La malnutrition est identifiée comme l’un des facteurs potentiellement responsables des mortalités élevées de colonies d’abeilles des dernières années au Québec. Pour contrer cela, les apiculteurs donnent des suppléments de pollen à leurs colonies, mais les impacts d’une telle pratique à diverses périodes sont méconnus. Les effets de la disponibilité du pollen sur le développement de colonies d’abeilles ont été mesurés pendant 3 différentes périodes : au printemps, durant la pollinisation de la canneberge et à la fin de l’été. À chacune des périodes correspondait une expérience distincte utilisant 40 colonies. Pour chaque expérience, des conditions d’abondance de supplément de pollen et de restriction de pollen naturel étaient créées chez les colonies pendant un mois selon un plan d’expérience factorielle 2x2. L’élevage du couvain et la récolte de miel ont été mesurés jusqu’à la fin de l’été (début de l’été suivant pour l’expérience de fin d’été). Au printemps, les colonies restreintes en pollen naturel ont élevé 18% moins de couvain (p<0.05) pendant la période de restriction et 11% de moins à la fin de l’été alors que l’utilisation du supplément n’a eu aucun effet (p>0.05). Les colonies supplémentées durant la pollinisation des canneberges ont élevé moins de couvain (p<0.05) à la fin de l’été. Pour l’expérience de fin d’été, les colonies supplémentées ont eut une meilleure reprise printanière (p<0.05) de l’élevage du couvain (60% de plus) alors qu’une restriction en pollen naturel avait un effet négatif (p>0.05). Les récoltes de miel ont été augmentées (p<0.05) de 1,3 kg pendant la pollinisation de la canneberge alors qu’elles ont été diminuées (p<0.05)par une restriction en pollen naturel de 4,2 kg à la fin de l’été et de 15 kg au printemps. / The use of pollen supplement is a countermeasure to honey bee malnutrition which is identified as one of the factors causing high colonies losses over the past few years in Quebec. There is little documentation on the results of using pollen supplement during different periods. The effects of pollen availability and supplementation on the development of honey bee colonies were examined during 3 different periods: in spring, during cranberry pollination and in late summer. Each period was a distinct study using 40 different colonies. In each study, pollen supplemented and pollen restricted conditions were created for one month in 10 colonies per treatment group in a 2x2 factorial design experiment. Brood rearing and honey yield were monitored until the end of summer for the spring and the cranberry pollination studies and until the end of the following spring for the late summer study. In the spring study, pollen restricted colonies reared 18% less brood (p<0.05) during the restriction period and 11% less brood (p<0.05) by the end of summer while pollen supplement had no effect (p>0.05). Colonies supplemented during cranberry pollination study reared less brood (p<0.05) by the end of summer. In the late summer study, supplemented colonies had a greater (p<0.05) spring build-up (60% more brood) and pollen restriction negatively influence (p<0.05) brood rearing. Honey yield was decreased (p<0.05) by 15 kg in colonies exposed to a pollen restriction in spring. It was increased by 1.3 kg (p<0.05) in pollen supplemented colonies during the cranberry pollination study and was reduced by 4.2 kg (p<0.05) in pollen restricted colonies in the late summer study. In conclusion, pollen supplement improved colonies population when fed in late summer and not during spring or in cranberry pollination and was without impact on honey yield.

