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Thesis (MScMedSc (Biomedical Sciences. Medical Biochemistry))--University of Stellenbosch, 2010. / ENGLISH ABSTRACT: Mycobacterium bovis has a wide host range and infects many wild and domestic animal species as well as humans. African buffalo (Syncerus caffer) is considered to be a wildlife reservoir of M. bovis in certain environments in South Africa, such as in the Kruger National Park (KNP) and Hluhluwe-iMfolozi Park (HiP). A detailed pathological study was conducted on 19 African buffalos (Syncerus caffer) from a herd in the HiP in South Africa. The animals tested positive to the intradermal bovine tuberculin test and were euthanazed during a test-and-cull operation to decrease the prevalence of bovine tuberculosis (bTB) in the park. The superficial, head, thoraxic and abdominal lymph nodes and the lungs were examined grossly for presence of tuberculous lesions and were scored on a 1-5 scale for macroscopic changes. The gross lesions were examined histologically and scored I-IV according to a grading system used for bTB lesions in domestic cattle. Macroscopical lesions were limited to the retropharyngeal, bronchial, and mediastinal lymph nodes and the lungs. The most frequently affected lymph nodes were the bronchial (16/19) and mediastinal (11/19). All four grades of microscopic lesions were observed, although grade II lesions were the most frequent. Acid-fast bacilli were observed only rarely. Bovine tuberculosis was confirmed by PCR analyses. All animals were in good body condition and most of the lesions were in an early stage of development, indicating an early stage of the disease. The absence of lesions in the mesenteric lymph nodes and the high frequency of lesions in respiratory tract associated lymph nodes suggest that the main route of M. bovis infection in African buffalo is inhalatory rather than alimentary. This study presents a systematic evaluation and semiquantification of the severity and stages of development of tuberculous lesions in buffalo. The results may contribute to i) the understanding of the pathogenesis of the disease, ii) the evaluation of experimental models of M. bovis infection in Syncerus caffer, and iii) the interpretation of pathological data from vaccination trials. / AFRIKAANSE OPSOMMING: Mycobacterium bovis het ‘n wye reeks van gashere en dit infekteer verskeie wilde en mak dierespesies, sowel as mense. Die buffel (Syncerus caffer) word beskou as die wild reservoir van M. bovis in sekere dele van Suid Afrika, soos in die Kruger Nasionale Park (KNP) en Hluhluwe-iMfolozi Park (HiP). ‘n Breedvoerige patologiese studie is uitgevoer op 19 buffels afkomstig vanaf ‘n trop in die HiP in Suid Afrika. Die diere het almal positief getoets vir die intradermale beestuberkulin toets en is uitgesit tydens ‘n toets-en-slag operasie met die doel om die voorkoms van beestuberkulose (bTB) in die park te bekamp. Die oppervlakkige, kop, toraks en abdominale limfknope en longe is oorsigtelik ondersoek vir die teenwoordigheid van tuberkulose letsels en was ‘n punt toegeken op ‘n skaal van 1-5 vir die teenwoordigheid van makroskopiese veranderinge. Die opsigtelike letsels is histologies ondersoek en ‘n I-IV punt toegeken volgens die gradering wat gebruik word vir bTB letsels in beeste. Makroskopiese letsels was beperk tot die retrofaringeale, brongiale, en mediastinale limfknope en in die longe. Die brongiale (16/19) en mediastinale (11/19) limfknope was meestal geaffekteerd. Al vier grade van mikroskopiese letsels is gevind, alhoewel graad II letsels die volopste was. Suur-vaste basille is slegs selde waargeneem. Beestuberkulose is bevestig deur PKR analises. Al die diere was in ‘n goeie kondisie en meeste van die letsels was in ‘n vroeë stadium van ontwikkeling, wat aandui op ‘n vroeë fase van die siekte. Die afwesigheid van letsels in die mesenteriese limfknope en die hoë frekwensie van letsels in die lugweg geassosieerde limfkliere dui daarop dat the belangrikste roete van M. bovis infeksie in die buffel deur inaseming geskied eerder as deur opname in die spysverteringskanaal. Hierdie studie bied ‘n stelselmatige evaluering en semi-kwantifisering van die graad van erns en die stadia van ontwikkeling van tuberkulose letsels in buffels. Die resultate kan bydra tot i) die begrip van die patogenese van die siekte, ii) die evaluering van eksperimentele modelle van M. bovis infeksie in Syncerus caffer, en iii) die interpretasie van patologiese data van inentingsproewe.

