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Efficacy and Safety of Intravenous and Oral Nadolol for Supraventricular Tachycardia in ChildrenMehta, A V., Chidambaram, B 01 March 1992 (has links)
The efficacy and safety of oral nadolol in supraventricular tachycardia were evaluated prospectively in 27 children (median age 5.5 years). Fifteen patients had an unsuccessful trial of digoxin therapy. Intravenous nadolol was given to seven patients during electrophysiologic study; five of these had an excellent response and two had a partial response (25% decrease in tachycardia rate). Six of these patients had a similar response to oral nadolol. Twelve patients received both propranolol and nadolol. Among six patients, intravenous propranolol was successful in four and unsuccessful in two; all six had a similar response to oral nadolol. With oral propranolol, tachycardia was well controlled in four patients and persistent in two; five of five patients had a similar response to oral nadolol. Twenty-six patients were treated with oral nadolol; the arrhythmia was well controlled in 23, 2 had recurrent tachycardia and 1 patient had tachycardia at a 25% slower rate. The effective dose of nadolol ranged between 0.5 and 2.5 mg/kg body weight once daily (median dose 1 mg/kg per day). During follow-up (3 to 36 months), compliance and tolerance were excellent; excluding 2 patients with reactive airway disease who developed wheezing, only 3 (12%) of 24 had side effects necessitating a change in drug therapy. Once a day nadolol is a safe and effective agent in the management of supraventricular tachycardia in children. Its long-term efficacy can be predicted by the short-term response to intravenous nadolol or propranolol during programmed electrophysiologic study.
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Severe neonatal hypernatraemia: a population based studyOddie, S.J., Craven, V., Deakin, K., Westman, J., Scally, Andy J. January 2013 (has links)
AIMS: To describe incidence, presentation, treatment and short term outcomes of severe neonatal hypernatraemia (SNH, sodium >/=160 mmol/l). METHODS: Prospective, population based surveillance study over 13 months using the British Paediatric Surveillance Unit. Cases were >33 weeks gestation at birth, fed breast or formula milk and <28 days of age at presentation. RESULTS: Of 62 cases of SNH reported (7, 95% CI 5.4 to 9.0 per 1 00 000 live births), 61 mothers had intended to achieve exclusive breast feeding. Infants presented at median day 6 (range 2-17) with median weight loss of 19.5% (range 8.9-30.9). 12 had jaundice and 57 weight loss as a presenting feature. 58 presented with weight loss >/=15%. 25 babies had not stooled in the 24 h prior to admission. Serum sodium fell by median 12.9 mmol/l per 24 h (range 0-30). No baby died, had seizures or coma or was treated with dialysis or a central line. At discharge, babies had regained 11% of initial birth weight after a median admission of 5 (range 2-14) days. 10 were exclusively breast fed on discharge from hospital. CONCLUSIONS: Neonatal hypernatraemia at this level, in this population, is strongly associated with weight loss. It occurs almost exclusively after attempts to initiate breast feeding, occurs uncommonly and does not appear to be associated with serious short term morbidities, beyond admission to hospital.
