<p>In this research paper, it evaluates the benefits achievable from static testing framework by analyzing and transforming the <em>JUnit3.8 </em>source code and static execution of transformed code. Static structure enables us to analyze the code statically during creation and execution of test cases. The concept of research is by now well established in static analysis and testing development. The research approach is also increasingly affecting the static testing process and such research oriented work has proved particularly valuable for those of us who want to understand the reflective behavior of <em>JUnit3.8 Framework</em>.</p><p><em> JUnit3.8 Framework</em> uses <em>Java Reflection API</em> to invoke core functionality (test cases creation and execution) dynamically. However, <em>Java Reflection API</em> allows developers to access and modify structure and behavior of a program.  Reflection provides flexible solution for creating test cases and controlling the execution of test cases. Java reflection helps to encapsulate test cases in a single object representing the test suite. It also helps to associate each test method with a test object. Where reflection is a powerful tool to perform potential operations, on the other hand, it limits static analysis. Static analysis tools often cannot work effectively with reflection.</p><p>In order to avoid the reflection, <em>Static Testing Framework</em> provides a static platform to analyze the <em>JUnit3.8</em> source code and transform it into non-reflective version that emulates the dynamic behavior of <em>JUnit3.8</em>. The transformed source code has possible leverage to replace reflection with static code and does same things in an execution environment of <em>Static Testing Framework</em> that reflection does in <em>JUnit3.8</em>. More besides, the transformed code also enables execution environment of <em>Static Testing Framework</em> to run test methods statically. In order to measure the degree of efficiency, the implemented tool is evaluated. The evaluation of <em>Static Testing Framework</em> draws results for different Java projects and these statistical data is compared with <em>JUnit3.8</em> results to measure the effectiveness of <em>Static Testing Framework</em>. As a result of evaluation, <em>STF</em> can be used for static creation and execution of test cases up to <em>JUnit3.8</em> where test cases are not creating within a test class and where real definition of constructors is not required. These problems can be dealt as future work by introducing a middle layer to execute test fixtures for each test method and by generating test classes as per real definition of constructors.</p>

Från 1900-talets början har banker och låneinstitut använt nyckeltal som hjälpmedel vid bedömning och kvantifiering av kreditrisk. För dagens investerare är den ekonomiska miljön mer komplicerad än för bara 40 år sedan då teknologin och datoriseringen öppnade upp världens marknader mot varandra. Bedömning av kreditrisk idag kräver effektiv analys av kvantitativa data och modeller som med god träffsäkerhet kan förutse risker. Under 1900-talets andra hälft skedde en snabb utveckling av de verktyg som används för konkursprediktion, från enkla univariata modeller till komplexa data mining-modeller med tusentals observationer. Denna studie undersöker om det är möjligt att prediktera att svenska företag kommer att gå i konkurs och vilka variabler som innehåller relevant information för detta. Metoderna som används är diskriminantanalys, logistisk regression och överlevnadsanalys på 50 aktiva och 50 företag försatta i konkurs. Resultaten visar på en träffsäkerhet mellan 67,5 % och 75 % beroende på vald statistisk metod. Oavsett vald statistisk metod är det möjligt att klassificera företag som konkursmässiga två år innan konkursens inträffande med hjälp av finansiella nyckeltal av typerna lönsamhetsmått och solvensmått. Samhällskostnader reduceras av bättre konkursprediktion med hjälp av finansiella nyckeltal vilka bidrar till ökad förmåga för företag att tillämpa ekonomistyrning med relevanta nyckeltal i form av lager, balanserad vinst, nettoresultat och rörelseresultat. / From the early 1900s, banks and lending institutions have used financial ratios as an aid in the assessment and quantification of credit risk. For today's investors the economic environment is far more complicated than 40 years ago when the technology and computerization opened up the world's markets. Credit risk assessment today requires effective analysis of quantitative data and models that can predict risks with good accuracy. During the second half of the 20th century there was a rapid development of the tools used for bankruptcy prediction. We moved from simple univariate models to complex data mining models with thousands of observations. This study investigates if it’s possible to predict bankruptcy in Swedish limited companies and which variables contain information relevant for this cause. The methods used in the study are discriminant analysis, logistic regression and survival analysis on 50 active and 50 failed companies. The results indicate accuracy between 67.5 % and 75 % depending on the choice of statistical method. Regardless of the selected statistical method used, it’s possible to classify companies as bankrupt two years before the bankruptcy occurs using financial ratios which measures profitability and solvency. Societal costs are reduced by better bankruptcy prediction using financial ratios which contribute to increasing the ability of companies to apply financial management with relevant key ratios in the form of stock , retained earnings , net income and operating income.

