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A multimodal investigation of distress intolerance and youth anxiety disordersElkins, Regina Meredith 04 December 2016 (has links)
Despite major advances in the development of evidence-based practices (EBPs) for child anxiety, there remains a critical need to improve upon current treatments. Identifying common, transdiagnostic processes underlying child anxiety disorders offers a promising avenue to refine conceptualizations of the etiology and maintenance of child anxiety disorders, to enhance the efficacy of interventions, and to facilitate the dissemination of EBPs. Distress intolerance (DI), defined as the perceived inability to tolerate negative somatic and emotional states or experiential discomfort (Simons & Gaher, 2005), is a transdiagnostic factor contributing to multiple forms of mental illness. Emerging research suggests that DI may be associated with elevated anxiety in community samples of youth; however, associations between DI and child anxiety have yet to be evaluated in a clinical population. The present multimodal investigation (N = 56) examined patterns and correlates of DI in a treatment-seeking sample of anxious youth (ANX, n = 28) relative to community controls (COM, n = 28). The aims of the study were to examine differences in DI between ANX and COM youth on self-report and behavioral measures of DI, and to determine the extent to which DI mediates links between child anxiety and associated behavioral avoidance. Youth ages 10-17 completed self-report measures assessing child anxiety symptoms, behavioral avoidance, and DI. Next, participants completed a behavioral task intended to provoke mild levels of distress that assessed behavioral persistence in the face of that distress. Consistent with hypotheses, ANX participants demonstrated higher levels of self-reported DI than COM participants, and greater anxiety-disorder severity was associated with higher levels of self-reported DI. Contrary to hypotheses, there were no between-group differences in behaviorally assessed DI. Mediation analyses revealed that a composite summary score of three self-report DI measures significantly mediated the link between anxiety status and behavioral avoidance. These findings provide compelling preliminary support that self-perceived DI may underlie the behavioral avoidance that is a cardinal feature across anxiety disorders. Results can inform the optimization of EBPs for child anxiety such that clinicians might directly target DI within treatment to better alleviate symptoms and yield more enduring treatment gains in anxiety-disordered youth.
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Development of enzyme electrodes for anaerobic glucose monitoring incorporating a polymeric redox mediatorChen, Chi Jin January 1992 (has links)
No description available.
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Alcohol Expectancies and Social Self Efficacy as Mediators of Differential Intervention Outcomes for College Hazardous Drinkers with Social AnxietyBlack, Jessica J. 30 September 2010 (has links)
No description available.
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Cutaneous Liver X Receptor Activation Prevents the Formation of Imiquimod-Induced Psoriatic Dermatitis / 皮膚のliver X受容体の活性化はイミキモド誘導乾癬モデルの形成を抑制するOTSUKA, MASAYUKI 23 March 2022 (has links)
京都大学 / 新制・課程博士 / 博士(医科学) / 甲第23814号 / 医科博第135号 / 新制||医科||9(附属図書館) / 京都大学大学院医学研究科医科学専攻 / (主査)教授 村川 泰裕, 教授 松村 由美, 教授 森本 尚樹 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM
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O professor mediador de leitura na biblioteca escolar da rede municipal de Londrina : formação e atuação /Silva, Rovilson José da. January 2006 (has links)
Orientador: Dagoberto Buim Arena / Banca: Edmir Perroti / Banca: Neuza Ceciliato de Carvalho / Banca: Renata Junqueira de Souza / Banca: Stela Miller / Resumo: Esta tese apresenta uma proposta de formação do mediador de leitura que atua em biblioteca escolar. Desde sua origem, este estudo tomou dimensões teórico-práticas da pesquisa-ação, uma vez que houve a intervenção na Rede Municipal de Ensino de Londrina, por meio da estruturação do projeto de leitura Bibliotecas Escolares: Palavras Andantes no período de 2002/2004. Posteriormente, em Barcelona de 2005/2006, foram coletados dados a respeito da mediação de leitura em duas bibliotecas escolares, a fim de estabelecer uma correlação dese processo entre Barcelona e Londrina/PR. Além disso, foram entrevistados professores participantes do referido Projeto e especialistas das áreas