Magistrinio darbo tyrimo tikslas - nustatyti, kiek/kokius inovatyviuosius mokymo(si) metodus naudoja pedagogai heterogeninėse pagrindinio ugdymo klasėse. Tyrimo objektas - inovatyviųjų mokymo(si) metodų taikymas heterogeninėse pagrindinio ugdymo klasėse. Tyrimui atlikti buvo pasirinktas kokybinis apklausos metodas – anketinė apklausa, kuri leido surinkti informaciją apie mokytojų ir mokinių požiūrį į mokymosi inovacijas, ir stebėjimo metodas, kuriuo tiesiogiai įvertintas didaktinis vyksmas klasėje. Tyrimui pasirinktos dvi respondentų grupės – bendrojo lavinimo mokyklų pagrindinio ugdymo mokytojai, turintys darbo su specialiųjų ugdymo(si) poreikių turinčiais mokiniais patirties, ir specialiųjų ugdymo(si) poreikių turintys mokiniai, besimokantys heterogeninėse pagrindinio ugdymo klasėse. Atlikus inovatyviųjų metodų taikymo, ugdant specialiųjų ugdymo(si) poreikių turinčius vaikus, heterogeninėse klasėse tyrimą, išsiaiškinta, kad pagrindinio ugdymo mokytojai inovatyviuosius mokymo metodus vertina teigiamai ir taiko juos savo pamokose, tačiau praktiniame ugdymo procese, pasak mokytojų, susiduria su problemomis taikant alternatyvius mokymo(si) metodus, kai klasėje mokosi skirtingų specialiųjų ugdymo(si) poreikių turintys mokiniai. Pamokų stebėjimas parodė, kad heterogeninėse pagrindinio ugdymo klasėse dominuoja tradiciniai mokymo metodai: aiškinimas, pasakojimas, demonstravimas. Įvertinus mokinių veiklą pamokoje, paaiškėjo, kad specialiųjų ugdymo(si) poreikių turinčio mokinio... [toliau žr. visą tekstą] / The purpose of the study of the graduation master courses work - to determine how many and what innovative teaching methods use teachers of the basic education schools in the heterogenic classes. The object of the study is the use of innovative teaching / learning methods in the heterogenic classes of the basic school. A quantitative survey method - questionnaire survey, which allowed the collection of information on teachers and pupils approach to learning innovations, and the tracking method, which directly assessed in the classroom didactic process were chosen for the investigation. Investigation of the respondents selected the two groups - general education teachers of the basic education schools that have experience of working with special educational needs pupils, and special educational needs pupils, learners of the basic education in the heterogenic classes. After study of applied innovative methods, educating pupils with the special educational needs in the heterogenic classes, it can be said, that the monitoring protocol analysis confirmed the questionnaire data and analysis has demonstrated that innovation can help the teacher to help pupils to better know themselves, to the successful acquisition of communication skills, to develop their creativity. Innovative methods have encouraged pupils to the freedom of thought and action, provokes a variety of individual answers, teaches respect the friends ideas, promote self-sufficiency. Most of the teachers approach to... [to full text]

Small intestinal neuroendocrine tumours (SI-NETs) are rare, hormone producing and proliferate slowly. Patients usually display metastases at time of diagnosis, the tumours are difficult to cure, and the disease course is unpredictable. The gene expression pattern was investigated in paper I, with emphasis on aggressive disease and tumour progression. Expression microarrays were performed on 42 tumours. Unsupervised hierarchal clustering revealed three clusters that were correlated to clinical features, and expression changes from primary tumour to metastasis. Eight novel genes, ACTG2, GREM2, REG3A, TUSC2, RUNX1, TGFBR2, TPH1 and CDH6 may be of importance for tumour progression. In paper II, expression of ACTG2 was detected in a fraction of SI-NETs, but not in normal enterochromaffin cells. Inhibition of histone methyltransferase and transfection of miR-145 induced expression and no effect was seen after DNA methylation or selective EZH2 inhibition in vitro. miR-145 expression was reduced in metastases compared to primary tumours. Overexpression of ACTG2 inhibited cell growth, and inducing ACTG2 may have therapeutic effects. TCEB3C (Elongin A3) is located on chromosome 18 and is imprinted in some tissues. In paper III a reduced protein expression was detected. The gene was epigenetically repressed by both DNA and histone methylation in a tumour tissue specific context. The expression was also induced in primary cell cultures after DNA demethylation and pyrosequencing revealed promoter region hypermethylation. Overexpression of TCEB3C inhibited cell growth by 50%, suggesting TCEB3C to be a tumour suppressor gene. In paper IV, 69 biomarkers were analysed in blood serum using multiplex proximity ligation assay. Nineteen markers displayed different levels between patients and controls. In an extended cohort, ELISA analysis showed elevated serum levels of Mindin, DcR3 and TFF3 in patients and protein expression in tumour cells. High levels of DcR3 and TFF3 were associated with poor survival, and DcR3 may be a marker for liver metastases. Mindin, DcR3, and TFF3 are potential novel diagnostic biomarkers for SI-NETs.