Bakgrund: Syftet med denna studie var att undersöka effekten av sju dagars tillskott av betain (2,5 gram/dag) på prestationsförmågan i idrottsspecifika tester för manliga vältränade cykelatleter. Metod: Sex (n=6) manliga testpersoner (genomsnitt ± standardavvikelse ålder, 31,7 ± 10,2 år; längd, 188,2 ± 3,6 cm; kroppsvikt; 82,5 ± 7,6 kg; fettfri massa, 71,6 ± 7,3 kg) genomförde förtester bestående av fem counter movement jumps, fyra stycken 12 s wingate-sprinter med 2,5 minuters aktiv vila följt av fem ytterligare counter movement jumps. De blev sedan indelade slumpmässigt i betain- eller placebogrupper. Första testet etablerade basvärden och eftertest ”1” samt ”2” föregicks med antingen sju dagars tillskott med placebo (2,5 g maltodextrin plus 12,5 mg riboflavin) eller betain (2,5 g trimetylglycin plus 12,5 mg riboflavin). Riboflavin användes för att undanröja den fiskliknande doften som kan uppstå vid tillskott av betain. Doseringen bestod av fyra kapslar per dag till måltid, varav två kapslar intogs på morgonen eller förmiddagen (före träning) och två kapslar intogs på eftermiddagen eller kvällen (efter träning). Vi använde oss av en dubbelblindad, kontrollerad randomisering cross-over design; med en veckas washout mellan placebo och betain. Maximum Peak Power, Average Peak Power, Maximum Average Power, Mean Average Power, Mean Relative Power Drop, Maximum Relative Power Drop, CMJ-Medel och CMJ-Max före och efter sprinterna analyserades med two-tailed t-test 2 och 3 för att jämföra skillnader före och efter intag av tillskott samt skillnaderna mellan grupperna.Resultat: Inga signifikanta skillnader kunde noteras. Konklusion: En veckas tillskott av betain gav inte någon signifikant förbättring jämfört med placebo i hopp- och sprintförmåga samt förmåga att ta ut sig själv maximalt hos aktiva cyklister. Fler studier med framförallt större testgrupper efterlyses för att utvärdera betainets ergogena effekt bland aktiva atleter. / The effect of betaine supplementation on counter movement jumps and sprint performance among male bicycle athletes Background: The purpose of this study was to investigate the effect of a seven days supplementation regimen with betaine (2,5 grams per day) on counter movement jumps and sprint performance in trained male bicyclists. Method: Six (n=6) male subjects (mean ± standard deviation age, 31,7 ± 10,2 years; height, 188,2 ± 3,6 cm; bodyweight, 82,5 ± 7,6 kg; lean body mass, 71,6 ± 7,6 kg) completed a 21 day study involving five counter movement jumps (no arm swing) followed by 4 consecutive modified 12 second Wingate sprints on a bicycle ergometer with active rest (2,5 minutes) followed by another set of five counter movement jumps. A double blind, controlled randomized cross over design was used and there was a 1 week washout between the supplementation startup for each group. Following pre-testing (baseline) the participants were randomly divided into groups by choosing one of the following supplements: “12” Placebo –2,5 grams of maltodextrine plus 12,5 mg riboflavin or “11” – Active 2,5 grams of trimethylglycine plus 12,5 mg riboflavin. Riboflavin was used so mask the “fishy odor syndrome” effect of high intakes of trimethylglycine that may cause trimethyluria. Daily consumption of capsules was divided into two doses of two capsules each with meals. One dose (two capsules) was consumed in the morning and one dose in the evening. The following variables were analyzed: Maximum Peak Power, Average Peak Power, Maximum Mean Power, Average Mean Power, Maximum Relative Power Drop, Average Relative Power Drop, Mean CMJ-Pre + Post sprints and Maximal CMJ-Pre + Post sprints. Results: None of the parameters showed statistical significance. Conclusion: Our study indicates that seven days of betaine ingestion does not seem significantly improve counter movement jump or sprint capacity in male trained bicyclists. Larger studies are needed to investigate the performance enhancing effects of betaine, especially among high performance athletes.

No description available.

Fundação de Amparo a Pesquisa no Estado do Rio Grande do Sul / The work was developed with the objective to evaluate the intake of forage and beef heifers performance from 15 to 18 months old, grazing in Alexandergrass (Urochloa plantaginea (Link) Hitch) under rotational grazing method, receiving rice bran (FAI) as a supplement, at different levels (0, 0.5 and 1.0% of body weight (BW)). The experimental design was completely randomized with repeated measures over time. The use of FAI increased the total intake of dry matter (DM), total intake of crude protein and total digestible nutrients in relation to heifers exclusively on pasture. The heifers that received 1.0% PC FAI reduced the intake of forage DM increasing by 18% stocking rate (SR) and 27% BW gain per hectare (BWA) compared with the system exclusively in pasture. In the system in which the heifers received FAI at 0.5% of BW the SR and BWA were similar to other systems. In this feed system daily weight gain 18% higher than heifers exclusively on pasture and similar gain to the use of FAI at 1.0% of BW were observed. In Alexandergrass pasture under rotational grazing, using FAI at 0.5% of BW for beef heifers from 15 to 18 months of age is recommended to promote higher production response when compared to heifers exclusively on pasture and similar production when provided FAI at 1.0% of BW. / O trabalho foi desenvolvido com o objetivo de avaliar o consumo de forragem e o desempenho de novilhas de corte dos 15 aos 18 meses de idade, em pastejo em papuã (Urochloa plantaginea (Link) Hitch), sob método rotativo de pastejo, recebendo farelo de arroz integral (FAI) como suplemento, em diferentes níveis (0, 0,5 e 1,0% do peso corporal (PC)). O delineamento experimental foi o inteiramente casualizado, com medidas repetidas no tempo. O uso de FAI aumentou o consumo total de matéria seca (MS), consumo total de proteína bruta e de nutrientes digestíveis totais em relação às novilhas exclusivamente em pastejo. O consumo total de fibra em detergente neutro foi similar nos diferentes sistemas alimentares. As novilhas que receberam 1,0% do PC de FAI reduziram o consumo de MS da forragem, aumentando em 18% a taxa de lotação (TxLot) e em 27% o ganho de PC por hectare (GPA) em comparação com o sistema exclusivamente a pasto. No sistema em que as novilhas receberam 0,5% do PC de FAI a TxLot e o GPA foram similares aos demais sistemas. Nesse sistema alimentar foi observado GDM 18% superior em relação as novilhas exclusivamente em pastejo e ganho similar ao uso de 1,0% do PC de FAI. Em pastagem de papuã, sob pastejo rotacionado, é recomendado o uso de 0,5% do PC de FAI para novilhas de corte dos 15 aos 18 meses de idade, por promover respostas produtivas superiores em relação as novilhas exclusivamente em pastejo e semelhantes as observadas quando fornecido 1,0% do PC de FAI.

