Universiẗat, Diss. u.d.T.: Wertfein, Monika: Emotionale Entwicklung im Vor- und Grundschulalter im Spiegel der Eltern-Kind-Interaktion--München, 2006.

Zugl.: München, Univ., Diss., 2006 u.d.T.: Wertfein, Monika: Emotionale Entwicklung im Vor- und Grundschulalter im Spiegel der Eltern-Kind-Interaktion

The allocation of frequency spectrum by the FCC for Ultra Wideband (UWB) communications in the 3.1-10.6 GHz has paved the path for very high data rate Gb/s wireless communications. Frequency synthesis in these communication systems involves great challenges such as high frequency and wideband operation in addition to stringent requirements on frequency hopping time and coexistence with other wireless standards. This research proposes frequency generation schemes for such radio systems and their integrated implementations in silicon based technologies. Special emphasis is placed on efficient frequency planning and other system level considerations for building compact and practical systems for carrier frequency generation in an integrated UWB radio. This work proposes a frequency band plan for multiband OFDM based UWB radios in the 3.1-10.6 GHz range. Based on this frequency plan, two 11-band frequency synthesizers are designed, implemented and tested making them one of the first frequency synthesizers for UWB covering 78% of the licensed spectrum. The circuits are implemented in 0.25µm SiGe BiCMOS and the architectures are based on a single VCO at a fixed frequency followed by an array of dividers, multiplexers and single sideband (SSB) mixers to generate the 11 required bands in quadrature with fast hopping in much less than 9.5 ns. One of the synthesizers is integrated and tested as part of a 3-10 GHz packaged receiver. It draws 80 mA current from a 2.5 V supply and occupies an area of 2.25 mm2. Finally, an architecture for a UWB synthesizer is proposed that is based on a single multiband quadrature VCO, a programmable integer divider with 50% duty cycle and a single sideband mixer. A frequency band plan is proposed that greatly relaxes the tuning range requirement of the multiband VCO and leads to a very digitally intensive architecture for wideband frequency synthesis suitable for implementation in deep submicron CMOS processes. A design in 130nm CMOS occupies less than 1 mm2 while consuming 90 mW. This architecture provides an efficient solution in terms of area and power consumption with very low complexity.

Die Dissertation besteht aus drei empirischen Beiträgen zur Analyse moralischer Emotionen sowie einer zusammenfassenden und integrierenden Synopse. Im Rahmen der Arbeit wird dabei zunächst (1) eine umfassende Theorie zur Klassifikation und Entstehungsbedingungen moralischer Emotionen entwickelt. Darauf aufbauend wird (2) die Entstehung moralischer Emotionen im Setting der Schule anhand der Urteile von Lehrern und Schülern sowie (3) unter entwicklungspsychologischer Perspektive überprüft. Die vorgeschlagene und empirisch überprüfte Theorie ermöglicht erstmals eine übergreifende Analyse der Entstehungsbedingungen moralischer Emotionen. Die Befunde werden vor dem Hintergrund der bisherigen Forschung zu einzelnen moralischen Emotionen diskutiert.

Die Dissertation besteht aus drei empirischen Beiträgen zur Analyse moralischer Emotionen sowie einer zusammenfassenden und integrierenden Synopse. Im Rahmen der Arbeit wird dabei zunächst (1) eine umfassende Theorie zur Klassifikation und Entstehungsbedingungen moralischer Emotionen entwickelt. Darauf aufbauend wird (2) die Entstehung moralischer Emotionen im Setting der Schule anhand der Urteile von Lehrern und Schülern sowie (3) unter entwicklungspsychologischer Perspektive überprüft. Die vorgeschlagene und empirisch überprüfte Theorie ermöglicht erstmals eine übergreifende Analyse der Entstehungsbedingungen moralischer Emotionen. Die Befunde werden vor dem Hintergrund der bisherigen Forschung zu einzelnen moralischen Emotionen diskutiert.

