (HR 3.03, p=0.005) of which ICU-care (HR 13.86, p=0.000) and re- operation (HR 5.48, p=0.000) were the best predictors of mortality using the univariate model. In the multivariate model age over 70 (HR 4.792, p=0.006), postoperative complications (HR 3.645, p=0.012), N1- or N2-stage (HR 5.490 and 16.397, p=0.003 and 0.000 respectively) and preoperative CRP over 5 mg/l (HR 3.227, p=0.045) were significant predictors of mortality. Including only elective patients, N2-stage (HR 12.829, p= 0.000), age over 70 (HR 5.240, p= 0.017) and ASA-classification III and IV (HR 4.465, p= 0.012) were correlated to excess mortality.Discussion: The results confirm previous studies and adds to the evidence in support of CRP as a predictor of mortality in patients with colorectal adenocarcinoma. In the future these results might be valuable in predicting mortality and tailoring the care for patients with colorectal adenocarcinoma. / Bakgrund: Tjock- och ändtarmscancer är ett folkhälsoproblem som drabbar cirka 6 100 personer årligen, vilket gör sjukdomen till den tredje vanligaste cancerformen. Det finns flera teorier om tjock- och ändtarmscancers uppkomstmekanism. En faktor som identifierats som grundläggande för all cancer är inflammation. Kroppen reagerar vid inflammation genom att bland annat uttrycka mer av vissa äggviteämnen. Ett sådant äggviteämne är C-reaktivt protein (CRP). Denna studies syfte är att undersöka om det finns någon korrelation mellan CRP och hur allvarlig cancern är, ålder, samsjuklighet, överlevnad och prognos hos patienter med tjock- och ändtarmscancer. Metod: Journaler från 525 patienter som inkluderats i ett lokalt kvalitetsregister för tjock- och ändtarmscancer användes för att jämföra hur nivån av CRP i plasma före och efter operation påverkar cancerutfallet för patienterna. En grupp på 271 patienter valdes ut baserat på tumörstadie och analyserades med statistiska metoder. Resultat: Pre- och postoperativt CRP är korrelerar till hög ålder (över 70 år), samsjuklighet, akut operation och överlevnad hos patienterna. Patienter äldre än 70 år, de som hade CRP över 5 mg/l, lymfkörtelmetastaser eller som drabbats av en komplikation efter operationen var överrepresenterade bland de avlidna. Delades patienterna in i två grupper baserat på CRP- koncentrationen i blodet sågs en ökad dödlighet hos de med CRP över 5 mg/l före operationen. Diskussion: Tidigare studier som gjorts på området visar liknande resultat. Fortsatta studier bör göras på patientgruppen då uppföljningstiden och antalet patienter i registret ökar. I framtiden kan man använda resultaten för att hitta de patienter som löper större risk att avlida och anpassa deras behandling för att minska risken.

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Bakgrund: Inför ett kirurgiskt ingrepp erhålls information kring pre/intra/post – operativa rutiner. Det är inte helt klarlagt hur patienter uppfattar och kan ta till sig denna information. Syfte: Att beskriva patienters erfarenheter av preoperativ information inför kolo-rektal cancer kirurgi. Design: Kvalitativ deskriptiv studie med semi-strukturerade intervjuer. Kontext: Intervjuerna genomfördes på en vårdavdelning tillhörande ett universitetssjukhus i Sverige. Deltagare: 14 deltagare tillfrågades att delta i studien varav sju accepterade att delta. Metod: Intervjuerna spelades in på band och transkriberades ordagrant, insamlad data analyserades efter latent innehåll utefter Graneheim och Lundmans modell för innehållsanalys. Resultat: Huvudtema: Personcentrerad omvårdnad, och fyra teman: 1. Betydelsen av individuellt anpassad information. 2. Tydliga besked och bra bemötande främjar trygghet. 3. Stöd av närstående är betydelsefullt. 4. Väntan på svar främjar ovisshet. Deltagarna var sammantaget nöjda med erhållen preoperativ information. Några av deltagarna hade dock svårigheter att minnas all information som givits. Att leva i ovisshet kring fortsatt prognos samt framtiden gav känslor av otrygghet och oro. Betydelsen av närstående och anhöriga var stor, dels för att uppfatta informationen korrekt, för att minnas den samt för emotionellt stöd. Behov av ytterligare information gällde biverkningar av läkemedel, kostråd efter kirurgi, provsvar, peroperativa förlopp samt information kring livet efter sjukhusvistelsen. Slutsats: : Att utgå från en personcentrerad vård, där patientens egna berättelse är i fokus, kan bidra till att ge en mer individbaserad preoperativ information, och på så sätt stärka patientens egna resurser under vårdtiden. / Background: Information regarding the pre/intra/post – operative routines is given prior to surgical interventions. It is not entirely clarified how patients perceive this information. Objective: To explore patients´ experiences regarding preoperative information before undergoing colo-rectal cancer surgery. Design: Qualitative descriptive study with semi-structured interviews. Setting: Interviews were conducted in a hospital ward on a university hospital in Sweden. Participants: 14 participants were asked to participate and seven accepted to participate in the study. Method: Interviews were tape recordered and collected data were transcribed verbatim and analyzed for latent content using Graneheim and Lundman´s outline for content analysis. Results: Main theme: Person-centered nursing care. Four themes were identified: 1. The meaning of individual-based information. 2. Explicit notifications and warm receptions promote feelings of safety. 3. Support from next of kin are meaningfull. 4. Waiting for answers promotes feelings of uncertainty. All of the participants were satisfied with acquired preoperative information. However, a few of the participants had difficulties remembering all of the information given. Feelings of uncertainty about the prognosis and the future were present and were experienced as to somewhat burdensome. The importance of relatives and next of kin were very important in regard of understanding and memorizing given information, but also for emotional support. The need for further desired information included pharmacological side effects, dietary advice following surgery, test results, perioperative complications and information regarding life after discharge. Conclusions: Providing person-centered care based on the narrative from the patient can help healthcare professionals to provide more accurate and individual based preoperative information.

