Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-07-11T18:07:57Z No. of bitstreams: 1 MariaAniollyQueirozMaia_DISSERT.pdf: 2902491 bytes, checksum: f9e2c1a51c59983c704e1e53c376521e (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-07-19T17:15:49Z (GMT) No. of bitstreams: 1 MariaAniollyQueirozMaia_DISSERT.pdf: 2902491 bytes, checksum: f9e2c1a51c59983c704e1e53c376521e (MD5) / Made available in DSpace on 2016-07-19T17:15:49Z (GMT). No. of bitstreams: 1 MariaAniollyQueirozMaia_DISSERT.pdf: 2902491 bytes, checksum: f9e2c1a51c59983c704e1e53c376521e (MD5) Previous issue date: 2015-12-07 / As revistas cient?ficas eletr?nicas correspondem a canais de publica??o e divulga??o da informa??o cient?fica. Por meio delas, os usu?rios podem disseminar seus estudos, assim como desenvolver novas pesquisas. Um dos sistemas utilizados para cria??o e gest?o de peri?dicos eletr?nicos ? o Sistema Eletr?nico de Editora??o de Revistas (SEER), utilizado na constru??o de portais de peri?dicos, assim como na cria??o de revistas isoladamente. Nesse sentido, acredita-se que os sistemas de gest?o e cria??o de revistas cient?ficas eletr?nicas devem ser desenvolvidos (interna e externamente) de acordo com as necessidades dos seus usu?rios. No caso do desenvolvimento interno, alguns desses processos se referem ao cadastro de autor e ? submiss?o de artigos, que, por sua vez, s?o tarefas relevantes no processo editorial. Assim, o trabalho proposto, de tem?tica Usabilidade de peri?dicos cient?ficos, objetiva analisar a usabilidade do processo de cadastro de autor e de submiss?o de artigos no SEER por meio da revista BiblioCanto, que integra o Portal de Peri?dicos Eletr?nicos da Universidade Federal do Rio Grande do Norte (UFRN). Para a efetiva??o da pesquisa, foram utilizadas duas t?cnicas de avalia??o: o Teste de Usabilidade e a Avalia??o Cooperativa, com um total de vinte participantes, divididos em quatro categorias. Para validar os instrumentos da pesquisa (o question?rio pr?-sess?o e o Questionnaire of User Interaction Satisfaction), foram realizados dois testes piloto antes da realiza??o da avalia??o em definitivo. Ap?s a execu??o do Teste de Usabilidade e Avalia??o Cooperativa em definitivo, os resultados apontaram que os dois processos analisados (cadastro de autor e submiss?o de artigos) necessitam de melhorias. Em se tratando do processo de cadastro, destacam-se as seguintes necessidades: sinaliza??o do ambiente de realiza??o de cadastro; descri??o e exclus?o de informa??es solicitadas no formul?rio para cadastramento. No processo de submiss?o de artigos, enfatizam-se melhorias dos aspectos: in?cio dos passos para submiss?o, sinaliza??o de campos obrigat?rios, descri??o concisa das etapas, minimiza??o e revis?o das etapas. Para Por fim, acredita-se que de uma forma geral o SEER atende parcialmente ?s necessidades dos seus usu?rios no tocante ? usabilidade do referido software. / The electronic journals correspond publishing channels and dissemination of scientific information. Through them, users can spread their studies as well as developing new researches. One of the systems used for creation and e-journals management is the Electronic System for Journal Publishing (SEER), used in the construction of periodic portals, as well as the creation of magazines in isolation. In this purport, it is believed that the management systems and creation of e-journals should be developed (internally and externally) according to the needs of its users. In the case of internal development, some of these processes refer to the copyright registration and submission of articles, which, in turn, are relevant tasks in the editorial process. Thus, the proposed study, thematic Usability of scientific journals, aims to analyze the usability of the copyright registration process and submission of articles in the Electronic System for Journal Publishing through BiblioCanto magazine, part of the Electronic Journals Portal of the Federal University of Rio Grande do Norte (UFRN). For the realization of the research, two valuation techniques were used: the Usability Test with a total of twenty participants and the Cooperative Evaluation, with the same number of participants separated in four categories considered target audience of that magazine, namely: undergraduate students, graduate students, teachers and librarians. The results indicated that the two analyzed processes (copyright registration and submission of articles) need improvement. In the case of the registration process, the following needs are: signalizing of the conducting registration ambient; description and exclusion of requested information on the registration form. In the process of article submission, it is emphasized improvement of aspects: the early steps to submission, signaling of required fields, concise description of the steps, minimization and review of the steps. To this end, it is believed that in general idea the SEER partially meets the needs of its users regarding the usability of such software.

