Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-05-10T22:28:10Z No. of bitstreams: 1 MikaelleKalineBezerraDaCosta_DISSERT.pdf: 2541653 bytes, checksum: 876e01a9cfee3a08a3a326bf68a54fef (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-05-17T19:36:05Z (GMT) No. of bitstreams: 1 MikaelleKalineBezerraDaCosta_DISSERT.pdf: 2541653 bytes, checksum: 876e01a9cfee3a08a3a326bf68a54fef (MD5) / Made available in DSpace on 2016-05-17T19:36:05Z (GMT). No. of bitstreams: 1 MikaelleKalineBezerraDaCosta_DISSERT.pdf: 2541653 bytes, checksum: 876e01a9cfee3a08a3a326bf68a54fef (MD5) Previous issue date: 2013-03-01 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / A partilha de alimentos ? uma pr?tica comum em pequenos agrupamentos principalmente entre parentes, comportamento evolutivo humano, abordado na ecologia humana como um redutor dos riscos a seguran?a alimentar. Dessa forma o estudo objetivou explicar o comportamento de partilha de alimentos entre fam?lias que vivem em uma vila de pescadores pertencente a Touros, RN, com alta depend?ncia dos recursos pesqueiros para economia, e nutri??o familiar, e que t?m as flutua??o ambientais como um redutor da capacidade de pesca. Para testar o comportamento de partilha de alimentos entre essas fam?lias foram testados modelos evolutivos de partilha como: sele??o de parentesco, altru?smo rec?proco, roubo tolerado e dist?ncia, para explicar as estrat?gias utilizadas pelas fam?lias da vila para reduzir os riscos nutricionais causados pelo decl?nio do sucesso de captura. Foram inseridas ao longo do estudo 32 fam?lia divididas em 2 grupos com 16 fam?lias cada: um dependente exclusivamente (DE) e outro n?o dependente exclusivamente (NDE) da pesca como atividade econ?mica. Atrav?s de um recordat?rio de 24 foras , durante 7 dias consecutivos ao m?s, durante 12 meses consecutivos entre setembro de 2011 ? agosto de 2012, fazendo um registro temporal de toda dieta, partilha e produ??o pesqueira das fam?lias. A dieta das fam?lias apresentou-se sob influ?ncia do comercio j? inserido na vila, aumentando o consumo de alimentos industrializados de baixa qualidade . Na partilha a entrada e sa?da de alimentos que subsidiam a car?ncia proteica principalmente em per?odos de declino pesqueiro no n?cleo familiar foi elevado.Dentre os modelos testados a exist?ncia do altru?smo rec?proco entre as fam?lias ? melhor respondeu as necessidades nutricionais das fam?lias, e a dist?ncia entre fam?lias influenciou mais que a rela??o de parentesco na escolha de parceiros para a partilha. / Food sharing is a common practice in small groups and it is understood by many authors as a behavior shaped by evolution, whose goals would be to decrease the risks of food shortage in harsher periods, to favor kin, and indirectly, favor one?s own individual fitness, to avoid conflicts, and even to establish alliances and partnerships. In this context, the current study describes the diet and investigates the food sharing behavior among families from an artisanal, but commercial, fishing village in the municipality of Touros, Rio Grande do Norte State (NE Brazil) with a high dependency on fishing resources affected by seasonal environmental fluctuations. The study was divided in two parts, here presented as two distinct chapters. For the first chapter, 32 families were sampled, after being divided in two groups of 16 families each: one exclusively dependent (FD) and another non-exclusively dependent on fisheries (NFD) as its main economic activity. The diet of these families was registered through the 24h- recall method along 10 consecutive days per month both in January (locally considered the most productive month for fisheries) and in June (considered the least productive month for fisheries). The diet and food sharing of the FD families were compared to the NFD for the high and low fisheries productivity period. This comparison showed that both groups, regardless of their dependence level on fisheries, have their diet and food sharing directly affected by the fisheries success. However, FD families tended to share slightly more food in periods of high productivity and they were also more subjected to a lower quality diet in periods of food shortage than NFD families. One of the likely explanations for such differences is the fact that FD families are more subjected to environmental unpredictability and sharing would help decrease such uncertainty. Such higher unpredictability associated to a consequent lower income would also explain the ingestion of lower nutritional quality food during shortage periods. For the second chapter, only the FD families were sampled, although in this case the sample took place along seven consecutive days per month during 12 months, between September 2011 and August 2012 (the three extra sampling days in January and June were not considered in this chapter), which allo wed the register of diet, food sharing and fisheries along the whole year. To investigate the food sharing behavior of these families, some evolutionary models were tested, such as kinship selection, reciprocal altruism, and tolerated theft (or tolerated scrounge), besides physical aspects that could indirectly support some of these models, such as geographical distance. These models were used with the intent of explaining the strategies used by these families