The thesis presents the research results obtained while studying novel chemical strategies for preparing Si(100)-based electrochemical platforms suitable for aqueous environments. A primary research aim was the preparation of well-passivated Si(100) surfaces amenable to further chemical derivatization. The preparation and functionalization of alkyne-terminated alkyl monolayers on Si(100) surfaces using the Huisgen 1,3-dipolar ???click??? cycloaddition of azides with surface-bound acetylenes is reported and shown to be a versatile, experimentally simple, chemically unambiguous modular approach to modified silicon surfaces. Covalently immobilized, structurally well-defined acetylenyl organic monolayers are prepared from a commercially available ??,??-diyne (1,8-nonadiyne) species using a one-step thermal hydrosilylation procedure. Subsequent derivatization of the alkyne-terminated monolayers in aqueous environments with representative azide species affords disubstituted surface-bound [1,2,3]-triazole species. Neither activation procedures nor protection/deprotection schemes are required, as is the case with more established grafting approaches for silicon surfaces. The described surface modification scheme has been used in preparing modified Si(100) electrode surfaces, where modular components such as ferrocene derivatives or electrochemically ???switchable??? linker molecules are introduced onto the passivated silicon surface. An implementation study to prepare modified light-addressable ???switchable??? Si(100) electrodes is also reported. Negligible oxidation of the substrate was generally observed after exposure to aqueous systems for extended periods (tens of hours), and the electroactive monolayers showed a robust and reversible behaviour. The proposed concept of modular components and high-yielding coupling procedures has been shown on Si(100) surfaces and also extended to illustrate the functionalization of porous silicon rugate filters.

Doctor of Philosophy / First part of the thesis is focused on experimental preparation of new hard quaternary amorphous materials Si-B-C-N with high thermal stability. Materials were prepared in the form of thin films using reactive magnetron sputtering. The technique used proved to be suitable for reproducible synthesis of these materials. The Si-B-C-N films were generally found to be amorphous with low compressive stress and good adhesion to silicon or glass substrates. The process and film characteristics were controlled by varying the sputter target composition, the Ar fraction in the N2–Ar gas mixture, the negative rf-induced substrate bias, and the substrate temperature. Main conclusions describe the relationships between process parameters, discharge and deposition characteristics and film properties (elemental composition, chemical bonding structure, material hardness, compressive stress or electrical conductivity of materials prepared). Second part of the thesis is focused on ab-initio simulations of structures of experimentally prepared Si-B-C-N materials. In the performed liquid-quench simulations, the Kohn-Sham equations for the valence electrons are expanded in a basis of plane wave functions, while core electrons were represented using Goedecker-type pseudopotentials. We simplified the ion bombardment process by assuming that the primary impact creates a localized molten region of high temperature and sufficiently short cooling time, commonly referred to as a thermal spike. Main conclusions deal with N2 formation in studied materials, effect of implanted Ar on structure and properties of prepared materials, ability of Si to relieve that part of compressive stress which is caused by implanted Ar, and ability of B to improve thermal stability of Si-B-C-N materials. The calculated results are compared with experiment.

