Background: In the life sciences, the amount of literature and experimental data grows at a tremendous rate. In order to effectively access and integrate these data, biomedical ontologies – controlled, hierarchical vocabularies – are being developed. Creating and maintaining such ontologies is a difficult, labour-intensive, manual process. Many computational methods which can support ontology construction have been proposed in the past. However, good, validated systems are largely missing. Motivation: The biocuration community plays a central role in the development of ontologies. Any method that can support their efforts has the potential to have a huge impact in the life sciences. Recently, a number of semantic search engines were created that make use of biomedical ontologies for document retrieval. To transfer the technology to other knowledge domains, suitable ontologies need to be created. One area where ontologies may prove particularly useful is the search for alternative methods to animal testing, an area where comprehensive search is of special interest to determine the availability or unavailability of alternative methods. Results: The Dresden Ontology Generator for Directed Acyclic Graphs (DOG4DAG) developed in this thesis is a system which supports the creation and extension of ontologies by semi-automatically generating terms, definitions, and parent-child relations from text in PubMed, the web, and PDF repositories. The system is seamlessly integrated into OBO-Edit and Protégé, two widely used ontology editors in the life sciences. DOG4DAG generates terms by identifying statistically significant noun-phrases in text. For definitions and parent-child relations it employs pattern-based web searches. Each generation step has been systematically evaluated using manually validated benchmarks. The term generation leads to high quality terms also found in manually created ontologies. Definitions can be retrieved for up to 78% of terms, child ancestor relations for up to 54%. No other validated system exists that achieves comparable results. To improve the search for information on alternative methods to animal testing an ontology has been developed that contains 17,151 terms of which 10% were newly created and 90% were re-used from existing resources. This ontology is the core of Go3R, the first semantic search engine in this field. When a user performs a search query with Go3R, the search engine expands this request using the structure and terminology of the ontology. The machine classification employed in Go3R is capable of distinguishing documents related to alternative methods from those which are not with an F-measure of 90% on a manual benchmark. Approximately 200,000 of the 19 million documents listed in PubMed were identified as relevant, either because a specific term was contained or due to the automatic classification. The Go3R search engine is available on-line under www.Go3R.org.

Em indivíduos saudáveis o desempenho motor e os parâmetros cinemáticos e espaçotemporais da tarefa de alcance já estão descritos na literatura. Até o momento nenhum estudo investigou a influência da dor crônica no ombro nessas variáveis durante a tarefa de apontamento com o corpo todo em diferentes demandas, e nem estabeleceram como é o comportamento motor. Por este motivo, o objetivo do presente estudo foi caracterizar o comportamento motor de uma tarefa de apontamento em indivíduos com dor no ombro e avaliar parâmetros de padrão de movimento, desempenho motor e equilíbrio. Trata-se de um estudo transversal realizado no Laboratório de Bioengenharia Elétrica da Escola Politécnica da USP. Participaram do estudo 20 sujeitos, sendo 11 no grupo controle (GC) e 9 no grupo com dor (GD). O experimento consistiu em realizar um alcance em três angulações distintas (menor, igual e maior que 90°) em duas velocidades (normal e rápida). Foram coletados dados de cinemática e plataforma de força. As principais medidas foram (1) índice de retidão (IR); (2) tempo de reação e movimento (3) deslocamentos angulares e lineares (4) COP e COM. Os resultados mostraram que o GD apresentou pior IR, maior tempo de reação e de movimento, os deslocamentos lineares e angulares foram mais estereotipados, os deslocamentos do COM e a velocidade de deslocamento do COP foram menores e as estratégias de equilíbrio foram menos utilizadas, gerando manutenção do controle em bloco. Desta forma, conclui-se que o comportamento motor é alterado no GD e as variáveis de padrão de movimento, desempenho motor e de equilíbrio foram piores na comparação com indivíduos saudáveis / In healthy subjects the motor performance and the kinematic parameters and spatiotemporal parameters of the task of reaching have already been described in the literature. Until now no study has investigated the influence of chronic shoulder pain on these variables during whole body pointing in different demands and did not establish how motor behavior works. For this reason, the aim of the present study was to characterize the motor behavior of a pointing task in individuals with shoulder pain and to evaluate patterns of movement pattern, motor performance and balance. This is a cross-sectional study conducted at the Bioengineering Laboratory of the Polytechnic School of USP. Twenty subjects participated in the study, being 11 in the control group (CG) and 9 in the pain group (PG). The experiment consisted in achieving a range in three distinct angles (smaller, equal and greater than 90 °) in two speeds (normal and fast). Kinematics and force platform data were collected. The main measures were (1) straightness index (RI); (2) reaction time and movement (3) angular and linear displacements (4) COP and COM. The results showed that the GD presented worse IR, longer reaction time and movement, linear and angular displacements were more stereotyped, the COM displacements and the COP displacement velocity were smaller and the equilibrium strategies were less used, generating maintenance of block control. However, we conclude that motor behavior is altered in GD and the variables of movement pattern, motor performance and balance were worse in comparison with healthy individuals

