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Background: Neuropilin (NRP) is a transmembrane protein, which has been shown to be a pro-angiogenic mediator and implicated as a potential driver of cancer progression. NRP-1 up-regulation in ovarian cancer tissue predicts poor prognosis. However, the clinical relevance of the soluble form of NRP-1 (sNRP-1) as a circulating biomarker in ovarian cancer patients is unknown. - Methods/patients cohort: sNRP-1 levels were quantified in a cohort of 88 clinically documented ovarian cancer patients by a commercially available sNRP-1 enzyme-linked immunosorbent assay (ELISA) kit (Biomedica, Vienna, Austria). Patients (81.8% with FIGOIII/IV) received primary cytoreductive surgery with the aim of macroscopic complete resection (achieved in 55.7% of patients) and the recommendation of adjuvant chemotherapy in line with national guidelines. - Results: Higher levels of sNRP-1 reflected more advanced disease (FIGO III/IV) and indicated a trend towards suboptimal surgical outcome, i.e. any residual tumor. sNRP-1 was neither related to the patients’ age nor the BRCA1/2 mutational status. Patients with higher sNRP-1 levels at primary diagnosis had a significantly reduced progression-free survival (PFS) (HR = 0.541, 95%CI: 0.304 - 0.963; p = 0.037) and overall survival (OS) (HR = 0.459, 95%CI: 0.225 - 0.936; p = 0.032). Principal component analysis showed that sNRP-1 levels were unrelated to the circulating hepatocyte growth factor (HGF) and the soluble ectodomain of its receptor the tyrosine kinase mesenchymal–epithelial transition (c-MET), suggesting that there is no proportional serological concentration gradient of soluble components of the NRP-1/HGF/c-MET signaling axis. - Conclusions: In line with the previously shown tissue-based prognostic role, we demonstrated for the first time that sNRP-1 can also act as a readily accessible, prognostic biomarker in the circulation of patients with ovarian cancer at primary diagnosis. Given its known role in angiogenesis and conferring resistance to the poly ADP-ribose polymerase (PARP) inhibitor olaparib in vitro, our results encourage more detailed investigation into sNRP-1 as a potential predictive biomarker for bevacizumab and/or PARP-inhibitor treatment.

Yes / The frequency of visits to Emergency Departments (ED) varies greatly between populations. This may reflect variation in patient behaviour, need, accessibility, and service configuration as well as the complex interactions between these factors. This study investigates the relationship between distance, socio-economic deprivation, and proximity to an alternative care setting (a Minor Injuries Unit (MIU)), with particular attention to the interaction between distance and deprivation. It is set in a population of approximately 5.4 million living in central England, which is highly heterogeneous in terms of ethnicity, socio-economics, and distance to hospital. The study data set captured 1,413,363 ED visits made by residents of the region to National Health Service (NHS) hospitals during the financial year 2007/8. Our units of analysis were small units of census geography having an average population of 1,545. Separate regression models were made for children and adults. For each additional kilometre of distance from a hospital, predicted child attendances fell by 2.2% (1.7%-2.6% p<0.001) and predicted adult attendances fell by 1.5% (1.2% -1.8%, p<0.001). Compared to the least deprived quintile, attendances in the most deprived quintile more than doubled for children (incident rate ratio (IRR) = 2.19, (1.90-2.54, p<0.001)) and adults (IRR 2.26, (2.01-2.55, p<0.001)). Proximity of an MIU was significant and both adult and child attendances were greater in populations who lived further away from them, suggesting that MIUs may reduce ED demand. The interaction between distance and deprivation was significant. Attendance in deprived neighbourhoods reduces with distance to a greater degree than in less deprived ones for both adults and children. In conclusion, ED use is related to both deprivation and distance, but the effect of distance is modified by deprivation.