de leitura, formação de leitores e biblioteca escolar do Brasil e da Espanha, respectivamente: Edmir Perrotti, Regina Zilberman, Teresa Colomer e Teresa Mañà. As conclusões obtidas no estudo apontam para a necessidade de fundamentar a prática do professor mediador com conteúdos voltados à concepção de leitura e suas relações com a do ato de ler na biblioteca da escola. / Abstract: The thesis presents a proposal for reading mediator formation, who directly acts at school libraries. The methodology used was the action research approach, which is divided into two periods. During the first period (2002/2003), the research was based on the "Bibliotecas Escolares: Palavras Andantes" (School Libraries: Walking Words) project, which is an initiative of the public educational system of the Londrina Municipality in Brazil. The second period (2005/2006) was located in Barcelona, Spain. The study has collected data regarding mediation activities in two Spaniard library schools, in order to establish a correlation of this process between Barcelona and Londrina. During the research, project participants and specialists in the field were interviewed in Brazil an Spain. The names are: Edmir Perrotti; Regina Zilberman; Teresa Colomer; and Teresa Mañà. The work conclusion presents that the reading mediator requires a bond among three aspects: the reading practice itself, the literature concept, and the relation betweem the initial two aspects with the reading experience in the school library. / Doutor
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Dynamics of protein folding and subunit interactions in assembly of the yeast mediator complexShaikhibrahim, Zaki, January 2009 (has links)
Diss. (sammanfattning) Umeå : Umeå universitet, 2010. / Härtill 2 uppsatser.
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Emotionsreglering som mediator i utvecklandet av emotionell ohälsa över tid hos adolescenter / Emotion regulation as a mediator of emotional distress development over time in adolescentsEkeroth, Julia, Jehrlander, Malin January 2014 (has links)
Depression- och ångestsymtom, som kan beskrivas som en del av emotionell ohälsa, är ett frekvent och växande problem inom den svenska ungdomspopulationen. Både en hög komorbiditet samt könsskillnader i ohälsa kan observeras. Samband mellan emotionsreglering och ohälsa har under senare år erhållit ett brett empiriskt stöd. Denna longitudinella studie syftade till att undersöka emotionsreglerings roll som mediator i utvecklandet av emotionell ohälsa över tid samt om det eventuella sambandet modereras av kön. Analyser visade att emotionsreglerings-strategierna kognitiv emotionsreglering och beteendemässigt undvikande medierade sambandet. Detta skiljde sig även åt mellan könen vad gäller kognitiv emotionsreglering. Utifrån studiens resultat dras slutsatsen att emotionsreglering kan utgöra en del av förklaringen av ökad emotionell ohälsa över tid hos ungdomar. Detta samband tycks även vara mer gällande för flickor. / Depressive and anxiety symptoms, which can be classified as types of emotional distress, anre common and growing issues among Swedish youth. Substantial comorbidity and gender differences concerning emotional distress have been observed. The relationship between emotion regulation and emotional distress have obtained convincing empirical support during the last couple of decades. This longitudinal study aimed to investigate the mediating role of emotion regulation in the development of emotional distress over time. The question of gender as a moderator of the relationship was also addressed. Analysis indicate that two emotion regulation strategies, cognitive emotion regulation and behavioral avoidance, do mediate the relationship. Gender differences were found in the cognitive strategy. The results of the study indicate that emotion regulation could be a part of the explanation for the increase of adolescent emotional distress over time. This relationship also seem to be more distinct for girls.
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[en] THE MEDIATOR ROLE IN MANAGEMENT AND CONFLICT NEGOTIATION IN CONCILIATION HEARINGS / [pt] O PAPEL DO MEDIADOR NO GERENCIAMENTO E NEGOCIAÇÕES DE CONFLITOS EM AUDIÊNCIAS DE CONCILIAÇÃOWANIA TEREZINHA LADEIRA 20 September 2005 (has links)
[pt] Baseando-se em teorias da Sociolingüística Interacional e
Análise da Conversa, mais
especificamente, da Fala-em-interação em contexto
institucional, analisa-se o papel
do mediador no gerenciamento de conflitos entre consumidor
e empresas reclamadas
em um Juizado Especial Cível de Relações de Consumo.
