藥品安定性試驗的目的乃在於確保該藥品具有優良藥品之特性，以保障消費者之權益。而藥品安定性試驗的品質良窳實取決於當地政府機關對其試驗之要求準則而定。近年來，我國不斷的在藥品安定性試驗方面進行研究和推擴，以提升國內市面上藥品之品質。本論文主要探討兩個主題：一是有關台灣在進行藥品安定性研究時，所規定藥品存放環境的溫度及溼度，以擬定出適合台灣環境之藥品儲存的溫溼度存放標準。二是針對藥品長期安定性試驗有效期限估算之軟體開發，使藥廠對藥品安定性試驗有效期限估算之研究分析更加便利。

University of Macau / Institute of Chinese Medical Sciences

本論文「客語打類、忍類及促類動詞中動力學之體現」從物理學中之動力學觀點來審視語言之現象，以Lai (2000)針對客語打類動詞詞彙化類型之研究以及Gao (2001), Gao & Cheng (2002)針對中文與英語中肢體接觸類動詞之研究為基礎，並進一步修正及採用Talmy (2000a)所提出之動力學架構來加以分析客語打類、忍類及促類三類近義動詞。客語之打類動詞涉及內在心理意圖與外在肢體接觸，亦即同時牽涉到心理層面與肢體層面中「力」的作用，忍類動詞中「力」的衝突發生於內在心理層面，亦即本我與自我之間產生衝突，而促類動詞則表現出交互心理層面中「力」的相對關係，亦即藉由溝通等方式與他人產生「力」的對抗。因此，本論文藉由分析此三類動詞，將得已呈現心理肢體(psychophysical)，內在心理(intrapsychological)以及交互心理(interpsychological)三個不同層面中動力學之體現，並能夠進一步檢視語意內涵「力」與此三類動詞之句法表現間之相互關係。 / Based on Lai’s (2000) study of verbs of hitting in Hakka and Gao’s (2001) and Gao & Cheng’s (2002) studies of verbs of physical action by impact in English and Mandarin Chinese, this study modifies the force-dynamic model proposed by Talmy (2000a) to analyze Hakka hitting verbs in psychophysical domain, Hakka refraining verbs in intrapsychological domain, and Hakka urging verbs in interpsychological domain. The analysis proposes that two force-dynamic patterns can be generalized from these three groups of verbs, one ONSET CAUSATION pattern, and the other ONSET DESPITE pattern. Moreover, the correlation between the semantic component FORCE and the syntactic manifestation has been examined. This force-dynamic opposition is manifested in syntax as demonstrated by resultative complements, BUN-constructions, LAU-constructions, the potential mode and verb-copying constructions along with the adverbs of duration. In addition, the confirmation of the speaker’s expectation can be achieved by adverbs of evaluation and adverbs of justification. The well-formedness of these syntactic structures and the felicity of the usage of the adverbs depend heavily on the interaction of the Antagonist’s force and the Agonist’s force.

本論文旨在審視中文使動性是否具有連續性。使動性的來源主要有兩種觀點：衍生語法認為使動性是由句法位移得到，而詞彙語法則認為使動性是詞彙本身所賦予的。本文根據「直接性」、「動力學」和「及物性」三個面向研究中文使動詞和使動結構的使動性，結果可分為高、中、低三個層次。高使動性傾向由中文使動詞表現而低使動性則傾向由使動結構表現。使動性的差異不僅支持詞彙語法對使動性來源的解釋，對衍生語法認為使動性源自於句法結構的說法提出反駁，也符合自然語言的象似性原則。 / Derivational grammarians propose that causativity comes from the syntactic structures whereas lexicalists suggest it is incorporated within the formation of the lexicon. This thesis aims to investigate Mandarin lexical and periphrastic causatives to see if their causativity varies depending on the category of causative to which they are assigned. Three frameworks are adopted here to examine causatives from diverse perspective, directness, force-dynamics and transitivity. This combined framework is utilized to examine Mandarin lexical causatives and typical periphrastic causatives including 使shi, 令ling, 讓rang, 叫jiao1, and 教 jiao2 constructions. The results indicate that causativity forms a continuum in which the degree of the causativity of lexical causatives ranges from high to intermediate but that for periphrastic causatives ranges from intermediate to low. The variation in the degree of causativity proves that the derivational account is incorrect. Moreover, this study supports the lexicalist viewpoints that the causativity has variations because it is integrated in the lexical formation. In addition, more evidence, such as adverb placement and resultative compound formation, is provided to demonstrate that lexicalist accounts take the advantage of explaining the causativity. Finally, the variation of causativity has demonstrated that the shorter the forms are, the greater the degree of causativity is. This observation conforms to the principle of iconicity, and is encoded in humans’ cognition and the natural language.