Em indivíduos saudáveis o desempenho motor e os parâmetros cinemáticos e espaçotemporais da tarefa de alcance já estão descritos na literatura. Até o momento nenhum estudo investigou a influência da dor crônica no ombro nessas variáveis durante a tarefa de apontamento com o corpo todo em diferentes demandas, e nem estabeleceram como é o comportamento motor. Por este motivo, o objetivo do presente estudo foi caracterizar o comportamento motor de uma tarefa de apontamento em indivíduos com dor no ombro e avaliar parâmetros de padrão de movimento, desempenho motor e equilíbrio. Trata-se de um estudo transversal realizado no Laboratório de Bioengenharia Elétrica da Escola Politécnica da USP. Participaram do estudo 20 sujeitos, sendo 11 no grupo controle (GC) e 9 no grupo com dor (GD). O experimento consistiu em realizar um alcance em três angulações distintas (menor, igual e maior que 90°) em duas velocidades (normal e rápida). Foram coletados dados de cinemática e plataforma de força. As principais medidas foram (1) índice de retidão (IR); (2) tempo de reação e movimento (3) deslocamentos angulares e lineares (4) COP e COM. Os resultados mostraram que o GD apresentou pior IR, maior tempo de reação e de movimento, os deslocamentos lineares e angulares foram mais estereotipados, os deslocamentos do COM e a velocidade de deslocamento do COP foram menores e as estratégias de equilíbrio foram menos utilizadas, gerando manutenção do controle em bloco. Desta forma, conclui-se que o comportamento motor é alterado no GD e as variáveis de padrão de movimento, desempenho motor e de equilíbrio foram piores na comparação com indivíduos saudáveis / In healthy subjects the motor performance and the kinematic parameters and spatiotemporal parameters of the task of reaching have already been described in the literature. Until now no study has investigated the influence of chronic shoulder pain on these variables during whole body pointing in different demands and did not establish how motor behavior works. For this reason, the aim of the present study was to characterize the motor behavior of a pointing task in individuals with shoulder pain and to evaluate patterns of movement pattern, motor performance and balance. This is a cross-sectional study conducted at the Bioengineering Laboratory of the Polytechnic School of USP. Twenty subjects participated in the study, being 11 in the control group (CG) and 9 in the pain group (PG). The experiment consisted in achieving a range in three distinct angles (smaller, equal and greater than 90 °) in two speeds (normal and fast). Kinematics and force platform data were collected. The main measures were (1) straightness index (RI); (2) reaction time and movement (3) angular and linear displacements (4) COP and COM. The results showed that the GD presented worse IR, longer reaction time and movement, linear and angular displacements were more stereotyped, the COM displacements and the COP displacement velocity were smaller and the equilibrium strategies were less used, generating maintenance of block control. However, we conclude that motor behavior is altered in GD and the variables of movement pattern, motor performance and balance were worse in comparison with healthy individuals

The Santa Ana River (SAR) is the largest river in Southern California. The flow of the SAR begins in the San Bernardino Mountains and discharges into the Pacific Ocean at Huntington Beach. The SAR contains one of the most essential and rare biodiversity hotspots on earth. In order to protect the wildlife, and suit population demands, the SAR must meet the Clean Water Act (CWA) regulations. The SAR Reach 6 is the uppermost segment of the river, and is currently listed under the CWA 303(d) List for impaired water due to contamination of cadmium, copper, and lead from an unknown source based on limited data provided in 1997 by the San Bernardino County Flood Control District (SBCFCD). This project focused on confirming the contemporary occurrence and identifying the potential source(s) of Cd, Cu, and Pb by comparing new water sample data with that of previous studies The analysis of previous data identified an interesting correlation between high water hardness and elevated lead levels. The new results from this study suggest that there continues to be a source of these metals in the upper parts of Reach 6 of the SAR. Moreover, the limited data obtained in this study suggests that the source of the contamination is upstream to the northeast of the primary sampling site, possibly on private lands. Future, more comprehensive studies will be required to determine whether Reach 6 of the SAR should remain on the 303(d) list. Source identification if necessary, will be a further challenge.