Minne, stress och sömn är tre faktorer som påverkar en individs välbefinnande, hälsa och prestation. Sömn- och stressproblematik har under de senaste åren ökat såväl hos vuxna som hos universitetsstudenter. Sömnbesvär och stress är en negativ bidragande faktor till studenters studieresultat. Retrospektiva minnen (RM) är en typ av bakåtriktade minnen medan prospektiva minnen (PM) är en typ av framåtriktade minnen. Det finns tidigare forskning som visar att vuxna tenderar att ha större minnesproblem kopplat till PM än till RM. En anledning till detta kan vara att de använder sig av olika perceptuella och kognitiva processer. Samtidigt finns det forskning som visar att stress påverkar både RM och PM negativt. Studier har visat att sömnproblem har ökat hos studenter under de senaste åren. Studenter utsätts för höga krav i form av föreläsningar, lektioner och examinationer under deras studietid som i sin tur kan leda till ökad stress. Ökad stress kan därmed leda till ökade sömnsvårigheter och försämrade resultat vid minnestester. Föreliggande studie hade som syfte att undersöka sambandet mellan prospektivt minne, retrospektivt minne, stress och sömn hos 90  universitetsstudenter. Den ämnade också undersöka om det fanns några skillnader mellan RM och PM och om dessa skillnader kunde bero på stress och sömn. Samtliga faktorer i studien var baserade på självskattade enkätsvar. Det fanns ett medelstark samband mellan stress och minnessvårigheter samt mellan sömnbesvär och stress. Studenterna upplevde sig ha något sämre PM än RM. Stress och sömn låg inte bakom skillnaden mellan PM och RM. / Memory, stress, and mind are three factors affecting an individual's well-being, health, and performance. In recent years, problems related to sleep and stress have increased both for adults and for university students. Problems related to sleep and stress are a negative contributing factor to a students' study results. Retrospective memories (RM) are a type of backward memories while prospective memories (PM) are a type of forward memories. There is previous research showing that adults tend to have greater memory problems linked to PM rather than to RM. One reason for this may be that they use different perceptual and cognitive processes. On the other hand, there is research showing that stress affects both RM and PM negatively. There are studies showing increased sleeping problems for students in recent years. Students are exposed to high demands because of lectures, lessons, and examinations during their studies, which in turn can lead to increased stress. Increased stress can thus lead to increased sleep difficulties and impaired results in memory tests. The aim of this study was to investigate the relationship between prospective memory, retrospective memory, stress, and sleep in 90 university students. It also aimed to investigate whether there were any differences between RM and PM and whether these differences could be due to stress and sleep. All factors in the study were based on self-reported questionnaire responses. There was a medium-strong relationship between stress and memory difficulties and between sleep problems and stress. The students felt that they had slightly worse PM than RM. Stress and sleep were not a reason behind the difference between PM and RM.

Das Feld der diskursiven und auch normativen Bestimmungen des Archivbegriffes ist in den letzten Jahren in Bewegung geraten. Das betrifft auch Fragen nach dem Zugang zu Geschichten der Aufführungskünste und die Praxis von Archivprozessen und Sammeltätigkeiten in künstlerischen und kuratorischen Kontexten. Dieses Arbeitsbuch fasst Ergebnisse des Forschungsprojekts „Verzeichnungen. Medien und konstitutive Ordnungen von Archivprozessen der Aufführungskünste“ zusammen. Es wurde zwischen 2012 und 2017, gefördert von der DFG, in Leipzig und Berlin durchgeführt. Enthält: Performance im Museum als Historisierung; Performance der Institution Museum; Performancekunst an der Schnittstelle von visueller und darstellender Kunst; Sammeln und Archivieren als Themen der Kunst; US-amerikanische Performancekunst; Performa New York; Rituals of Rented Island New York; Radical Presence/ Black Performance; Karneval und Performance; Performancekunst in/aus Osteuropa; Reenactment und Re-Staging; MUMOK Factory und Tanzquartier Wien; dispositive Konstellationen Museum und Theater / The discursive and normative field of archivalities has considerably shifted in recent years. This shift also concerns questions of access to histories of performance-based arts as well as archival practices both in artistic and curatorial contexts. This workbook presents results of the research project “Records and Representations. Media and constitutive systems of archiving performance-based arts” conducted between 2012 and 2017 in Leipzig and Berlin with funding by DFG (German Research Foundation).