隨著全球化的發展，廿一世紀的國際安全情勢更為錯綜複雜，其中「恐怖攻擊」具備成本低、效果高、機動性強的條件，讓恐怖攻擊行動沒有時間、空間的限制，亦無道德、規範的侷限，此種全然改變戰爭本質的非傳統型態戰爭行為，儼然已成為危害國際社會發展與人類生存的一種新形態危機。 今日國際社會所要面對的「恐怖攻擊」危機，是由人為所誘發的危機。受到不同社會系統內政治、文化、經濟、種族、宗教等因素相對之間的動態性互動影響，使得危機的源頭更趨向於多元與複雜，因此，若能及早偵知危機預將發生或能判明引爆危機的原由，對於危機管理甚有助益。 針對「動態性複雜」問題，Peter M. Senge發展一套源自於系統動力學的「系統思考」途徑，透過「資訊回饋」的特性，由整體思考方式與觀察環狀因果的互動關係，能看出一再重複發生的結構型態，釐清複雜事件背後運作的簡單結構，並經由模式設計改善組織及工作指導準則。 研究發現，在危機管理的系統思考途徑中，事件層次的反應式作為僅能有限度地預防危機與處理危機；行為變化型態層次的順應變動中的趨勢，能從變動趨勢中警覺危機、發現危機與危機處理，若要全方位預防危機、有效危機處理以避免後遺，就必須從系統結構層次的觀點著手，改造行為的變化型態。 依據九一一事件的分析，人為所誘發危機的關鍵在於「人」，以及「人與人的互動關係」，爭奪的重點就在「利益」，也就是「得」與「失」之間；恐怖主義濫殺無辜，不可原諒也不可寬容，但另一方面，反恐政策也不應如美國政府在九一一事件後「擴張軍武、推銷軍售、共同發展武器」等作為就可以達成。 美、英等強權國家在探討反恐策略為何失敗、譴責恐怖攻擊手段兇殘之際，是否也應該反省文明衝突與族群對立的源頭，以及阿富汗、伊拉克人民的死傷慘狀，以及在其他地方所發生的殺戮與飢餓問題，才能避免強權國家一意孤行的後果，由全球的無辜者共同承擔。同時，基於地球的資源有限，如何和平共處、分享資源，才是遠離「人為誘發危機」的最佳方法。 / Following the development of globalization, the international security situation of 21st century becomes more complicated. The "terror attack" has the conditions of low cost, high effect, and high mobility, which make the terrorist no limitation of time and space and no restriction of moral and norm. The kind of non-traditional type warfare behavior completely changes the nature of war. That solemnly becomes the new type crisis to endanger the development of international community and the existence of human being. Today’s international community should face the "terror attack" crisis which is brought out by mankind. The factors of politics, culture, economy, race, and religion of different kind of community systems have relatively dynamic interaction effect which makes the crisis origin trend to more diverse and complicated. For this reason, if we can early detect the cause of the crisis, when and where, it will be very helpful for crisis management. Being aimed at "dynamic complexity", Peter M. Senge developed the "systems thinking" approach from systematic dynamics which goes through the characteristic of "information feedback" from the interaction of integrated thought manner and observed circle effect, and find out the repeated configuration to clear the back performance of simple structure of complicated event, and improve the guidelines of organization and work by mode design. Findings discover that during the approach of systems thinking of crisis management, event-arrangement behavior can only limitedly prevent from crisis and handle crisis. The variation-orientated trend of behavior variation arrangement can watch crisis, discover crisis, and handle crisis from variation trend. If someone wants to dimensionally prevent crisis, effectively handle crisis and avoid sequela, he should do it from the viewpoint of systematic constructive arrangement and to change the behavior variation type. According the 911 analysis, the key point of man-made crisis is "man", and the key point of argument from "interaction of the men" is "benefit", which is between "to gain" and "to lose". The terrorism causes the death of innocence, which can not be forgiven. But in the other side, counter-terrorist policy should not be achieved by "arms drive, promoting military sale, and mutually developing weapons", provided from US government after 9/11. When the powerful states, such as US, UK, probe into failure of counter-terrorist policy and condemn the cruel measure of terrorist attack, they should make themselves-examination of the fountainhead of civilization conflict and clan confrontation, and the casualty of Afghanistan and Irapi, and the slaughter and starvation of other places. Considering those things, we can avoid the result of powerful state doing, which put on the innocence of the world. At the same time, based on the limited resources of the earth, the best way to keep off "man-made crisis" is to live peace and to share resources.