Utiliza-se, como dados,
gravações de fala-em-interação em audiências de
conciliação desse juizado. A
resolução de conflitos em ambiente institucional difere da
disputa informal por contar
com um mandato institucional particular que direciona uma
organização interacional,
na qual os direitos de participação são restritos,
diferentemente da conversa cotidiana.
Expectativas de normas, status de participação
diferenciados e seqüência de
procedimentos caracterizam a audiência de conciliação e
possibilitam a sua divisão
em dois momentos principais: a narrativa e a negociação.
Analisando o papel do
mediador nesses dois momentos, observa-se que ele co-
constrói a história do
consumidor, por meio de perguntas e de formulações. Assim,
durante o relato do
conflito, o mediador se alinha, na maior parte das vezes,
com o consumidor. Durante
a negociação, o mediador pode mudar o seu alinhamento com
a finalidade de cumprir
a sua tarefa institucional de negociar e conseguir
conciliar os adversários. Desse
modo, pode-se concluir que os alinhamentos do mediador são
direcionados para a sua
tarefa institucional. / [en] Based on Interactional Sociolinguistics and Conversation
Analysis theories, this work
investigates the mediator role in conflict management
between costumers and product
and services suppliers in conciliation hearings in a
brazilian Small Claim Court
(Juizado Especial de Relações de Consumo). The date
consist of tape recordings of
talk-in-interaction in work place. Conflict resolution in
institutional settings is distinct
from informal dispute because its procedures define
especific roles for each
interaction participant. A particular institutional
mandate determine a interactional
organization where the participants rigths suffer
restrictions that are absent in
ordinary conversation. Norms expectations, distinct
participation status and sequence
of procedures are features of conciliation hearings that
make possible to identify two
moments in the hearings: narrative and negociation.
Analysing the mediator role in
the narrative moment, it was observed his co-contruction
of the consumer narrative
by questions and formulations. Thus, the mediator align
himself most of the time with
the consumer side during the conflict narrative. In the
negotiation moment, he may
change his alignment in order to do a institutional task
of making agreement between
disputants. Finally, there is an argument that mediator
alignments are oriented by his
institutional work.
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Top of the tops: Combining searches for Dark Matter with top quarks at √s = 13 TeV with the ATLAS detectorLiberatore, Marianna 23 January 2023 (has links)
Trotz der zahlreichen astrophysikalisch und kosmologisch überzeugenden Beweise für Dunkle Materie bleibt ihre wahre Natur unbekannt. Eine Motivation für die Suche nach Dunkler Materie am Large Hadron Collider (LHC) und insbesondere mit dem ATLAS-Experiment ist die besonders vielversprechende Möglichkeit, dass Wechselwirkungen zwischen gewöhnlicher Materie und Dunkler Materie durch neue Spin-0-Teilchen vermittelt werden. Solche Teilchen würden das Standardmodell um einen potentiellen Dunklen Sektor erweitern, zu dem die Teilchen der Dunklen Materie gehören. ähnlich wie das Higgs-Boson interagieren diese neuen Mediatoren am stärksten mit den schwersten Teilchen über Kopplungen vom Yukawa-Typ, wodurch sie empfänglicher für die damit verbundene Produktion durch Quarks mit schwerem Flavour werden.
Diese Dissertation präsentiert die Ergebnisse der statistischen Kombination von zwei Suchen, die auf die mit Dunkler Materie verbundene Produktion von einem Top-Quark-Paar oder einem einzelnen Top-Quark, jeweils zwei geladenen Leptonen im Endzustand, abzielen. Diese beiden Kanäle weisen komplementäre Eigenschaften auf, und eine Kombination kann die Empfindlichkeit gegenüber Dunkle-Materie-Signalen erheblich verbessern. Diese Kombination wird unter Verwendung von 139 fb-1 pp-Kollisionsdaten durchgeführt, die bei einer Schwerpunktsenergie von 13 TeV erzeugt und vom ATLAS-Detektor am LHC aufgezeichnet wurden.