Introdução – O tratamento da hipertensão portal continua sendo um desafio e muitos desses pacientes necessitam até transplante de fígado, como tratamento definitivo. Nesse contexto a derivação porto-sistêmica intra-hepática transjugular (Transjugular Intrahepatic Portosystemic Shunt – TIPS) surgiu como uma alternativa atraente para esta complicação da doença hepática crônica, sobretudo por não requerer laparotomia e efetivamente reduzir a pressão portal. O conhecimento da distância entre as veias hepáticas e os ramos portais e outros dados anatômicos, no fígado cirrótico, são requisitos importantes no planejamento e execução desse procedimento. Objetivos - Determinar as distâncias e diâmetros das veias hepáticas direita e média para os ramos portais e para a bifurcação da veia porta, no fígado cirrótico humano, com vistas à construção do TIPS. Tipo de estudo – Estudo anatômico descritivo e macroscópico em moldes vasculares de resina obtidos por corrosão de fígados humanos isolados e cirróticos. Material e método – O estudo foi autorizado pelo Comitê de Ética em Pesquisa do HUOC/Procape-UPE e todos os pacientes, ou seus representantes legais, assinaram Termo de Consentimento Livre e Esclarecido. Foram obtidos 21 moldes de resina acrílica dos ramos portais e veias hepáticas de fígados cirróticos, de pacientes transplantados, dos hospitais Jayme da Fonte e Universitário Oswaldo Cruz, do Recife/PE. Após a completa corrosão do parênquima, foram medidas as distâncias e diâmetros das veias hepáticas e ramos da veia porta. Para testar a hipótese de diferença da média estimada em relação a um valor de referência, foi aplicado o teste t-Student para uma amostra. Resultados - A distância média da veia hepática direita para o ramo direito da veia porta e para a sua bifurcação foram, respectivamente, de 33 (±6,4) e 36 (±7,4) mm, ambos significativamente menores (p<0,0001 e p<0,0002) que os resultados encontrados na literatura, em fígados normais. A distância média da veia hepática média para o ramo direito e para o ramo esquerdo da veia porta foi, respectivamente, de 36 (±6,8) e 26 (±8,8) mm . Conclusão – As distâncias entre a veia hepática direita e o ramo direito da veia porta ou a bifurcação da mesma, em fígados cirróticos, foram significativamente menores que as anteriormente relatadas em fígados normais. A veia hepática média é confirmada como uma via alternativa adequada. / Introduction - The treatment of portal hypertension remains a challenge and many of these patients need liver transplantation as definitive treatment. In this context the Transjugular Intrahepatic Portosystemic Shunt (TIPS) has emerged as an attractive alternative to this complication of chronic liver disease, especially for not requiring laparotomy and effectively reducing the portal pressure. Knowing the distance between the hepatic veins and portal branches and other anatomical data in the cirrhotic liver, they are important requirements in the planning and execution of this procedure. Purpose: To determine spatial arrangements and diameters of right and middle hepatic veins relative to portal vein branches in cirrhotic human livers, gaining strategic insight to percutaneous procedures as transjugular intrahepatic portosystemic shunt. (TIPS). Materials and Methods: This study was authorized by an area Research Ethics Committee, and each study subject or legal representative granted signed informed consent. Acrylic corrosion casts of 21 resected cirrhotic livers were generated. Diameters of hepatic veins and portal branches and pertinent intervening distances were measured. To assess differences in estimated average (relative to reference values), Student's t-test for one sample was applied. Results: Mean distances from right hepatic vein to right portal branch and to portal vein bifurcation were 33±6.4 mm and 36±7.4 mm, respectively, both significantly shorter than published reference values in healthy human livers (p<0.0001 and p<0.0002, respectively). Mean distances from middle hepatic vein to right and left branches of portal vein were 36±6.8 mm and 26±8.8 mm, respectively. Conclusion: Distances separating right hepatic vein and portal vein (right branch and bifurcation) are diminished in cirrhotic livers compared to healthy ones. The middle hepatic vein is confirmed as a suitable alternative route.