Applied research project (D. Min.)--School of Theology and Missions, Oral Roberts University, 2003. / Includes abstract and vita. Translated from Korean. Includes bibliographical references (leaves 212-218).

Applied research project (D. Min.)--School of Theology and Missions, Oral Roberts University, 2003. / Includes abstract and vita. Includes bibliographical references (leaves 160-165).

Submitted by Mayara Brandão Venturini null (mayarabventurini@hotmail.com) on 2017-12-18T12:20:52Z No. of bitstreams: 1 DISSERTAÇÃO - MAYARA BRANDÃO VENTURINI.pdf: 1794311 bytes, checksum: 8cb2b63d5bab101e64a75e9618bd8879 (MD5) / Submitted by Mayara Brandão Venturini null (mayarabventurini@hotmail.com) on 2017-12-21T12:31:26Z No. of bitstreams: 1 DISSERTAÇÃO - MAYARA BRANDÃO VENTURINI.pdf: 1794311 bytes, checksum: 8cb2b63d5bab101e64a75e9618bd8879 (MD5) / Approved for entry into archive by Laura Odette Dorta Jardim null (laura@franca.unesp.br) on 2018-01-17T19:07:21Z (GMT) No. of bitstreams: 1 DISSERTAÇÃO - MAYARA BRANDÃO VENTURINI.pdf: 1794311 bytes, checksum: 8cb2b63d5bab101e64a75e9618bd8879 (MD5) / Made available in DSpace on 2018-01-17T19:07:21Z (GMT). No. of bitstreams: 1 DISSERTAÇÃO - MAYARA BRANDÃO VENTURINI.pdf: 1794311 bytes, checksum: 8cb2b63d5bab101e64a75e9618bd8879 (MD5) Previous issue date: 2017-11-24 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / A presente dissertação é resultado de uma pesquisa de mestrado que objetivou mapear o projeto de si construído por Thomas Jefferson - terceiro presidente dos Estados Unidos da América e redator da Declaração de Independência - em sua narrativa autobiográfica. Jefferson nasceu em 1743 e morreu em 1826, no dia 04 de julho, coincidentemente, aniversário de cinquenta anos de Independência do país que ajudou a fundar. Sua autobiografia foi escrita em 1821, ocasião na qual o político, na idade de 77 anos, dedicou-se a retomar parte de sua vida e trajetória política. Os anos narrados no documento, no entanto, abrangeram um recorte temporal limitado, restringindo-se aos anos 1743 (seu nascimento) e 1790 (ano em que assumiu o cargo de Secretário de Estado do governo de George Washington). A narrativa, deste modo, não abordou alguns grandes acontecimentos de sua vida, como os dois mais altos cargos políticos ocupados por ele: a Vice Presidência e a Presidência do país (1800 – 1809). A análise se propôs a apresentar uma perspectiva geral da fonte, suas características técnicas, estruturais, conteudistas e editoriais, para depois aprofundar em algumas temáticas selecionadas entre os diversos assuntos narrados por ele no texto do documento. Os temas considerados dignos de destaque foram: a escravidão, a religião, a educação e a revolução. O primeiro, a escravidão, foi escolhido por se tratar de uma referência bastante comum à imagem do político, e que acumulou durante quase dois séculos visões completamente divergentes acerca de seus posicionamentos sobre o assunto. Os outros três, religião-educação-revolução, compõe o tripé de feitos escolhidos por ele para serem inscritos em sua lápide e, portanto, foram considerados temas de destaque e essenciais no mapeamento que fizemos de sua narrativa autobiografia. Os quatro temas de destaque, entre outros trabalhados no primeiro capítulo da dissertação, foram pensados no sentido de delinear qual “Jefferson” o autor-personagem intencionou registrar no documento, qual face de si ele buscou delegar à posterioridade. / The present dissertation is a result of a master’s research that aimed to map the “Project of self” built by Thomas Jefferson – third President of United States of America and redactor of the Declaration of Independence – on his autobiographical narrative. Jefferson was born in 1743 and died in 