Made available in DSpace on 2014-12-17T15:34:49Z (GMT). No. of bitstreams: 1 ItaniaMMA_DISSERT.pdf: 824423 bytes, checksum: afea5ac43f7f8530cfb948b922808ef4 (MD5) Previous issue date: 2014-02-27 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / The objective of this work was to evaluate the effect of supplements feeding on growth of calves grazing a Panicum maximum cv. Momba?a pasture during the dry season. The experimental design was a randomized blocks with three treatments and three replications. The treatments were: mineral salt ad libidum; multiple mixture (MM) fed at 0.2% of live weight (PV); and, concentrate feed (SC) fed at 0.7% of PV. Thirty six weaned calves averaging eight months and 192 kg of initial live weight were utilized. The masses and pasture components, nutritive value and rate of forage growth were evaluated. Animal performance was measured as average daily gain (ADG) and live weight gain (LWG). The supplemental feeding was adjusted after weighing. There was no difference between periods for forage mass and leaf: stem ratio. The highest values for forage green mass, leaf blades mass and stem percentage were observed in the first trial period. The canopy height and the available forage on offer did not differ among treatments. The percentage of dead was higher for the last periods of evaluation. The leaf: stem ratio and the leaf percentage were greater in the second period. There was significant difference (p<0,05) among treatments for the ADG and were 250, 460 and 770 g/day for salt, MM and SC, respectively. The biggest LWG was observed in the treatment SC. contents of PB, DIVMO, NDF and LDA on leaf blades, thatched roofs and dead material dead not differ among treatments. The highest GPV was observed in the SC treatment. The contents of PB, DIVMO, NDF and LDA for leaf blades stem and dead material did not differ among treatments. Independent of the use supplements , it is possible to keep steers gaining weight, during dry season, since the stocking rate is appropriately adjusted / O objetivo deste trabalho foi avaliar o efeito de suplementos na recria de bovinos em pastos de Panicum maximum cv. Momba?a na ?poca seca. Utilizou-se o delineamento experimental de blocos ao acaso, com tr?s tratamentos e tr?s repeti??es. Os tratamentos constitu?ram-se de: sal mineral ? vontade; mistura m?ltipla (MM), fornecida a 0,2% do peso vivo (PV); e, suplemento concentrado (SC), fornecido a 0,7% do PV. Foram utilizados 36 bezerros desmamados, com idade m?dia de oito meses e peso m?dio inicial de 192 kg. Mensalmente, os pastos foram amostrados para as estimativas de altura, massa de forragem (MF), massa de forragem verde (MFV), massa de l?mina foliar (MLF), porcentagens de folha (PF), colmo (PC) e morto (PM), rela??o folha:colmo (RFC) e folha:n?o folha, oferta de forragem e taxa de ac?mulo de forragem (TAF), sendo os dados agrupados em quatro per?odos. Os animais foram pesados a cada 28 dias e a produ??o animal foi avaliada quanto ao ganho m?dio di?rio (GMD) e ganho de peso vivo por ?rea (GPV). A quantidade de suplemento foi ajustada a cada pesagem. N?o houve diferen?a entre per?odos para a massa de forragem e rela??o folha:colmo. Os maiores valores para massa de forragem verde, massa de l?mina foliar e porcentagem de colmo foram observados no primeiro per?odo de avalia??o. A altura do dossel e a oferta de forragem n?o diferiram entre os tratamentos. A porcentagem de material morto foi maior nos ?ltimos per?odos de avalia??o. A rela??o folha:n?o folha e a porcentagem de l?mina foliar foram maiores no segundo per?odo. O GMD foi de 250, 460 e 770 g/animal/dia, respectivamente, para sal, MM e SC. O maior GPV foi observado no tratamento SC. Os teores de PB, DIVMO, FDN e LDA nas l?minas foliares, colmo e material morto n?o diferiram entre os tratamentos. Independente do uso de suplementos, ? poss?vel manter o ganho de peso dos animais durante a esta??o seca, desde que a taxa de lota??o seja ajustada de forma adequada

The influence of biological supplement AEN 700 in broiler chicken fattening was traced in operating conditions of broiler houses Kladruby.This influence was analysed economically.Compared to year 2005 when the antibiotic stimulators of growth were used there are well-balanced zootechnical and economical results.The results of development confirmed that the biological supplement AEN 700 has minimally equivalent effect in production and in economical effect compared to antibiotic stimulators of growth.