Die Ergebnisse der Kombination werden in Bezug auf vereinfachte Modelle für Dunklen Materie mit einem skalaren oder pseudoskalaren Spin-0-Mediator interpretiert. Die statistische Kombination weitet die bei einem Konfidenzniveau von 95% ausgeschlossenen Massen auf bis zu 350 GeV sowohl für skalare als auch für pseudoskalare Mediatoren aus. Die beobachteten Ausschlu{\ss}grenzen des Wirkungsquerschnitts werden für den ska\-laren (pseudoskalaren) Mediator um 20%(30%) gegenüber dem Besten des einzelnen Kanals verbessert. / Despite the multiple astrophysical and cosmological compelling evidences for Dark Matter, its true nature remains unknown. A motivation to dark matter searches at the Large Hadron Collider (LHC), and in particular in the ATLAS experiment, is the especially promising possibility that interactions between ordinary matter and dark matter are mediated by new spin-0 particles. Such particles would extend the Standard Model with a potential dark sector, to which dark matter particles belong. Similarly to the Higgs boson, these new mediators interact strongest with the heaviest particles via Yukawa-type couplings, making them more prone to associated production with heavy-flavour quarks.
This thesis presents the results of the statistical combination of two searches targeting dark matter associated production with a top quark pair and a single top quark, targeting two charged leptons in the final state. These two channels present in fact complementary properties and a combination could enhance significantly the sensitivity to dark matter signals. This combination is carried out using 139 fb-1 of pp collision data produced at centre-of-mass of 13 TeV recorded by the ATLAS detector at the LHC. The results of the combination are interpreted in terms of simplified dark matter models with a spin-0 scalar or pseudoscalar mediator particle. The statistical combination extends the exclusion at 95 % Confidence Level (CL) of masses up to 350 GeV for both scalar and pseudoscalar mediators. The observed upper limits on the cross-section are improved up by 20 %(30 %) for scalar(pseudoscalar) mediator with respect to the best of the individual channel.
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Ancestor christology and Jesus' identity : a study based on the Epistle to the Hebrews / Jacob Terhemba IgbaIgba, Jacob Terhemba January 2013 (has links)
The aim in this thesis is to determine whether African ancestor Christology, a contextual attempt to explicate the identity of Jesus within African theology, adequately correlates with and captures the identity of Jesus presented in the exordium of Hebrews 1:1-4. Ancestor Christology utilises the pre-existing notion of the traditional African ancestors as a frame of reference. Consequently, understanding the place and function of the ancestors is essential to this research. This research undertakes a critical and analytical review of ancestor Christology presented in the works of some of the proponents of the concept including Pobee (1979), Nyamiti (1984), Bujo (1992), Bediako (1980, 2004) and Nyende (2005), among others. Using a combination of historical-grammatical exegesis and theological interpretation, this dissertation undertakes an investigation of Hebrews 1:1-4 to evaluate ancestor Christology. 12:1 is examined to determine the place and function of the ancestors in Hebrews. Though this research noted the value of the ancestor Christology concept as a worthwhile attempt towards contextual Christology in Africa, the research argues that the concept is counterproductive because the failure of the concept to capture important aspects of Jesus‘ identity outlined in the exordium translates to presenting Him inadequately. This applies especially to his identity as the summation and perfection of mediation, whose scope of mediation is salvific and redemptive and whose mediation is without an end as signified by his linkage in Hebrews to the king-priest Melchizedek. Furthermore, conceptualising Jesus using ancestor categories has the potential of exasperating the perennial problem of belief in both Jesus and the ancestors as mediators between God and men. / MA (New Testament), North-West University, Potchefstroom Campus, 2014
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