1826, on July 4th, coincidentally, the fiftieth independence anniversary of a country he helped to build. His autobiography was written in 1821, occasion in which the politician, at age of 77 years-old, dedicated to recapture part of his life and political trajectory. However, the years narrated on the document cover a limited temporal frame, restricting it to the years of 1743 (his birth) to 1790 (on which he assumed the office of the Secretary State of George Washington government). The narrative, thus, did not approached some of the greatest events of his life, as the two of the highest political offices occupied by him: the Vice Presidency and the Presidency (1800 – 1809). The analysis proposed to present a general perspective of the source, its technical structural and editorial characteristics, and his concern about dates and facts, in order to, posteriorly, deepen in some of the selected thematic between the several subject narrated by him in the document's text. The selected topics considered worthy of note were: slavery, religion, education and revolution. The first, the slavery, was chosen for being a fairly common reference to the image of the politician, and which accumulated during almost two centuries completely divergent visions over his positioning about the subject. The others, religion – education – revolution, are part of group of events chosen by him to be written in his grave and, therefore, were considered featured topics and essential to the mapping that we made of his autobiography narrative. The four featured topics, among others discussed at chapter one of this dissertation, were thought in a way to outline which Jefferson the author/character meant to register in the document, which part of himself the aimed to delegate to posterity.

abstract: Silicon nanowires were grown epitaxially on Si (100) and (111) surfaces using the Vapor-Liquid-Solid (VLS) mechanism under both thermal and plasma enhanced growth conditions. Nanowire morphology was investigated as a function of temperature, time, disilane partial pressure and substrate preparation. Silicon nanowires synthesized in low temperature plasma typically curved compared to the linear nanowires grown under simple thermal conditions. The nanowires tended bend more with increasing disilane partial gas pressure up to 25 x10-3 mTorr. The nanowire curvature measured geometrically is correlated with the shift of the main silicon peak obtained in Raman spectroscopy. A mechanistic hypothesis was proposed to explain the bending during plasma activated growth. Additional driving forces related to electrostatic and Van der Waals forces were also discussed. Deduced from a systematic variation of a three-step experimental protocol, the mechanism for bending was associated with asymmetric deposition rate along the outer and inner wall of nanowire. The conditions leading to nanowire branching were also examined using a two-step growth process. Branching morphologies were examined as a function of plasma powers between 1.5 W and 3.5 W. Post-annealing thermal and plasma-assisted treatments in hydrogen were compared to understand the influences in the absence of an external silicon source (otherwise supplied by disilane). Longer and thicker nanowires were associated with longer annealing times due to an Ostwald-like ripening effect. The roles of surface diffusion, gas diffusion, etching and deposition rates were examined. / Dissertation/Thesis / Ph.D. Materials Science and Engineering 2011