The topic of my graduation thesis is ``The Final Accounts and Statement of Balances in a Company``. The aim of this graduation thesis is a representation of process of the final accounts and statement of balances in a particular company. The graduation thesis has two parts. In the first part are defined the basic concepts which are included in the final accounts and in the statement of balances. I deal with an individual preparation work in the statement of balances for instance, a stock taking, rectifying items, time resolution of cost and revenues, etc. Further there it is dealt with closing books of accounts, tax due and deferrate tax of corporated income tax, and finally, a proper statement of balances which represent balance, profit and loss statement, supplement, eventually a statement about cash flows and an overview of changes in the shareholders´ capital. The duties link with statement of balances do not end with the fiscal period closing. The duties include audit of the statement of balances, making a record of an annual report of a company, publication of the statement of balances and the annual report of a company in a digest of documents of the Company Register and an income tax return must be submitted. In the second part of my graduation thesis is described a process of the 2007 final account and statement of balances in the Transport Undertaking in the town České Budějovice, Inc.

INTRODUÇÃO: Metionina (Met), cisteína (Cys), homocisteína (Hcy) e taurina (Tau) são os quatro aminoácidos sulfurados (AAS), mas apenas a Met e Cys são incorporadas em proteínas. Os três principais produtos doS AAS, glutationa, (GSH), Hcy e Tau influenciam, principalmente, as respostas inflamatória e imune. A Tau e GSH diminuem a inflamação, enquanto que a Hcy apresenta efeito oposto. Os pacientes HIV+ apresentam baixos níveis de GSH e outros nutrientes antioxidantes, mostrando relação direta entre Cys (e GSH) com células CD4+. Não se conhece o mecanismo pelo qual as mudanças na ingestão dos AAS influenciam este fenômeno. Paralelamente, as relações entre Hcy, doenças inflamatórias e alterações in vitro no comportamento das células imunes levantou ressalvas sobre a suplementação de dietas com AAS. OBJETIVOS : investigar as vias dos AAS em pacientes HIV+ nas condições de jejum e pós-sobrecarga de Met frente à dieta habitual (OH) isolada ou acompanhada da suplementação de Cys (NAC) ou glutamina (Gln). MÉTODOS : 12 pacientes HIV+ (6 M e 6 F, de 25 a 36 anos), sob tratamento anti-retroviral pelo esquema tríplice, sem infecções secundárias e 20 controles saudáveis (10M e 10F, 23-28 anos) foram randomicamente distribuídos para suplementação com NAC (N-acetilcisteína, 1g/d) ou Gln (20 g/d) em estudo cruzado com 7 dias de dieta separados por uma semana de washout (Wo com DH). Amostras de sangue após jejum noturno de 10 a 12 horas foram coletadas antes (MO) e após (M1) cada regime dietético. A seguir, os indivíduos ingeriram metionina (100 mg/kg), com coletas de sangue após 2 e 4 horas para a determinação da área abaixo da curva (AAC). No MO, ambos os grupos foram avaliados quanto à antropometria (IMC, kg/m2), funções glomerular (uréia, creatinina) e hepatocelular (&#947;-GT), estados nutricional (albumina, cálcio, ácido fólico e vitamina 812) e antioxidante (ácido úrico, GSH, GSSG, Hcy), glicose, lipídios (triacilgliceróis e frações de colesterol) e AAS, serina (Ser), glicina (Gly), glutamato (Glu) e Gln. O grupo HIV também foi caracterizado pela carga viral e contagem de CD4+ e CD8+. As comparações estatísticas entre os grupos e entre as dietas mostraram homogeneidade para IMC, albumina, cálcio, vitamina 812, Hcy, HDL-colesterol, uréia e creatinina. Os pacientes apresentaram valores maiores de glicose, triacilgliceróis, &#947;-GT, LDL-colesterol e GSSG paralelalemente às menores concentrações de ácido úrico, GSH e todos os AAS, exceto Hcy. A sobrecarga de metionina igualou (pelos