Waterways have been geomorphically altered or disturbed by development, mining, agriculture and other human activities for many years. Section 404 of the Clean Water Act determined that these impacts to our waterways must be mitigated for channel alterations. Stream restoration has been one method to mitigate for these impacts to our water resources. Stream restoration is considered to be a measurable improvement to the channel stability, water quality, habitat or overall function of a degraded stream system. Practices of stream restoration have changed in the last 10 to 20 years with the introduction of natural channel design methods. Natural channel design involves rebuilding a stream channel with the appropriate channel dimensions, slope, and planform to accommodate water and sediment inputs from its drainage basin without excessively aggrading or degrading. Dimensions of restored stream channels are based on a stage that is termed bankfull. The bankfull discharge is the flow that fills the channel just to the tops of its banks to the incipient point of flooding. Design dimensions used in natural channel design are based on bankfull stage and discharge because practitioners believe it is responsible for the average morphology of a stream channel. Practitioners of stream restoration use two tools to aid in the determination of these stable channel conditions: they are 1) regional channel geometry and discharge relations to drainage area (regional curves) and 2) reference reach derived dimensionless bankfull channel geometry ratios. These tools are developed for ecoregions that have similar climates, topography, geology, soils, hydrology and vegetation because these are also the features that dictate stream channel form. Regional curves and reference reach dimensionless ratios were developed for the Level III Ecoregion 67 Ridge and Valley, Tennessee. The regional power function equations of bankfull cross sectional area, width, mean depth, and discharge to drainage, and the dimensionless bankfull channel geometry ratios of reference reaches will help determine the bankfull channel dimensions used in natural channel design.

This paper explores public health campaigns as they relate to tweens and their use of technology. After considering how this demographic utilizes both traditional and new media, further examination was done on general health problems that affect this group. Three major health issues were then chosen for analysis. A relevant campaign for each issue was also evaluated, as were its overall marketing and communication efforts. The health problems and corresponding campaigns chosen include childhood obesity and the “Let’s Move” campaign, electronic aggression and the “Stop Bullying” campaign and youth suicide and the “WeCanHelpUs” campaign. From these analyses, recommendations for ways to improve each campaign were provided, as were general conclusions for reaching this demographic more efficiently and effectively. / text

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Σκοπός της εργασίας αυτής είναι η ανάλυση του νέου νομικού καθεστώτος διαχείρισης και ελέγχου των χημικών ουσιών σε ευρωπαϊκό επίπεδο και η ανάδειξη των ποικίλων διακυβευμάτων που αυτό θέτει. Το νέο αυτό νομικό καθεστώς, παρά την μακροχρόνια διαβούλευση του, δεν είναι τελικά απαλλαγμένο από αδυναμίες και προβλήματα εφαρμογής. Πρόκειται για τον νέο κανονισμό REACH (αρχικά του Registration, Evaluation and Authorisation of Chemicals) ή κανονισμό 1907/2006/ΕΚ. Ο κανονισμός REACH αποτελεί ένα ενιαίο ευρωπαϊκό νομοθέτημα για την καταχώριση, την αξιολόγηση, την αδειοδότηση και τους περιορισμούς των χημικών ουσιών, αντικαθιστώντας 40 διαφορετικά