Der Vortrag zeigt die Neuigkeiten in PTC Creo Simulate 3.0 auf. Zudem werden 10 "Tips & Tricks" erklärt, welche das Arbeiten effizienter machen.

Introdução: O linfoma difuso de grandes células B é o mais freqüente grupo de linfoma não- Hodgkin, perfazendo quase 50% dos casos no serviço de hematologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo e Instituto do Câncer do Estado de São Paulo. Possui heterogeneidade clínica e biológica traduzida em mais de vinte subtipos na Organização Mundial da Saúde. Sua terapêutica se baseia na associação do anticorpo monoclonal anti-CD20 e quimioterapia com antracíclico, esquema que resulta em 43,5% de sobrevida global em 10 anos. Determinantes de prognóstico clínico como o Índice Internacional de Prognóstico e o Índice Internacional de Prognóstico Revisado carecem de acurácia, pois até 20% dos pacientes de baixo risco falecerão da doença e 60% dos pacientes de alto risco estarão vivos em quatro anos. Essas discrepâncias podem, em parte, ser atribuídas a fatores genéticos. A assinatura gênica do linfoma difuso de grandes células B tipo centro germinativo apresenta sobrevida global superior ao tipo células B ativadas (76% versus 16%, p=0,01), contudo o perfil de expressão gênica por microarray ainda não está disponível na prática clínica. Entretanto, o escore preditivo de mortalidade para linfoma difuso de grandes células B baseado no valor prognóstico da expressão dos genes BCL2, BCL6, CCND2, FN1, LMO2 e SCYA3 por PCR em tempo real quantitativa mostrou-se independente do Índice Internacional de Prognóstico na era pré-rituximabe. Mas não foi significante em pacientes de alto risco clínico tratados com R-CHOP. Os genes BCL2, CCND2 e SCYA3 integram a assinatura de células B ativadas, BCL6 e LMO2 a do centro germinativo e FN1 a linfonodal. Objetivo: Avaliar o impacto da expressão absoluta dos genes BCL2, BCL6, CCND2, FN1, LMO2 e SCYA3 em população brasileira com linfoma difuso de grandes células B tratada com R-CHOP em relação à resposta global, sobrevida livre de doença, sobrevida livre de progressão e sobrevida global. Métodos: A expressão gênica foi analisada por PCR em tempo real quantitativa de RNA extraído de amostras parafinadas de 63 pacientes, porém foi avaliável em 42. Seus valores foram normatizados pelo gene endógeno ABL e transformados em escala logarítmica na base 2 para posterior correlação com variáveis clínicas e de desfecho. Resultados: Com mediana de seguimento de 29 meses, as sobrevidas global, livre de doença e livre de progressão foram, respectivamente, 82,8%, 97,14% e 87,53%, enquanto a resposta completa foi 82,5%. A expressão de LMO2>3logs e BCL6>3,5logs definiu um grupo de maior sobrevida global (91% versus 64,3%, p=0,040) e sobrevida livre de doença (95,5% versus 70,7%, p=0,03), independentemente do Índice Internacional de Prognóstico (p=0,010 e p=0,042) e com significativa hiperexpressão do SCYA3 (p=0,046). Não se observou associação entre escore preditivo de mortalidade baseado nos seis genes e prognóstico. Assim, foi criado novo escore genético prognóstico baseado no poder da expressão concomitante de LMO2 e CCND2, definindo-se grupos de baixo risco (<2,5) e alto risco (>=2,5) com distintas sobrevidas global (92,4% versus 57,1%, p=0,011) e livre de progressão (96,2% versus 66,7%, p=0,013), independentes do IPI. Conclusão: Em pacientes com linfoma difuso de grandes células B tratados com R-CHOP, a hiperexpressão de BCL6, LMO2 e SCYA3 correlacionou-se com melhor prognóstico. O novo escore genético prognóstico definido por LMO2 e CCND2 estratificou grupos de risco de prognósticos distintos independentes do Índice Internacional de Prognóstico / Introduction: Diffuse large B-cell lymphoma is the most common type of non-Hodgkin lymphoma; which accounts for almost 50% of the cases at the Hematology Department of Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo and Instituto do Câncer do Estado de São Paulo. Its clinical and biological heterogeneity results in more than twenty subtypes according to the World Health Organization classification. Its treatment is based on a combination of anti-CD20 monoclonal antibody and antracycline-based chemotherapy, with a 10-year overall survival of 43.5%. Clinical prognostic determinants such as the International Prognostic Index and the Revised International Prognostic Index lack accuracy, since up to 20% of low-risk patients will die from the disease and up to 60% of high-risk patients will be alive within four years. Such discrepancies can partially be attributed to genetic