全球運籌的大趨勢使得紡織業必須轉換為全球佈局的產區導向。在台灣內部環境變遷和全球整體大環境劇烈改變下，紡織業早已將生產據點外移，轉移到生產成本更低的地方，增加企業的競爭力。紡織業也是台灣最早進行全球生產佈局的產業之一。因此，將紡織業設置在全球生產、行銷、研發的據點，與台灣營運總部互相連結，紡織業全球運籌之效率及整體的競爭力才能得以更加提昇。 以績效指標作為企業管理的核心，方能有效追蹤經營管理專案執行的狀況。運用績效指標訂立出企業維持營運的重要資訊數字，亦可事先預測企業表現並即時監督改善。透過績效指標的推動與實施，能夠幫助企業達到績效極大化的目標。因此，當企業規劃全球運籌的營運活動時，「指標」可謂評估上絕對不可或缺的一項重要管理工具。 過去對於台灣紡織業之全球運籌績效指標的研究相當少見，本研究所提出之紡織業全球運籌績效指標參考架構，藉由文獻探討，將供應鏈、紡織業、全球運籌此三個領域特性考量在此架構中，並與經濟部技術處示範性資訊應用開發計畫之八家個案廠商所提出的績效指標結合，所得到之結果再利用德爾菲法與學者專家訪談後分析結果，瞭解學者專家對初步之架構之建議，以強化此初步參考架構的適切與完整性。後以嚴謹的方式建立紡織業供應鏈之系統動力學模型，利用電腦模擬工具Powersim建構聚紡織業供應鏈之系統動態模式，並以情境分析模擬，評估在不同產業情境下，不同關鍵績效指標對於產業供應鏈績效之敏感度，以提供業者作為發展供應鏈績效指標架構之參考。 關鍵字： 紡織業、績效指標、系統動力學、灰色理論、全球運籌 / The trend of global logistic makes companies to change the pattern of supply chain. In Taiwan and the global environment, the companies have to locate elsewhere, to lower production costs, to increase the competitiveness of enterprises. The companies have to link the global production, marketing, research and development base with the headquarter of Taiwan to cooperate. Thus the efficiency of global logistic and the overall competitive can be more upgraded. We proposed a Global logistic performance indicators framework, through literature review in three areas in this framework: supply chain, the textile industry and global logistic. And then we compare the framework with performance indicators of eight cases of the textile industry. And the results have been used Delphi interviews with scholars and experts. After analysis of the Delphi’s results, we use a rigorous approach to build a system dynamics model of Taiwan's textile industry’s supply chain. We use simulation to test the sensitivities of each indicator in the framework to selected key indicators which can meet Taiwan textile industry’s need and rapidly respond to the real situation. Keywords: Global logistic、Performance indicator、System dynamic、Gray statistics、textile industry