Este estudo teve como objetivo avaliar e quantificar o efeito do sombreamento artificial proporcionado por diferentes tipos de materiais de cobertura sobre a fisiologia, o comportamento e o desenvolvimento de novilhas leiteiras, em ambiente de pastagens. A pesquisa foi realizada no período de 08/01/2007 à 30/04/2007. A área experimental foi dividida em 16 parcelas adjacentes e iguais com 84 m² cada. Foram comparados a testemunha (sem sombra) com três tipos de cobertura: telhas de fibrocimento sem cimento amianto, telhas galvanizadas e tela de polipropileno 80% As dimensões dos abrigos foram 2m x 4m e 4m de altura (4m² de sombra.animal-1), sem paredes laterais. Foram utilizadas 16 novilhas Holandesas e 16 Hol x Jersey com idade e peso iniciais de 17,2 ± 5,6 meses e 265,3 ± 66,9kg, respectivamente, pareadas em função da uniformidade de peso e idade. As novilhas permaneciam em piquetes de capim elefante (Penissetum purpureum) durante a noite e após as 9:00h eram conduzidas para as parcelas. A tgn foi registrada por minidatalogger conectado a globo negro para cálculo de CTR e ITGU em cada parcela. As variáveis meteorológicas foram obtidas no posto agrometeorológico da ESALQ/USP. Semanalmente foram registradas FR, TR e TP. As observações comportamentais foram realizadas em dias não consecutivos por 24 horas pelo método focal. As pesagens dos animais foram realizadas mensalmente. As condições ambientais durante o período da pesquisa foram caracterizadas como estressantes para novilhas. A análise física dos materiais (tgn, CTR e ITGU) indicou diferença entre os materiais de cobertura (P<0,05) sendo a telhas de fibrocimento sem amianto a mais confortável termicamente, seguida da telha galvanizada e da tela. Os valores de FR foram menores sob as telhas de fibrocimento (P<0,05) e semelhantes entre telha galvanizada e tela (P>0,05), os valores de TR não apresentaram diferença entre tratamentos somente entre horários e para a TP houve diferença (P<0,05) entre o tratamento fibrocimento e a testemunha, porém não houve entre os demais (P>0,05). A FR apresentou as respostas mais imediatas às alterações ambientais. Houve correlação da TR com a FR e a TP. Não foram observadas alterações comportamentais entre os tratamentos, os animais ficaram sob as sombras nas horas mais quentes do dia, preferencialmente em pé, o comportamento diário seguiu os padrões conhecidos para bovinos. O ganho de peso não foi alterado pelos tratamentos. A análise de custo indicou a cobertura de fibrocimento como a mais indicada para a construção de abrigos considerando-se os resultados encontrados. A pesquisa indicou haver melhora no bem estar térmico das novilhas, porém, não conseguiu determinar ganhos efetivos na utilização da sombra. / The objective of the present study was to evaluate and quantify the effect of artificial shade given by different types of roofing materials on the physiology, behavior and development of dairy heifers in a pasture environment. The present study took place from January 8, 2007 to April 30, 2007. The experimental area was divided into 16 equal, adjacent plots with 84 m2. Three roofing treatments (fiber-cement roofing tiles without amianthus, galvanized roofing tiles and 80% polypropylene screen) were compared to a control (no shade). Shelter structures had no lateral walls and measured 2m x 4m x 4m height (4m² shaded per animal). Animals consisted of 16 Holstein heifers and 16 Holstein x Jersey heifers with initial age and weight being 17.2 ± 5.6 months and 265.3 ± 66.9 kg, respectively. Animals were equally distributed among the treatments according to weight and age. At night, heifers were kept in fields with Pennisetum purpureum, also known as elephant grass. After 9:00 am, animals were taken to the experimental plots. Black globe thermometer temperature (tbg) was measured using a mini-datalogger connected to a black globe. Values were then used to calculate Radiant Thermic Load (RTL) and Black Globe Humidity Index (BGHI) of each plot. Meteorological variables were obtained from the agricultural-meteorological post at the ESALQ/USP. Respiration rate (RR), rectal temperature (RT) and skin temperature (ST) were registered weekly. Behavioral observations were recorded every other day using the focal method. Animals were weighed monthly. Environmental conditions during the research period were characterized as stressful for the heifers. Physical analysis of the material (tbg, RTL and BGHI) indicated the roofing treatments to be significantly different (P<0.05), with the fiber-cement roofing tiles without amianthus to be the most comfortable regarding temperature, followed by the galvanized roofing tiles and the 80% polypropylene screens. Respiration rate was lower under the fiber-cement roofing tiles (P<0.05) and similar under the galvanized tiles and polypropylene screen (P>0.05). RR values were lower under the fiber-cement tiles (P<0.05) and similar under the galvanized roofing tiles and polypropylene screen (P>0.05). There were no significant differences in RT values among treatments; however, a difference was found among data collection times. Concerning ST, fiber-cement tiles were significantly different from the control (P<0.05). On the other hand, there were no significant differences regarding ST among the other treatments (P>0.05). RR presented the most immediate response to environmental alterations. RT presented correlation with RR and ST. No behavioral alterations were observed among the treatments. Daily behavior followed known bovine patterns. Weight gain was not altered by the treatments. A cost analysis indicated fibercement roofing tiles to be better for shelter construction. The present study also indicated improved heifer thermal well-being; however, no effective gains could be determined from shade use.