factors. Diffuse large B-cell lymphoma germinal center gene signature shows superior overall survival compared to activated B-cell signature (76% versus 16%, p=0.01), however microarray gene expression profile is not yet available in clinical practice. Nonetheless, the Mortality Predictor Score for diffuse large B-cell lymphoma based on the prognostic value of BCL2, BCL6, CCND2, FN1, LMO2 and SCYA3 gene expression by quantitative real-time PCR has proved to be independent from the International Prognostic Index in the pre-rituximab era. But it was not significant in high clinical risk patients treated with R-CHOP. The genes BCL2, CCND2 and SCYA3 compose activated B-cell signature, whereas BCL6 and LMO2 compose the germinal center signature and FN1 the lymph-node signature. Objective: Evaluate the impact of BCL2, BCL6, CCND2, FN1, LMO2 and SCYA3 absolute gene expression in Brazilian population diagnosed with diffuse large B-cell lymphoma and treated with R-CHOP, with respect to overall response, disease free survival, progression free survival and overall survival. Methods: Gene expression was analyzed by quantitative real-time PCR of RNA extracted from paraffin-embedded samples of 63 patients, although evaluable in 42. Their values were normalized by endogenous gene ABL and log- transformed on a base 2 scale for subsequent correlation with clinical and outcome variables. Results: With a median follow-up of 29 months, overall survival, disease free survival and progression free survival accounted for 82.8%, 97.14% and 87.53% respectively, while complete response was 82.5%. The expression of LMO2>3logs and BCL6>3.5logs defined a group with higher overall survival (91% versus 64.3%, p=0.040) and progression free survival (95.5% versus 70.7%, p=0.03), independent of International Prognostic Index (p=0.010 and p=0.042) and with significant overexpression of SCYA3 (p=0.046). It was not identified any association between six gene Mortality Predictor Score and prognosis. As a result, we developed the New Genetic Prognostic Score based on the power of concomitant expression of LMO2 and CCND2, defining low-risk (<2.5) and high-risk (>=2.5) groups with distinct overall survival (92.4% versus 57.1%, p=0.011) and progression free survival (96.2% versus 66.7%, p=0.013), independent of International Prognostic Index. Conclusion: In patients with diffuse large B-cell lymphoma treated with R-CHOP, hyperexpression of BCL6, LMO2 and SCYA3 was correlated with a better prognosis. The New Genetic Prognostic Score, defined by LMO2 and CCND2, stratified risk groups with different prognosis, independent of International Prognostic Index

No presente estudo, 30 pacientes, do sexo masculino com idade mediana de 29 anos, portadores de hérnias inguinais / inguino-escrotais, unilaterais, indiretas e primárias, sem encarceramento ou estrangulamento, foram submetidos à hernioplastia inguinal, por meio de inguinotomia, sob raqui-anestesia em regime de internação hospitalar. A técnica de correção utilizada foi a de Bassini modificada, sendo que estas modificações repousam no tipo da incisão, abordagem da fáscia transversalis e no reforço da parede posterior do canal inguinal. Os objetivos foram os de avaliar os resultados do pós-operatório mediato quanto aos eventos: intensidade e duração da dor pós-operatória e o tempo de retorno às atividades normais, estabelecendo assim a duração maior ou menor do período de convalescença. Das hérnias operadas 33,33% e 66,67% foram classificadas no intra-operatório como tipos I e II de Nyhus, respectivamente. A duração da cirurgia variou entre 45 e 85 minutos, com média de 66,46 minutos e mediana de 66,5 minutos. A permanência hospitalar foi menor que 24 horas. O índice de mortalidade foi nulo e o seguimento foi feito no 10º e 30° dias de pós-operatório. A intensidade média da dor pós-operatória atingiu seu pico máximo no 1º dia, alcançando 2,93 na escala analógica decimal, sendo que a partir do 5° dia de pós-operatório se tornou insignificante. O retorno às atividades habituais e sociais se deu em um período médio de 5,34 dias. O tempo de retorno ao trabalho alcançou a média de 11,23 dias e mediana de 5 dias. Observou-se complicação leve em dois pacientes (6,67%), que apresentaram edema de bolsa escrotal de rápida resolução. Não se observou complicações infecciosas apesar do não uso de antimicrobianos. A análise dos dados obtidos permite concluir que o procedimento é exeqüível, com boa aceitação por parte dos pacientes, apresentando resultados comparáveis aos obtidos na literatura / In the present study, 30 patients, of the male sex, with an average age of 29, victims of inguinal hernias/ inguino-scrotum, unilateral, indirect and primaries, without confinement or strangulation, were submitted to inguinal hernioplasty, thru inguinotomy, under rachianesthesia on a regimen as hospital in--patients. The correction technique used was the modified- Bassini, since these modifications lie in the kind of incision, approaching of the fascia transversalis and in the reinforcement of the posterior wall of the inguinal duct. The purposes were of evaluating the mediate post-operative results as to the events: intensity and duration of the post-operative pain in the period of time of return to the normal activities, thus determining the longer or shorter duration of the recovery period. Among the operated hernias 33.33% and 66.67% they were classified in the intra-operative as types I and II of Nyhus, respectively. The duration of the surgery varied between 45 and 85 minutes, with an average of 66.46 minutes and median of 66.5 minutes. The in-patients stay in the hospital was less than 24 hours. The mortality rate was null and the follow up was made on the 10th and 30th days of the post operative. The average intensity of the post-operative pain reached its appex on the 1st day, reaching 2.93 in the decimal analogical scale, and as of the 5th day of the post-operative it became insignificant. The return both to the usual and social activities happened in an average period of time of 5.34 days. The period of time of returning to work reached an average of 11.23 days and a median of 5 days. A slight complication was observed in two patients (6.67%), who had edema in the scrotum pouch of fast solution. No infectious complications were detected in spite of not using any anti-microbians. The analysis of the data obtained allow to conclude that the procedure is feasible, with good approval on the part of the patients, presenting results comparable to the ones obtained in the literature

In this research paper, it evaluates the benefits achievable from static testing framework by analyzing and transforming the JUnit3.8 source code and static execution of transformed code. Static structure enables us to analyze the code statically during creation and execution of test cases. The concept of research is by now well established in static analysis and testing development. The research approach is also increasingly affecting the static testing process and such research oriented work has proved particularly valuable for those of us who want to understand the reflective behavior of JUnit3.8 Framework. JUnit3.8 Framework uses Java Reflection API to invoke core functionality (test cases creation and execution) dynamically. However, Java Reflection API allows developers to access and modify structure and behavior of a program.  Reflection provides flexible solution for creating test cases and controlling the execution of test cases. Java reflection helps to encapsulate test cases in a single object representing the test suite. It also helps to associate each test method with a test object. Where reflection is a powerful tool to perform potential operations, on the other hand, it limits static analysis. Static analysis tools often cannot work effectively with reflection. In order to avoid the reflection, Static Testing Framework provides a static platform to analyze the JUnit3.8 source code and transform it into non-reflective version that emulates the dynamic behavior of JUnit3.8. The transformed source code has possible leverage to replace reflection with static code and does same things in an execution environment of Static Testing Framework that reflection does in JUnit3.8. More besides, the transformed code also enables execution environment of Static Testing Framework to run test methods statically. In order to measure the degree of efficiency, the implemented tool is evaluated. The evaluation of Static Testing Framework draws results for different Java projects and these statistical data is compared with JUnit3.8 results to measure the effectiveness of Static Testing Framework. As a result of evaluation, STF can be used for static creation and execution of test cases up to JUnit3.8 where test cases are not creating within a test class and where real definition of constructors is not required. These problems can be dealt as future work by introducing a middle layer to execute test fixtures for each test method and by generating test classes as per real definition of constructors.