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Improving the safety of chemotherapy administration: an oncology nurse-led failure mode and effects analysisAshley, L.J., Dexter, R., Marshall, F., McKenzie, B., Ryan, M., Armitage, Gerry R. January 2011 (has links)
No / PURPOSE/OBJECTIVES: To assess and improve the safety of hospital-based adult chemotherapy administration. DESIGN: Prospective, systems-focused clinical risk assessment. SETTING: An adult inpatient and outpatient oncology unit in a large urban hospital in the United Kingdom. SAMPLE: 8-person nurse-led multidisciplinary team, which included managerial staff and patient safety researchers. METHODS: Failure mode and effects analysis (FMEA), a prospective, systems-focused risk assessment methodology, was undertaken in biweekly team meetings and included mapping the chemotherapy administration process, identifying and numerically prioritizing potential errors (failure modes) for each process step, and generating remedial strategies to counteract them. MAIN RESEARCH VARIABLES: The analysis aimed to identify chemotherapy administration failure modes and to generate remedial strategies to address them. User feedback on the FMEA process also was collected. FINDINGS: Several specific chemotherapy failure modes were identified, the majority of which had not previously been recognized, and several novel strategies to counteract them were generated. Many of the strategies were specific, environment-focused actions, which are simple, quick, and inexpensive to implement; however, more substantive, longer-term initiatives also were generated. User feedback generally was very positive, and the process of undertaking the analysis improved multidisciplinary teamwork and communication. CONCLUSIONS: Although time and resource intensive, FMEA is a useful safety improvement tool. IMPLICATIONS FOR NURSING: Nurses should be aware of and informed about FMEA as a tool they can use in partnership with management and other disciplines to proactively and collectively improve the safety of high-risk oncology procedures such as chemotherapy administration.
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Effectiveness of fluoroscopy-guided intra-articular steroid injection for hip osteoarthritisSubedi, N., Chew, N.S., Chandramohan, M., Scally, Andy J., Groves, C. 05 September 2015 (has links)
No / To demonstrate the benefits of fluoroscopy-guided intra-articular steroid injection in the hip with varying degrees of disease severity, and to investigate the financial aspects of the procedure and impact on waiting time. MATERIALS AND METHODS: A prospective study was undertaken of patients who underwent fluoroscopic intra-articular steroid injection over the 9-month study period. Comparative analysis of the Oxford hip pain score pre- and 6-8 weeks post-intra-articular injection was performed. Hip radiographs of all patients were categorised as normal, mild, moderate, or severe disease (four categories) based on the modified Kellgren-Lawrence severity scale, and improvement on the Oxford hip pain score on each of these four severity categories were assessed. RESULTS: Within the study cohort of 100 patients, the mean increase in post-procedure hip score of 7.32 points confirms statistically significant benefits of the therapy (p<0.001, 95% confidence interval: 5.55-9.09). There was no significant difference in pre-injection hip score or change in score between the four severity categories (p=0.51). Significant improvement in hip score (p<0.05) was demonstrated in each of the four severity categories 6-8 weeks post-injection. No associated complications were observed. CONCLUSION: The present study confirms that fluoroscopy-guided intra-articular steroid injection is a highly effective therapeutic measure for hip osteoarthritis across all grades of disease severity with significant cost savings and the potential to reduce waiting times.
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A new methodology for costing wound careHarding, K., Posnett, J., Vowden, Kath January 2013 (has links)
No / Increasing pressure on health care budgets highlights the need for clinicians to understand the true costs of wound care, in order to be able to defend services against indiscriminate cost cutting. Our aim was to develop and test a straightforward method of measuring treatment costs, which is feasible in routine practice. The method was tested in a prospective study of leg ulcer patients attending three specialist clinics in the UK. A set of ulcer-related health state descriptors were defined on the basis that they represented distinct and clinically relevant descriptions of wound condition ['healed', 'progressing'; 'static''deteriorating; 'severe' (ulcer with serious complications)]. A standardised data-collection instrument was used to record information for all patients attending the clinic during the study period regarding (i) the health state of the ulcer; (ii) treatment received during the clinic visit and (iii) treatment planned between clinic visits. Information on resource use was used to estimate weekly treatment costs by ulcer state. Information was collected at 827 independent weekly observations from the three study centres. Treatment costs increased markedly with ulcer severity: an ulcer which was 'deteriorating' or 'severe' cost between twice and six times as much per week as an ulcer which was progressing normally towards healing. Higher costs were driven primarily by more frequent clinic visits and by the costs of hospitalisation for ulcers with severe complications. This exercise has demonstrated that the proposed methodology is easy to apply, and produces information which is of value in monitoring healing and in potentially reducing treatment costs.