υφιστάμενα νομοθετικά μέτρα. Η εργασία χωρίζεται στην εισαγωγή, σε έξι κεφάλαια και τέλος τα συμπεράσματα. Στην εισαγωγή παρουσιάζεται η υφιστάμενη νομοθεσία της ευρωπαϊκής ένωσης για τις χημικές ουσίες, τα προβλήματα από την εφαρμογή της καθώς και η ανάγκη για ένα νέο νομοθετικό πλαίσιο το οποίο θα αντικαταστήσει το υφιστάμενο και θα έχει ως πρωταρχικό σκοπό την προστασία της ανθρώπινης υγείας και του περιβάλλοντος. Αναφορά γίνεται στην βιώσιμη ανάπτυξη και την πράσινη χημεία, καθώς αποτελούν βασικούς πυλώνες του κανονισμού. Επίσης παρουσιάζονται οι βασικές αρχές του κανονισμού (αρχή της προφύλαξης, της υποκατάστασης κλπ) καθώς και οι επιδιωκόμενοι στόχοι από την εφαρμογή του. Στο πρώτο κεφάλαιο γίνεται μια αναλυτική παρουσίαση της αρχής της προφύλαξης, η οποία αποτελεί βασική και θεμελιώδης αρχή του κανονισμού. Γίνεται αναφορά στην σχέση της με την αρχή της πρόληψης, στην πορεία της μέσα στο ευρωπαϊκό δίκαιο και στη διατροφική πολιτική της ευρωπαϊκής ένωσης καθώς και η αντιμετώπισή της από το ελληνικό δικαιικό σύστημα. Στο δεύτερο κεφάλαιο παρουσιάζεται αναλυτικά η οικοδόμηση του κανονισμού REACH, μέσω των σημαντικότερων χρονολογικών γεγονότων που άλλοτε ενίσχυσαν και άλλοτε αποδυνάμωσαν το κανονισμό, ικανοποιώντας κάθε φορά και διαφορετικά συμφέροντα ή απαιτήσεις, έως την οριστικοποίηση του τελικού του κειμένου. Ειδική αναφορά γίνεται στο ρόλο του Παγκόσμιου Οργανισμού Εμπορίου για τη διαμόρφωση του τελικού κειμένου του κανονισμού. Στη συνέχεια, στο τρίτο κεφάλαιο, παρουσιάζονται αναλυτικά το πεδίο εφαρμογής του κανονισμού, τα θεσμικά όργανα και οι αρμοδιότητές τους καθώς και οι βασικές διατάξεις του κανονισμού, η καταχώριση, η αξιολόγηση, η αδειοδότηση και περιορισμοί των χημικών ουσιών. Ακολουθεί το τέταρτο κεφάλαιο, όπου παρουσιάζεται ο κανονισμός CLP (αρχικά του Classification, Labelling, Packaging) για την ταξινόμηση, την επισήμανση και συσκευασία χημικών ουσιών και μειγμάτων ή κανονισμός 1272/2008/EK. Ο κανονισμός CLP συμπληρώνει και τροποποιεί τον κανονισμό REACH στο κενό που παρουσιάζει όσον αφορά την ταξινόμηση, την σήμανση και τη συσκευασία των χημικών ουσιών και τον εναρμονίζει με το Παγκόσμιο Εναρμονισμένο Σύστημα ταξινόμησης και επισήμανσης για τις χημικές ουσίες και τα μείγματα των Ηνωμένων Εθνών. Στο πέμπτο κεφάλαιο γίνεται μια αναλυτική αποτίμηση του κανονισμού REACH, καθώς παρουσιάζονται και αναλύονται τόσο οι θετικές του όψεις όσο και οι αδυναμίες του. Αναλυτική αναφορά γίνεται στο κόστος εφαρμογής του κανονισμού καθώς και στα οικονομικά οφέλη που προκύπτουν από την εφαρμογή του. Επίσης παρουσιάζοντα τα προβλήματα ερμηνείας και εφαρμογής του κανονισμού. Ακολουθεί το έκτο κεφάλαιο, στο οποίο γίνεται αναφορά στην εφαρμογή του κανονισμού REACH στην Ελλάδα καθώς παρουσιάζεται η υπεύθυνη αρμόδια αρχή για την εφαρμογή του κανονισμού και ο ρόλος της, το πεδίο εφαρμογής του κανονισμού (επιχειρήσεις χημικών προϊόντων) καθώς και ο ρόλος του Συνδέσμου Ελληνικών Χημικών Βιομηχανιών. Τέλος στα συμπεράσματα γίνεται μια συγκεντρωτική παρουσίαση και σύγκριση των αρνητικών και θετικών χαρακτηριστικών του κανονισμού και αποτιμάται ο βαθμός της επίτευξης των αρχικών στόχων του μέσα στο χρονικό διάστημα από την ημερομηνία εφαρμογής του έως σήμερα. Επίσης παρουσιάζεται πως ο κανονισμός REACH αποτελεί καινοτόμο νομοθετικό εργαλείο στα χέρια της διοίκησης αν και αποδυναμωμένος σε σχέση με το αρχικό του κείμενο και την αρχική πεποίθηση για ολοκληρωμένη και υψηλού επιπέδου προστασία της ανθρώπινης υγείας και του περιβάλλοντος. / Aim of this work is the analysis of new legal regime of management and control of chemical substances in European level and the emergence of diverse implications that this poses. This new legal regime, despite