This thesis examines the political implications of the integrated development planning process embarked upon by South African municipalities in the period 1998-2004. Through the use of case study methodology that focuses on the Eastern Cape municipalities of Buffalo City and Ngqushwa, the conventions of municipal planning are examined. This inquiry into municipal planning draws upon official government documents and reports and publications from the nongovernment sector. The thesis is particularly focused on the claims made in policy documents and related secondary sources and compares these to more critical reports and publication as well as the author's personal experience of the integrated development planning process. Of key interest is the possibility that planning serves political interests and the material needs of an emerging municipal elite and that this is seldom acknowledged in official planning documentation or government sanctioned publications on the topic. The primary findings of the thesis are as follows: • That the 'reason' of expert policy formulations that accompanied integrated development planning has weakened political economy as a prism of understanding and separated itself from the institutional reality of municipal government • That the dominant critique of planning and other post-apartheid municipal policy is concerned with the triumph of neoliberalism but this critique, while valid, does not fully explain successive policy failures especially in the setting of Eastern Cape local government • That function of policy and its relationship to both the state and civil society is usually understood only in the most obvious sense and not as an instrument for wielding political power • That planning still derives much of its influence from its claim to technical rationality and that this underpinned the 'authority' of the integrated development planning project in South Africa and reinforced its power to make communities governable.

Made available in DSpace on 2014-08-20T14:37:54Z (GMT). No. of bitstreams: 1 tese_maria_cecilia_florisbal_dame.pdf: 53923 bytes, checksum: e82c085a8b324064158221bf46a754ba (MD5) Previous issue date: 2013-12-12 / This thesis is a continuation of a research project started with a diagnosis of dermatosis mechano-bullosa in a herd of buffaloes from a farm in southern Rio Grande do Sul. After this diagnostic it was created an experimental herd where several congenital defects and / or hereditary disorders have been diagnosed during more than two decades. These diseases were studied by a research group which the author of this thesis is a member. Thus, three papers are presented: the first one is a literature review about what has been diagnosed in Brazil on congenital defects and hereditary diseases in buffalo. It was concluded that undesirable genes are widespread in the population of buffaloes in the country; the second was a study conducted in partnership with UNESP / Jaboticabal, SP and UFCG / CSTR-Patos, PB to identify the mutation in the gene that determines the oculo-cutaneous albinism in Murrah buffalo. Another paper was accomplished to describe the occurrence of malignant melanoma in two albino buffalo. Although it is not a congenital or hereditary disease it was observed only in the buffalo with oculocutaneous albinism and probably the condition is associated with a predisposition of these animals to develop tumors in the skin. / Esta tese dá continuidade a um projeto de pesquisa iniciado com o diagnóstico de dermatose mecanobolhosa em 1985 em um rebanho de búfalos pertencente a uma propriedade da zona sul do Rio Grande do Sul. A partir desse diagnóstico foi criado um rebanho experimental no qual por mais de duas décadas foram diagnosticados diversos defeitos congênitos e/ou hereditários que foram estudados por um grupo de pesquisa do qual faz parte a autora desta tese. Assim sendo, são apresentados três artigos científicos: o primeiro trata-se de uma revisão bibliográfica sobre o que foi diagnosticado no Brasil em relação a defeitos congênitos/doenças hereditárias em bubalinos concluindo-se que alguns genes indesejáveis estão disseminados na população de búfalos no País; o segundo foi um trabalho realizado em parceria com a UNESP/Jaboticabal, SP e com a UFCG/CSTR-Patos, PB que identificou a alteração no gene que determina o albinismo óculo-cutâneo em búfalos da raça Murrah. O terceiro artigo trata-se da descrição de melanoma maligno observado em dois búfalos albinos. Embora não seja um defeito congênito ou hereditário este neoplasma ocorreu somente nos búfalos com albinismo óculo-cutâneo do rebanho e acredita-se que a condição esteja associada à predisposição desses animais a desenvolverem tumores de pele.

This study looked at the opportunities and challenges faced in promoting smallholder farming as an element in rural economic development. The main objective is to highlight the key factors affecting smallholder production; and how those factors affect smallholder farmers in rural areas of Buffalo City Municipality, and hence identify the ones likely to predict success for future use in intervention programs. The content and scope of this study is limited to the socio-economic constraints (economic activities, household assets e.g. natural assets, physical assets, financial assets etc.) faced by rural households and therefore prescribe the necessary interventions to enhance rural livelihoods. Data was collected through review of secondary sources, direct observation through field visits and interviews with households. Questionnaires were used as the main tool of inquiry to gather data from households in selected villages within Buffalo City Municipality. The collected survey data was coded and analyzed using Statistical Package for Social Sciences (SPSS) Version 19.0. The study used Descriptive, Gini Coefficient and Binary Logistics model to analyze the collected survey data. For the descriptive model, the main pointers that were employed for this study were frequencies and mean values. The Gini Coefficient model was used to measure the contribution of different sources of income to overall inequality. The binary logistic regression model was used to uncover the correlates of the household income for different rural groups (famers and non-farmers). The results reveal that farm income has a strong association to overall household income per capita. Unearned income sources also have a substantial contribution to household income. Remittances and child grants were significant to non-farming household income per capita. Given the diminishing farm size of smallholder-led agriculture; these results suggest that a diversified household income portfolio is vital in addressing poverty in rural areas. Based on the results this study concluded that agricultural activities cannot solely enhance food security.

