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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / The following thesis aims at offering a broad and systematic interpretation of the doctrine highest good. Based on that, we defend that the idea of highest good represents a necessary complement to Kant‟s moral theory. In order to defend that, it is needed to present the context in which the idea of highest good is introduced by Kant, observing that in this period there was no moral theory itself yet, which was based on the autonomy of the will. It is important to emphasize that both during development and among the different phases of critical philosophy the idea of highest good has been there. Thus, it is essential to analyze the relationship between the idea of highest good and the theory of morality, taking into consideration that sometimes the concept seems to be unstable regarding the foundations of the moral theory. It happens that, although the concept or idea of highest good has already its legitimacy ensured since the beginning of critical period, it is from a practical perspective of reflective judgment that it will become an essential part of the moral theory and of the architectonic of pure reason. On one hand, the following thesis has the objective of rebuilding Kant‟s argumentation regarding the idea of highest good during the critical period and, on the other hand, showing that the concept of highest good does not compromise the fundamental principle of morality. Besides that, considering that the idea of highest good is constantly retaken by Kant himself in his critical philosophy, we defend that the highest good not only has an assured place, but a privileged one in moral philosophy. Even though the highest good is an object of faith for practical pure reason moral it theologically complements moral theory representing pure reason ultimate goal for rational human beings. / A presente tese procura oferecer uma interpretação abrangente e sistemática da doutrina do sumo bem. Nessa perspectiva, defende-se que a ideia do sumo bem representa uma complementação necessária à teoria moral kantiana. Para tal empreendimento faz-se necessário apresentar o contexto no qual a ideia do sumo bem é introduzida por Kant, observando que nesse período ainda não existia uma teoria moral propriamente dita, baseada na autonomia da vontade. Cabe ressaltar que tanto no desenvolvimento quanto nas diferentes etapas da filosofia crítica a ideia do sumo bem esteve presente. Com efeito, torna-se imprescindível analisar a relação entre a ideia do sumo bem com a teoria da moralidade, tendo em vista que em alguns momentos esse conceito parece instável no tocante à fundamentação da teoria moral. Ocorre que, embora o conceito ou ideia de sumo bem já tenha a sua legitimidade assegurada desde o início do período crítico, é a partir de uma perspectiva prática da faculdade de julgar reflexionante que ele passa a se constituir como uma parte indispensável da teoria moral e da arquitetônica da razão pura. A tese tem, por um lado, o objetivo de reconstruir a argumentação kantiana referente à ideia do sumo bem no período crítico e, por outro lado, demonstrar que essa ideia do sumo bem não compromete o princípio fundamental da moralidade. Além disso, visto que a ideia de sumo bem é constantemente retomada pelo próprio Kant em sua filosofia crítica, defende-se que a ideia do sumo bem não somente tem um lugar assegurado, mas um lugar privilegiado na filosofia moral. Mesmo que o sumo bem seja um objeto de fé da razão prática pura moral ele complementa teleologicamente a teoria moral representando o fim último da razão pura para os seres racionais humanos.

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / This master thesis aims at reconstructing the Kantian concept of the Highest Good (höchstes Gut) since its presentation in the Critique of pure reason`s Transcendental doctrine of method (1781), passing by Groundwork of the metaphysic of morals (1785) and the Critique of practical reason (1788), until the preface of The religion within the limits of reason alone (1793). We intend here to clarify the definition that Kant presents about the concept of the Highest Good, as well as its relation with morality. That way, we maintain that in the development of the critical philosophy Kant presented different perspectives about the Highest Good, taking into account the different meanings this concept has in Kant. The same applies to Kant s conception of the foundations of moral, considering that his arguments in different stages of the critical philosophy sometimes are unstable about the determination of the origin of the moral law. Thus, it is necessary to analyze the relation of morality to the Highest Good, because it is an extremely important element of this concept. After clarifying this relation, we approach the question, linked to Highest Good and morality, about how happiness can be an element of the concept of such object without compromising its characteristic of originating from pure rational will. Furthermore, we approached the problem of the importance of the Highest Good for Kant`s practical philosophy. We take the doctrine of the practical reason`s postulates as relevant to this question. Finally, we go into Kant`s philosophy of religion in which the concept of the Highest Good seems to adopt an anthropological character, representing the final end that rational human beings aim to attain. / Este trabalho consiste em uma reconstrução do conceito kantiano de Sumo Bem (höchstes Gut) desde sua apresentação na Doutrina transcendental do método da Crítica da razão pura (1781), perpassando pela Fundamentação da metafísica dos costumes (1785) e a Crítica da razão prática (1788), até o prefácio de A religião nos limites da simples razão(1793). Busca-se aqui, esclarecer a definição que Kant apresenta do conceito de Sumo Bem, assim como, de sua relação com a moralidade. Nesse sentido, observa-se que no desenvolvimento da teoria crítica, Kant expõe diferentes perspectivas a respeito do Sumo Bem, merecendo, por isso, atenção aos distintos significados usados desse conceito. O mesmo ocorre com a compreensão que ele possui da fundamentação moral, tendo em vista que sua argumentação nas diferentes etapas da filosofia crítica, por vezes, se revela instável no tocante à determinação da origem da lei moral. Por isso, faz-se necessário analisar a relação da moralidade com o Sumo Bem, uma vez que ela consiste num elemento extremamente relevante para esse conceito. Tendo esclarecida essa relação, aborda-se a questão vinculada ao Sumo Bem e a moralidade acerca de como a felicidade pode compor o conceito de tal objeto sem comprometer sua característica de ter origem na vontade racional pura. Ademais, aborda-se o problema referente à importância do Sumo Bem à filosofia prática de Kant. Para tanto, toma-se a doutrina dos postulados práticos como relevantes para a tentativa de solucionar essa questão. Por fim, adentra-se na filosofia da religião de Kant em que o conceito de Sumo Bem parece adquirir caráter antropológico, tendo em vista que ele representa o fim último da razão pura que os seres humanos racionais visam alcançar.

