M.Ing. (Engineering Management) / The current research investigated the inter-relationship between Steve Jobs and Apple Company. The study looked at Steve if he launched Apple with business orientation. The researcher used Yin’s (1994) single case, holistic design research method and looked at the data gathered from thirty-seven authors. Steve Jobs’ business orientation was measured using Snaddon (2008) business measures. Symbols were used to indicate whether the evidence found from different sources is direct, indirect, negative or if there was no evidence at all. A score that ranged from -1 for negative evidence to +2 for direct evidence was assigned to evidence from each author; then the total score that represented evidence from all thirty- seven authors on each business measure was presented in the results column (see table 4). Based on the total score of each measure, the strength of the relationship was established. The results showed that there was an inter-relationship between Steve Jobs’ business strategy and the Snaddon (2008) business measures. The evidence gathered did not support the hypothesis that Steve Jobs had little business orientation and the conclusion drawn was that Steve was business oriented when he (and his partners) launched Apple Company.

Penicillium expansum est un contaminant commun des pomaceae (pommes et poires) causant la pourriture bleue. Ce champignon est le principal responsable de la présence de patuline dans les pommes et ses produits dérivés. Actuellement, la voie de biosynthèse de la patuline n’est que partiellement élucidée et le cluster de gènes correspondant n’est décrit que chez Aspergillus clavatus, champignon tellurique incapable de se développer dans les pommes. La caractérisation moléculaire de la voie de biosynthèse de la patuline est la condition sine qua none à toute étude visant à comprendre la régulation de la biosynthèse de la patuline, mais également à toute action permettant de limiter sa synthèse. C’est pourquoi le premier objectif de cette thèse a été de caractériser le cluster de gènes spécifique de la voie de biosynthèse chez Penicillium expansum. Celui-ci est caractérisé par une taille de 40 kb et contient les 15 mêmes gènes qu’Aspergillus clavatus, les seules différences résidant dans l’organisation et l’orientation des gènes. La caractérisation de la seconde étape de la voie de biosynthèse de la patuline a été ensuite entreprise chez Aspergillus clavatus, organisme modèle. Le gène patG code pour l’acide 6-méthylsalicylique décarboxylase responsable de la conversion de l’acide 6-méthylsalicylique en m-crésol. Pour faire suite au premier objectif, la régulation de la voie de biosynthèse de la patuline a été étudiée. Pour cela, une souche mutante pour le facteur de régulation spécifique à la patuline patL a été généré puis la production de patuline ainsi que l’expression des gènes du cluster analysés. Les résultats de cette étude ont montré que le gène patL joue le rôle d’interrupteur au sein du cluster. L’absence de patL conduit à une extinction totale de l’expression des gènes du cluster et à une abscence de production de patuline par Penicillium expansum. Dans cette même étude, des tests de pathogénicité ont été entrepris sur des pommes de différentes variétés démontrant ainsi que la patuline peut être un facteur de virulence facilitant l’infection de certaines variétés de pommes telles que la Golden Delicious ou la Pink Lady. Enfin, l’influence de la lumière a été évaluée en analysant l’impact de différentes longueurs d’ondes sur la croissance et la production de patuline de Penicillium expansum. Que ce soit in-vitro ou in-vivo, la croissance et la production de patuline sont très affectés par les lumières blanche, bleue et rouge. Favoriser le stockage des pommes sous les lumières blanche, bleue ou rouge plutôt qu’à l’obscurité pourrait devenir un moyen de prévention contre la contamination par Penicillium expansum. En conclusion, cette thèse présente un aspect fondamental avec la caractérisation du cluster de gènes chez Penicillium expansum et la caractérisation de la seconde étape de la voie de biosynthèse de la patuline ; mais aussi un aspect appliqué avec l’utilisation des lumières de différentes couleurs comme méthode de prévention contre Penicillium expansum durant le stockage des pommes. / Penicillium expansum is the common contaminant of apples and the causal agent of blue mold rot. This fungus is the main patulin producer in apple based products. Actually, the patulin biosynthesis is partially elucidates and the gene cluster has been elucidated in Aspergillus clavatus, a telluric fungi unable to grow on apples. The molecular characterization of the patulin biosynthetic pathway is the key step for a better understanding of the mechanisms leading to patulin production and will help to define strategies to reduce its presence in apple products. The first objective of this thesis was the characterization of the patulin gene cluster in Penicillium expansum. The latter includes the same 15 genes as in Aspergillus clavatus but in a different order and orientation. Then, the second step of this biosynthetic pathway has been characterized and the patG gene encode for the 6-methylsalicylic decarboxylase involved in the 6- methylsalicylic acid conversion into m-cresol. The second objective consists of the study of the patulin regulation. For that, a patL mutated strain was generated and the patulin production and the patulin gene cluster expression were assessed. The mutation of this gene results in a down-regulation of the rest of the genes in the cluster associated with a lack of patulin production. Pathogenicity tests on apples revealed that patulin could act as a virulence factor in some apple varieties, like Golden Delicious or Pink Lady. In the last part of this thesis, the influence of different wavelength lights on the growth and the patulin production by Penicillium expansum were assessed in vitro and in vivo. In both cases, growth and patulin production were significantly affected under white, blue and red lights. Consequently, the apple storage under these lights could be a good alternative to the storage in the dark. In conclusion, this thesis presents a fundamental aspect that consist in the characterization of the patulin gene cluster in Penicillium expansum and the characterization of the second step of this pathway. An applied aspect is also provided by the use of the different wavelength lights to prevent the Penicillium expansum contamination during apple storage.