This thesis mobilizes the concept of “colonial entanglement” to emphasize the deep complexity and unpredictability of Indigenous and non-Indigenous relationships within what is now known as the Banff-Bow Valley. Responding to various literatures—including Indigenous Studies, Settler Colonial Studies, Political Theory, and Canadian Politics—I posit that the concept of colonial entanglements offers a parallax view of contexts, such as the Banff-Bow Valley, and events like the Buffalo Reintroduction Project. Not only does such a concept reveal how Indigenous nations— both human and non-human—are targeted by the racializing and gendered entanglements of colonizing regimes that seek to break up and replace them, but it also shows how these nations continue to persist and resist despite colonizing efforts to achieve otherwise. In other words, colonial entanglements compel one to also consider how nations like the Ĩyãħé Nakoda also exert influence on other Indigenous and non-Indigenous life in the Banff-Bow Valley—albeit, in different ways and to different degrees. After unpacking the concept in the first chapter, I use colonial entanglement to show how colonizing regimes and their expansionist modes of relationship react to the Indigenous nations they become entangled with. Using the signing of Treaty 7 and the establishment of a national park in Banff, I reveal how the Canadian state seeks to erect colonizing regimes of property that cater to capital as they transit the Banff-Bow Valley by ‘breaking up’ and ‘breaking from’ Indigenous nations and their expansive modes of relationship. Next, I consider how such reactionary violence is continually justified and legitimated through the articulation and reiteration of state of nature fictions that rely on notions of wilderness and tropes of Indigeneity to delegitimize the enduring presence of Indigenous nations. Specifically, I look at the Indian Act, the prohibition of hunting in the Park, and the Banff Indian Days festival to show how state of nature fictions articulate a supposed transition from a “past state of nature” to a contemporary “state of (dis)possession” entangled with white supremacist and heteropatriarchal forms of power. In doing so, these fictions make and reproduce colonial subjects who buy into and support colonizing violence and breakage that disproportionately targets those Indigenous to place. In the final chapter, I turn to focus on the Buffalo Reintroduction Project. Here, I consider how the project presents contemporary opportunities for both Indigenous and non-Indigenous people to support and/or disrupt colonizing states of (dis)possession and the state of nature fictions they rely on, while also considering the project’s potential for a politics oriented towards expansive modes of relationship revolving around principles of decolonization and anti-colonial internationalism. / Graduate

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One of the key determinants of the “quality” of a neighbourhood is the extent to which owners maintain their properties. Much has been written about the impact of neighbourhood blight or the physically rejuvenating impact of gentrification. To better understand why some neighbourhoods are thriving, and others not, a critical variable that has seen little exploration is the type of tenure. This thesis, focused mostly on data from the City of Rochester NY, comparing absentee landlords, resident landlords and owner-occupiers, looking for differences in the level of maintenance of residential properties. Using a procedure developed by the author, every house in Rochester, Buffalo, and Syracuse containing 1-6 units was assessed, creating a quantitative analysis that is both more current, and on a much larger scale than previous work. Findings mostly confirmed observations and theories in the literature, but there were a number of significant differences. The key observation within Rochester was that, regardless of geographic scale, absentee owners consistently took the worst care of their properties, followed by resident landlords and then owner-occupiers. Further, size and type of absentee landlord mattered. Tenure was found to be the driving force in predicting maintenance outcomes, compounded by variables such as property values and race. Evidence from Buffalo and Syracuse indicated that findings may be generalizable, at least for declining industrial cities. / Thesis / Master of Applied Science (MASc)

Les Conventions patrimoniales de l'UNESCO telles que la *Convention concernant la protection du patrimoine mondial culturel et naturel* de 1972 et *la Convention pour la sauvegarde du patrimoine culturel immatériel* de 2003 sont les principaux instruments de droit international avec la *Convention sur la protection et la promotion de la diversité des expressions culturelles* de 2005 qui visent la protection de la diversité culturelle. Cette dernière ne peut être pleinement satisfaite si les droits et libertés de ceux qui la portent ne sont pas respectés. Les droits culturels des communautés groupes et individus, et plus précisément leur droit de participer à la vie culturelle et leur droit à l'identité culturelle doivent ainsi être respectés par les Conventions patrimoniales dans le cadre de leur mise en œuvre. Nous nous intéresserons aux deux Conventions dédiées au patrimoine, à savoir, la *Convention concernant la protection du patrimoine mondial culturel et naturel* de 1972, la *Convention pour la sauvegarde du patrimoine culturel immatériel* de 2003. De nombreux éléments de la culture des