Yes / Objectives: Young onset dementia is associated with distinctive support needs but existing research on service provision has been largely small scale and qualitative. Our objective was to explore service use, cost and satisfaction across the UK. Methods: Information about socio‐demographic characteristics, service use and satisfaction were gathered from people with young onset dementia (YOD) and/or a family member/supporter via a national survey. Results: Two hundred and thirty‐three responses were analysed. Diagnosis was most commonly received through a Memory Clinic or Neurology. The type of service delivering diagnosis impacted on post‐diagnostic care. Those diagnosed in specialist YOD services were more likely to receive support within the first 6 weeks and receive ongoing care in the service where they were diagnosed. Ongoing care management arrangements varied but generally care was lacking. Around 42% reported no follow‐up during 6‐weeks after diagnosis; over a third reported seeing no health professional within the previous 3 months; just over a third had a key worker and just under a third had a care plan. Satisfaction and quality of care were highest in specialist services. Almost 60% of family members spent over 5 h per day caring; median costs of health and social care, 3 months, 2018, were £394 (interquartile range £389 to 640). Conclusions: Variation across diagnostic and post‐diagnostic care pathways for YOD leads to disparate experiences, with specialist young onset services being associated with better continuity, quality and satisfaction. More specialist services are needed so all with YOD can access age‐appropriate care. / Alzheimer's Society. Grant Number: 278 AS-PG-15b-034

Uppsatsen är en komparativ studie, där James D. G. Dunns och Thomas R. Schreiners tolkningar av vad som enligt Paulus gör att en människa räknas som rättfärdig samt varför Kristus dog utifrån Gal 2:15-21, 3:10 jämförs och värderas. Viktiga begrepp för tolkningen av dessa verser är rättfärdighet, δικαιοσύνη och laggärnigar, ἔργων νόμου. Dunn anser att rättfärdighet enligt Paulus nås genom att vara i Kristus, ἐν Χριστῷ vilket leder till en förändring av människans väsen till Kristuslikhet. Schreiner tolkar däremot rättfärdighet och rättfärdiggörelse som främst juridiskt, där det centrala är att tillräknas rättfärdighet från Kristus genom hans ställföreträdande syndaoffer. Utifrån de argument av Dunn och Schreiner som jag tar upp i analysen av Gal 2:15-21, 3:10 anser jag att Dunns tolkning av vad som leder till rättfärdighet enligt Paulus är mest rimlig. Om varför Kristus dog anser Dunn att det främst var för att göra förbundet med Gud tillgängligt för hedningarna, medan Schreiner anser att det främst var för att sona för människornas synder. Även på denna punkt anser jag att Dunns argument för sin ståndpunkt är mest rimliga.

Voltage-gated ion channels play fundamental roles in neural excitability and thus dysfunctional channels can cause disease. Understanding how the voltage-sensor of these channels activate and inactivate could potentially be useful in future drug design of compounds targeting neuronal excitability. The opening and closing of the pore in voltage-gated ion channels is caused by the arginine-rich S4 helix of the voltage sensor domain (VSD) moving in response to an external potential. Exactly how this movement is accomplished is not yet fully known and an area of hot debate. In this thesis I study how the opening and closing in voltage-gated potassium (Kv) channels occurs. Recently, both experimental and computational results have pointed to the possibility of a secondary structure transition from α- to 3(10)-helix in S4 being an important part of the gating. First, I show that the 3(10)-helix structure in the S4 helix of a Kv1.2-2.1 chimera protein is significantly more favorable compared to the α-helix in terms of a lower free energy barrier during the gating motion. Additional I suggest a new gating model for S4, moving as sliding 310-helix. Interestingly, the single most conserved residue in voltage- gated ion channels is a phenylalanine located in the hydrophobic core and directly facing S4 causing a barrier for the gating charges. In a second study, I address the problem of the energy barrier and show that mutations of the phenylalanine directly alter the free energy barrier of the open to closed transition for S4. Mutations can either facilitate the relaxation of the voltage-sensor or increase the free energy barrier, depending on the size of the mutant. These results are confirmed by new experimental data that supports that a rigid, cyclic ring at the phenylalanine position is the determining rate-limiting factor for the voltage sensor gating process. / QC 20110616