The main objective of this thesis is to study the impact of Apple Inc. innovation activities on its successful performance. Specification of this goal implies the existence of a direct relationship between the development of company's net sales and the development of its market value. The thesis is divided into theoretical and practical part where the theoretical part is focused on the issues of invention and innovation, the innovation process and, last but not least, the link between innovation, strategic management and marketing. The theoretical part also defines the understanding of the term "successful performance of the company" in accordance with the main objective of this thesis. The practical part is focused on the application of gathered knowledge. It aims to assess the impact of innovation activities on the development of Apple Inc. net sales and to analyze the competitive position of its major product categories in the context of individual markets. Furthermore, the practical part is focused on Apple Inc. market capitalization, as a defined indicator of the company's success, its historical position and comparison with major competitors in the technology industry. Applying the method of linear regression analysis, the final section of the thesis evaluates the existence of the relationship described above and provides a possible product innovation charter of Apple Inc.

The main subject of this diploma thesis is the mobile digital distribution market. The first chapter defines important terms and describes the area comprehensively. The second chapter lists examples of some platforms, shows statistical data and introduces common business models. The third chapter compares the Apple App Store and Google Play based on selected criteria. The fourth chapter deals with conducted survey data in order to test the hypothesis that czech consumers in general do not show a difference in attitude towards mobile distribution storefronts compared to their foreign peers. The fifth and last chapter tries to analyze technical backgrounds of varying content availability across different countries. Also, it deals with selected legal issues.

The goal of this thesis is to analyze whole new market of touch devices. It describes main competitors of this market and tries to uncover reasons of their success. Main focus of this paper is to descibe new concepts of those touch devices, which through its disruptive inovations created whole new trend in the field of information technology. Another goal of this thesis is to describe ways of doing business with those devices. To do this, thesis focuses on applications for touch devices, mainly on Apple devices and operationg systém iOS. After that thesis defines few forms in which this business can be done (which are basically forms of application development). Because of that thesis is further focused mainly on applications themselves. App Store, as a revolutionary distribution method for applications, is described in detail. In the end of this paper there is a complete example of creating application.