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Bilateral changes in foveal structure in individuals with amblyopiaBruce, Alison, Pacey, Ian E., Bradbury, J.A., Scally, Andy J., Barrett, Brendan T. January 2013 (has links)
No / PURPOSE: To examine foveal structure in amblyopia using spectral-domain optical coherence tomography (SD-OCT). DESIGN: Prospective, cross-sectional study. PARTICIPANTS AND CONTROLS: Two subject groups were recruited to the study: 85 amblyopes (34 adults, 51 children) and 110 visually normal controls (44 adults, 66 children). METHODS: A detailed eye examination, including an SD-OCT scan, was performed in all participants. A total of 390 eyes of 195 subjects were imaged using a 3-dimensional (3D) macula scan covering a nominal 6 x 6-mm area with a resolution of 256 x 256 (65,536 axial scans). Data from the B-scans bisecting the fovea both horizontally and vertically were fitted with a mathematical model of the fovea to determine a range of foveal parameters. MAIN OUTCOME MEASURES: Foveal thickness, foveal pit depth, and foveal pit slope. RESULTS: Bilateral differences between the eyes of amblyopes compared with visually normal controls were found. The difference between foveal structure in amblyopic participants relative to structure in subjects with normal vision persisted even when variables such as age, ethnicity, axial length, and sex were taken into account. Amblyopes showed increased foveal thickness (+8.31 mum; P = 0.006) and a reduction in pit depth in the horizontal meridian (-10.06 mum; P = 0.005) but not in the vertical meridian (P = 0.082) when compared with subjects with normal vision. Foveal pit slopes were found to be approximately 1 degree flatter in the nasal (P = 0.033) and temporal (P = 0.014) meridians in amblyopes, but differences between amblyopes and controls in the superior (P = 0.061) and inferior (P = 0.087) meridians did not reach statistical significance. No statistically significant interocular differences were found in the foveal structure between amblyopic and fellow eyes. CONCLUSIONS: Differences were found in the foveal structure in both eyes of amblyopes compared with subjects with normal vision. These differences consisted of increased foveal thickness, reduced pit depth when measured along the horizontal meridian, and flattening of the nasal and temporal sides of the foveal pit.
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Ultrassonografia intraoperatória para avaliação da necessidade de duroplastia no tratamento cirúrgico de doentes com malformação de Chiari tipo I / Intra operative ultrasonography for evaluation of the need of duroplasty in surgery for Chiari I malformationBrock, Roger Schmidt 03 April 2017 (has links)
Objetivos: Malformação de Chiari do tipo I (MC-I) é a principal doença malformativa congênita da junção craniovertebral, manifestando-se com ampla variedade de sinais e sintomas neurológicos. A melhor técnica cirúrgica a ser empregada no tratamento dos pacientes com malformação de Chiari do tipo I é ainda controversa. A descompressão das estruturas da fossa craniana posterior com plástica de ampliação dural é considerada procedimento padrão. Embora efetiva e de baixa morbidade, a craniectomia occipital isolada, sem abertura e ampliação dural, implica maior taxa de recidiva dos sintomas. Métodos que selecionam os pacientes quanto a necessidade da duroplastia não foram estabelecidos. O presente trabalho avalia a eficácia da mensuração intraoperatória da velocidade do fluxo do líquido cefalorraquidiano através da ultrassonografia (USG) na seleção da técnica cirúrgica a ser utilizada. Métodos: Foram analisados de forma prospectiva 49 pacientes submetidos à cirurgia para MC-I. A indicação de craniectomia da fossa posterior associada ou não à plástica de ampliação da dura-máter baseou-se na velocidade do fluxo do líquido cefalorraquidiano, mensurada pela ultrassonografia intraoperatória. Dor cervical, cefaleia e qualidade de vida foram avaliadas antes e após o tratamento cirúrgico. Resultados: Dos 49 pacientes incluídos, 36 pacientes (73%) apresentavam fluxo do líquido cefalorraquidiano superior a 3 cm/s e não foram