peuples autochtones sont protégés et/ou sauvegardés par ces deux instruments. Certains sites du patrimoine mondial faisant l'objet de mesures de conservation sont utilisés par des peuples autochtones afin de perpétuer leurs pratiques culturelles. Certains rituels et savoir-faire autochtones figurent sur la liste représentative de la Convention pour la sauvegarde du patrimoine culturel immatériel. Ces Conventions, malgré leurs champs d'application et leurs objectifs distincts, veillent ainsi, toutes deux, à la protection et la sauvegarde de la culture des peuples autochtones. Cependant, les droits culturels de ces derniers ne sont pas pleinement respectés au sein des initiatives, des mesures et des programmes mettant en œuvre ces deux traités. Aucun mécanisme juridique particulier adapté aux spécificités culturelles des peuples autochtones n'est aussi déployé en leur sein. Depuis 1994, le Comité des droits de l'homme établit que, dans le cas des peuples autochtones, la satisfaction de leurs droits culturels implique le droit au respect de leur mode de vie particulier qui est associé à l'utilisation des ressources naturelles. Ces droits sont également intrinsèquement reliés au droit à l'autodétermination comme l'affirme la *Déclaration des Nations Unies sur les droits des peuples autochtones* (2007) qui est considérée aujourd'hui comme l'instrument de référence en ce qui concerne les droits des peuples autochtones. À ce jour, malgré les efforts des États pour mettre en œuvre la Déclaration des Nations Unies de 2007, les mécanismes actuels développés dans le cadre de deux Conventions patrimoniales demeurent insuffisants puisqu'ils ne tiennent pas compte d'une approche intégrée de la nature et de la culture ni ne proposent de stratégies précises guidant les États parties à mettre en place un système de gouvernance plus inclusif en collaboration pleine et entière avec les peuples autochtones. Ces deux conditions sont pourtant fondamentales pour satisfaire les droits culturels des peuples autochtones. Dans cette perspective, en plus de démontrer les lacunes des mécanismes des Conventions patrimoniales, notre projet proposera des moyens juridiques incitant les États parties aux Conventions à éviter le piège de la dissociation des ressources naturelles et culturelles et à garantir une pleine participation des peuples autochtones sur les questions qui les concernent directement. / UNESCO's heritage Conventions, such as the 1972 *Convention concerning the Protection of the World Cultural and Natural Heritage* and the 2003 *Convention for the Safeguarding of the Intangible Cultural Heritage*, are the main international legal instruments, along with the 2005 *Convention on the Protection and Promotion of the Diversity of Cultural Expressions* that aimed at protecting cultural diversity. Cultural diversity cannot be fully satisfied if the rights and freedoms of its bearers are not respected. The cultural rights of communities, groups and individuals, and more specifically their right to participate in cultural life and their right to cultural identity, must therefore be respected by the Heritage Conventions as part of their implementation. We will be focusing on the two Conventions dedicated to heritage: the 1972 *Convention concerning the Protection of the World Cultural and Natural Heritage*, and the 2003 *Convention for the Safeguarding of the Intangible Cultural Heritage*. Many elements of Indigenous Peoples' culture are protected and/or safeguarded by these two instruments. Some World Heritage sites subject to conservation measures are used by Indigenous Peoples to perpetuate their cultural practices. Some indigenous rituals and skills are included on the Representative List of the *Convention for the Safeguarding of the Intangible Cultural Heritage*. Despite their different scopes and objectives, these Conventions both aim to protect and safeguard the culture of Indigenous Peoples. However, the Indigenous Peoples' cultural rights are not fully respected in the initiatives, measures and programs implementing these two treaties. Nor are there any specific legal mechanisms adapted to their cultural specificities. Since 1994, the Human Rights Committee has established that, in the case of Indigenous Peoples, the satisfaction of their cultural rights implies the right to respect for their particular way of life, which is associated with the use of natural resources. These rights are also intrinsically linked to the right to self-determination, as affirmed by the *United Nations Declaration on the Rights of Indigenous Peoples* (2007), which is considered today to be the reference instrument with regard to the rights of Indigenous Peoples. To date, despite the efforts of States to implement the 2007 United Nations Declaration, the current mechanisms developed within the framework of two Heritage Conventions remain insufficient. They neither take into account an integrated approach to nature and culture, nor propose precise strategies to guide States Parties in setting up a more inclusive system of governance in full collaboration with indigenous peoples. Yet these two conditions are fundamental to satisfying the cultural rights of Indigenous Peoples. With this in mind, in addition to demonstrating the shortcomings of the mechanisms of the Heritage Conventions, our project will propose legal means to encourage States Parties to the Conventions to avoid the trap of dissociating natural and cultural resources, and to guarantee the full participation of Indigenous Peoples on issues that directly concern them.