O objetivo da pesquisa é avaliar o acesso à informação legislativa digital dos municípios do estado do Rio Grande do Sul. Em revisão de literatura, aborda a importância da informação legislativa no que concerne ao ordenamento jurídico como um todo, à segurança jurídica, ao acesso à informação e à inflação legislativa. Para realizar a avaliação, estabelece checklist e, posteriormente, aplica o instrumento aos portais de legislação das Câmaras de Vereadores e Prefeituras Municipais dos municípios selecionados por amostragem aleatória simples estratificada e na capital do Estado. O checklist é fundamentado em literatura acerca da avaliação de portais da web e da avaliação de portais de legislação em específico, sendo composto por 26 requisitos básicos desejáveis para os portais de legislação, divididos em 5 parâmetros: Usabilidade, Cobertura, Acessibilidade, Relacionamentos e Ferramentas Ao todo, analisa 62 portais de Prefeituras Municipais e 62 portais de Câmaras de Vereadores. Os resultados demonstram falta de planejamento e de profissionalismo na concepção e manutenção dos portais. Demonstram, ainda, não haver grande preocupação por parte dos gestores dos portais de legislação em garantir a completude do portal, a acessibilidade das normas, disponibilizar o texto atualizado (alterado e consolidado), facilitar o acesso à informação concernente à normas relacionadas, fonte, projeto de origem e ADIN, prover espaço com conteúdo de ajuda, bem como em gerar confiança a partir da disponibilização de informações sobre a responsabilidade do portal. Conclui que o acesso à informação legislativa dos municípios do Rio Grande do Sul é precário. / This research aims to evaluate the access to digital legislative information in municipalities of Rio Grande do Sul. The literature review explains the importance of legislative information to the legal order as a whole, to the legal certainty, access to information and legislative inflation. To concrete the evaluation, it establishs a checklist and applies the instrument to the Câmara de Vereadores’s and Prefeituras Municipais’s legislation websites selected by simple stratified random sampling and state’s capital. The checklist is based on literature about general websites and legislative websites evaluation, consisting on 26 basic requirements of legislative websites, sectioned in 5 parameters: usability, coverage, accessibility, relationships and features. In total, it analise 62 Prefeituras Municipais’s websites and 62 Câmaras de Vereadores’s websites. The results demonstrate lack of planning and professionalism in the design and maintenance of the websites. They also demonstrate that the site’s managers show no great concern in ensuring the completeness of the website, the accessibility to law, in making available the updated text (modified and consolidated), in facilitating access to related law, source, draft project and ADIN, in providing help content, as well as generating confidence from the availability of information on the responsibility of the website. It concludes that the access to legislative information of the municipalities of Rio Grande do Sul is precarious.

Nowadays more and more radiotherapy departments use intensity modulated beams for treatment of patients. Intensity modulated radiotherapy (ImRT) is able to modificate intensity of radiation across the iradiated field. In this way it is posible to achieve better dose conformity than in conventional radiotherapy. Implementation of ImRT allows us to escalate dose to target volume with same side effects of organs at risk as in conventional radiotherapy or to reduce normal tissue complication - decrease dose to organ at risk with the same tumour dose. This fact reguires extension of our guality system to all network of delivery dose to patients, inclusive linear accelerator with multileaf collimator, treatment planning system, electronic portal imaging device and so on. Quality assurance is guaranteed both periodical user tests and independent verification of The State Office for Nuclear Safety. The aim of this work is finding the optimal and effective way for the verification treatment plans, determining criteria for evaluation measured results, proposing summary all aspects of radiation protection patients which are treate ionisation beams with intensity modulated radiotherapy. The optimization one of the principles of radiation protection will be provided by routin verification treatment plans.