submetidos a duroplastia ampliadora. Nos 13 (27%) pacientes com fluxo inicial inferior a 3 cm/s, indicou-se craniectomia occipital com duroplastia de ampliação. Não houve diferença significativa entre os dois grupos com relação aos parâmetros estudados. Conclusão: A ultrassonografia intraoperatória com avaliação da dinâmica e velocidade do fluxo do líquido cefalorraquidiano da junção craniovertebral auxilia a indicação de duroplastia durante descompressão da fossa craniana posterior em pacientes adultos com MC-I / Objectives: Chiari malformation Type I (CM-I) is the main congenital malformation disease of the craniovertebral junction, and may be responsible for a variety of neurological symptoms. The ideal surgical technique used to treat patients with CM-I is still controversial. Invasive procedures that enters CSF space and are associated with dural repair, are considered the gold standard. Although effective and less morbidity, isolated bone decompression without dural opening, implies greater recurrence of symptoms. Objective parameters to select patients, who need or not to have a duroplasty performed, have not been established. Our study evaluates the efficacy of intra-operative CSF flow measurement through the use of ultrasonography (USG) as a determining parameter in the selection of these patients. Methods: We analyzed prospectively 49 posterior fossa surgeries for patients with CM-I. Patients underwent decompressive surgery with or without opening of the dura mater after conducting USG intra-operatively with measured flow rate, being adopted 3cm/s flow rate as a determining value. The quality of life before and after surgery and the improvement of neck pain and headache were the parameters evaluated. Results: Of the 49 patients enrolled, 36 patients (73%) had adequate CSF flow above 3 cm / s and have not undergone duroplasty. In 13 (27%) patients with initial flow < 3 cm / s an opening in dura mater was performed together with duroplasty. There was no significant difference between the two groups regarding the parameters studied. Conclusion: Intraoperative ultrasound with measurement of CSF flow, having a flow of 3 cm / s as cut-off, allows the proper selection of patients with CM-I that can have a less invasive surgery with bone decompression without duroplasty
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Estudo prospectivo para avaliar a evolução radiológica de 12 pacientes portadores de esclerodermia da face e perfil demográfico, manifestações clínicas e alterações laboratoriais de 34 casos / Prospective study to evaluate the radiological evolution of 12 patients with localized scleroderma of the face and the demographic, clinical and laboratory findings of 34 casesCareta, Mariana Figueiroa 17 July 2013 (has links)
Introdução: A esclerodermia é rara doença do tecido conectivo que se manifesta através da esclerose cutânea e variável acometimento sistêmico. Duas categorias de esclerodermia são conhecidas: esclerose sistêmica, caracterizada por esclerose cutânea e acometimento visceral e a esclerodermia localizada ou morfeia que classicamente apresenta evolução benigna e autolimitada, confinada a pele e/ou tecidos subjacentes. Estudos recentes demonstram que a forma localizada possa eventualmente apresentar acometimento de órgãos internos e morbidade variável. Objetivo: Neste estudo objetivamos determinar as características demográficas, a prevalência de manifestações sistêmicas e alterações laboratoriais, bem como a associação com doenças autoimunes, em pacientes com esclerodermia da face. Métodos: Pacientes com esclerodermia localizada, incluindo os casos de esclerodermia em golpe de sabre, síndrome de Parry-Romberg e morfeia em placas com acometimento facial, foram avaliados e submetidos à investigação neurológica, incluindo exame clínico neurológico e ressonância magnética de crânio, e avaliação oftalmológica. Após 3 anos, o subgrupo de pacientes disponível para seguimento foi ressubmetido à ressonância magnética. Resultados: Foram estudados 34 pacientes com esclerodermia localizada da face. Deste total, 64,7% apresentavam uma ou mais manifestações extracutâneas, sendo