in order to decrease the nutritional risks brought about by fisheries seasonal fluctuations. The results showed that FD families shared food mostly due to reciprocal altruism, and, secondarily due to the distance between households. Families tended to share more and more often with families that paid their favor back, but especially with those that were living geographically close. Despite the commercial insertion of this group, basal mechanisms, such as reciprocal altruism, still work, probably because the essential conditions for its continuation are still there, such as living in small groups and having repetitive interactions between cooperative pairs. This suggests that commerce, with all of its likely associated socioeconomic changes, is not necessarily a disruptor of evolutionary cooperation mechanisms (at least for reciprocal altruism), probably as long as other conditions, such as group size and constant interactions, are kept. As such, this study not only details how the diet and food sharing of coastal families are affected directly and indirectly by fisheries, but it also helps understand cooperation maintenance mechanisms regarding food sharing.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-02-13T19:44:50Z No. of bitstreams: 1 MenillaMariaAlvesDeMelo_DISSERT.pdf: 3756380 bytes, checksum: ee8b551187bf0b88e2a2414cc2bfa94e (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-02-14T21:18:32Z (GMT) No. of bitstreams: 1 MenillaMariaAlvesDeMelo_DISSERT.pdf: 3756380 bytes, checksum: ee8b551187bf0b88e2a2414cc2bfa94e (MD5) / Made available in DSpace on 2017-02-14T21:18:32Z (GMT). No. of bitstreams: 1 MenillaMariaAlvesDeMelo_DISSERT.pdf: 3756380 bytes, checksum: ee8b551187bf0b88e2a2414cc2bfa94e (MD5) Previous issue date: 2016-07-29 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq) / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / Venenos de escorpi?es constituem uma rica fonte de pept?deos, que podem ser classificados como pept?deos com liga??es dissulfeto e pept?deos sem liga??es dissulfeto. Pept?deos ani?nicos correspondem aos componentes sem liga??es dissulfeto mais abundante na pe?onha do escorpi?o Tityus stigmurus (esp?cie prevalente no nordeste brasileiro), sendo ricos em res?duos de ?cidos asp?rtico e glut?mico. Esta abordagem apresenta, pela primeira vez, a caracteriza??o estrutural e a avalia??o da atividade biol?gica de um pept?deo ani?nico presente na pe?onha do escorpi?o Tityus stigmurus, denominado TanP. A estrutura tridimensional do TanP foi predita por modelagem computacional e refinada por simula??es de din?mica molecular, sendo a estrutura secund?ria obtida por dicro?smo circular, e estabilidade estrutural avaliada em diferentes meios, pH, temperatura e presen?a de ?ons cobre. Al?m disso, utilizou-se a espectroscopia UV-vis?vel para avaliar a atividade quelante de TanP na presen?a de cobre. As atividades antimicrobiana, citot?xica, imunomoduladora e antioxidante tamb?m foram avaliadas. As an?lises de CD indicaram uma predomin?ncia de conforma??o rand?mica em meio aquoso, bem como mudan?as estruturais dependentes de pH e temperatura. Os ?ons cobre, ao se ligarem ao pept?deo, modificaram a estrutura do mesmo. Tais dados corroboraram com o que foi demonstrado na din?mica molecular. A raz?o molar de liga??o (TanP:cobre) na din?mica molecular foi 1:5, enquanto no ensaio de reatividade observou-se raz?es de 1:7 e 1:3, a depender da concentra??o de TanP na solu??o. TanP n?o induziu citotoxicidade para as c?lulas normais e cancer?genas testadas, e apresentou capacidade de inibir, in vitro, a libera??o de ?xido n?trico por macr?fagos estimulados por LPS. Desta forma, os resultados sugerem que TanP ? um pept?deo promissor para aplica??o terap?utica como um agente quelante, bem como agente imunomodulador e antioxidante. / Scorpion venoms are a rich source of peptides, which may be classified as disulfide-bridged or non-disulfide-bridged peptides. Among them, there are anionic peptides, rich in aspartic and glutamic acid residues. Despite being the most abundant component in the venom gland of Tityus stigmurus (the prevalent scorpion species in Northeast Brazil), they are poorly characterized in the literature. This work presents, for the first time, structural characterization and biological activity assays of an anionic peptide from the venom of the scorpion T. stigmurus, named TanP. The three-dimensional structure of TanP was obtained by computational modeling and refined by molecular dynamic (MD) simulations. Furthermore, we have performed circular dichroism (CD) analysis to predict TanP secondary structure, and UV-visible spectroscopy to evaluate its chelating activity. CD indicated predominance of random coil conformation in aqueous medium, as well as changes in structure depending on pH and temperature. TanP has chelating activity on copper ions, which modified the peptide?s secondary structure. These results were corroborated by MD data. The molar ratio of binding (TanP:copper) depends on the concentration of peptide. TanP was not cytotoxic to normal or cancer cell lines, and showed an ability to inhibit the in vitro release of nitric oxide by LPS-stimulated macrophages. In this way, the results suggest TanP is a promising peptide for therapeutic application as a chelating, immunomodulatory and antioxidant agent.

