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[pt] O município de Silva Jardim cuja região possui uma rica biodiversidade tanto em flora, quanto fauna, em seu bioma fragmentado. Um dos aliados para o processo de conservação dos biomas são as leis implementadas pelo Lei de Proteção da Vegetação Nativa, pois, visa proteger principalmente as áreas mais frágeis e de extrema importância para a recuperação da paisagem. Nesse sentido essa dissertação teve por objetivo avaliar o potencial de conservação a partir da integração da análise dos fragmentos florestais e da Lei de Proteção da Vegetação Nativa- LPVN. Para isso, a metodologia se debruçou em levantado todo o processo histórico de ocupação do município. Espacializar a LPVN através de técnicas de geoprocessamento em ambiente SIG. Utilizando os princípios da ecologia da paisagem, se escolheu as métricas de paisagem para avaliação dos fragmentos no software V-Late, podendo assim caracterizar o cenário atual. Tivemos como resultado 33,2 porcento do total de Silva Jardim protegidos pela LPVN. Os fragmentos muito pequenos e grandes foram os que mais chamaram atenção na análise final, tendo 45 porcento de suas áreas protegidas, devido a sua distribuição pela paisagem. Finalmente, quando analisamos a eficiência da LPNV, não podemos anular o processo de ocupação, dado que as áreas mais fragmentadas estão nos limites de APP de curso d água em áreas planas. Sendo assim, é preciso pensar em planos de educação e conscientização da população para a conservação da Mata Atlântica. / [en] The municipality of Silva Jardim, whose region has a rich biodiversity in both flora and fauna, in its fragmented biome. One of the allies for the conservation process of the biomes are the laws implemented by the Native Vegetation Protection Law because it aims to protect mainly the most fragile areas and of extreme importance for the recovery of the landscape. In this sense, this dissertation aimed to evaluate the conservation potential based on the integration of forest fragment analysis and the Native Vegetation Protection Law (Law 12.651 / 12). For that, the methodology looked at the entire historical occupation process of the county. Specialize Native Vegetation Protection Law through geoprocessing techniques in a GIS environment. Using the principles of landscape ecology, were chosen the landscape metrics to assess fragments in the V-Late software, thus being able to characterize the current scenery. As a result, 33.2 percent of Silva Jardim s total was protected by the Native Vegetation Protection Law. The very small and large fragments were the ones that attracted the most attention in the final analysis, with 45 percent of their areas protected, due to their distribution across the landscape. Finally, when we analyze the efficiency of Native Vegetation Protection Law, we cannot cancel the occupation process, given that the most fragmented areas are within the limits of permanent preservation watercourse sector in flat territories. Therefore, it is necessary to think about education and awareness plans for the conservation of the Atlantic Forest.