cefaleia a queixa mais frequente, encontrada em 61,8% dos pacientes. Dos 23 pacientes submetidos à avaliação neurológica, 56,5% apresentaram alterações neurológicas possivelmente associadas à esclerodermia. Alterações à ressonância magnética foram observadas em 50% dos casos. O achado mais frequente foi a presença de lesões parenquimatosas com alteração de sinal em 50% dos pacientes. Dos pacientes que apresentavam alteração neurológica, 80% também apresentavam alguma alteração à ressonância magnética. Doze pacientes foram ressubmetidos a novo exame após 3 anos. Em todos os pacientes os achados de imagem se mantiveram inalterados. Durante esse intervalo de 3 anos, 25% dos pacientes apresentaram sinais de atividade da esclerodermia. Quanto à avaliação oftalmológica, 67,9% dos pacientes avaliados apresentaram alteração, sendo os achados mais frequentes a ocorrência de alterações orbiculares da esclerodermia (20,6%) e xeroftalmia (10,7%). Conclusão: Pacientes com esclerodermia localizada da face apresentam alta prevalência de alterações neurológicas e oftalmológicas. Baseado nestes achados, sugerimos que todos os casos de esclerodermia localizada da face devam ser detalhadamente examinados quanto à presença de alterações sistêmicas / Introduction: Scleroderma is a rare connective tissue disease that manifests as skin sclerosis and variable systemic involvement. Two categories of scleroderma are known: systemic sclerosis, characterized by cutaneous sclerosis and visceral involvement and localized scleroderma or morphea which classically presents benign evolution and selflimited, confined to the skin and / or underlying tissue. Recent studies show that the localized form may possibly course with involvement of internal organs and variable morbidity. Objective: This study aimed to determine the demographic characteristics, the prevalence of systemic manifestations and laboratory findings, as well as the association with autoimmune diseases, in patients with scleroderma of the face. Methods: Patients with localized scleroderma, including cases of scleroderma en coup de sabre, Parry-Romberg syndrome and morphea plaque with facial involvement were evaluated and underwent neurological examination, including neurologic examination and magnetic resonance imaging, and ophthalmology evaluation. After 3 years, the subgroup of patients available for follow-up was subjected again to MRI. Results: We studied 34 patients with localized scleroderma of the face. Of this total, 64,7% had one or more extracutaneous manifestation, headache being the most frequent complaint found in 61,8% of patients. Of the 23 patients undergoing neurological evaluation, 56,5% had neurological changes possibly associated with scleroderma. MRI changes were observed in 50% of cases. The most frequent was the presence of parenchymal lesions with signal alteration in 50% of patients. Of the patients who had neurological deficits, 80% also had a change to MRI. Twelve patients were subjected again to another MRI scan after 3 years. In all patients, imaging findings were unchanged. During this interval of 3 years, 25% of patients showed signs of activity of scleroderma. As for ophthalmologic evaluation, 67,9% of patients showed abnormalities, with the most frequent findings being the occurrence of orbicular changes of scleroderma (20.6%) and xerophthalmia (10.7%). Conclusion: Patients with localized scleroderma face have a high prevalence of neurological and ophthalmological changes. Based on these findings, we suggest that all cases of localized scleroderma of the face should be thoroughly examined for the presence of systemic changes
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Utilização de potenciais evocados a laser para avaliação da dor neuropática crônica durante a estimulação do gânglio da raiz dorsal / Use of laser-evoked potentials for evaluation of chronic neuropathic pain during dorsal root ganglion stimulationBarros Filho, Marcos Fortunato de 26 February 2019 (has links)