Pollination-dependent fruit trees grown in home gardens play an important role in the agricultural based economy of Central Asian countries, yet little is known about the status of pollinator communities, the cultivated plant composition or the factors that influence management practices in Kyrgyz home garden agroecosystems. As agricultural systems are human created and managed, a logical approach to their study blends anthropological and ecological methods, an ethnoecological approach. Over three years, I investigated how species richness and abundance of Hymenoptera, cultivated plants, and home garden management were related using quantitative and qualitative methods in the Issyk-kul Man and Biosphere reserve. Structured surveys were undertaken with heads of households using a random sample stratified by village. Gardens were then mapped with participation of household members to inventory edible species in gardens, most of which are pollinator-dependent, and to compare home garden diversity as reported by respondents during interviews. Apple diversity was studied to the variety level to understand respondents’ classification system in the context of in situ agrobiodiversity conservation. Household members identified 52 edible plant species when mapping the garden, compared with 32 reported when interviewed. The proportion of plant species received from others through exchange and the number of plots cultivated significantly explained the variation in edible plant diversity among gardens. Insects were sampled in gardens and orchards to determine potential pollinator community composition and the effect of different management practices on Hymenoptera richness and abundance. I collected 756 Hymenoptera individuals (56 bee; 12 wasp species); 12 species were new records for Kyrgyzstan or within Kyrgyzstan. Economic pressures to intensify cultivation could impact management practices that currently promote diversity. A home garden development initiative was undertaken to study management practice improvement. Participants in the initiative had higher adoption rates than controls of management practices that improve long-term yield, ecological sustainability and stability of home gardens. Home gardens, as currently managed, support abundant and diverse pollinator communities and have high cultivated plant diversity with few differences in community composition between garden management types.

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Teams are being used more in organizations to do important work. However, both positive and negative effects come with the increased use of teams. One problem is the "bad apple" effect where a highly disagreeable team mate, for example, damages team performance. This research aims to study how this person damages team performance and what can be done to minimize the negative impact. I propose that a disagreeable teammate negatively impacts team affective states which in turn give rise to defensive behaviors among teammates. These defensive behaviors impact team processes which in turn impact the team's performance. In addition, I propose that team interdependence moderates the impact of disagreeableness on teammate affective reactions such that teammates in less interdependent contexts will react less negatively to the "bad apple." I designed a 2x2 lab experiment with a confederate, or trained research participant, to test these hypotheses. I manipulated disagreeableness through the behaviors of the confederate and I manipulated interdependence through the information, goals, and rewards of the teams. Results support all the hypothesized relationships. Of note, I found that interdependence interacted with disagreeableness to predict team affective reactions as measured by salivary cortisol - a well established biomarker for affective reactions. I also found support for a mediating model using team core affect or affective culture mediating the impact of disagreeableness on team process. Finally, I found support for a mediated moderation model demonstrating that the moderation of interdependence and disagreeableness on team process was mediated by team cortisol. However, the impact on process was in the opposite direction than expected. Namely, that more interdependent teams had higher processes despite elevated cortisol levels indicating a negative affective, or stress reaction. This counterintuitive finding has implications for future research attempting to discover useful methods of minimizing the impact of a disagreeable teammate on the team.