The diploma thesis deals with the proposal to increase labor productivity and economic evaluation in the company EKOSTAVBY Brno. The introductory section describes the theoretical background, the following analysis of the company. The work is based on the current status in the company, focusing mainly on the centre of mechanization and transport. The aim of this paper is to propose certain changes and measures, which would lead to a reduction in the loss rate of the centre.

Abstract Achilles tendon rupture (ATR) conservative treatment result usually good clinical outcome, but despite the treatment method calf muscle strength deficit persist. Recent evidence suggests that surgery might surpass conservative treatment in restoring strength after ATR, but structural explanations for surgery-related improved strength remain uncertain. The purposes of this thesis were to compare calf muscle isokinetic strength recovery, calf muscle volume, fatty degeneration and AT elongation after conservative treatment or after open surgical repair of ATR. An additional aim was to assess the role of fascial augmentation in terms of calf muscle isokinetic strength recovery, AT elongation, calf muscle volume atrophy and fatty degeneration, and their relationship with calf muscle isokinetic strength in long-term follow-up after ATR surgery. Surgery resulted in 10% to 18% greater plantar flexion strength (P = 0.037) compared to conservative treatment. The mean differences between affected and healthy soleus muscle volumes were -18% after surgery and -25% after conservative treatment (P = 0.042). At 18 months, AT were, on average 19 mm longer in patients treated conservatively compared to surgery (P &#60; 0.001). At 18 months, patients with greater (2–3) fatty degeneration had lower soleus muscle volumes and plantar flexion strength in the healthy leg. In long term, augmentation did not affect any of the strength variables, but the injured side showed 12% to 18% strength deficit compared with the healthy side (P &#60; 0.001). The AT was, on average, 12 mm longer in the affected leg than in the healthy leg (P &#60; 0.001). The mean soleus muscle volume was 13% lower in the affected leg than in the healthy leg (P &#60; 0.001). The mean volumes of the medial- and lateral gastrocnemius muscles were 12% and 11% lower in the affected leg than in the healthy leg, respectively (P &#60; 0.001). AT elongation correlated substantially with plantar strength deficit (ρ = 0.51, P &#60; 0.001) and with both gastrocnemius (ρ = 0.46, P = 0.001) and soleus muscle atrophy (ρ = 0.42, P = 0.002). Calf muscle fatty degeneration was more common in the affected leg compared healthy leg (P &#8804; 0.018). In conclusion, surgery of ATR restored calf muscle isokinetic strength earlier and more completely than conservative treatment. Conservative treatment resulted in greater soleus muscle atrophy and AT elongation compared surgery, which may partly explain the surgery related better strength results. Augmentation provided no long-term benefits compared with simple suturation, and a 12 to 18% plantar flexion strength deficit compared to the healthy side persisted. AT elongation may explain the smaller calf muscle volumes, greater fatty degeneration, and plantar flexion strength deficit observed in long-term follow-up after surgical repair of ATR. / Tiivistelmä Akillesjännerepeämän (ATR) konservatiivisella ja leikkaushoidolla hoidolla saavutetaan hyvät kliiniset tulokset. Viimeisimmät tutkimukset kuitenkin viittaavat leikkaushoidolla saavutettavan paremmat voimat kuin konservatiivisella hoidolla, mutta rakenteelliset selitykset leikkaushoidon paremmalle pohjelihaksen voimille ovat epäselviä. Työn tarkoituksena oli verrata pohjelihaksen isokineettisten voimien