The issue of the vertical /or horizontal operation of the Bill of Rights (chapter 3) is a controversial one. The interim constitution deals with this controversy in a subtle way by avoiding direct horizontal operation of Chapter 3. Instead, it provides for the so-called 'seepage to horizontal relationships' in terms of section35{3). This apparently was a political compromise between the pro-vertical only and the pro-horizontal groups. The human rights history of this country justifies a Bill of Rights that would have both vertical and horizontal operation. However, in section 35 (3) there is potential for the values enshrined in the constitution and Chapter 3, and the spirit hereof, to permeate and filter through the entire legal system in all it's applications. It would seem, however, as demonstrated by the decision in De Klerk v Du Plessis, that the extent to which this filtering process will benefit individuals in their private relations, will depend on the interpretation given to section 35 (3) by the courts. If courts, as it happend in De Klerk's case fail to realise the full import of section 35 ( 3) aspects of the existing law which are unjust could remain and the process of creating a just, open and democratic society will be hampered. / Constitutional, International & Indigenous Law / LL.M.

This thesis explores an autoethnography which is written in the spirit of ubuntu, with and through others. Viewing this as an ethically responsible methodology for educational research conducted in and between the Global North and the Global South, this autoethnography foregrounds both self and other. The story of a practitioner- researcher unfolds around a move from disillusionment with the examinations factories of the English education system into exploring a human ethic of essential care (Boff, 2005) and a pedagogy of unconditional love (Andreotti, 2011) in a Brazilian non- government organisation. In these shifting contexts, the writer shares a journey of critical reflection (Brookfield, 1995; 2000) on ethical relationships in research and education, deconstructing the hegemonic assumptions underpinning her worldview. Borrowing insight from postmodern philosophy for education and actionable postcolonial theory in education, a journey of (un)learning unfolds as the author grapples with taken-for-granted assumptions about and in the Global South. The aims of the study emerge from a life lived forward (Muncey, 2005) through critical reflection on the ends of education and the role of the practitioner-researcher. As such, the nature of data collection becomes a process of data creation incorporating a rich tapestry of research conversations, images, sounds and other embodied memories. As ethical relations become a central focus of the author’s critical reflection, the author has sought to minimise her inflection on the data and in doing so includes many of the original contributions gifted to her throughout a two year period. Through critical self- scrutiny and reflection the author has been able to examine her own educational and cultural assumptions through a different lens in the Global South. The beauty of this autoethnography lies in exploring the kinds of intercultural spaces the author and others inhabit in twenty-first century research and classrooms.

Contexte: À date, il existe peu de données sur l’adhésion, la persistance et les coûts associés aux antidépresseurs selon le type d’assurance médicament (privé ou public). Objectif: Comparer selon le régime d’assurance médicament (privé ou public), l'adhésion, la persistance et les coûts des antidépresseurs. Méthodes de recherche: Une étude de cohorte appariée a été réalisée en utilisant des bases de données du Québec. Sujets: Nous avons sélectionné 194 patients assurés par un régime privé et 1923 patients assurés par le régime public de la Régie de l’assurance maladie du Québec (RAMQ) (18-64 ans) qui ont rempli au moins une ordonnance pour un antidépresseur entre décembre 2007 et septembre 2009. Mesures: L’adhésion, mesurée sur une période d’un an, a été estimée en utilisant le proportion of prescribed days covered (PPDC). Un modèle de régression linéaire a été utilisé afin d’estimer la différence moyenne en PPDC entre les patients assurés par un régime privé et ceux assurés par le régime public de la RAMQ. La persistance a été comparé entre ces deux groupes avec un modèle de régression de survie Cox, et le coût mensuel d'antidépresseurs ($ CAN) a été comparé entre ces deux groupes en utilisant un modèle de régression linéaire. Résultats: Le PPDC parmi les patients assurés par un régime privé était de 86,4% (intervalle de confiance (IC) 95%: 83,3%-89,5%) versus 81,3% (IC 95%: 80,1%-82,5%) pour les patients assurés par le régime public de la RAMQ, pour une différence moyenne ajustée de 6,7% (IC 95%: 3,0%-10,4%). La persistance après un an parmi les patients assurés par un régime privé était de 49,5% versus 18,9% pour les patients assurés par le régime public de la RAMQ (p <0,001), et le rapport de risque ajusté était de 0,48 (IC 95%: 0,30-0,76). Comparativement aux patients assurés par le régime public de la RAMQ, les patients ayant une assurance privée ont payé 14,94 $ CAD (95% CI: $12,30-$17,58) de plus par mois en moyenne pour leurs antidépresseurs. Conclusion: Les patients assurés par un régime privé avaient une meilleure adhésion, persistance, mais avaient aussi un plus haut coût pour leurs antidépresseurs que ceux assurés par le régime public de la RAMQ. Cette différence de coûts peut être due aux différentes exigences de paiement en pharmacie entre les deux régimes ainsi qu’aux limites des honoraires des pharmaciens imposés par le régime public. / Background: The influence of the type of drug insurance on adherence, persistence and cost of antidepressants is not well known. Objective: To compare adherence, persistence and cost of antidepressants in patients with private and public drug insurance. Research Design: A matched cohort study was conducted using prescription claims databases from Quebec, Canada. Subjects: 194 privately and 1923 publicly insured patients (18-64 years) who filled at least one prescription for an antidepressant between December 2007 and September 2009. Measures: Adherence over one year was estimated using the proportion of prescribed days covered (PPDC). The difference in mean PPDC between patients with private and public drug insurance was estimated with a linear regression model. Persistence was compared between the groups with a Cox regression model, and the monthly cost of antidepressants (CAD$) was compared between the two groups using linear regression. Results: The PPDC was 86.4% (95% CI: 83.3-89.5) in patients with private and 81.3% (95%CI: 80.1-82.5) in patients with public drug insurance and the adjusted mean difference was 6.7% (95% CI: 3.0-10.4). Persistence was 49.5% in patients with private and 18.9% in patients with public drug insurance at one year (p<0.001), and the adjusted hazard ratio was 0.48 (95%CI: 0.30-0.76). Patients privately insured paid 14.94$ CAD (95% CI: 12.30; 17.58) more per month on average for their antidepressants. Conclusion: Better adherence and persistence and higher costs were observed in privately insured patients. Cost difference might be due to different pharmacy payment requirements and pharmacists’ honorary restrictions under the public plan.