valores de delta) os grupos para Met, Hcy, Tau e Gln. As suplementações de NAC e Gln levaram o grupo HIV+ a concentrações maiores de GSH (NAC > Gln), atuando diferentemente em seus precursores: G/y (Gln > NAC) e Cys (NAC > Gln) e resultando em consumo similar de Ser e produção de Tau. Ambas as dietas reduziram GSSG/GSH (NAC > Gln) e apenas NAC aumentou (6 x) a Hcy. Esta última foi piorada pela sobrecarga de Mel. Assim, HIV+ resulta em deficiências múltiplas de vitaminas e aminoácidos levando a menores níveis de GSH e GSSG/GSH mais elevada. Os principais problemas de menor formação de Cys e menor incorporação de Cys em GSH foram resolvidos dando-se Met, NAC e Gln aos pacientes, ainda permanecendo a desvantagem do aumento da Hcy com Met ou suplementação de NAC. / BACKGROUNO: Methionine (Met), cysteine (Cys), homocysteine (Hcy), and, taurine (Tau) are the 4 sulfur-containing amino acids (SAA), but only Met and Cys are incorporated into proteins. The 3 major products of SAA, glutathione (GSH), Hcy and Tau influence, mainly, inflammatory and of immune responses. Tau and GSH ameliorate inflammation whereas Hcy has the opposite effect. HIV+ patients present low levelis of GSH and other antioxidants nutrients, showing a direct relationship between Cys (and GSH) with CD4+/ cells. How changes in SAA intake influence this phenomenon is unknown and the relationships among Hcy, inflammatory diseases, and in vitro alterations in immune cell behavior create a cautionary note about supplementation of diets with SAA. OBJECTIVE: To investigate SAA pathways in HIV+ patients on fast and Met-overload (Met-DL) states after taken diet habitual without (HD) or with supplements of Cys (NAC) or glutamine (Gln). METHOOS: 12 HIV+ (6M and 6F, 25-36 yrs old) patients under HAART without secondary infections and 20 healthy (10M and 10F, 23-28 yrs old) controls were randomly assigned to either NAC (N-acetylcysteine, 1g/d) or Gln (20g/d) diets, in a 7-day diet crossover design, separated by a 7-day washout (with HD) period. Blood samples were drawn after overnight fast before (MO) and after each dietary treatments (M1) for the resting measurements. Immediately after blood sampling ali subjects started the Met-DL by ingesting at once 100 mg Met/kg BW and having the blood draw after 2 and 4 hours for the area under the curve (AUC) determination. At MO both groups were assessed for anthropometry (BMI, kg/m2), glomerular (plasma urea and creatinina) and hepatocellular (plasma &#947;GT activity) funetions, nutritional (albumin, calcium, folic acid and vitamin B12) and antioxidant (uric acid, GSH, GSSG, Hey) states, glucose, lipids (triglycerides and cholesterol fractions) and SAA, serine (Ser), glyeine (Gly), glutamate (Glu) and Gln. The HIV+ group was characterized also by viral load, CD4+ and CD8+ counts. The statistical comparisons between groups and among diets showed group homogeneity for 8MI, albumin, calcium, vitamin B12, Hey, HDL-cholesterol, urea and creatinine. The patients presented higher values of glucose, triglycerides, &#947;-GT, LDL-cholesterol, and GSSG along with lower concentrations of uric acid, GSH and all but Hcy amino acids. The Met-OL equalized (&#916; values) the groups for Met, Hcy, Tau and Gln. NAC and Gln diets led the HIV+ group to a higher concentrations of GSH (NAC > Gln) by acting differently on its precursors: Gly (Gln > NAC) and Cys (NAC > Gln), resulting similar consumption of Ser and production of Tau. Both diets reduced GSSG/GSH (NAC > Gln) and only NAC increased (6 x) Hey. The later was worsened by Met-OL. Thus HIV+ results in multiple deficiencies of vitamins and amino acids leading to lower levels of GSH and higher GSSG/GSH ration. The main problems of lower formation of Cys and low ineorporation of Cys and Gly into GSH were greatly solved by giving Met, NAC and Gln to the patients, hence remaining the drawback of increasing Hcy with Met or NAC supplements.