Submitted by PPGE PPGE (pgedu@ufba.br) on 2013-10-30T14:28:32Z No. of bitstreams: 1 DISSERTAÇÃO COMPLETA 01.pdf: 667363 bytes, checksum: 4a3c92360319e9d6b801d0463b17873b (MD5) / Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-26T14:32:27Z (GMT) No. of bitstreams: 1 DISSERTAÇÃO COMPLETA 01.pdf: 667363 bytes, checksum: 4a3c92360319e9d6b801d0463b17873b (MD5) / Made available in DSpace on 2013-11-26T14:32:27Z (GMT). No. of bitstreams: 1 DISSERTAÇÃO COMPLETA 01.pdf: 667363 bytes, checksum: 4a3c92360319e9d6b801d0463b17873b (MD5) / CAPES / Este trabalho objetivou identificar na educação que nasce com a modernidade os mecanismos produtores da subjetividade e que encontram-se apresentados na obra de Michel Foucault. Foram considerados os conceitos de arqueologia, genealogia e ética para verificar a constituição do sujeito na relação com a verdade, com o poder e com a ética, pesquisando, respectivamente, a formação dos saberes orientadores da pedagogia através das ciências humanas; as técnicas disciplinares através das instituições sociais, com destaque para a escola; e os modos de subjetivação em relação aos quais o sujeito escolar moderno passa a constituir a sua subjetividade e as experiências sobre si mesmo. Para sua efetivação, apesar das pesquisas brasileiras sobre as contribuições da filosofia de Foucault para o âmbito da educação ainda existirem em pequeno número, buscou-se acompanhar as indicações fornecidas pelo próprio filósofo e pelos seus comentadores acerca da constituição do sujeito moderno e os mecanismos de poder-saber responsáveis por tal feito. Evidenciou-se o processo de formação dos saberes que pretendem dizer a verdade sobre os sujeitos e que na esfera da educação conduzem as teorias e práticas pedagógicas. Tratou-se também das tecnologias disciplinares nas escolas, dos controles dos comportamentos, da produção da individualidade dos sujeitos escolares. Apresentou-se ainda os modos de subjetivação vivenciados pelos povos greco-romanos, a profunda influência destes para a cultura ocidental moderna, resultando em modos de relação a si intermediados pelos dispositivos de poder e de saber, transformando a ética e a moral em instrumentos para a produção de seres sujeitados às “verdades”, aos dispositivos pedagógicos. / Cette étude visait à identifier la formation qui vient avec des mécanismes modernes de la subjectivité et que les producteurs sont présentés dans les travaux de Michel Foucault. Nous avons considéré les concepts de l'archéologie, de généalogie et d'éthique afin de déterminer la constitution du sujet par rapport à la vérité, avec la puissance et l'éthique, la recherche, respectivement, la formation des connaissances par les directeurs de la pédagogie des sciences humaines, par des techniques disciplinaires institutions sociales, en particulier les écoles, et des modes de subjectivité pour laquelle le sujet est l'école moderne est leur subjectivité et des expériences sur vous-même. Pour être efficace, malgré les recherches brésiliennes sur la philosophie de Foucault contributions au domaine de l'éducation existent encore en petit nombre, nous avons essayé de suivre les instructions données par le philosophe et ses commentateurs sur la constitution du sujet moderne et les mécanismes pouvoir-savoir en compte pour un tel exploit. Démontré le processus de formation des connaissances qui veulent dire la vérité sur le sujet et de mener le domaine des théories et des pratiques éducatives d'enseignement. Il a été également les technologies disciplinaires dans les écoles, le comportement des contrôles, la production de l'individualité de l'école sujet. Il a également présenté les modes de subjectivité vécue par le peuple gréco-romaine, à l'influence profonde de la culture occidentale moderne, résultant par rapport à d'autres modes médiée par les systèmes de pouvoir et de connaissances, de transformer l'éthique et la morale à outils production d'êtres humains soumis à des «vérités», les dispositifs pédagogiques.