This diploma thesis focuses on Internet marketing of a tradesman. The theoretical part consisting of the first four chapters introduces Internet marketing and its tools, provides details about search engine optimization (SEO), search engine marketing (SEM) and Google Analytics - tool used to analyze website traffic. The final chapter focuses on Internet marketing of Mr. Škoch, a roofer from Lubná. The thesis analyzes his original website and strategy and then describes the process of creation of a new website, its optimization, creation of paid campaign and a Facebook page. Both websites and strategies are evaluated at the end of the chapter, recommendations are introduced and a list of steps for realization of Internet marketing is compiled. The aim of this thesis is to compile a summary of optimal Internet marketing tools universally applicable especially for tradesmen.

Purpose: The purpose of this paper is to offer small to medium-sized organizations (SMOs) with global business aspirations an innovative approach to performance measurement and management. Design/methodology/approach: The first phase of this research is based on a literature review. The second phase capitalizes on the literature review to offer a conceptual framework aimed at improving the performance measurement approach utilized by SMOs. The advocated approach stresses performance measurement, benchmarking, and effective implementation. Findings: The conceptual approach offered in this study represents the main outcome of this applied research. The advocated approach integrates several frameworks in an effort to address practical concerns related to performance measurement, management, and improvement. Research limitations/implications: The research offered in this study has practical and theoretical implications. The proposed approach offered by this study should be refined and validated through future research. Practical implications: The approach presented in this study offers practicing managers a systematic and practical approach to performance measurement, management, and improvement. Originality/value: The approach offered in this study capitalizes on several methodologies and tools to offer managers a benchmarking-based performance management approach suitable for SMOs with global operational aspirations.

Made available in DSpace on 2015-04-14T13:38:49Z (GMT). No. of bitstreams: 1 446246.pdf: 3553381 bytes, checksum: ed56ed9d6b2ff5ce9fef4ad323e543ab (MD5) Previous issue date: 2013-01-07 / Research in the area of third language (L3) acquisition is still preliminary if compared to the studies on bilingual acquisition. If studies about multilingual acquisition carried out with hearing participants users of oral languages are incipient, they are even rarer with deaf learners of oral third languages because very little has been investigated so far. The present study aims at analyzing how deaf Brazilian learners of the English Language (EL) as a L3 learn English. By doing so, we try to investigate the role played by lexical and semantic transfer of the two languages previously learned Brazilian Sign Language (LIBRAS) and the Portuguese Language (PL) on the lexicon of the EL. For that purpose, this study will analyze the data collected among 9 deaf young and adult students of elementary school, students of the public system, users of LIBRAS as a mother tongue (L1) in an intermediate level, learners of PL as a second language (L2) in a basic level and beginners of EL as a L3. Having in mind the main objective of this study, we try to investigate the following: if a process of lexical transfer also occurs in languages of different modalities (sign and oral languages); if there is evidence of lexical transfer of the languages previously learned (LIBRAS and PL) on the EL and if there is a relationship between the proficiency level acquired in the previous languages (LIBRAS and PL) on the lexical and semantic acquisition of the EL. This study also searches to examine the kinds of mistakes most commonly made by deaf learners of EL (L3) whose L1 is LIBRAS and also the