its long-lasting consultation, is not finally exempted from weaknesses and problems of application. This is the new REACH Regulation (initials of the Registration, Evaluation and Authorisation of Chemicals) or regulation 1907/2006/EC. REACH is a uniform European legislation on the registration, evaluation, authorisation and restriction of chemicals, replacing 40 different existing legislative measures. The work is divided into the introduction, six chapters and finally conclusions. The introduction presents the existing EU legislation on chemicals, the problems of implementation as well as the need for a new legal framework which will replace the existing and will have as fundamental aim the protection of human health and environment. Reference is made to sustainable development and green chemistry, which are key pillars of the regulation. It also presents the basic principles of the regulation (precautionary principle, substitution principle, etc) as well as the objectives pursued by its application. In the first chapter becomes an analytic presentation of precaution principle, which constitutes basic and fundamental principle of regulation. Reference is made in relation to the prevention principle, in European law and food policy in the European Union as well as its confrontation from Greek law system. In the second chapter is presented in detail the construction of REACH regulation, by means of the most important chronological facts that sometimes reinforced and sometimes watered down regulation, satisfying each time and different interests or requirements, until the finalization of the final text. Special reference to the role of the World Trade Organization is made for the configuration of final text of regulation. Afterwards, in the third chapter, are presented in detail the field of application of regulation, the institutional bodies and their competences as well as the basic provisions of regulation, the registration, evaluation, authorisation and restriction of chemicals. Fourth chapter follows, where regulation CLP is presented (initials of the Classification, Labeling and Packaging) for the classification, labeling and packaging of substances and mixtures or regulation 1272/2008/EC. Regulation CLP supplements and modifies regulation REACH in the void that it presents with regard to the classification, labeling and packing of chemical substances and it harmonizes REACH with the World Harmonized System of classification and labeling for the chemical substances and mixtures of United Nations. In the fifth chapter becomes an analytic assessment of regulation REACH, while are presented and analyzed both positive aspects and weaknesses. A detailed reference becomes in the cost of implementing the regulation and to the economic benefits arising from its application. Also the problems in the interpretation and application of the regulation are presented. Following the sixth chapter, in which reference is made in the implementation of reach in Greece as the responsible authority for the application of the regulation and its role, the field of application of regulation (enterprises of chemical products) as well as the role of the Association of Greek Chemical Industries. Finally, in the conclusions is a summary and comparison of negative and positive characteristics of regulation and evaluation of the extent of the initial objectives within the period from the date of application until now. It also shows that REACH is an innovative legislative tool in the hands of the administration, although weak compared to the initial text, and the initial conviction for integrated and high level of protection of human health and environment.