A gestão empresarial, de uma forma em geral, enfrenta novos contextos quanto à sua estrutura organizacional que suporte a dinâmica do mercado, que incentive a aprendizagem, que esteja antecipada as tendências de consumo e necessidades dos clientes; e que possa ser criativa o suficiente para promover a inovação. Neste sentido, o conhecimento se torna um recurso estratégico para as empresas. Este estudo teve como objetivo propor diretrizes para um portal colaborativo para a transferência do conhecimento no contexto de ambientes de desenvolvimento de empreendimentos inovadores visando a melhoria no processo de inovação e desenvolvimento dos negócios das empresas incubadas. Quanto ao desenvolvimento, baseado em estudos norteadores sobre gestão do conhecimento, transferência do conhecimento para aspectos da colaboração e portais, foi aplicada a metodologia de modelagem organizacional Enterprise Knowledge Development (EKD). Os resultados abordaram três perspectivas: o modelo do estado atual, a análise das necessidades de mudança e o modelo do estado futuro, que apresentam em principal, o modelo de componentes e requisitos técnicos que norteiam as diretrizes para o portal colaborativo, para a transferência do conhecimento, integrado aos objetivos organizacionais, regras do negócio, atores e recursos. / The corporate management, in a general way, faces new contexts for their organizational structure wich supports the market dynamics, wich encourages learning, that is in advance to consumer trends and customer needs, and wich can be creative enough to foster innovation. In this way, knowledge becomes a strategic resource for companies. This research aims to propose guidelines for a collaborative portal for knowledge transfer in the context of innovative projects development in order to improve the innovation process and the development of business of incubated companies. Regarding development, based on guiding studies on knowledge management, knowledge transfer for collaboration aspects and portals, was applied the organization modeling methodology Enterprise Knowledge Development (EKD). The results discussed three perspectives: the as-is model, needs-for-change analysis and the to-be model, in which presents mainly the technical components and requirements model that provide the guidelines for collaborative portal for knowledge transfer, integrated with organizational goals, business rules, actors and resources.

The aim of this thesis project is to create a user interface for a web based film production project management portal. This implies creating a site map and a functionality specification based on the needs of the people working in the film production industry. The project was made on account of The Chimney Pot, a post production company in Stockholm. For the scope of this project, the research was concentrated on the part of film production that concerns The Chimney Pot, i.e. the procedures that take place after a film has been recorded. The research also focused on people working in the area of Stockholm, even if their clients and customers in other areas of Sweden and abroad were indirectly included in order for the project portal to be a usable tool in projects where these people are involved. Before any visible results can be seen in a web production project, a range of preparation steps needs to be taken. Planning is essential if the final product shall work properly. Extensive research has to be done into the industry. In order to make the product usable, the intended users, their requirements, work procedures and environment need to be examined. Only when there are substantial results and enough knowledge about the industry, the actual implementation can start. The first step is to make a functionality specification, next a site map should be produced and the technical architecture should be specified. These are the areas that are covered in this project, but there are also recommendations about how the further development should be made. Important aspects in the next phase are to create a budget, to put together a development team and to create a graphic user interface. In the whole process the issues of usability need to be considered, i.e. efficiency, flexibility, learnability and satisfaction. The key requirements for the project portal turned out to be speed and effectiveness. The user interface was designed to be intuitive and to be shallow, which means that the user should be able to perform any task with the least amount of mouse clicks possible. Another intention with the produced user interface is for it to be clearly divided into the four main areas that could be extracted from the user requirements. They are planning, project details, communication and file sharing. Directly after logging on to the project portal, the user should get an overview of all these areas. Other important considerations were security, version control and seamlessness. These issues demand a thorough planning of the technical architecture and this thesis provides some useful tips for the further development of the technical specification.