mistakes most frequently made by these students who are also learners of the PL as L2. The data concerning the five objectives were obtained by means of four different lexical tasks involving the participants three languages. In order to collect data, the software E-Prime was used in the first three tasks, the last one was a word production task in EL. Information of the first and second objectives of this study showed that there is a partial transfer of lexical items from a sign (LIBRAS) to an oral language (EL). Data related to the third objective demonstrated that LIBRAS (L1), more stable language, plays a more influential role than PL (L2) in transferring its linguistic elements to EL (L3). The fourth objective suggested that deaf learners of the EL as a L3, native users of LIBRAS tend to make phonological mistakes or mistakes due to the relation between fingerspelling and the first letter of the written word, but this kind of transfer does not always occur. The fifth objective indicated that deaf learners of the EL (L3) are likely to transfer linguistic items from the LP (L2) to the EL (L3), at least partially. In sum, the results of the present study are similar to researches conducted with oral languages and hearing participants according to which all languages are active in a bilingual/multilingual s mind. / As pesquisas que se dedicam a investigar os processos de aprendizagem de uma L3 ainda s?o escassas se comparadas ?s pesquisas sobre a aquisi??o de duas l?nguas. Se os estudos sobre o multilinguismo conduzidos com participantes ouvintes usu?rios de l?nguas orais s?o incipientes, bem mais raras s?o as pesquisas com sujeitos surdos aprendizes de uma L3 de modalidade oral-auditiva. Este estudo tem o objetivo de analisar como alunos surdos brasileiros aprendizes da L?ngua Inglesa (LI) aprendem aspectos l?xico-sem?nticos dessa l?ngua como L3, enfatizando-se o papel da transfer?ncia lingu?stica das duas primeiras l?nguas aprendidas LIBRAS e L?ngua Portuguesa (LP) sobre o l?xico da LI. Para tanto, este estudo analisa os dados coletados entre 9 jovens e adultos, alunos do Ensino Fundamental da rede p?blica - EJA - usu?rios da LIBRAS como L1 em n?vel intermedi?rio, aprendizes da LP como L2 em n?vel b?sico e da LI como L3 em est?gio inicial de aprendizagem. A partir do objetivo geral delimitado acima, procurou-se investigar se a transfer?ncia lexical entre l?nguas de modalidades diferentes (espa?o-visual e oral-auditiva) podia ser verificada; se havia ind?cios de transfer?ncia das l?nguas previamente aprendidas (LIBRAS e LP) sobre a LI e se existia rela??o entre a profici?ncia adquirida nas l?nguas anteriores (LIBRAS e LP) sobre a aquisi??o l?xico-sem?ntica da LI. Buscou-se tamb?m examinar o tipo de erro mais recorrente entre aprendizes surdos de LI, nativos da LIBRAS, caso a transfer?ncia no sentido LIBRAS-LI ocorresse. Da mesma forma, buscou-se investigar o tipo de erro mais comum na LI desses informantes, oriundos da transfer?ncia da LP. Os dados foram obtidos por meio da aplica??o de tr?s tarefas lexicais, utilizando-se o programa E-Prime, juntamente com um teste de produ??o de palavras escritas em LI. Os dados do primeiro e segundo objetivos apontaram a exist?ncia de transfer?ncia parcial entre l?nguas de modalidades distintas, quais sejam, a LIBRAS (1) e a LI (L3). J? os dados do terceiro objetivo indicaram que a LIBRAS, l?ngua mais estabilizada, possui um papel mais determinante por desencadear a influ?ncia dessa l?ngua sobre a LI, ainda que de forma parcial. Por sua vez, o quarto objetivo demonstrou que aprendizes surdos nativos da LIBRAS est?o mais sujeitos a cometer erros de ordem quir?mica ou fruto da rela??o alfabeto manual/letra ao aprender a LI, mas que esse tipo de influ?ncia nem sempre se verifica. Os dados do quinto objetivo indicaram a ocorr?ncia, de forma parcial, de erros de transfer?ncia da LP sobre a LI. Os resultados alcan?ados neste estudo est?o em conson?ncia com as pesquisas conduzidas com participantes ouvintes e l?nguas orais, segundo as quais todas as l?nguas est?o ativas na mente de um bi/multil?ngue.