Objetivos: A dor neuropática crônica origina-se em consequência direta de uma lesão ou doença que afete o sistema somato-sensitivo. Pacientes que são refratários ao tratamento conservador são considerados candidatos a procedimentos invasivos, principalmente de ordem neuro-modulatória. A estimulação do gânglio da raiz dorsal é uma técnica recente de neuromodulação utilizada para o tratamento das dores neuropáticas crônicas de diferentes etiologias. Apesar do sucesso clínico da estimulação do gânglio da raiz dorsal no tratamento de dor neuropática já ter sido relatado em diversos trabalhos da literatura, os mecanismos neurofisiológicos responsáveis pelo alivio da dor ainda permanecem pouco esclarecidos. O presente trabalho avalia o efeito da estimulação do gânglio da raiz dorsal no processamento cortical da dor através do método de potenciais evocados a laser (PELs). Métodos: Avaliamos prospectivamente por 3 anos 34 doentes com dor inguinal (grupo 1), 62 doentes com dores neuropáticas diversas (grupo 2) que foram submetidos a estimulação do gânglio da raiz dorsal. Nestes 2 grupos foram analisadas variáveis relacionadas a intensidade da dor, incapacidade relacionada a dor, níveis de depressão e pensamentos catastróficos relacionados a dor. Adicionalmente, um subgrupo de 12 pacientes submetidos à cirurgia de estimulação do gânglio da raiz dorsal para tratamento de dor neuropática crônica unilateral da região inguinal, joelho ou perna por lesão direta de nervo periférico após procedimento cirúrgico, síndrome do insucesso da cirurgia espinhal ou síndrome dolorosa regional complexa tipo II foi avaliado de forma prospectiva (grupo 3). O lado normal foi utilizado como controle. PELs foram evocados por meio de estimulação a laser de CO2 na área desaferentada e normal. Latências e amplitudes dos componentes N2 e P2 e amplitudes do complexo N2-P2 foram correlacionados à intensidade da dor antes da terapia e após 1 e 6 meses de tratamento com estimulação do gânglio da raiz dorsal. Testes sensitivos quantitativos, escalas de intensidade da dor, incapacidade relacionada a dor, qualidade de vida, e depressão foram avaliadas. Resultados: Houve aumento significante das amplitudes do complexo N2-P2, igualando-se ao lado normal, e em paralelo diminuição significativa da intensidade de dor e na incapacidade relacionada à dor após 1 e 6 meses de tratamento em comparação com o estado pré-tratamento. Houve melhora significativa em 2 dos 8 itens de qualidade de vida avaliados. Não houve alteração significativa nos testes sensitivos quantitativos e na escala de depressão. Conclusão: A estimulação do gânglio da raiz dorsal restabeleceu as amplitudes dos PELs oriundos do giro do cíngulo anterior, ínsula e áreas temporais mediais, restaurando o processamento cortical fisiológico de dor em pacientes com dor neuropática crônica / Objectives: Chronic neuropathic pain originates as a direct consequence of an injury or disease that affects the somatosensory system. Patients who are refractory to conservative treatment are considered candidates for invasive procedures, mainly of neuro-modulatory order. Dorsal root ganglion stimulation is a recent neuromodulation technique used for the treatment of chronic neuropathic pain of different etiologies. Although the clinical success of dorsal root ganglion stimulation in the treatment of neuropathic pain has already been reported in several studies in the literature, the neurophysiological mechanisms responsible for pain relief remain unclear. The present study evaluates the effect of dorsal root ganglion stimulation on cortical pain processing through the use of laser evoked potentials (LEP). Methods: We evaluated prospectively during 3 years 34 patients with groin pain (group 1), 62 patients with various forms of neuropathic pain (group 2) who underwent dorsal root ganglion stimulation. In these 2 groups, variables related to pain intensity, pain-related disability, depression levels and painrelated catastrophic thoughts were analyzed. In addition, we prospectively analyzed a subgroup of 12 patients treated with dorsal root ganglion stimulation for treatment of chronic unilateral neuropathic pain of the groin region, knee or leg caused by direct injury of the peripheral nerve after surgical procedure, failed back surgery syndrome or