Detta arbete har utförts med syftet att ta reda på hur området "designa för olikheter" kan integreras med personas, för att öka användbarheten i ett intranät. "Designa för olikheter" anser att systemdesigners ska ta hänsyn till att alla människor är olika. Personas är fiktiva personer som håller systemdesigners fokuserade på användarna under hela systemutvecklingsprocessen. För att uppnå syftet med rapporten har målet varit att utveckla integrerade användarprofiler (personas integrerat med "Designa för olikheter"), som ett hjälpmedel vid projektet att utveckla Högskolan i Skövdes studentportal. Ett samarbete utfördes med projektteamet för att skapa integrerade användarprofiler som representerar alla potentiella användarna för studentportalen. Tre integrerade användarprofiler togs fram som sedan granskades av projektgruppen och representativa användare. Granskningen visade att de integrerade användarprofilerna representerade atypiska användare och därav uppnått sitt syfte. Det främsta bidraget med detta arbete är att integrerade användarprofiler hjälper till att skapa användbara system för både atypiska och typiska användare. / Utveckling av HS studentportal

Hintergrund: Ziel der Studie war der Vergleich von Patienten mit duktalem Pankreaskarzinom (PDAC) im progressionsfreien und Gesamtüberleben sowie im Rezidivmuster in Abhängigkeit einer Resektion der Vena portae oder der Vena mesenterica superior (PV/SMV). Methoden: Es wurde eine retrospektive Analyse durchgeführt. Hierbei wurden Patienten betrachtet, die zwischen 2005 und 2015 eine pyloruserhaltende partielle Pankreatoduodenektomie (PPPD), eine klassische Pankreatoduodenektomie (kPD) oder eine totale Pankreatektomie (TP) erhielten. Diese wurden in drei Gruppen eingeteilt. Die P+I+- Gruppe bestand aus Patienten mit Venenresektion (P+), bei denen eine pathohistologische Infiltration der PV oder SMV vorlag (I+). Fand sich bei durchgeführter Venenresektion keine portalvenöse Infiltration (I-), wurden die Patienten der P+I--Gruppe zugeordnet. Als Kontrollgruppe galten Patienten ohne Venenresektion (P-I-), welche zu denen der P+I+- Gruppe gematcht wurden. Die statistischen Analysen wurden mit dem R Softwarepaket durchgeführt. Das Signifikanzlevel wurde für alle Berechnungen auf α = 0,05 festgelegt. Ergebnisse: Insgesamt wurden 179 Patienten eingeschlossen. 113 erhielten eine portalvenöse Resektion. Davon hatten 36 (31,9%) eine pathohistologische Lumeninfiltration (P+I+), bei 77 (68,1%) lag dagegen keine Infiltration vor (P+I-). 66 Patienten ohne Venenresektion wurden zu den Patienten der P+I+-Gruppe gematcht (P-I-). Zwischen den drei Gruppen waren die meisten pathohistologischen Parameter vergleichbar. 17 Patienten (9,5%) wurden neoadjuvant therapiert, davon erhielten 16 eine Venenresektion (P+). Für das Gesamtüberleben konnten signifikante Unterschiede nachgewiesen werden (11,9 Monate [P+I+] vs. 16,1 Monate [P+I-] vs. 20,1 Monate [P-I-]; p=0,01). In der univariaten Überlebensanalyse konnte für den erhöhten präoperativen CA19-9 Wert, den Resektionsstatus (R), den Lymphknotenstatus (N), das Lymphknotenverhältnis (LNR), die mikroskopische Veneninvasion (V) sowie die pathohistologisch gesicherte Infiltration der PV/SMV ein negativer Einfluss nachgewiesen werden. In der multivariaten Analyse blieb die wahre Infiltration der PV/SMV als einziger signifikanter negativer Einflussfaktor auf das Gesamtüberleben erhalten (p=0,014). Die Inzidenz an Fernmetastasen war in der P+I+- Gruppe signifikant erhöht (75% [P+I+] vs. 45,8% [P+I-] vs. 54,7% [P-I-], p=0,01). Für ein Lokalrezidiv fanden sich dagegen keine Häufigkeitsunterschiede zwischen den Gruppen (p=0,96). Das mediane progressionsfreie Überleben war für Patienten der P+I+-Gruppe signifikant verkürzt (7,4 Monate [P+I+] vs. 10,9 Monate [P+I-] vs. 11,6 Monate [P-I-]; p=0,02). Die Lumeninfiltration der PV/SMV, die mikroskopische Veneninvasion (V), der präoperative CA19-9 Wert sowie der Differenzierungsgrad (G) waren negative Einflussfaktoren auf das progressionsfreie Überleben. In der multivariaten Analyse blieben die pathohistologisch gesicherte Infiltration sowie das Grading als negative unabhängige Einflussfaktoren nachweisbar. In 25% der Fälle manifestierte sich das Rezidiv initial in der Leber. Schlussfolgerung: Die pathohistologisch gesicherte Infiltration der PV/SMV ist ein unabhängiger Risikofaktor für das progressionsfreie und das Gesamtüberleben. Die Inzidenz an Fernmetastasen ist für die Patienten der P+I+-Gruppe erhöht. Eine potentiell kurative venöse Resektion kann den Einfluss der aggressiven Tumorbiologie und des fortgeschrittenen Krankheitsbildes nicht vollständig kompensieren. / Background. The present study aims to evaluate the longterm outcome and metastatatic pattern of patients who underwent an operation for pancreatic ductal adenocarcinoma (PDAC) with portal or superior mesenteric vein (PV/SMV) resection. Methods. Patients who underwent a pylorus preserving pancreaticoduodenectomy (PPPD), Whipple procedure (kPD) or total pancreatoduodenectomy (TP) between 2005 and 2015 were retrospectively analyzed. The patients were categorized in three subgroups. Those whom received a vein resection with pathohistological tumor invasion of the PV/SMV (P+I+) those at whom underwent vein resection but without pathohistological tumor invasion (P+I-) and lastly a third group (P-I-) matched to the P+I+ included patients without vein resection. Statistical analysis was performed using the R software package. The significance level for all calculations was set at α = 0.05. Results. The study cohort included 179 patients, 113 of whom underwent simultaneous PV/SMV resection. 