關於供應商評選模式的探討與研究，是現今於供應鏈管理中非常重要的議題，而對於國內外供應商評選的相關性研究中，往往只考量供應商本身績效，而缺乏整體性的考量，有鑑於此，當企業在評選供應商時，不僅是針對單一供應商績效的考量，而對於供應商本身上下游廠商的整體績效的考量，也是相當重要的評選因素。本研究運用資料包絡分析法(Data Envelopment Analysis, DEA)與簡易多屬性評等技術(Simple Multi-Attribute Rating, SMART)，以建構較完整的供應商評選模式，協助企業的決策者選擇最適的供應商。 在進行供應商與供應商所屬的供應鏈之績效評估時，利用資料包絡分析法中的交叉模式計算供應商與供應商所屬的供應鏈之平均效率，再藉由平均效率值以排序供應商與供應商所屬的供應鏈之優先順位，但因兩者之順序會產生不一致的情形，利用SMART法中的排序加總法計算兩者之權重值，最後以加總法計算綜合效率值，依據綜合效率值加以排序以評選最適的供應商，而此兩種方法的結合， 則需透過驗證的方式以確定運用之正確性，利用系統動力學(System Dynamics, SD)以建構供應鏈之整體廠商的經營環境，模擬供應鏈整體廠商之績效評估模式，以產生模擬驗證排序，最後再將綜合排序與驗證排序，利用Spearman等級相關係數驗證其相關性，而最終證明兩排序具有高度相關性，也證實本研究所提出的供應商評選模式富有參考價值。 / The research of supplier selection model is a very important issue in supply chain management (SCM). Even though the research on supplier selection is abundant, the most works usually only consider the performance of the supplier. This situation can result in a lack of integral deliberation. Therefore, the decision-maker wants to select his vendor in the company, it is important that the decision-maker not only focus on the business unit but also add to the overall organization of the supply chain. In this paper the Data Envelopment Analysis (DEA) and the Simple Multi-Attribute Rating (SMART) are developed to construct the effective supplier evaluation model depends upon the constituent parts of the supply chain, which may be helpful for selecting the appropriate vendor. When evaluating the performance of the supplier and the supplier’s supply chain, the cross-efficiency model of DEA is applied to compute average efficiency both the supplier and the supply chain. According to average efficiency, we can arrange the priority order that may be have the inconsistent order for the suppliers and their supply chains. The rank sum weighting of SMART is employed to determine the weights of suppliers and their chains and then the weighted method is used to calculate overall efficiency that ranking of the suppliers is obtained. Above of two methods, we must be verify the model. The System Dynamics (SD) is designed to implement the whole components of the supply chain for business environment and simulate the performance model. Based on this performance model, we can acquire a confirmation list. In the end, the Spearman’s rank correlation coefficient is provided to testify the correlation between the overall order and the confirmation list. The result of the statistic analysis is illustrated the strength of the association. The model can be tailored and applied by firms that are making decisions on supplier selection.

本論文乃是藉由現代中醫科學研究，進一步指出中醫科學化的可能性及其問題。由於中醫理論十分駁雜，筆者將焦點主要集中於中醫脈診之上，藉由汪叔游和王唯工的研究，來討論中醫脈診科學化的可能性和問題。 本論文進行方式，主要可分為兩個步驟，首先針對傳統中醫理論地位的問題加以討論，其次乃是針對現代中醫實驗。 在第一步驟中，筆者提出一個理論作為科學理論所必須符合的最低標準，即是科學化三原則，分別是：可落實原則、主體際性原則以及系統化原則。藉由科學化三原則筆者嘗試論證傳統中醫並非是科學理論或是經驗有效的理論，最多僅能將中醫醫療實踐視為經驗有效的醫療診斷技術。 在第二步驟中，筆者藉由汪叔游和王唯工的實驗，來討論其經驗上和概念上的問題。藉由兩人的研究，筆者將進一步指出中醫科學化的過程中，必須經過理論的重新建構，而不是僅在於累積客觀的經驗資料就可證實中醫理論。

量子擾動及挫折性兩者均可破壞絕對零溫的磁序，為近代凝態物 理關注的有趣現象。在外加橫場下的三角晶格易辛反鐵磁兼具量子臨 界現象(quantum criticality)及幾何挫折性，可謂量子磁性物質之一典 範理論模型。本論文利用平衡態及非平衡態量子蒙地卡羅(quantum Monte Carlo)方法探測三角晶格易辛反鐵磁之量子相變，其界定零溫 時無磁性的順磁態及具 Z6 對稱破缺的有序態(所謂時鐘態)。這裡的 量子蒙地卡羅方法為運用算符的零溫投射(zero-temperature projector) 及隨機序列展開(stochastic series expansion)演算法。在非平衡模擬 中，我們分別沿降溫過程及量子絕熱過程逼近量子相變點，藉此我們 得到動力學指數，及其它相關臨界指數。 / The destruction of magnetic long-range order at absolute zero temperature arising from quantum fluctuations and frustration is an interesting theme in modern condensed-matter physics. The triangular lattice Ising antiferromag- net in a transverse field provides a playground for the study of the combined effects of quantum criticality and geometrical frustration. In this thesis we use quantum Monte Carlo methods both in equilibrium and non-equilibrium setups to study the properties of the quantum critical point in the triangular lattice antiferromagnet, which separates a disordered paramagnetic state and an ordered clock state exhibiting Z6 symmetry breaking; The methods are based on a zero-temperature projector algorithm and the stochastic series ex- pansion algorithm. For the non-equilibrium setups, we obtain the dynamical exponent and other critical exponents at the quantum critical point approached by slowly decreasing temperature and through quantum annealing.