Submitted by Márcia Masson Mendes dos Santos (marciamassonuema@gmail.com) on 2018-11-21T20:34:28Z No. of bitstreams: 1 Dissertação_Márcia_Masson_Mendes_dos_Santos.pdf: 2013418 bytes, checksum: a7ffdc8519b32629b31668be09788774 (MD5) / Rejected by Neli Silvia Pereira null (nelisps@fcav.unesp.br), reason: Solicitamos que realize correções na submissão seguindo as orientações abaixo: 1- O agradecimento à CAPES deve ter a seguinte redação: O presente trabalho foi realizado com apoio da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Código de Financiamento 001 2- A numeração das páginas com os números arábicos está incorreta. O correto é iniciar a numeração arábica com o número 1 e não com 11 como está. Agradecemos a compreensão. on 2018-11-22T11:27:39Z (GMT) / Submitted by Márcia Masson Mendes dos Santos (marciamassonuema@gmail.com) on 2018-11-22T18:07:52Z No. of bitstreams: 1 Dissertação_Márcia_Masson_Mendes_dos_Santos.pdf: 1256487 bytes, checksum: b81e3608c69ac9372514e78e527c28de (MD5) / Approved for entry into archive by Neli Silvia Pereira null (nelisps@fcav.unesp.br) on 2018-11-23T16:58:24Z (GMT) No. of bitstreams: 2 Dissertação_Márcia_Masson_Mendes_dos_Santos.pdf: 1256487 bytes, checksum: b81e3608c69ac9372514e78e527c28de (MD5) santos_mmm_me_jabo.pdf: 1256487 bytes, checksum: b81e3608c69ac9372514e78e527c28de (MD5) / Made available in DSpace on 2018-11-23T16:58:24Z (GMT). No. of bitstreams: 2 Dissertação_Márcia_Masson_Mendes_dos_Santos.pdf: 1256487 bytes, checksum: b81e3608c69ac9372514e78e527c28de (MD5) santos_mmm_me_jabo.pdf: 1256487 bytes, checksum: b81e3608c69ac9372514e78e527c28de (MD5) Previous issue date: 2018-08-23 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / O mineral silício (Si) é considerado um elemento essencial para o ser humano, tendo diversas funções, especialmente a para formação óssea. O tomate é amplamente consumido no mundo, mas apresenta baixo teor de Si, não atendendo a exigência do ser humano. A pulverização foliar de Si em plantas tomate pode promover a biofortificação associada à melhora na qualidade pós-colheita, dependendo da fonte e da concentração do elemento na calda. Neste estudo, objetivou-se obter tomates biofortificados via pulverização foliar com Si, em diferentes fontes e concentrações, e avaliar sua qualidade tecnológica. O experimento foi conduzido em casa de vegetação, em sistema de cultivo hidropônico, em vasos (8 dm3) preenchidos com areia, contendo uma planta por vaso. Os tratamentos consistiram da combinação de quatro fontes de Si (silicato alcalino estabilizado; nanossílica; ácido silícico estabilizado e silicato de potássio) e quatro concentrações de Si (0,0; 0,2; 0,4 e 0,6 g L-1), dispostos em blocos casualizados, com cinco repetições. Realizaram-se cinco pulverizações com Si nas plantas de tomate cultivar Micro Tom, iniciando-se no florescimento, uma vez por semana. A pulverização foliar de Si durante a fase reprodutiva das plantas de tomate foi eficiente para biofortificar o fruto e incrementar o teor de ácido ascórbico, a acidez titulável e a firmeza do fruto, destacando-se a fonte nanossílica e ácido silícico na concentração próxima de 0,4 g L-1. / The mineral silicon (Si) is considered an essential element for humans, having several functions, especially for bone formation. Tomato is a fruit widely consumed in the world but the low Si content does not meet the standard requirements for human beings. To this end, foliar spraying of tomato plants with Si may promote biofortification associated with improved post-harvest quality, depending on the source and concentration of Si used in the spraying mixture. This study aimed at producing tomatoes biofortified with Si at varying concentrations from different sources via foliar spraying, and evaluating their technological quality as well. The experiment consisted of pots (8 dm3) filled with sand containing one Micro-Tom cultivar tomato plant per pot in a greenhouse, in a hydroponic culture system. The treatments consisted of a combination of four Si sources (stabilized alkali metal silicate, nano silica, stabilized silicic acid, and potassium silicate) and four Si concentrations (0.0; 0.2; 0.4; and 0.6 g L-1), arranged as a randomized block design, with five replications. Five spraying mixtures containing Si were applied to the tomato plants once a week as the flowering stage started. Foliar spraying of Si during the reproductive phase of tomato plants effectively biofortified the fruit, increasing the ascorbic acid content, titratable acidity and fruit firmness, highlighting as particularly effective the nano silica and silicic acid sources at the approximate concentration of 0.4 g L-1. / 001