The purpose of this thesis is to present methods for visibility determination and to design and implement an application to demonstrate visibility determination in a 3D maze.

This diploma thesis is aiming on drafting a marketing strategy proposal and recommendation for TPF group s.r.o. company, which runs an online discount marketplace called Slevoking.cz with a focus on travelling. First part contains explanation of theoretical knowledge associated with this topic. Second part is focusing on application of this knowledge and carries out an analysis of current marketing strategy and communication channels of the company. The findings serve as a core of the last section of the thesis that provides specific recommendations for adjustment and improvement of the company’s marketing strategy. The goal of these recommendations is to enhance the company’s competitiveness in the market, acquire new customers and maintain the existing ones.

Le foie possède une capacité de régénération importante qui lui permet de reconstituer son volume suite à une agression. L’induction d’une régénération hépatique est réalisée en pratique courante en chirurgie hépatique afin de préparer le foie à une hépatectomie majeure. Elle est également utilisée dans de nombreux modèles animaux afin de favoriser la prise de greffe hépatocytaire au cours de la transplantation d’hépatocytes pour le traitement de maladies métaboliques héréditaires hépatiques. Les principaux objectifs de ce travail ont été d’étudier une méthode peu invasive pour induire une importante régénération hépatique : d’une part pour élargir les possibilités de prise en charge des patients nécessitant une hépatectomie, et d’autre part pour favoriser la prise de greffe des hépatocytes transplantés pour le traitement des maladies métaboliques héréditaires hépatiques.Dans un premier temps, nous avons mis au point chez le rat une technique d’embolisation portale partielle résorbable répétée (EPPRR) visant à entrainer un stimulus additionnel de régénération hépatique. Ces travaux ont validé le concept de la méthode d’EPPRR en montrant une augmentation de la prolifération hépatocytaire et une hypertrophie dans la partie du foie non embolisée.Ce protocole d’EPPRR a ensuite été appliqué dans un modèle préclinique de gros animal. Nous avons étudié chez le porc les conséquences de l’EPPRR et montré que cette technique était reproductible, bien tolérée, et qu’elle permettait une hypertrophie de la partie du foie non embolisée.Parallèlement, nous avons appliqué l’EPPRR avant transplantation d’hépatocytes chez le rat. A partir du foie de rats transgéniques exprimant la GFP (green fluorescent protein), nous avons pu isoler des hépatocytes GFP+. Ces cellules ont été transplantées dans le foie de rats receveurs GFP- en association avec une EPPRR. Nous avons montré que le stimulus de régénération répété provoqué par l’EPPRR permettait une augmentation de la prise de greffe.En conclusion, l’EPPRR est une technique peu invasive capable d’induire une régénérative hépatique efficace. Cette approche pourrait jouer un rôle dans la prise en charge des tumeurs hépatique et l’optimisation de la transplantation d’hépatocytes pour le traitement des maladies métaboliques héréditaires hépatiques. / The liver has an important regenerative capacity allowing reconstitution of the hepatic volume after an aggression. The induction of liver regeneration is used in routine clinical practice before liver surgery in order to prepare the liver for major hepatectomy. It is also used in numerous animal models in order to increase hepatocyte engraftment during hepatocyte transplantation for the treatment of inherited metabolic liver diseases. The main objective of this work was to evaluate a minimally invasive approach to induce substantial liver regeneration: firstly, to expand the therapeutic options for patients requiring an hepatectomy, and secondly to increase the engraftment of transplanted hepatocytes for the treatment of inherited metabolic liver diseases.In a first study, we developed in the rat model a technique of repeated reversible portal vein embolization (RRPVE) to induce an additional stimulus of liver regeneration. This study established the proof of concept of the RRPVE method, showing an increase in hepatocyte proliferation and hypertrophy in the non-embolized liver.This RRPVE protocol was then used in a preclinical model of large animal. We studied in swine the consequences of the RRPVE and showed that the procedure was reproducible, well tolerated, and allowed hypertrophy of the non-embolized liver.In parallel, we applied RRPVE before hepatocyte transplantation in the rat model. From the liver of transgenic rats expressing GFP (green fluorescent protein), we were able to isolate GFP+ hepatocytes. These cells were transplanted in the liver of recipient GFP- rats in association with RRPVE. We demonstrated that the repetition of the regeneration stimulus induced by RRPVE allowed increased hepatocyte engraftment.In conclusion, RRPVE is a minimally invasive technique able to induce efficient liver regeneration. This approach could play a part in the management of hepatic malignancies and the optimization of hepatocyte transplantation in the treatment of inherited metabolic liver diseases.