À l’origine de la présente étude se trouve l’invocation par Michel Houellebecq des lectures dix-neuvièmistes qui ont marqué sa jeunesse ainsi que sa nette opposition à des écrivains du XXe siècle auxquels il préfère les écrits du XIXe siècle. Notre intérêt a été suscité par ses constantes références et allusions à des noms tels Balzac, Zola, Huysmans, Auguste Comte, Schopenhauer, Nietzsche, Lamartine, Baudelaire. Qu’ont-ils à lui dire ? Si Michel Houellebecq s’oriente vers cette période du passé, c’est parce qu’elle coïncide avec les premières protestations antimodernes contre la froideur du libéralisme, du capitalisme, de l’esprit irréligieux, c’est-à-dire contre les trois maux responsables de l’ébranlement de la structure sociale (post)moderne. La première partie de notre analyse comparative introduit les romans de Houellebecq dans le tissu du réalisme - en écho à Balzac -, du naturalisme - en référence à Zola -, du décadentisme - en évoquant Huysmans. La deuxième a pour fil conducteur les raisonnements philosophiques d’Auguste Comte, de Schopenhauer et de Nietzsche dont Houellebecq nourrit ses jugements au sujet de l’amour et de la religion, sous l’emprise d’un ressentiment tantôt discret, tantôt criard. La dernière partie intervient également sur le territoire de la poésie houellebecquienne. En écho à Lamartine et à Baudelaire nous découvrirons un Houellebecq éclairé par une sensibilité qu’il manie dans des projets prophétiques à portée utopique ou dystopique. Son œuvre appartient certainement à la tradition littéraire postmoderne, mais elle a bien le mérite de revaloriser les voix des romantiques et premiers témoins des temps modernes. / At the origin of this study lies the invocation by Michel Houellebecq of the nineteenth-century readings that marked his youth and also his clear opposition to writers of the XXth century to whom he prefers the writings of the XIXth century. Our interest was aroused by his constant references and allusions to names such as Balzac, Zola, Huysmans, Auguste Comte, Schopenhauer, Nietzsche, Lamartine, Baudelaire. What do they have to say to him? If Michel Houellebecq moves towards this period of the past, it is because it coincides with the first anti-modern protests against the coldness of liberalism, of capitalism, the irreligious spirit, that is against the three evils which are responsible for the disruption of the (post)modern social structure.The first part of our comparative analysis introduces the novels of Houellebecq into realism - an echo to Balzac -, to naturalism - in reference to Zola, relating to decadence - evoking Huysmans. The second is the thread of philosophical reasoning of Auguste Comte, Schopenhauer and Nietzsche, of which Houellebecq feeds his judgments about love and religion, under the influence of a resentment sometimes discreet, sometimes sharp. The last part also enters on the territory of the Houellebecq poetry. In echo to Lamartine and Baudelaire we will discover a Houellebecq enlightened by a sensitivity that he uses in prophetic projects with utopian or dystopian reach. His work certainly belongs to the postmodern literary tradition, but it has the merit of revalorizing the voices of the romantics and the first witnesses of modern times.

THE INFLUENCE OF STRETCHING EXERCISES ON THE RANGE OF JOINT FLEXIBILITY IN STUDENTS AT JAN EVANGELISTA PURKYNĚ UNIVERSITY IN ÚSTÍ NAD LABEM The dissertation evaluates the influence of stretching exercises on the range of joint flexibility in students of the study programme Physical Education and Sport at Jan Evangelista Purkyně University in Ústí nad Labem. In total, 128 students aged 21 - 25 (78 women, 50 men) enrolled in the subject Basic Gymnastics took part in the experiment, conducted in the period from February to May of the academic year 2008/2009. Of these, 59 students were excluded by a physiotherapist - i.e. hypermobile men and hypermobile women as well as women with normal flexibility (excluded purposefully) subject to the results of the Thomayer test. In total, data from 39 men and 30 women were used. From April 2009, over a period of six weeks (before the end of the summer term tuition), an intervention flexibility programme including the Anderson static stretching method and the PNF stretching method by Sölveborn were applied for the research file. To evaluate the level of joint flexibility, the Sit and Reach Test and credit exercise to estimate joint flexibility were used. In a controlled interview, out-of-school activities were analysed, which contained stretching exercises with a...