palautumista, pohjelihastilavuuksia, rasvadegeneraatiota ja akillesjänteen (AT) pidentymistä ATR:n konservatiivisen- ja leikkaushoidon jälkeen. Tarkoituksena oli arvioida lihaskalvovahvikkeen merkitystä pohjelihaksen isokineettisten voimien palautumisessa pitkäaikaisseurannassa. Lisäksi tutkimme AT pidentymisen, pohjelihastilavuuksien ja rasvadegeneraation suhdetta pohjelihaksen isokineettisiin voimiin ATR:n leikkaushoidon jälkeen 14 v seurannassa. Leikkaushoidolla saavutettiin 10–18 % paremmat pohjelihaksen voimat verrattuna konservatiiviseen hoitoon. Leikkaushoidon jälkeen soleuslihasten tilavuuksien puoliero terveen jalan hyväksi oli 18 % ja konservatiivisen hoidon jälkeen 25 %. 18 kk kohdalla konservatiivisesti hoidettujen AT oli 19 mm pidempi verrattuna leikkauksella hoidettuihin. 18 kk kohdalla potilaat, joilla vamma jalan soleuslihaksen rasva-degeneraatio oli korkea (2–3), kärsivät suuremmasta soleuslihaksen atrofiasta ja pohjelihaksen voima puolierosta. Voimat eivät muuttuneet 12 kk ja 14 v kontrollien välillä. Lihaskalvovahvikkeella ei ollut merkitystä voimien palautumisessa pelkkään suoraan ompeluun verrattuna, mutta vammapuoli jäi 10–18 % heikommaksi verrattuna terveeseen jalkaan. Vammajalan akillesjänne oli 12 mm pidempi terveeseen jalkaan verrattuna. Vammajalan kolmipäisen pohjelihaksen tilavuus oli 11–13 % pienempi verrattuna terveeseen jalkaan. Akillesjänteen pituus korreloi pohjelihaksen voimapuolieron sekä pohjelihasatrofian kanssa. Akillesjännerepeämän leikkaushoidolla pohjelihaksen isokineettiset voimat palautuvat nopeammin ja täydellisemmin kuin konservatiivisella hoidolla. Leikkaushoitoon verrattuna konservatiivinen hoito johtaa suurempaan soleuslihaksen atrofiaan ja akillesjänteen pidentymään, mikä selittää osittain leikkaushoidon paremmat voimatulokset. 14 v seurannassa lihaskalvovahvikkeesta ei ole etua akillesjännerepeämän leikkaushoidossa. Akillesjännerepeämän leikkaushoidosta huolimatta potilaalle jää terveeseen jalkaan verrattuna 10–18 % pohjelihasten voimapuoliero. Akillesjänteen pidentyminen mahdollisesti selittää pohjelihasten atrofian, rasvadegeneraation ja pysyvän pohjelihasten voimapuolieron akillesjännerepeämän leikkaushoidon jälkeen 14 v seurannassa.

The graduation thesis aims to specify and define, with respect to the Czech legislation, the profit and loss statement of the insurance companies and those items of revenues and expenses that are specific for the insurance companies. The thesis deals with the principal characteristics of the revenues and the expenses of the insurance companies as well as with the matter whether insurance companies can in any means influence their management result. It also focuses on the field of the insurance security -- what is the insurance security in the Czech Republic in relation to the European Union, and on the quantity limits of the profit and loss statement, in the Czech insurance sector. It also assesses the efficiency of the local insurance companies in relation to this, what is the share of the earned premium when taking in account the insurance claims, the operating costs and the management result. The graduation thesis came to the conclusion that an insurance company can quite easily influence its accounting management result and therefore it is necessary for the company to respect the relevant accounting measures. Furthermore, the Czech Republic in comparison to the other EU countries indicates relatively low level of insurance security. With respect to the efficiency it is possible to conclude (in relation to the year 2012 and the local insurance companies) that the earned premium comprises of more that 60% of the claimed damages, 30% of the operating costs and 10% of the earned premium represents the net profit.

No description available.