Made available in DSpace on 2015-04-14T13:39:05Z (GMT). No. of bitstreams: 1 454131.pdf: 2168503 bytes, checksum: 6bb12016bd2517a9db25c07b7294fa6c (MD5) Previous issue date: 2014-01-08 / Learning and using two or more languages are experiences that impact linguistic and cognitive functioning. Bilingual and multilingual speakers must select the language to be used and, at the same time, suppress the interference of the language not being used. It has been shown that bilinguals/multilinguals have superior performance compared to monolinguals in tasks that tap into executive functioning, due the joint activation of the languages. In case of tasks with linguistic stimuli, the studies are scarce, and the results are less consensual. In the Brazilian context, the effects of bilingualism have not been always found, especially in the speakers of the variety of the German language called Hunsr?ckisch. Therefore, the goal of this study is to investigate the performance of speakers of Hunsr?ckisch, bilinguals and multilinguals (the multilinguals learned standard German as well), compared to monolinguals in two tasks. The first task was nonlinguistic, the Attentional Network Task (ANT), and the second was a linguistic task, the Sentence Comprehension Task (TCF), in which the participants listen to canonical sentences (active voice) and noncanonical ones (passive voice), in two languages with or without interference of another sentence. Fifty-nine participants were divided in three groups: monolinguals, bilinguals and multilinguals, consisting of adults (mean age = 28.9 years); these participants were mainly from the city of S?o Jos? do Hort?ncio (RS). The participants completed a questionnaire about linguistic and cognitive issues, made a working memory task and the above tasks. With statistical tests, we analyzed the dependent variables response time and accuracy in the two tasks. The results showed that there are no differences between the groups on the accuracy of the ANT. The difference happened on the time it took to respond: multilinguals were faster than monolinguals on all experimental conditions. Bilinguals were faster too, but the difference was not significant. In another task, the TCF, the monolinguals had better overall accuracy. All groups were more accurate and faster in comprehension of canonical sentences in comparison to noncanonical ones, and in comprehension without interference in comparison to comprehension with interference. There were no differences between the groups on the global response times. The results show that multilinguals have an advantage in comparison to monolinguals on the executive processing with nonlinguistic stimuli. It seems they have a more developed ability of the multilinguals on responding faster in a nonlinguistic task, that involves the executive functions, and not necessarily only on the inhibitory control. When the task has linguistic stimuli, the results are not so uniform. In this study, we found that in the Brazilian context of minority languages, especially the multilingualism can provide positive effects on the cognition, especially in the global response times. / A aprendizagem e o uso de duas ou mais l?nguas s?o experi?ncias capazes de impactar o funcionamento lingu?stico e cognitivo. Falantes bil?ngues e multil?ngues precisam selecionar a l?ngua a ser usada e, ao mesmo tempo, suprimir a interfer?ncia da l?ngua que n?o est? em uso durante a situa??o de comunica??o, devido ? coativa??o das l?nguas. Por esse motivo, tem sido constatado que bil?ngues/multil?ngues podem ter desempenho superior em compara??o a monol?ngues em tarefas com situa??es de interfer?ncia, principalmente quando h? est?mulos n?o lingu?sticos. Essas tarefas envolvem o controle inibit?rio e as fun??es executivas em geral. No caso de tarefas com est?mulos lingu?sticos, os estudos s?o mais escassos, e os resultados, menos consensuais. No ?mbito brasileiro, os efeitos positivos do bilinguismo n?o t?m sido sempre encontrados, sobretudo nos bil?ngues falantes da variedade da l?ngua alem? denominada Hunsr?ckisch. Por esse motivo, o objetivo geral deste estudo ? investigar o desempenho de participantes falantes de Hunsr?ckisch, bil?ngues e multil?ngues (falantes de alem?o padr?o com alto n?vel de profici?ncia), em compara??o com monol?ngues, em duas tarefas. A primeira ? uma tarefa n?o lingu?stica, a Attentional Network Task (ANT), e a segunda ? uma tarefa lingu?stica, a Tarefa de Compreens?o de Frases (TCF), na qual os participantes escutam frases can?nicas (voz ativa) e n?o can?nicas (voz passiva) em duas l?nguas com ou sem a interfer?ncia de outra frase. Cinquenta e nove participantes foram divididos em tr?s grupos: monol?ngues, bil?ngues e multil?ngues, compostos por adultos (m?dia de idade = 28,9 anos) residentes principalmente na cidade de S?o Jos? do Hort?ncio (RS). Os participantes preencheram um question?rio sobre aspectos lingu?sticos e cognitivos, realizaram uma tarefa de mem?ria de trabalho e as tarefas supracitadas. Analisamos as vari?veis dependentes tempo de resposta e acur?cia nas duas tarefas. Os resultados revelaram que na acur?cia da tarefa ANT n?o houve diferen?a significativa entre os grupos. A diferen?a ocorreu no tempo que levaram para responder: os multil?ngues foram mais r?pidos que os monol?ngues em todas as condi??es experimentais na ANT. Os bil?ngues tamb?m foram mais r?pidos que os monol?ngues, mas a diferen?a n?o foi sempre significativa. Na outra tarefa, a TCF, os monol?ngues tiveram, em geral, mais acur?cia. Todos os grupos foram mais acurados e r?pidos na compreens?o de frases can?nicas e sem interfer?ncia. N?o houve diferen?a entre os grupos nos tempos de resposta globais, ou seja, na totalidade dos resultados. Houve diferen?a significativa na compreens?o de frases n?o can?nicas entre multil?ngues e bil?ngues ao responderem sobre a frase em Hunsr?ckisch, com interfer?ncia em portugu?s. Os resultados mostram que os multil?ngues apresentaram uma vantagem sobre monol?ngues no processamento executivo com est?mulos n?o lingu?sticos. Eles parecem possuir uma habilidade mais desenvolvida em responder mais rapidamente na tarefa n?o lingu?stica, que envolve as fun??es executivas, e n?o necessariamente somente no controle inibit?rio. Na tarefa com est?mulos lingu?sticos, os resultados n?o foram t?o uniformes. Neste estudo, constatamos que, em contexto brasileiro de l?nguas minorit?rias, especialmente o multilinguismo pode proporcionar efeitos positivos na cogni??o, sobretudo nos tempos de resposta globais.