Die Fachinformationsquelle Internet wird zunehmend mehr in Forschung und Lehre genutzt. Was im Wissenschaftsbereich mit dem Online-Stellen von Vorlesungsscripten und einfachen JAVA-Appletts begann, geht heute bis hin zu kommerziellen virtuellen Lernplattformen mit unterschiedlichstem Content. Die Didaktik spricht dann von blended learning. Schränkt man die Betrachtung auf frei zugängliche, online verfügbare Materialien ein, stellt sich die Frage nach der Auffindbarkeit. Wo gibt es Angebote für welches Fach und auf welchen Level? Im folgenden sollen die zwei unterschiedliche Fächer Geschichte und Physik als Repräsentanten für die Entwicklung in den Geistes-/ Sozialwissenschaften bzw. den Naturwissenschaften näher betrachtet werden. Dabei wird einerseits die Einbettung der Lehr-/ und Lernmaterialien in die jeweiligen Fachportale untersucht sowie deren Kennzeichnung durch Metadaten detailliert beschrieben. Danach wird das Augenmerk auf fächerübergreifende Server im Bereich Schule / Hochschule gelegt und dort sowohl die Einordnung wie das Angebot beschrieben. Einen Schwerpunkt bildet die Frage, welche Konsequenzen sich daran für interdisziplinäre Darstellung ziehen lassen. Den Abschluss bildet ein Projekt aus dem Bereich der Bibliotheken. Im einzelnen werden dies sein: Clio-Online, LiLi, Deutscher Bildungsserver, ZUM, META-AKAD -> AKLEON.

(in English) The thesis examines the use of medical thesauri and classifications in portals containing medical information for laymen. The thesis first describes the selected thesauri, classifications and individual portals. A survey was carried out exploring users' reasons for researching medical information. Subsequently, selected subjects were observed researching information on previously selected portals. The observation was complemented with semi- structured interviews with the subjects. The observed results were used to discern the key manifestations of the connection between portals and medical thesauri. The individual portals were further evaluated and their features most important to users were identified.

With the development of high-speed railroads the dynamic behaviour of railroad bridges is increasingly important to explore. Deeper knowledge about the influence of different factors and what should be included in a model is essential if the designer shall be able to make reliable estimates of responses in existing and new structures. One factor is the soil-structure interaction (SSI), describing how the foundation of the bridge and the soil properties affect the behavior of the bridge under dynamic loading. In this thesis, the influence of including SSI in a model of a portal frame railway bridge is studied, and an analysis procedure in the frequency domain for models with frequency-dependent boundary conditions is described. A 3D finite element model of an e isting bridge has been built up, based on the theory of linear elasticity. The model has been given three different types of boundary conditions: clamped, static stiffness and frequency-dependent stiffness from SSI. Results from simulated train passages, with a train set consisting of two wagons, were compared for the different boundary conditions. The models have also been compared with measurement data from the bridge, which has given indications about which model describes reality in the best way. The results show that the model in which SSI is included by frequency dependent boundary conditions is in slightly better agreement with measurement data than the clamped model and the model with static stiffness. The model gives a slightly better damping of the free vibrations and the natural frequencies correspond better with experimental data. The difference in maximum acceleration from a train passage is very small between the different models, even if it is found that the clamped model generally has lower accelerations and hence is non-conservative. It appears that the train speed affects the maximum acceleration, the size of the free vibrations and the natural frequencies that are present in the free vibrations in the models. Further studies are suggested where it is emphasized that an analysis with longer trains, which give resonance phenomena, should be made to see how the different eigenfrequencies in the models affect the accelerations at different speeds. It is also noted that more measurements would be needed in order to draw more general conclusions about the degree of correspondence between the measurements and the models, and to calibrate the parameters of the model against measurement data.