[pt] Um espectrômetro de massa PDMS-252Cf-TOF (Time-of-Flight Plasma Dessorption Mass Spectrometry) foi usado para analisar amostras condensadas de água pura e misturas de H2O:C2H2, H2O:C2H6 e H2O:N2O, em temperaturas entre 10 e 100 K. Os íons dessorvidos devido ao impacto foram identificados e seus rendimentos de dessorção determinados. Observa-se que a distribuição desses rendimentos em função da massa dos íons pode ser descrita pela soma de duas exponenciais. Este resultado sugere fortemente que ocorrem dois processos de formação de agregados: um, via emissão direta de fragmentos do sólido e outro, via recombinação de fragmentos na fase gasosa. Para H2O puro, os principais agregados dessorvidos são: ((H2O)nH2O+, (H2O)nH3O+, On +, (H2O)nO−, (H2O)nOH− e On −. Para misturas de gelos H2O:C2H2 e H2O:C2H6, são observadas as séries (C2H2)n + e (C2H6)n +. Para H2O:N2O, as séries Nn +, (O)nN2 +, (O)nN2−, (O)nN4−, e (N2)nNO+ são as mais abundantes. A Teoria do Funcional da Densidade (DFT), no nível B3LYP/6-31G, foi usada para calcular a estabilidade molecular dos íons moleculares secundários emitidos. Cálculos para as estruturas C2Hm + (com m = 1 a 6) geraram 26 estruturas estáveis. As curvas de estabilidade por massa/carga obtidas são comparadas com aquelas obtidas experimentalmente para os rendimentos de dessorção por massa/carga para os mesmos íons. Tal metodologia é utilizada para prever as conformações mais prováveis dos íons dessorvidos. / [en] A PDMS-252Cf-TOF (Time-of-Flight Plasma Desorption Mass Spectrometry) mass spectrometer was used to analyze condensed samples of pure water and mixtures of H2O:C2H2, H2O:C2H6 and H2O:N2O, at temperatures between 10 and 100 K. The ions desorbed due to the projectile impact were identified and their desorption yields determined. It is observed that the yield distributions as a function of the mass of the ions can be described by the sum of two exponentials. This result strongly suggests that two processes of aggregate formation occur: one, via direct emission of fragments from the solid and the other, via recombination of fragments in the gas phase. For pure H2O, the main desorbed aggregates are: ((H2O)nH2O+, (H2O)nH3O+, On +, (H2O)nO−, (H2O)nOH− and On −. For mixtures of ices H2O:C2H2 and H2O:C2H6, the series (C2H2)n + and (C2H6)n + are observed. For H2O:N2O, the series Nn +, (O)nN2 +, (O)nN2−, (O)nN4−, and (N2)nNO+ are the most abundant. Density Functional Theory (DFT), at the B3LYP/6-31G level, was used to calculate the molecular stability of emitted secondary molecular ions. Calculations for the C2Hm + structures (with m = 1 to 6) generated 26 stable structures. The stability curves per mass/charge obtained are compared with those obtained experimentally for the desorption yields per mass/charge for the same ions. Such methodology is used to predict the most likely conformations of the desorbed ions.

Mémoire en recherche-création / je parlerai des amélanchiers de saint-maxime-du-mont-louis est un récit en fragments composé en quatre sections/saisons. Ce texte-mosaïque dépeint une certaine écologie haute-gaspésienne : communauté, horticulture, amour, déchirures, solidarité, distance, violence, partage, résilience, autosuffisance. Ce récit, qui fait le pari de la douceur et de l’espoir, laisse entendre une critique des jeux de pouvoir permis par le capitalisme et son régime de propriété privée. je parlerai des amélanchiers de saint-maxime-du-mont-louis laisse entrevoir un monde de possibilités (complexes et fluides) où la nature impose son rythme. ARWEN 37 – une tentative est un essai en fragments qui propose une analyse des visées et des effets du texte Un œil en moins, de Nathalie Quintane. Le texte pose (et incarne) la question de la littérature comme espace de résistance politique : l’essai (la tentative) donne lieu à un exercice de déconstruction des normes et exigences qui entourent la rédaction d’un mémoire en littératures de langue française. ARWEN 37 – une tentative explore le thème de la séparation (ou du rattachement) entre « politique » et « littérature ». Ce texte, qui puise à la fois dans l’intime et le social, dénonce les dynamiques de pouvoir qui régissent nos rapports avec l’institution (politique, économique ou universitaire). / je parlerai des amélanchiers de saint-maxime-du-mont-louis is a collection of fragments written in four sections/seasons. The narrative takes the form of an ecological mosaic, representing the reality of a certain community in Haute-Gaspésie (horticulture, trauma, solidarity, kindness, violence, resilience, self-sufficiency). This text, guided by hope and tenderness, addresses the abuses enabled by capitalism and private ownership. je parlerai des amélanchiers de saint-maxime-du-mont-louis shows a world of complex and fluid possibilities, where nature stands its ground: trees are still growing, and birds chirping. ARWEN 37 – une tentative is a fragmented essay analyzing the aims and effects of Nathalie Quintane’s novel Un œil en moins. The text analyzes the separation (or ties) between politics and literature, and questions the extent to which literature can perform political resistance. While bringing up both personal and social stories, this essay attempts to deconstruct the norms ordering the redaction of a masters’ dissertation in littératures de langue française. This text provides a critique of the power dynamics defining our relations with political, economic and academic institutions.

