Global ETD Search

521	Electrostaticanalisys the Ras active site Khan, Abdul Kareem 05 March 2009 (has links) La preorganització electrostàtica del centre actiu s'ha postulat com el mecanisme genèric de l'acció dels enzims. Així, alguns residus "estratègics" es disposarien per catalitzar reaccions interaccionant en una forma més forta amb l'estat de transició, baixant d'aquesta manera el valor de l'energia dactivació g cat. S'ha proposat que aquesta preorientació electrostática s'hauria de poder mostrar analitzant l'estabilitat electrostàtica de residus individuals en el centre actiu.Ras es una proteïna essencial de senyalització i actúa com un interruptor cel.lular. Les característiques estructurals de Ras en el seu estat actiu (ON) són diferents de les que té a l'estat inactiu (OFF). En aquesta tesi es duu a terme una anàlisi exhaustiva de l'estabilitat dels residus del centre actiu deRas en l'estat actiu i inactiu. / The electrostatic preorganization of the active site has been put forward as the general framework of action of enzymes. Thus, enzymes would position "strategic" residues in such a way to be prepared to catalyze reactions byinteracting in a stronger way with the transition state, in this way decreasing the activation energy g cat for the catalytic process. It has been proposed thatsuch electrostatic preorientation should be shown by analyzing the electrostatic stability of individual residues in the active site.Ras protein is an essential signaling molecule and functions as a switch in thecell. The structural features of the Ras protein in its active state (ON state) are different than those in its inactive state (OFF state). In this thesis, an exhaustive analysis of the stability of residues in the active and inactive Ras active site is performed. dinàmica centre actiu relacions d'estructura activitat preorganització reorganització estat de transició estat actiu estabilitat electrostàtica interacción proteïna-proteïna test de ranks de Wilcoxon P-loop G1 motif HVR metastability RMSD substrate assisted catalysis sequence alignment beta sheet helix Z-test wilcoxon rank test protein-protein interactions electrostatic stability active state dynamics signal transduction electrostatic stabilization ras effectors guanine exchange factor GTPase-activating proteins quantum mechanics/molecular PDLD/S-LRA X-ray crystallography solvation energy free energy perturbation statistical analysis GTP hydrolysis guanosine diphosphate guanosine triphosphate computer simulation thermodynamics protein conformation electrostatics interruptor II interruptor I llaç P motiu G1 HVR (regions altament variables) metaestabilita RMSD catàlisi assistida pel substrat aliniament de seqüència fulla beta hèlix test Z transducció del senyal estabilització electrostàtica efectors de ras factor de bescamvi de guanina proteïnes activadores de l'activitat mecànica quàntica/mecànica PDLD/S-LRA cristalografia de raigs X energia de solvatació perturbació de l'energia lliure anàlisi estadística hidròlisi de GTP difosfat de guanosina trifosfat de guanosina simulació computacional termodinàmica conformació proteïca electrostàtica switch-I switch-II 537 576
522	The crime threat analysis process, an assessment Krause, André 30 November 2007 (has links) The study investigated the application of the crime threat analysis process at station level within the Nelson Mandela Metro City area with the objective of determining inhibiting factors (constraints) and best practices. Qualitative research methodology was applied and interviews were conducted with crime analysts and specialised investigators/intelligence analysts. The research design can be best described as descriptive and explorative in nature. The crime threat analysis process embroils the application of various crime analysis techniques and the outcomes thereof intends to have a dual purpose of generating operational crime management information in assisting crime prevention initiatives and crime detection efforts, mainly focussing on the criminal activities of group offenders (organised crime related), repeat offenders and serial offenders. During the study it became evident that crime analysts understand and thus apply the crime threat analysis process indifferently, which impeded on the relevancy and the utilisation thereof as an effective crime management tool. / Criminology and Security Science / M.Tech. (Policing) Crime threat analysis process Crime analysis Crime series Viz. crime threat Crime statistical analysis Crime trend analysis Crime threshold analysis Crime pattern analysis Case docket analysis Linkage crime analysis Fieldwork Profiling Crime management information Repeat offenders and serial offenders 363.25096875 Police -- South Africa -- Eastern Cape Digital mapping
523	Hodnocení tepové frekvence a saturace krve kyslíkem pomocí chytrého telefonu / Heart rate and blood oxygen saturation estimation using smartphone Jordánová, Ivana January 2018 (has links) Heart rate, Oxygen saturation, HR, SpO2, MATLAB, smartphone, mobile phone, photopletysmogram, PPG
524	Railway curve squeal: Statistical analysis of train speed impact on squeal noise Asplund, Ruben January 2024 (has links) No description available. ml operation maintenance railway maintenance railway curve machine learning statistics railway train passenger train x60 squeal noise curve squeal squealing noise squeal wheel squeal squealing programming system development computer engineering data visualization data preprocessing industrial computer systems matlab python vibration vibrations vibration signals signals and systems filtering signal processing computer systems communication system infrastructure technology infrastructure track t-test z-test random forest xgboost feature importance speed detection band-pass filter script yaw angle angle of attack decision tree gbdt filter temperature humidity dew point curve radius cloud accelerometers sensors track rail statistical analysis acoustics sound ai artificial intelligence gradient boosting decision trees curve software development drift underhåll järnvägsunderhåll järnvägskurva maskininlärning statistik järnväg tåg x60 skrikljud snäva kurvor kurvradie kurvskrik hjulskrik programmering systemutveckling datateknik data industriella datorsystem matlab python vibration signaler vibrations signaler signaler och system filtrering signalbehandling datorsystem kommunikationssystem infrastrukturteknik infrastruktur spår t-test z-test random forest Södertälje band-pass filter hastighets detektion attackvinkeln anfallsvinkel IMx SKF temperatur fuktighet daggpunkt accelerometer järnvägskurvskrik tåg hastighetens statistisk analys akustik ljud ai kurva kurvor mjukvaruutveckling artificiell intelligens Infrastructure Engineering Infrastrukturteknik Signal Processing Signalbehandling Communication Systems Kommunikationssystem Computer Systems Datorsystem

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