Light-frame shearwall assemblies have been successfully used to resist gravity and lateral loads, such as earthquake and wind, for many decades. However, there is a need for maintaining the structural integrity of such buildings even when large openings in walls are introduced. Wood portal frame systems have been identified as a potential alternative to meet some aspects of this construction demand. The overarching goal of the research is to develop wood portal frame bracing systems, which can be used as an alternative or in combination with light-frame wood shearwalls. This is done through investigating the behavior of wood portal frames using the MIDPLY shearwall framing technique. A total of 21 MIDPLY corner joint tests were conducted with varying bracing details. Also, a finite element model was developed and compared with test results from the current study as well as studies by others. It was concluded from the corner joint tests that the maximum moment resistance increased with the addition of metal straps or exterior sheathings. The test results also showed a significant increase in the moment capacity and rotational stiffness by replacing the Spruce-Pine Fir (SPF), header with the Laminated Veneer Lumber (LVL) header. The addition of the FRP to the standard wall configuration also resulted in a significant increase in the moment capacity. However, no significant effect was observed on the stiffness properties of the corner joint. The FE model was capable of predicting the behavior of the corner joints and the full-scale portal frames with realistic end-conditions. The model closely predicted the ultimate lateral capacity for all the configurations but more uncertainty was found in predicting the initial stiffness.The FE model used to estimate the behavior of the full-scale portal frames constructed using the MIDPLY framing techniques showed a significant increase in the lateral load carrying capacity when compared with the traditional portal frame. It was also predicted using the full-scale FE model that the lateral load carrying capacity of the MIDPLY portal frame would increase with the addition of the metal straps on exterior faces. A parametric study showed that using a Laminated Strand Lumber (LSL) header increased the lateral load carrying capacity and the initial stiffness of the frames relative to the SPF header. The study also showed that there was an increase in the capacity if high strength metal straps were used. Doubling of the nail spacing at header and braced wall segment had a considerable effect on the lateral capacity of portal frame. Also, the initial stiffness was reduced for all the configurations with the doubling of the nail spacing at the header and braced wall segment in comparison with the reference frame.

Am 9. Mai eröffnete Staatssekretär Dr. Knut Nevermann beim Sächsischen Bibliothekarstag in Schloss Forderglauchau das Bibliotheksportal Sachsen.

Syftet med denna uppsats är att undersöka hur berättarteknik i tv-spel skulle kunna undervisas om på gymnasienivå. Hur teoretiserar vi det mediespecifikt narrativa i tv-spel, det vill säga hur spelmekaniken i sig förmedlar en narrativ upplevelse, och hur kan denna teoretisering i sin tur anpassas för undervisning? För detta ändamål analyseras här tv-spelet Portal med hjälp av den teori om tv-spelsnarrativ som Henry Jenkins lägger fram i ”Game Design as Narrative Architecture” (2004), där han särskiljer fyra sätt som tv-spel förmedlar berättelser genom sin spatiala design: suggestiva rum, utagerade berättelser, inlemmat narrativ, framväxande narrativ. Analysen finner att berättandet i Portal främst uppvisar drag av kategorierna utagerade berättelser, inlemmat narrativ och suggestiva rum och i diskussionen framkommer det att nackdelen med Jenkins teori är att dessa tre kategorier egentligen borde anses vara varianter av samma kategori, utagerade berättelser, fast med olika betoning. I den didaktiska diskussionen framkommer det avslutningsvis att ett sätt att undvika denna begreppsförvirring och därtill anpassa teorin för gymnasieundervisning i svenskämnet är att ersätta detta begreppspar med hård och mjuk karaktärisering, där hård karaktärisering innebär att spelarkaraktären definieras tydligt i förväg och mjuk karaktärisering innebär att spelaren själv inbjuds att definiera spelarkaraktären.

The main purpose of this master's thesis is to create language version tools for web Portal of BUT. There are possibilities of applications using databases or without them. The next part of the thesis analyses current situation of the web Portal of BUT. I described individually servers, tools and mainly solution ensuring multilingual sites. Thereinafter I attend to design and implementation of required system. This system consists of some single scripts and web applications for web developers and translators. Finally I will describe the procedure of integration of this system to current web Portal of BUT.