Writers and historians from earlier centuries imagined Anne Boleyn as a villain; a forward and evil woman intent on destroying Henry VII and his image. Modern accounts have been more accommodating, offering that she was misunderstood due to the constraints of the times. In an attempt to discover the historical Anne, I will be comparing and contrasting how she has been perceived in fiction and non-fiction literature, and will examine how the perception of Anne has shifted through time.

No description available.

A doença de von Willebrand (DvW) é uma coagulopatia hereditária, causada por defeitos qualitativos ou quantitativos do fator de von Willebrand. O tratamento e a prevenção das intercorrências da DvW são bastante dispendiosos e, em geral, se baseiam na administração de concentrado de Fator VIII/FvW (CFVIII/FvW) e/ou da Desmopressina (DDAVP). Em muitas situações, o DDAVP é um tratamento eficaz que não expõe os pacientes aos riscos de contaminação viral e apresenta custo inferior quando comparado ao CFVIII/FvW. No entanto, a dificuldade de diagnóstico e classificação da DvW, bem como o baixo número de pacientes que se submetem ao teste para avaliação da resposta ao DDAVP, restringem a indicação do DDAVP como alternativa terapêutica para esses pacientes. O objetivo deste estudo foi avaliar retrospectivamente a indicação, o uso e o custo dos medicamentos no tratamento de pacientes com DvW com DDAVP e CFVIII/FvW no Hemocentro de Belo Horizonte no período entre 2011 a 2013. Este estudo incluiu 124 (24,22%) pacientes com DvW atendidos no hemocentro. Em 18 pacientes (14,52%) o diagnóstico de DvW não pode ser confirmado. Doze pacientes (9,68%) não puderam ser classificados e 73 foram classificados como tipo 1, 19 como tipo 2 e 2 pacientes como tipo 3. Oitenta e um pacientes fizeram o teste de DDAVP, sendo que 87,65% foram considerados responsivos. Nos pacientes tipo 1, a taxa de resposta ao DDAVP foi de 92%. Quase 32% dos pacientes tipo 1 não realizaram o teste. No período avaliado, foram utilizadas 3.794mcg de DDAVP (R$13.165,18) e 1.582.250 UI de CFVIII/FvW (R$1.075.930,00). Vinte por cento dos pacientes responsivos ao DDAVP utilizaram CFVIII/FvW em indicações onde o DDAVP poderia ter sido considerado (69.200UI de CFVIII/FvW versus 131 ampolas de DDAVP). Nos pacientes potencialmente responsivos ao DDAVP 108.700UI de CFVIII/FvW (R$73.916,00) poderiam ter sido substituídas por 247 ampolas de DDAVP (R$3.428,36). A escolha do DDAVP nessas situações poderia representar uma economia de 95,7% do valor gasto no tratamento do grupo de 27 pacientes responsivos e potencialmente responsivos ao DDAVP e 10,6% do valor total gasto para todo o tratamento dos pacientes no período do estudo. Estudos mais complexos de farmacoeconomia serão necessários para avaliar a magnitude da economia gerada com esse uso. O presente estudo mostrou que o DDAVP é uma alternativa terapêutica de menor custo, cuja indicação e utilização podem ser ampliadas no tratamento dos pacientes com DvW. Dessa maneira, a implementação de estratégias visando melhorar o diagnóstico, a classificação da doença, o acesso à testagem quanto à resposta ao DDAVP, bem como a conscientização dos profissionais de saúde e pacientes, quanto ao custo e segurança do DDAVP podem contribuir para o uso racional dos recursos destinados a essa parcela da população. / Von Willebrand disease (VWD) is a hereditary coagulopathy caused by qualitative or quantitative defects on von Willebrand factor. The treatment and the prevention of VWD complications is quite expensive and is generally based on the administration of vWF:FVIII Concentrates and/or Desmopressin (DDAVP). In many situations, DDAVP is an effective treatment that does not expose patients to viral contamination risks and presents a lower cost when compared to vWF:FVIII concentrates. However, the difficulty of diagnosis and classification of VWD, as well as the low number of patients tested to their responsiveness to DDAVP, restrict the use of DDAVP as an alternative treatment for these patients. The aim of this study was to evaluate retrospectively the clinical indications, the use and the cost of treatment of VWD patients with DDAVP and vWF:FVIII concentrates in the Blood Center of Belo Horizonte between 2011 and 2013. This study enrolled 124 (24.22%) VWD patients attended at the Blood Center.For18 (14.52%) patients, the diagnosis of VWD could not be confirmed. Twelve patients (9.68%) could not be classified and 73patients were classified as type 1, 19 as type 2 and 2 as type 3. Eighty-one patients were tested for DDAVP response and 87.65% (n=71) were considered responsive for the treatment. For type 1 VWD patients, the response rate to DDAVP was 92%. Almost 32% of type 1 VWD patients were not tested. In the period evaluated, 3,794mcg of DDAVP (R$ 13,165.18) and 1,582,250 IU of vWF:FVIII concentrates (R$ 1,075,930.00) were used. Between the cases with clinical indication of DDAVP use, 20% patients used vWF:FVIII concentrates (69.200UI of vWF:FVIII versus 131ampoules of DDAVP). In patients with good responsive to DDAVP, 108,700 IU of vWF:FVIII concentrates used (R$ 73,916.00) could be replaced by 247 ampoules of DDAVP (R$ 3,428.36). The choice of DDAVP in these situations could represent an economy of 95.7% of the value spent on the treatment of the 27 responsive and potentially responsive patients to DDAVP and 10.6% of the total value spent for the entire treatment of patients in the study period. More detailed studies of pharmacoeconomics are necessary to assess the magnitude of the economy generated by the use of DDAVP. This study demonstrated that DDAVP is a lower cost therapeutic alternative whose indication and use can be enhanced in the treatment of VWD patients. In this context, adoption of strategies to improve the differential diagnosis, expand the DDAVP responsiveness test, and aware health professionals and patients about the costs and safety use of DDAVP, could contribute to the rational use of resources designated to treatment of VWD.