Ce travail doctoral a eu pour but de comprendre le rôle dynamique des moments de différentes intensités et valences perçues aux trois périodes d'une expérience de service (début, milieu, fin) sur la satisfaction globale dans le temps. Une revue de la littérature a été effectuée, s'articulant autour de quatre axes de recherche : l'expérience de service, la satisfaction du client, l'évaluation rétrospective d'une séquence temporelle et la mémoire, combinée alternativement à l'étude qualitative. Notre étude empirique comporte deux phases. Tout d'abord, une étude préalable a été réalisée par la méthode expérimentale en laboratoire comprenant 3 sous pré-tests. L'étude a eu pour but d'identifier 12 événements de services qui constituent ensuite une expérience (un festival) composée de trois périodes dont chacune comprend 4 différents événements (4 moments). L'étude principale a traité de ce festival en contexte réel (trois expérimentations, au Vietnam) en manipulant trois dimensions (saillance, valence et position temporelle de l'événement) avec une mesure longitudinale de la satisfaction globale (immédiatement après l'expérience, trois semaines après et six mois plus tard). Les tests des hypothèses sont réalisés à partir d'ANOVA-mesure répétée, d'équations structurelles, et d'analyse de dominance / This doctoral work attempts to understand the dynamic role of different moments within a service experience having different intensities, valences and existing across different service periods (start, middle, and end) on global satisfaction levels within a longitudinal perspective. The literature review which focuses on four streams: service experience, client satisfaction, retrospective evaluation of a temporal sequence, and memorization, was conducted alongside a qualitative study. It was followed by our empirical study which has two phases. The first phase is the preliminary studies in the laboratory wherein 3 pre-tests were conducted in order to identify 12 different moments of a service experience suitable for enactment in the final study as a real life festival. Moreover, the structure of the festival was also selected from the results of these pre-tests. In the second phase, a real life festival (3 different experiments, in Vietnam) was organized and the three dimensions (intensity, valence and temporal position) of the moments were manipulated. Additionally, a longitudinal measurement of global satisfaction (immediately after the festival, 3 weeks after the festival, 6 months after the festival) was taken. The data was subsequently treated with repeated measures ANOVA, structural equation modeling and dominance analysis. Results show differential effect of the moments on global satisfaction over time depending on the different levels of intensity, valence and temporal position