Iodine is an essential nutrient for humans, which is often not ingested through food in adequate quantities. Currently, Germany is once again one of the countries in which there is an iodine deficiency in the population. Women between the ages of 20 and 40 are particularly affected, a critical situation since pregnant and lactating women have an increased iodine requirement. Iodization of table salt is a widely used prophylactic measure. However, this method is not sufficient and may become less important in the future if further dietary salt reduction occurs, as nutritionists are demanding. Alternative approaches are therefore needed to improve the supply. One of these approaches is the agronomic biofortification of food crops. In this process, iodine is applied via fertilization measures during the cultivation of the plants. This gives the plants the ability to take up the mineral, which is only available in the soil to a very limited extent. In recent years, many studies have been published on the biofortification of vegetables and cereals. Foliar fertilization measures have proven to be significantly more efficient than soil fertilization measures. Nevertheless, up to now few results are available on the biofortification of fruit crops. However, fruit is also important for a healthy diet and the iodine supply of humans can only be improved if as many iodine-rich foods as possible are available. Therefore, the aim of this work was to investigate iodine biofortification of berry and tree fruit species in more detail. In order to be able to achieve this objective, trials were performed over several years with strawberries, apple and pear trees. In addition to suitable application methods, the aim was to determine the iodine form (iodide and iodate) and the necessary iodine quantity. On the one hand, the measured iodine contents in the fruit and leaf tissue allowed conclusions to be drawn about the translocation of iodine in the plant. On the other hand, this made it possible to evaluate the basic suitability for iodine biofortification of the fruit crops investigated. Since iodine has a phytotoxic effect above a certain amount, the plant compatibility should also be tested. In addition, common household processing methods, such as washing or peeling the fruit, as well as fruit storage over several months, should provide information on the extent to which such measures could reduce the iodine content. Another study parameter was the soluble solids content, as there is evidence that iodine can affect the sugar content of fruit. Furthermore, a combined application of potassium nitrate and selenium was carried out and their influence on iodine and sugar content was investigated. Selenium is also an essential trace element, which is usually inadequately absorbed through the diet. The results of the investigations showed that it was possible, in principle, to raise the iodine content of strawberries, apples and pears to a level of 50 to 100 µg iodine per 100 g fresh mass. In the case of strawberries, however, this was only feasible if the plants were in their first year of cultivation and the iodine was applied by foliar fertilization shortly before harvest. In the 2nd and 3rd year of cultivation, the plants had a very dense canopy, which prevented direct wetting of the fruit. However, direct wetting of the fruit surface with the iodine solution is imperative, as this was the only way to achieve a reliably high iodine content in the fruit mass. Soil fertilization proved to be completely unsuitable in trials with strawberries and apple trees. The translocation of iodine after soil fertilization occurred mainly via the xylem transport into the strongly transpiring leaves and not into the fruits. In addition, compared to a foliar application, a significantly higher iodine application rate was required. Furthermore, experiments with apple trees cultivated in a plastic tunnel, protected from precipitation, showed that the iodine transfer via the phloem into the fruits was only marginal. With regard to the phytotoxic effect of iodine application, no consistent difference was observed between potassium iodide and potassium iodate. Both forms of iodine did not affect yield or average individual fruit weight. Damage to fruit was not observed in any variant. However, with increasing iodine levels, significant damage to leaves was noticeable. Apple and pear trees also showed early leaf fall. Iodide generally led to significantly higher iodine contents in the plant mass after foliar application, but this was also associated with high fluctuations. With iodate, it was possible to reliably achieve the targeted iodine content in the fruit mass of apple and pear trees with an application rate of 1.5 kg iodine per hectare and meter canopy height. Washing the fruit reduced the iodine content of strawberries by up to 30%. For apples and pears, this value was about 14% at harvest and about 12% after 3 months of storage. Peeled apples and pears showed a significantly reduced iodine content. 51% of the iodine in apples was bound in the fruit peel or the cuticular waxes. A reduction of 73% was determined for pears. Cold storage for 3 months resulted in a significant loss of iodine in parts of the apple peel. At this point, the release of volatile iodine compounds is probably the cause of the reduction. However, this would still have to be confirmed by further investigations. Iodine application had a negative effect on the soluble solids content of strawberries above a certain level. It was not possible to observe significant changes for pome fruit in the trials conducted. However, the application of potassium nitrate (alone and in combination with iodine) resulted in an increase. Iodine uptake remained unaffected by the combined application of potassium nitrate and selenium. However, it was shown that selenium has a comparable uptake and translocation pattern to iodine and that a combined biofortification with both minerals is, in principle, possible. Accordingly, apple and pear trees are well suited for biofortification with iodine by foliar fertilization. However, further trials in commercial orchards are necessary to implement this process. In the future, appropriately fortified fruit could make an important contribution to the alimentary iodine supply for humans.

Positioning of mobile phones or other handheld devices in indoor environments is hard because it’s often not possible to retrieve a GPS-signal. Therefore, other techniques need to be used for this. Despite the difficulties with indoor positioning, the Swedish mining company LKAB want to do exactly this in their processing plants. LKAB has developed an Apple iPhone mobile application to maintain real-time process data and documents for their machines. To retrieve the information an OCR code need to be manually scanned with the application. Instead of manually scanning these codes, LKAB want to develop an Indoor Positioning System that can automatically locate handheld devices in their production plants. This thesis aimed to create a proof of concept Apple iOS application that can position devices without GPS-signals. In the system developed Bluetooth Low Energy iBeacons is used to transmit data to the application. From this data Received Signal Strength Indication values is collected and sent off to a server that transform the values into positioning fingerprints. These fingerprints are used together with the classification algorithms K-Nearest Neighbour to determine in which, on pre-hand created, group the user is located. In these created groups there is a defined set of machines that is being presented back to the user. Test results conducted with the proof of concept application shows that the implemented system works and gives a positioning accuracy of up to 75%.