Nach Befunden des Bundes-Gesundheitssurveys 1998/99 (Zusatzsurvey „Psychische Störungen“) litten im Jahr der Erhebung 32% (=15,6 Millionen) der erwachsenen deutschen Bevölkerung im Alter von 18–65 unter einer oder mehreren psychischen Störungen. Jeder dritte Betroffene (36%) steht oder stand im Jahr vor der Erhebung wegen der psychischen Störung in Kontakt mit ambulanten oder stationären psychiatrisch/psychotherapeutischen Diensten oder seinem Hausarzt. Der Anteil von Betroffenen, die eine im weitesten Sinne adäquate Therapie nach modernen wissenschaftlichen Kriterien erhalten, kann konservativ auf ca.10% geschätzt werden. Die niedrige Versorgungsquote betrifft dabei nicht alle spezifischen Störungsgruppen in gleichem Ausmaß; niedrige Versorgungsraten ergaben sich insbesondere für somatoforme und Suchterkrankungen. Ferner ergaben sich zum Teil markante regionale Unterschiede (z.B. besonders schlechte Versorgungslage in Regionen, die weder über eine nahe Universität noch über psychotherapeutische Weiterbildungsinstitutionen verfügen).Ungeachtet unterschiedlich weiter oder enger Definitionen des Begriffs Behandlungsbedarf, zeigt sich eine gravierende Unterversorgung von Personen mit psychischen Erkrankungen. Quantitativ bedeutsame Hinweise auf eine Fehl- oder Überversorgung von Betroffenen lassen sich nicht aufzeigen. / Data from the German Health Interview and Examination Survey, Mental Health Supplement (N=4181) reveal that 32% (15,6 million people) of the adult population between 18 and 65 years of age suffer from one or more mental disorders. Among those only 36% receive treatment which also varies in type, duration, and adequacy. The proportion of cases receiving “adequate evidence- based treatments” was estimated to be about 10%.Lowest treatment rates were found for somatoform disorders and substance abuses, highest for psychotic disorders, panic disorder, generalised anxiety disorder, and dysthymia. The data reveal substantial regional differences with regard to treatment rates (e.g. lower rates in regions without universities or institutions offering postgraduate mental health education).The paper concludes that, depending on the diagnosis, a considerable degree of unmet medical needs exist for the majority of people affected by mental disorders. No evidence was found for an excessive supply of health care for the patients suffering from mental disorders or for treatments without an existing clinical need.

<p>Aging erodes motivation, cognition, sensory modalities and physical capacities, effectively depleting quality of life. Declining sensory, cognitive and motor function are reliable biomarkers of aging and mortality risk. These declines are associated with dysregulation of systemic and cellular processes. We developed a complex dietary supplement (DSP) designed to ameliorate five mechanisms of aging (oxidative processes, inflammation, mitochondrial function, insulin resistance and membrane integrity). Remarkably, normal mice fed the DSP retained youthful functionality into old ages, reflecting slower aging rates. Marked improvements in motor function, memory capacity, spatial learning, muscle strength, visual acuity, olfaction, fecundity and important behavioral functions were observed in aging supplemented mice. Conversely, untreated control animals showed age-related declines in all of the above. Functional improvements were associated with reduced oxidative damage, elevated mitochondrial activity, positive cellular energy balance, improved glucose tolerance, boosted neurotransmitters, greater synaptic density and higher neuronal numbers throughout the brain. A 30% reduction in cancer rates was also documented for DSP treated p53+/- mice. The vast functional benefits greatly exceed the modest longevity extension (11%) in normal supplemented mice. For aging humans, maintaining functionality and performance into later years may provide greater socioeconomic and health benefits than simply prolonging lifespan. Implications of these findings extend to common age-related pathologies including dementia and neurodegenerative diseases, diabetes, cancer, sarcopenia and age-related macular degeneration. Although identifying the role of specific ingredients remains outstanding, results provide proof of principle that complex dietary cocktails can powerfully ameliorate biomarkers of aging and modulate mechanisms considered ultimate goals for aging interventions.</p> / Doctor of Philosophy (PhD)