The regional security aspect is becoming increasingly more important within security studies. The United Nations and the United Nations Security Council has expressed an intent to utilize regional organizations as security actors with regards to maintaining international peace and security, with the purpose of achieving a greater sense of legitimacy for conflict resolution. This study aims to explore the possibilities of using such organizations within regions of varying stability, and how this usage can relate to the idea of legitimacy. Based on regional security complex theory, this study seeks to show how regional organizations have been used by the Security Council within different security sectors, and how this usage is affected by the degree of integration within the region. The result of the study show that the idea of legitimacy is easiest to achieve in regions with a mid-level degree of regional integration and concerning questions of political security. The results also show a tendency within the Security Council to use organizations from other regions with higher levels of integration in regions with lower levels of integration, and raises the question if this way of using regional organizations may risk harming the ultimate goal of legitimacy.

The subject of this thesis is strength design of pipe connecting furnace of continuous catalytic reforming with reactor. First is realize analytical design of individual parts according to ASME VIII, ČSN EN 12952-3 a ČSN EN 13480-3. It is also design and optimize supporting pipe using Caesar II. At the end of work is creating isometric documentation.

Background: Studies have described the aggregate results of federal funding for health professions education at the national level, but analysis of the long‐term impact of institutional participation in these programs has been limited. Purpose: To describe and assess federally supported curricular innovations at East Tennessee State University designed to promote family medicine and nurse practitioner graduate interest in rural and underserved populations. Methods: Descriptive analysis of a survey to determine practice locations of nurse practitioner graduates (1992‐2002) and graduates of 3 family medicine residencies (1978‐2002). Graduates’ (N = 656) practice locations were documented using specific federal designations relating to health professions shortages and rurality. Results: Overall, 83% of family medicine residency and 80% of nurse practitioner graduates selected practice locations in areas with medically underserved or health professions shortage designations; 48% of family physicians and 38% of nurse practitioners were in rural areas. Conclusions: Graduates who study in an educational setting with a mission‐driven commitment to rural and community health and who participate in curricular activities designed to increase their experience with rural and underserved populations choose, in high numbers, to care for these populations in their professional practice.