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / This master's degree work approaches the concept the highest good in three different moments of the Kant s philosophy practical. Its objective is to show that Kant attributes different papers in the ethics, in the religion and in the political philosophy for the highest good, that is, it can have different functions in the horizon of his philosophy. In the first chapter, the highest good is characterized in the Dialectics of the Critique of Practical Reason as object of the pure practical reason and it is sustained that is necessary to admit for his accomplishment that the postulates of the practical reason, God and immortality of the soul, as their possibility conditions. In the second chapter, from the Religion Within the Limits of Reason Alone, it is described the idea of the highest good as last end of the man's moral conduct through the moral community's formation and it is shown how the radical evil show itself in the human nature. In the last chapter, it is presented the conception secular or political of the highest good as a social end. This subject is analyzed in the context of the political philosophy of Kant and it is sustained that the accomplishment of the highest good political requests the union of States in a common juridical body and, besides, it is necessary the elaboration of a cosmopolitan Constitution. / Este trabalho de mestrado aborda o conceito de sumo bem em três diferentes momentos da filosofia prática kantiana. Seu objetivo é mostrar que Kant atribui diferentes papéis na ética, na religião e na filosofia política para o sumo bem, isto é, que ele pode ter diferentes funções no horizonte da sua filosofia. No primeiro capítulo, caracteriza-se o sumo bem na Dialética da Crítica da Razão Prática como objeto da razão prática pura e sustenta-se que para a sua realização é preciso admitir que os postulados da razão prática (Deus e imortalidade da alma) são as suas condições de possibilidade. No segundo capítulo, descreve-se, a partir da Religião nos Limites da Simples Razão, a idéia do sumo bem como fim último da conduta moral do homem através da formação da comunidade moral e mostra-se como o mal radical figura na natureza humana. No último capítulo, apresenta-se a concepção secular ou política do sumo bem como um fim social. Essa questão é analisada no contexto da filosofia política de Kant e sustenta-se que a realização do sumo bem político requer a união dos Estados num corpo jurídico comum e, além disso, é necessária a elaboração de uma Constituição cosmopolita.

La SUMOylation est une modification post-traductionnelle réversible permettant de diversifier les fonctions de centaines de substrats. Elle est impliquée dans des processus essentiels à la cellule et à l'organisme, tels que la réparation de l'ADN, la mitose, la transcription. A l'aide de modèles murins génétiquement modifiés déficients pour l'unique enzyme E2 de SUMOylation, UBC9, nous avons caractérisé les conséquences de la réduction de la SUMOylation sur l'immunité innée et l'oncogenèse.Nous révélons un rôle majeur de la SUMOylation dans la régulation négative du gène codant pour l'IFN- . La dérégulation de ce gène par l'absence d'Ubc9 a des conséquences importantes sur l'immunité innée, avec une augmentation de l'expression du programme transcriptionnel inflammatoire, une hypersensibilité au choc endotoxique, et une protection contre les infections virales. L'étude du profil chromatinien de SUMO autour du gène Ifnb1 a révélé trois nouveaux domaines à potentiel régulateur. Enfin, la SUMOylation régule l'expression de rétrovirus endogènes, potentiellement déclencheurs d'une réponse interféron.Le second axe de recherche a permis de caractériser les conséquences de la réduction de la SUMOylation sur la transformation cellulaire et l'oncogenèse colorectale. Nous montrons une sensibilité accrue des cellules transformées à la perte de SUMOylation comparées aux cellules primaires. De plus, les souris hétérozygotes pour Ubc9 présentent une réduction du nombre de polypes intestinaux dans un modèle d'oncogenèse colorectale.Ces résultats permettent d'affiner nos connaissances sur le rôle de la SUMOylation dans l'oncogenèse et l'immunité innée. / SUMOylation is a reversible post-translational modification modifying the functions of hundreds ofproteins. It is implicated in essential cellular and organismal processes, such as nuclear shuttling, DNArepair, mitosis, transcription. Using genetically modified models, deficient for the uniqueSUMOylation E2 enzyme UBC9, we characterized the consequences of a decrease in globalSUMOylation in two processes: innate immunity and oncogenesis.We reveal a major role for SUMOylation in the negative regulation of the gene coding for IFN-.Deregulation of this gene in the absence of Ubc9 has dramatic consequences on innate immunity, withincreased inflammatory transcriptional program expression, endotoxic shock hypersensitivity, andprotection against viral infection. Chromatin binding profile analysis of SUMO surrounding the Ifnb1gene revealed three new putative regulatory domains. Finally, SUMOylation regulates endogenousretroviruses expression, potential triggers for interferon response.Our second research axis allowed the characterization of the consequences of global SUMOylationdecrease on cellular transformation and colorectal oncogenesis. Our results show increased sensitivityof transformed cells to SUMOylation loss, when compared to primary cells. Furthermore, decreasingUBC9 levels by half causes a two-fold decrease in intestinal polyp numbers developing in the colon ofmice, in a chemically-induced model of colorectal oncogenesis.Altogether, these results helped increasing our knowledge of the role of SUMOylation in majorcellular processes implicated in oncogenesis and innate immunity.