complex regional pain syndrome type II (group 3). The healthy side was used as control. LEPs were evoked by means of CO2 laser stimulation in the deafferented and normal areas. Latencies and amplitudes of the N2 and P2 components and amplitudes of the N2-P2 complex were correlated to the pain intensity before therapy and after 1 and 6 months of treatment with dorsal root ganglion stimulation. Quantitative sensory testing, pain intensity scales, pain-related disability, quality of life, and depression were assessed. Results: There was a significant increase in N2-P2 complex amplitudes, matching the normal side, and in parallel a significant decrease in pain intensity and pain-related disability after 1 and 6 months of treatment compared to the pre-treatment state. There was a significant improvement in 2 out of 8 quality of life domains evaluated. There was no significant change in quantitative sensory testing and depression levels. Conclusion: Stimulation of the dorsal root ganglion reestablished the amplitudes of the LEPs originated from the anterior cingulate gyrus, insula, and medial temporal areas, restoring physiological cortical pain processing in patients with chronic neuropathic pain
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Dosis - Wirkungs - Studie zum Einsatz von inhalativem Stickstoffmonoxid bei Patienten mit schwerem akutem LungenversagenBösel, Matthias 06 July 2004 (has links)
Studienziel: Untersuchung der Dosis-Wirkung von inhalativem Stickstoffmonoxid (NO) bei Patienten mit schwerem akuten Lungenversagen (ARDS) und der diese Wirkung beeinflussenden Faktoren. Design: Prospektive, offene Beobachtungsstudie. Setting: Universitäts-Klinikum. Intensivstation. Patienten: 26 Intensivpatienten mit hohem pulmonal-vaskulärem Druck (PAP) bei zugrunde liegendem ARDS. Behandlung: Patienten mit ARDS wurden einer Therapie mit konventioneller Beatmung und Beimischung von inhalativem NO zugeführt. Das Protokoll sah die Applikation von NO in steigender Dosierung von 0,01 parts per million (ppm), 0,01 ppm, 1, 10 und 100 ppm vor. Zischen den Messungen wurden für 15 bis 20 Minuten Nullmessungen durchgeführt. Ein Anstieg des pulmonal-areriellen Sauerstoffdrucks (Pao2) um 20% wurde als "Responding" definiert. Messungen: Es wurden die Parameter des pulmonalen Gasaustausches wie PaO2, PaCo2 und CaO2 gemessen. Des Weiteren wurden die Werte für den mittleren systemischen Blutdruck (AP), den mittleren pulmonal-arteriellen Druck (PAP), den systemischen Widerstand (SVR), den pulmonalvaskulären Widerstand (PVR), die Herzfrequenz (HR), den Herzindex (CI), das Herz-Zeit-Volumen (HZV), den Wedgedruck (PCWP) und die venöse Beimischung registriert. Ergebnisse: NO verursachte einen dosisabhängigen Anstieg des Pao2 von 0,01 bis 10 ppm (p / STUDY OBJECTIVE: To determine the dose responsiveness to nitric oxide in adult patients with acute respiratory distress syndrom (ARDS), especially in those patients with pulmonary hypertension. To find factors influencing the response to NO. DESIGN: Prospective, open, nonblinded observation study. SETTING: University teaching hospital. PATIENTS: 26 ICU patients suffering from ARDS demonstrating pulmonary hypertension. INTERVENTIONS: Patients with severe acute respiratory distress syndrome received inhalation therapy with NO. Inhaled NO was sequentially titrated from 0,01 parts per million to 0,1 ppm, 1, 10, and 100 ppm at 15-minute intervals followed by a 15 to 20 min OFF interval. Changes in hemodynamics and gas exchange were monitored. An increase of at least 20 % in the oxygenation index was considered as a therapeutic response. MEASUREMENTS: Heart rate, mean arterial pressure, mean pulmonary arterial pressure, pulmonary vascular resistance (PVR), peripheral vascular resistance, cardiac index,rigt to left shunting , venous admixture and right ventricular ejection fraction were monitored throughout the study, as well as the Pao2, Cao2 and PaCo2. RESULTS: 26 patients received inhaled NO. Nitric oxide induced a dose-dependent increase in Pao2 for inspiratory nitric oxide concentrations ranging between 0.01 and 10 ppm (p
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