In the sixteenth century, Martin Luther's Protestant Reformation generated multiple reform movements and political transformations in Europe. Within this general period of reform, political and cultural changes from the Tudor era (1485-1603) created a separate English Reformation. The English Reformation evolved from the different agendas of the early Tudor monarchs and occurred in two distinct waves: an initial, more moderate Henrician Reformation and a later, more complete Edwardian Reformation. Henry VIII and Edward VI's attempts to redefine monarchy through a new State and Church identity drove English church reform during this period, giving these religious shifts distinct political roots. Cultural artifacts were prominent indicators of these differing political goals, and Henry VIII and Edward VI adjusted and removed images and texts according to their propaganda methods. These royal manipulations of culture are well-documented, but historians have overlooked important components in the communication process. Lay responses to imagery changes ranging from compliance to rebellion demonstrate the complex relationship of images, monarchy, and reform. Examining images' function as propaganda with questions of intent, reception, and comprehension in royal communication is imperative for assessing the impact of royal messages on Tudor culture. Analyzing Tudor art as a form of political communication that disseminated idealized political representation reveals a strong visual discourse between the King and the English people. Images held key powers within royal discourse to create and disseminate propaganda of a kingship.

Les cristaux d'UMS sont connus comme agents étiologiques de la goutte et au cours de l'accès goutteux, le neutrophile est une des premières cellules immunitaires à s'accumuler en grand nombre au site inflammatoire dans les cavités articulaires. Durant l'inflammation, le plasma traverse les vaisseaux sanguins et transporte les protéines vers le site enflammé. Plusieurs protéines plasmatiques peuvent alors servir à recruter le neutrophile, comme les composants du complément (C5a ), les kinines (bradykinine ou agonistes du récepteur B1) et bien d'autres. Au début de l'inflammation, initialement les cristaux interagissent probablement avec le plasma et ses protéines recouvrent les cristaux. Cependant, nous savons que le plasma ayant servi à l'opsonisation des cristaux d'urate monosodique subit des changements conduisant à l'activation du système du complément. Ainsi, les objectifs de ce mémoire étaient de confirmer la libération du facteur C5a et de la bradykinine dans le plasma humain activé par les cristaux d'urate monosodique et de déterminer les effets de ces facteurs plasmatiques sur l'activité du neutrophile. La chimiotaxie a été étudiée en réponse au plasma activé par les cristaux, mettant en évidence la présence de facteurs du complément, en particulier le C5a qui est majoritairement responsable de cette chimiotaxie. Le plasma activé provoque aussi une mobilisation de calcium par l'intermédiaire du C5a et certainement par d'autres facteurs qui ne sont pas encore identifiés. Les résultats obtenus ont aussi montré que l'agoniste du récepteur B1 des kinines induisait la migration des neutrophiles. En revanche, nous n'avons pas réussi à identifier la bradykinine dans le plasma ayant servi à l'opsonisation des cristaux d'UMS. Les résultats de notre travail servirons de base pour des études subséquentes sur le plasma activé par les cristaux d'UMS.

A number of recent successful authorship studies have relied on a statistical analysis of language features based on function words. However, stylometry has not been extensively applied to Elizabethan and Jacobean dramatic questions. To determine the effectiveness of such an approach in this field, language features are studied in twenty-four plays by Shakespeare and eight by Fletcher. The goal is to develop procedures that might be used to determine the authorship of individual scenes in The Two Noble Kinsmen and Henry VIII. Homonyms, spelling variants and contracted forms in old-spelling dramatic texts present problems for a computer analysis. A program that uses a system of pre-edit codes and replacement /expansion lists was developed to prepare versions of the texts in which all forms of common words can be recognized automatically. To evaluate some procedures for determining authorship developed by A. Q. Morton and his colleagues, occurrences of 30 common collocations and 5 proportional pairs are analyzed in the texts. Within-author variation for these features is greater than had been found in previous studies. Univariate chi-square tests are shown to be of limited usefulness because of the statistical distribution of these textual features and correlation between pairs of features. The best of the collocations do not discriminate as well as most of the individual words from which they are composed. Turning to the rate of occurrence of individual words and groups of words, distinctiveness ratios and t-tests are used to select variables that best discriminate between Shakespeare and Fletcher. Variation due to date of composition and genre within the Shakespeare texts is examined. A multivariate and distributionfree discriminant analysis procedure (using kernel estimation) is introduced. The classifiers based on the best marker words and the kernel method are not greatly affected by characterization and perform well for samples as short as 500 words. When the final procedure is used to assign the 459 scenes of known authorship (containing at least 500 words)almost 112 95% are assigned to the correct author. Only two scenes are incorrectly classified, and 4.8% of the scenes cannot be assigned to either author by the procedure. When applied to individual scenes of at least 500 words in The Two Noble Kinsmen and Henry VIII, the procedure indicates that both plays are collaborations and generally supports the usual division. However, the marker words in a number of scenes often attributed to Fletcher are very much closer to Shakespeare's pattern of use. These scenes include TNK IV.iii and H8 I.iii, IV.i-ii and V.iv.