"transgression" is a poetry collection with claws and nail polish. Across four acts, Reres uses a chorus of voices to interrogate the role of the transgressing woman—both present and past, privately and publicly. Transgressing, for Reres, is a performance. Moreover, it is a performance in which women have been asked, coerced—even forced—to participate for millenia. By stepping into the role of the transgressing woman deliberately, Reres turns this tradition on its head. In these pages, she shows that there is power in putting on masks and costumes, just as there is power in taking them off. The difference—between performance as power and performance as prison—resides in the freedom to choose. / Master of Fine Arts / "transgression" is a poetry collection.

This study examines the object biographies of musical instruments and the function of age in the cultural and material history of the lute. It follows the central question of why old instruments were valued more greatly than new ones and what measures had to be executed to adapt the objects to the ever-changing musical style. It traces the lute in its several cultural functions from the 17th to the 19th century: as a musical instrument, as a symbol, as a commodity, and as an object that had to be adapted, repaired, and altered by several generations of lute makers. This interdisciplinary approach uses a broad spectrum of sources from treatises, lute manuals, forewords in printed lute music, and depictions of lutes in literature, poetry, and visual arts to construct a narrative of the appreciation of old musical instruments. It investigates the material changes that were necessary to ensure their continued use by a profound study of more than 100 instruments in public and private collections. The different business models and prices in the trade of lutes are compared and connected to the common knowledge about old instruments and their brand characteristics among lute players. This study employs methods from musicology, organology, material culture studies, acoustics, economics, art history, technology, and digital humanities. This multivalent approach enhances the understanding of the general dynamics of commodities as status symbols, object biographies, and functional objects and connects them to the material and cultural history of objects using the lute as a case study. / Die Studie untersucht die Objektbiografien von Musikinstrumenten und die Funktion des Alters für die kulturelle und materielle Geschichte von Lauteninstrumenten. Sie geht der zentralen Frage nach, warum alte Instrumente höher geschätzt wurden als neue und welche Maßnahmen ergriffen werden mussten, um die Objekte an den sich ständig verändernden Musikstil anzupassen. Sie verfolgt die Laute in ihren verschiedenen kulturellen Funktionen vom 17. bis zum 19. Jahrhundert: als Musikinstrument, als Symbol, als Gebrauchsgegenstand und als Objekt, das von mehreren Generationen von Lautenbauern angepasst, repariert und verändert werden musste. Der interdisziplinäre Ansatz nutzt ein breites Spektrum von Quellen wie Traktate, Lautenhandbücher, Vorworte in gedruckter Lautenmusik und Darstellungen von Lauten in Literatur, Poesie und bildender Kunst, um die Geschichte der Wertschätzung alter Musikinstrumente nachzuverfolgen. Anhand einer eingehenden Untersuchung von mehr als 100 Instrumenten in öffentlichen und privaten Sammlungen werden die Eingriffe untersucht, die notwendig waren, um ihre weitere Nutzung zu gewährleisten. Die unterschiedlichen Geschäftsmodelle und Preise im Handel mit Lauten werden verglichen und mit dem Wissensvorrat unter Lautenisten über alte Instrumente und deren Markencharakteristiken in Verbindung gebracht. Die Studie verwendet Methoden aus der Musikwissenschaft, der Organologie, der materiellen Kulturwissenschaft, der Akustik, der Ökonomie, der Kunstgeschichte, der Instrumentenbautechnologie und der Digital Humanities. Der multivalente Ansatz verbessert das Verständnis der allgemeinen Dynamik von Waren als Statussymbole, von Objektbiografien funktionaler Objekte und verbindet sie mit der materiellen und kulturellen Geschichte der Objekte am Beispiel der Laute.