Με την εργασία έγινε μελέτη του σηματοδοτικού μονοπατιού Sonic Hedgehog σε 96 περιστατικά καρκίνου πνεύμονα με τη μέθοδο της ανοσοϊστοχημείας. Επίσης μελετήσαμε την πιθανή συμμετοχή του μεταγραφικού παράγοντα FoxM1 στο καρκίνωμα του πνεύμονα και την πιθανή συσχέτισή του με το μονπάτι του Hedgehog. Έγινε μελέτη της έκφρασης των μορίων Shh, Ptch1, Smo, Gli1, Gli2 και FoxM1. Τα αποτελέσματα αποκάλυψαν μια έντονη έκφραση των μορίων του μονοπατιού και αυξημένα ποσοστά ενεργοποίησής του. Επίσης βρέθηκε στατιστικά σημαντική συσχέτιση με τα πλακώδη καρκινώματα και με τα χαμηλού grade καρκινώματα. Ανάλογη σημαντική συσχέτιση βρέθηκε και με το φύλο,συχνότερα ενεργοποιημένο μονοπάτι στους άντρες. Ακόμα ανιχνεύτηκε μια συσχέτιση της έκφρασης του FoxM1 με το ενεργοποιημένο μονοπάτι. / The hedgehog (HH)-signaling pathway is implicated in developmental processes and its aberrant activation in adult tissues has been associated with malignancy. The aim of this study was to determine the expression pattern of HH-signaling molecules in lung carcinomas, as well as the involvement of the transcription factor FOXM1, that controls cell proliferation, in this process. Paraffin-embedded tissue sections of 96 lung cancer cases and adjacent non-neoplastic lung parenchyma were immunohistochemically analyzed with anti-SHH, anti-Patched1 (PTCH1), anti-Smoothened (SMO), anti-GLI1, anti-GLI2 and anti-FOXM1 antibodies. Correlations of HH molecules with clinicopathological parameters and FOXM1 expression were evaluated. All the HH-signaling molecules examined were overexpressed in lung cancer compared with the adjacent non-neoplastic lung parenchyma. HH pathway activity and expression of PTCH1 and SMO were significantly higher in squamous cell carcinomas compared to other histological types. Activation of HH pathway and PTCH1 expression were correlated with tumor grade being higher in low grade tumors. There was a significant correlation of lymph node metastases with expression of SMO in all histological types and with the gender higher in men. Overexpression of FOXM1 in lung cancer was also significantly correlated with PTCH1, SMO and GLI1 expression. In conclusion, HH-signaling pathway is activated in lung cancer and correlates with histological type, prognostic parameters of the tumors as well as with the increased expression of FOXM1.

?rea de concentra??o: Multidisciplinar. / Submitted by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2015-01-09T16:41:29Z No. of bitstreams: 2 Vania_maria_fernandes_nunes.pdf: 4796742 bytes, checksum: 26285373e915a717cb2cd90d41846b4e (MD5) license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2015-01-09T16:42:16Z (GMT) No. of bitstreams: 2 Vania_maria_fernandes_nunes.pdf: 4796742 bytes, checksum: 26285373e915a717cb2cd90d41846b4e (MD5) license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) / Rejected by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br), reason: alterar nome do arquivo on 2015-01-09T16:42:51Z (GMT) / Submitted by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2015-01-09T16:53:19Z No. of bitstreams: 2 vania_maria_fernandes_nunes.pdf: 4796742 bytes, checksum: 26285373e915a717cb2cd90d41846b4e (MD5) license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2015-01-09T16:54:00Z (GMT) No. of bitstreams: 2 vania_maria_fernandes_nunes.pdf: 4796742 bytes, checksum: 26285373e915a717cb2cd90d41846b4e (MD5) license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2015-01-09T16:54:29Z (GMT) No. of bitstreams: 2 vania_maria_fernandes_nunes.pdf: 4796742 bytes, checksum: 26285373e915a717cb2cd90d41846b4e (MD5) license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) / Made available in DSpace on 2015-01-09T16:54:32Z (GMT). No. of bitstreams: 2 vania_maria_fernandes_nunes.pdf: 4796742 bytes, checksum: 26285373e915a717cb2cd90d41846b4e (MD5) license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) Previous issue date: 2013 / O objetivo deste estudo foi verificar a implementa??o da Pol?tica de Aten??o ? Sa?de e Seguran?a do Trabalho do Servidor P?blico Federal (PASS) nos ?rg?os referenciados ? Unidade do Subsistema Integrado de Aten??o ? Sa?de do Servidor (SIASS) da Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM) e em outras institui??es p?blicas federais localizadas em cidades que acolhem a UFVJM, um dos campi do CEFET/MG, as ger?ncias e ag?ncias do INSS de Diamantina e Te?filo Otoni. Para tanto, foi realizado um estudo descritivo transversal com 205 indiv?duos (201 servidores ativos e quatro gestores de recursos humanos e, ou diretores), que, em rela??o aos servidores ativos, teve como objetivo conhecer as demandas relacionadas aos planos de sa?de, caracteriz?