Traffic simulation is a growing research field which enables study and evaluation of the dynamics of a traffic system with the help of today’s various traffic simulation models. Rural roads with separated oncoming lanes and alternating lanes for overtaking, so-called 2+1 roads, are becoming increasingly common in Sweden due to its positive safety effects. In Sweden, there is today only one traffic simulation model developed for simulation of these road types, RuTSim (Rural Traffic Simulator). RuTSim is a research tool which makes it difficult to apply for others than the developers. This study therefore investigated whether the more accessible open-source code traffic simulation model SUMO (Simulation of Urban MObility) developed for urban and motorway traffic can be modified for modeling of traffic operations on 2+1 roads. Simulations of a virtual 2+1 road section were examined qualitatively and quantitatively using various comparison metrics aimed at capturing the characteristic traffic operations and human driver behavior on 2+1 roads. The results were further compared with an identical road section simulated in RuTSim. By adjusting parameters in the SUMO model and using its source code in its original form, the results show that it is to some extent possible to reflect the traffic operations and human driver behavior on 2+1 road, while some important mechanisms cannot be fully captured. By further modifying the source code in such a way that the speed of overtaking vehicles is temporarily increased, some of these missing mechanisms are successfully captured. The conclusion is that SUMO to some extent can model 2+1 roads, but the simulation model still lacks some basic mechanisms for capturing some of the traffic operations. For future studies, it is recommended to focus on further developing the sub-models for the merging behavior at the end of the two-lane sections, which differs compared to merging at on-ramps or lane closures since merging on 2+1 roads are part of an overtaking process.

Automated shuttles are designed to provide a clean transportation and improve access to areas such as where travelers have to walk long distances to/from bus stops. The introduction of automated shuttles in the road network might affect the safety of pedestrians and cyclists as well as traffic performance of motorized vehicles. Several demonstration trials are being conducted to study how automated shuttles operate in real traffic conditions, but they are limited to few vehicles and evaluations of traffic effects at higher penetration rates are not possible. Traffic simulation is a tool that can be used to study effects on traffic performances at different penetration rates of e.g., automated shuttles. However, automated shuttles have not yet been modeled, calibrated, and validated in microscopic traffic simulation tools. Therefore, the objective of this thesis is to model, calibrate and validate automated shuttle’s behavior using the simulation tool SUMO and data collected from the demonstration trial on the area of campus Valla Linköping University, Sweden. The pilot study consists of two automated shuttles, and they operate on a 2.1 km fixed route. The collected data by one of the automated shuttles is analyzed with a focus on the free driving behavior. The analysis shows that the automated shuttle has different maximum operation speeds at different locations and defining one value for the maximum speed when setting up the simulation is not enough. Therefore, virtual speed limits are derived by mimicking the maximum operation speed of the shuttle from the data and used to define segment specific speed limits in the simulation. Additionally, the data is used to calibrate the acceleration and deceleration parameters. The Krauss and the IDM car-following models have been investigated by calibrating the acceleration and deceleration parameters for the free driving situation. The results indicate that both the Krauss and IDM car-following models follows the general trend of the speed and acceleration profiles. The speed profiles produced with the IDM model have smoother profiles at the start and end of acceleration and deceleration phases while in Krauss model the transition of the speed change is more direct and there are in principle no delays for reaction. Although the IDM model performs slightly better for the free driving situation, it can be of interest to consider both models for the calibration of interactions with other roads users since both models are able to capture the general trend of the speed and acceleration profiles. / <p>Examensarbetet är utfört vid Institutionen för teknik och naturvetenskap (ITN) vid Tekniska fakulteten, Linköpings universitet</p>

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