Background: Structure-based drug repositioning has emerged as a promising alternative to conventional drug development. Regardless of the many success stories reported over the past years and the novel breakthroughs on the AI-based system AlphaFold for structure prediction, the availability of structural data for protein–drug complexes remains very limited. Whereas the chemical libraries contain millions of drug compounds, the vast majority of them do not have structures to crystallized targets,and it is, therefore, impossible to characterize their binding to targets from a structural view. However, the concept of building blocks offers a novel perspective on the structural problem. A drug compound is considered a complex of small chemical blocks or fragments, which confer the relevant properties to the drug and have a high proportion of functional groups involved in protein binding. Based on this, we propose a novel approach to expand the scope of structure-based repositioning approaches by transferring the structural knowledge from a fragment to a compound level. - Results: We fragmented over 100,000 compounds in the Protein Data Bank (PDB) and characterized the structural binding mode of 153,000 fragments to their crystallized targets. Using the fragment’s data, we were able to artificially reconstruct the binding mode of over 7,800 complexes between ChEMBL compounds and their known targets, for which no structural data is available. We proved that the conserved binding tendency of fragments, when binding to the same targets, highly influences the drug’s binding specificity and carries the key information to reconstruct full drugs binding mode. Furthermore, our approach was able to reconstruct multiple compound-target pairs at optimal thresholds and high similarity to the actual binding mode. - Conclusions: Such reconstructions are of great value and benefit structure-based drug repositioning since they automatically enlarge the technique’s scope and allow exploring the so far ‘unexplored compounds’ from a structural perspective. In general, the transfer of structural information is a promising technique that could be applied to any chemical library, to any compound that has no crystal structure available in PDB, and even to transfer any other feature that may be relevant for the drug discovery process and that due to data limitations is not yet fully available. In that sense, the results of this work document the full potential of structure-based screening even beyond PDB.

The artist discusses the artwork of her Master of Fine Arts exhibition, Groundswell, held at Tipton Gallery in Johnson City, March 11 – 22, 2024. The exhibition includes wall pieces, sculpture, plaster, and ceramic objects that explore the traditional parameters of painting and its presentation. Ideas discussed include the philosophy of history, and the origin of European art tropes such as odalisques, flowers, and birds. Framing devices, deconstructed paintings, fiber arts, ceramics, 18th Century decorative art, plaster, the studio practice, Walter Benjamin, David Lowenthal, Gustave Courbet, Jean Honoré Fragonard, Titus Kaphar, Valerie Hegarty, and maximalism are also surveyed.

No / Recently published research indicates that soluble oligomers of beta-amyloid (Abeta) may be the key neurotoxic species associated with the progression of Alzheimer's disease (AD) and that the process of Abeta aggregation may drive this event. Furthermore, soluble oligomers of Abeta and tau accumulate in the lipid rafts of brains from AD patients through an as yet unknown mechanism. Using cell culture models we report a novel action of Abeta on neuronal plasma membranes where exogenously applied Abeta in the form of ADDLs can be trafficked on the neuronal membrane and accumulate in lipid rafts. ADDL-induced dynamic alterations in lipid raft protein composition were found to facilitate this movement. We show clear associations between Abeta accumulation and redistribution on the neuronal membrane and alterations in the protein composition of lipid rafts. In addition, our data from fyn(-/-) transgenic mice show that accumulation of Abeta on the neuronal surface was not sufficient to cause cell death but that fyn is required for both the redistribution of Abeta and subsequent cell death. These results identify fyn-dependent Abeta redistribution and accumulation in lipid rafts as being key to ADDL-induced cell death and defines a mechanism by which oligomers of Abeta and tau accumulate in lipid rafts.

Devant son incapacité à expliquer tant sa naissance que sa mort, l'homme cherche à se définir, et c'est en se mesurant à son environnement qu'il le fait. Ainsi de tout temps la relation le liant à l'animal est teintée par son désir de se définir par la mise en place de divers rapports dualistes. Ma production artistique questionne ce rapport ainsi que les dualités associées. C'est en utilisant le fragment comme fil conducteur que nous traverseront les différentes étapes de ma création artistique toujours imprégnée par ce rapport et de différentes notions connexes telle que la perception. Ce mémoire complète l'exposition "Arias" qui a présenté à la galerie des Arts Visuels les oeuvres produites lors des deux années passées à la Maîtrise en Arts visuels. Ces dernières malgré les diverses formes prises ( sérigraphie, reliure, animation, installation, sculpture, etc.) ont toutes été conçues suivant les idées amenées dans ce document.