-los quanto ao absente?smo/doen?a ou acidentes em servi?o e ainda quanto ? insalubridade/periculosidade, al?m de verificar o conhecimento desses servidores em rela??o ?s a??es propostas pela PASS j? implantadas nos referidos ?rg?os. Junto aos gestores de recursos humanos e, ou diretores procurou-se identificar as dificuldades enfrentadas para a implementa??o das a??es propostas por essa pol?tica. Este estudo demonstra a necessidade de cria??o de canais de comunica??o que possibilitem manter os servidores das institui??es envolvidas atualizados em rela??o ?s a??es propostas pela PASS. Aponta a import?ncia do benef?cio da sa?de suplementar e ratifica a relev?ncia da a??o de acompanhamento da qualidade e aprimoramento da assist?ncia prestada pelos planos de sa?de. Confirma que a coopera??o t?cnica entre os ?rg?os p?blicos pode favorecer a resolu??o de quest?es periciais de servidores e aponta que os dados de absente?smo/doen?a s?o similares aos de outros estudos realizados. Apresenta informa??es relacionadas com promo??o e vigil?ncia nos ?rg?os envolvidos e recomenda novos estudos para melhor entendimento dessas a??es. / Disserta??o (Mestrado Profissional) ? Programa de P?s-Gradua??o em Sa?de, Sociedade e Ambiente, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2013. / ABSTRACT The aim of the current study was to verify the implementation of the Policy of Attention to the Health and Safety of Work of Federal Workers (PASS) in public agencies referenced to the SIASS Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM) and other federal institutions located in cities that host UFVJM, as well as one of the campuses of CEFET/MG and the INSS agencies in Diamantina and Te?filo Otoni. A descriptive transversal study was done with 205 individuals (201 active public servants and four human resource managers) which, in regard to the public servants, had the following aims: to find out about demands related to healthcare plans; to characterize the plans as to absenteeism/illness or on-the-job accidents and, further, to examine issues of unwholesomeness and danger in the workplace; and lastly, to verify awareness of these plans in relation to proposed PASS actions already introduced into the abovementioned public agencies. Together with human resource directors, the study sought to identify the difficulties faced in implementing PASS proposals. This study demonstrates the need to establish channels of communication in order to keep public servants updated and involved in regard to any actions proposed by PASS. It also points out the importance of supplementary health benefits and of being aware of the quality of the healthcare plans and any proposed changes to them. Furthermore, the study confirms that technical cooperation among public agencies could aid in the resolution of issues related to public servants and that data regarding absenteeism and illness are similar to other studies. The study presents data related to public agency oversight of these matters and recommends further studies aimed at improving understanding of healthcare-related actions.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-09-05T19:56:01Z No. of bitstreams: 1 LidiaMariaCostaAraujoMagalhaes_DISSERT.pdf: 1291807 bytes, checksum: 13d365211a04f1ad84978d09c6fd54af (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-09-15T23:43:49Z (GMT) No. of bitstreams: 1 LidiaMariaCostaAraujoMagalhaes_DISSERT.pdf: 1291807 bytes, checksum: 13d365211a04f1ad84978d09c6fd54af (MD5) / Made available in DSpace on 2017-09-15T23:43:49Z (GMT). No. of bitstreams: 1 LidiaMariaCostaAraujoMagalhaes_DISSERT.pdf: 1291807 bytes, checksum: 13d365211a04f1ad84978d09c6fd54af (MD5) Previous issue date: 2017-07-04 / Os Indicadores de Sa?de do Trabalhador (IST) s?o par?metros relevantes para o planejamento de a??es, com vistas ? vigil?ncia em Sa?de do Trabalhador. No Brasil, as a??es de Sa?de e Seguran?a no Trabalho (SST) para servidores p?blicos federais foram normatizadas de acordo com a Pol?tica de Aten??o ? Sa?de e Seguran?a do Trabalho (PASS). O objetivo deste estudo ? conhecer os IST, com foco na Per?cia Oficial em Sa?de e Exame M?dico Peri?dico dos servidores da Universidade Federal do Rio Grande do Norte. Trata-se