Thesis (MPhil)--Stellenbosch University, 2003 / ENGLISH ABSTRACT: The object of this study is to assess African Christian beliefs in ancestors in lieu of a responsible interpretation of 1 Corinthians 8 :4 - 6. Warranting this assessment is the confusion that arises from the perception that African beliefs in ancestors and the tenets of Christian faith are compatible. Scriptural teaching seems to address the question of "ancestral worship" and does seem to portray it as something mutually exclusive to the tenets of Christian faith. Some of the authors cited in the thesis attest to this, and others seem to be rising in defence of "ancestor worship" by accommodating it without any problem on the same level as Christianity. Syncretism arises in the desire to strike a compromise between the two religions and allow African Christians to practise "ancestor worship" whilst confessing to be Christians at the same time. The selected text, ] Corinthians 8: 4-6, will be the centre of the assessment into the practice of "ancestor worship" by African Christians. This is because it contains a passage where Paul addresses the issue of food dedicated to idols. Paul's resolution of the issue - with his intention of maintaining harmony in the church and in the spirit of love - seems to accommodate the eating of meats offered to idols, but encourages abstinence in consideration of the weak. This principle of love may seem to bring accommodation, yet after a rigorous discussion the thesis concludes that the text still excludes the worship of idols. "Ancestor worship" is in this thesis seen to be within the given definitions of idolatry as it involves the sacrificing of meats and foods to ancestors and the deceased. In the final analysis the quest for a solution to ancestor beliefs and practices by African Christians challenges the Church to focus on a responsible interpretation of Biblical texts, and in such a way that it would bring light as to whether ancestor beliefs and practices are in continuation with Biblical perspectives or not. / AFRIKAANSE OPSOMMING: Die doel van hierdie studie is om Afrika-Christene se opvattings met betrekking tot hul voorouers aan die hand van 'n verantwoorde verstaan van 1 Korintiers 8:4-6 te evalueer. Die studie is genoodsaak deur verwarring oor die vraag of die beginsels en praktyke van "voooroueraanbidding" met die Christelike geloof versoen kan word. Vol gens die studie blyk dit dat die gekose teks die vraag van "vooroueraanbidding" aanspreek, en wel as onversoenbaar met die wesensaard van die Christelike geloof. Sommige van die bronne waarna die tesis verwys, onderskryf hierdie standpunt, terwyl ander "vooroueraanbidding" verdedig en probleemloos op dieselfde vlak as die Christelike geloof akkommodeer. Die gevolg is dat sinkretisme ontstaan as 'n kornpromis tussen die twee perspektiewe, wat dit vir belydende Afrika-Christene moontlik maak om "vooroueraanbidding" te bedryf. 1 Korintiers 8:4-6 vonn die kemgesigspunt vanwaar die praktyk van "vooroueraanbidding" deur Afrika-Christene geevalueer word. In die gedeelte bespreek Paulus die vraag of Christene voedsel mag eet wat aan afgode gewy is. In die lig van sy bedoeling om 'n gees van liefde en eenheid in die gemeente aan te moedig, laat hy ruimte vir Christene se vryheid om afgodsvleis te eet, maar beveel aan dat dit ter wille van swakkeres in die geloofliefs gelaat moet word. Hoewel die liefdesbeginsel ruimte mag laat vir die akkommodering van "vooroueraanbidding", kom die tesis 11<'1 indringende bespreking tot die slotsom dat I Korintiers 8:4-6 dit as 'n opsie vir Christene uitsluit, "Vooroueraanbidding" word hier gedefinieer as afgodery, aangesien dit die offerande van vleis en ander kos aan voorouers en afgestorwenes insluit. Om enigsins 'n oplossing vir die probleem van "vooroueraanbidding" deur Afrika- Christene te vind, vra in die finale instansie dat kerke sal fokus op 'n verantwoorde interpretasie van die Bybel, wat sal kan aandui of sodanige geloofspraktyke 'n voortsetting van Bybelse perspektiewe is al dan nie.