36 patients (31,9%) had pathohistological tumor infiltration (P+I+), 77 (68,1%) did not (P+I-). 66 patients without vein resection (P-I-) were balanced by the P+I+ group. Most of pathohistological tumor characteristics were comparable between groups. 17 patients (9.5%) received neoadjuvant therapy, 16 of them were in vein resection group (P+). The study revealed differences in overall median survival (11.9 months [P+I+] vs. 16.1 months [P+I-] vs. 20.1 months [P-I-]; p=0.01). Univariate survival analysis shown negative consequences for CA19-9, resection margin (R), status of nodal metastasis (N), lymph node ratio (LNR), microvascular vein invasion (V) and true invasion of the PV/SMV. Multivariate survival analysis identified true invasion of the PV/SMV as the only significant, negative prognostic factor (p= 0.01). Whereas the incidence of local tumor recurrence was comparable (p=0.96), the proportion of patients with distant metastasis showed significant differences (75% [P+I+] vs. 45.8% [P+I-] vs 54.7% [P-I-]; p=0.01). The median time to progression were significantly shorter if the PV/SMV was infiltrated (7,4 months [P+I+] vs. 10,9 months [P+I-] vs. 11,6 months [P-I-]; p=0.02). Univariate progression analysis revealed significances for true invasion of the PV/SMV, microvascular vein invasion (V), CA19-9 and histologic classification (G). Multivariate progression analysis detected pathohistological invasion of the PV/SMV and histologic classification (G) as independent factors. Initial liver metastasis occurred in 25% of the patients. Conclusions. Pathohistological invasion of the PV/SMV is an independent risk factor for overall and progression free survival. Patients of P+I+-group had a higher incidence of distant metastasis, local progression is comparable. Even radical and complete resection cannot completely compensate for aggressive tumor biology and advanced disease. Modifiziert nach Mierke et al., 2016

Cirrhosis is characterized by the progressive development of portal hypertension. Portal hypertension, associated with sodium retention, leads to the formation of ascites. Ascites may be difficult to treat and, thereby, become "refractory". To date, the mortality of patients with refractory ascites remains high. In order to offer patients adequate treatment, it is important to identify complications that may develop and the factors of good and poor prognosis affecting their survival. One can retain five specific complications of cirrhosis with ascites: hepatorenal syndrome, spontaneous bacterial peritonitis, paracentesis induced circulatory dysfunction, hepatic hydrothorax and dilutional hyponatremia. This thesis reported an update of pathogenesis, complications and treatment of refractory ascites. Our original clinical research has, meanwhile, focused on the identification of different prognostic factors in refractory ascites in direct relation to these five complications. We have focused on the effect of the administration of beta blockers in patients with refractory ascites: this treatment is widely prescribed for prevention of gastrointestinal bleeding. It is associated in these patients with higher mortality and a high incidence of paracentesis induced circulatory dysfunction. We specified that the severe hyponatremia, leading to withhold diuretic therapy, is a more accurate prognostic factor than the MELDNa score in refractory ascites. With regard to the hepatorenal syndrome of slow onset (type 2), we emphasized the high frequency of this syndrome in refractory ascites. We showed that there was an association between the level of portal hypertension and the incidence of spontaneous bacterial peritonitis. Furthermore, we demonstrated that the presence of bacterial DNA in ascites of outpatients suffering from refractory ascites was particularly low. The detection of this DNA is not a precursor to infection of ascites. In conclusion, with a systematic analysis of various prognostic factors related to complications of ascites in cirrhotic patients, this work gives a better understanding of their chances of survival. This will allow a more adequate stratification in the decision trees for a cure of the disease such as liver transplantation. / Doctorat en Sciences médicales / info:eu-repo/semantics/nonPublished

My study focuses on methods of the human resources management in an information company. Human resources management and personal information systems present nowadays a very important aspect not only in terms of a management but also in terms of long-term company strategies. Proper human resources management and information system functioning provide an organization with a priceless competitive advantage in the form of effective usage of human resources. At first, human resources management is examined from the theoretic point of view and after that these theoretical needs are set against possibilities of a usage of personal information systems. Consequently, different functions of personal information systems and their supply on the Czech market are analyzed. In the separate chapter I bring in a practical example which summarizes the present state of human resources management and personal information systems in the Tyllco s.r.o. company and which also comprises my recommendation for an improvement.