de um estudo explorat?riodescritivo, transversal, de abordagem quantitativa e natureza retrospectiva, com dados referentes ao per?odo de 2011 a 2015, na cidade de Natal/RN. Quanto ao absente?smo por doen?a, o perfil dos servidores se caracterizou por predom?nio do sexo feminino, com idade de 51 a 60 anos, ocupante de cargos de n?vel m?dio e fundamental. Ao longo da s?rie hist?rica, observou-se que o n?mero de dias perdidos de trabalho por servidor e a frequ?ncia de licen?as aumentaram, apesar da diminui??o do ?ndice de Dura??o do Absente?smo (IDA) e estabiliza??o da Frequ?ncia de Trabalhadores com Licen?a M?dica (FTLM). No que se refere ?s causas do absente?smo, prevaleceram doen?as respirat?rias (25,6%), osteomusculares (16,2%) e infecciosas e parasit?rias (13,0%) entre as licen?as de curta dura??o e, para os afastamentos homologados atrav?s de avalia??o pericial, predominaram as doen?as osteomusculares (18,4%), transtornos mentais (17,2%) e doen?as respirat?rias (9,2%). Quanto ? ades?o dos servidores ? realiza??o do EMP, foi decrescente, com maior percentual no ano de 2012 (35,3%). Durante o per?odo analisado, 5.186 servidores realizaram o EMP, e a maioria (60,6%) apresentou peso n?o ideal; 41,1% s?o sedent?rios; 33,2% t?m dislipidemia; 29,0% s?o etilistas; 3,2%, tabagistas; 5,9%, diab?ticos; 16,4% referiram ru?do elevado no local de trabalho; 27,8%, ilumina??o inadequada e 35,9%, mobili?rio de trabalho inadequado. Diante dos resultados, observa-se a necessidade de manuten??o e fortalecimento da PASS e, consequentemente, implementa??o de estrat?gias de impacto positivo para a SST. / The Occupational Health Indicators (OHI) are relevant parameters for planning actions aimed at the surveillance on Occupational Health. In Brazil, Occupational Health and Safety (HOS) actions for federal public servants were standardized according to the Occupational Safety and Health Care Policy (PASS in Portuguese). The objective of this study is to know the OHI focused on the Official Health Expertise and the Periodical Medical Examination (PME) of the servants of the Federal University of Rio Grande do Norte. This is an exploratory-descriptive and cross-sectional research, with a quantitative approach and a retrospective nature, with data relating to the period from 2011 to 2015, in the city of Natal/RN. As for the absenteeism due to disease, the profile of the servants licensed for health treatment was characterized by the predominance of women aged between 51 and 60 years and working at medium and elementary-level positions. Throughout the historical series, the number of lost days of work per servant and the frequency of leaves increased, although the Absenteeism Duration Index (ADI) decreased and the Frequency of Workers with Medical Leave (FWML) kept stable. Regarding the causes of absenteeism, there was a prevalence of respiratory diseases (25.6%), musculoskeletal diseases (16.2%) and infectious and parasite diseases (13.0%) among the short-time leaves. Musculoskeletal diseases (18.4%), mental disorders (17.2%) and respiratory diseases (9.2%) prevailed in relation to leaves approved by means of expert evaluation. As for the adhesion of the servers to the PME, it was decreasing, with a higher percentage in the year 2012 (35.3%). During the analyzed period, 5,166 servers performed the PME and the majority (60.6%) presented nonideal weight, 41.1% were sedentary, 33.2% had dyslipidemia, 29.0% were alcoholic, 3.2% were smokers, 5.9% diabetics, 16.4% reported high noise in the workplace, 27.8% inadequate lighting and 35.9% inadequate work furniture. In view of the results, there is need to maintain and strengthen the PASS and, consequently, to implement positive impact strategies for HOS.

The past few years have seen the emergence of new types of civic engagement. Citizens are now more capable to organize themselves than ever before and this creates a new pattern of social mobilization that has not previously been the centre of academic focus. This work analyses the particular case of the Romanian winter protests of 2012 in an attempt to prove that current mainstream theories of resource mobilization and framing do not fully explain the emergence of unstructured movements. The results aim to pave the way for a new theory of civic engagement that fits the newly observed realities and could be generalized to explain all forms of structured or unstructured participation to collective action.