Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / Cystic echinococcosis (CE) is a zoonotic disease caused by Echinococcus genus. The larval stage (hydatid cyst) of the parasite causes serious public health problems, and affects various species of animals, causing economic losses to the meat industry. This study aimed to identify samples of fertile hydatid cysts in cattle and characterize them molecularly, analyzing in vitro and ex vivo Melaleuca alternifolia oil activity (tea tree oil - TTO) and its formulation in nanoemulsion (NE-TTO) and saris an (terpinen 4-ol) front to protoscolices of Echinococcus spp. Two thousand three hundred and ninety-six samples with cysts derived from an abattoir in the central region of the RS were analyzed, where 295 samples were classified as hydatid cysts by the presence of protoscolices. In PCR reactions for the 12S gene, 251 positive samples were identified for the group of genotypes G5/G6/G7 (E. ortleppi/ E. canadensis) and 40 samples for the G1 genotype (E. granulosus sensu stricto). In PCR subsequently, 250 samples were positive for G5 (E. ortleppi) and one sample for G7 (E. canadensis). A sample (n=12) of PCR products using the region of cox I gene, which was sequenced and compared with samples deposited in Genbank. Phylogenetic analysis identified three distinct groups E1, E2 and E3, which were grouped in sequences with greater similarity. The organ most affected by echinococcosis in cattle was the lung. After confirming the fertility of the cyst, protoscolices were removed and evaluated for viability using eosin 0.1%. For in vitro testing, concentrations of 2.5, 5 and 10 mg/mL of TTO, 10mg/mL of NE-TTO and 1, 1.5 and 2 mg/mL of terpinen-4-ol were analyzed front to protoscolices of E. ortleppi previously identified, in times of 5, 10, 15 and 30 minutes. For ex vivo test, TTO 10mg/mL and 20mg/mL was injected directly into hydatid cysts of E. ortleppi (n = 20) at times of 5, 15 and 30 minutes, and for each time one aliquot of protoscolices was removed for feasibility detection and implementation of PCR to confirm the species involved in the parasitism. Results of this in vitro study showed the protoscolicidal effect of M. alternifolia in all tested formulations and concentrations. Terpinen-4-ol (2mg/mL) had a better action when compared with the highest concentration of pure oil (TTO 10mg/mL). Nanoemulsion formulations (10mg/mL) showed a good activity front to the protoscolices. In ex vivo analysis, TTO (20mg/mL) showed 100% protoscolicidal action in hydatid cyst in 15 minutes. This study is pioneer in Brazil in identifying the potent effect of protoscolicidal M. alternifolia front protoscolices of E. ortleppi, being this kind of Echinococcus genus responsible for most fertile hydatid cysts analyzed in cattle in RS. / A equinococose cística (EC) é uma infecção zoonótica causada por parasito do gênero Echinococcus. O estágio larvário (cisto hidático) do parasito causa sérios problemas de saúde pública, além de acometer várias espécies de animais, ocasionando prejuízos econômicos à indústria de carnes. Neste contexto, o objetivo desse estudo foi identificar amostras de cistos hidáticos férteis em bovinos e caracterizá-las molecularmente, além de analisar in vitro e ex vivo a atividade anti-helmíntica do óleo de Melaleuca alternifolia (TTO), bem como sua formulação em nanoemulsão (NE-TTO) e seu componente majoritário (terpinen 4-ol) frente aos protoescóleces de Echinococcus spp. Foram analisadas 2396 amostras de cistos oriundos de bovinos abatidos em frigorífico da região central do RS, onde 295 amostras foram classificadas como cistos hidáticos pela presença de protoescóleces. Nas reações de PCR para o gene 12S, pode-se identificar 251 amostras positivas para o grupamento de genótipos G5/G6/G7 (E. ortleppi/ E. canadensis) e 40 amostras para o genótipo G1 (E. granulosus sensu stricto). Em subsequente PCR foram identificadas 250 amostras positivas para G5 (E. ortleppi) e uma amostra positiva para G7 (E. canadensis). Uma amostragem (n=12) dos produtos de PCR utilizando o gene da região cox I, foi sequenciada e comparada com amostras depositadas no Genbank. A análise filogenética identificou três grupos distintos E1, E2 e E3, onde agruparam-se sequências com maior similaridade. O órgão mais acometido pela parasitose em bovinos foi o pulmão. Após a confirmação da fertilidade do cisto, os protoescóleces foram retirados e avaliados quanto à viabilidade utilizando eosina 0.1%. Para o teste in vitro, concentrações de 2.5, 5 e 10mg/ml de TTO, 10mg/ml de NE-TTO e 1, 1.5 e 2mg/ml de Terpinen 4-ol foram analisadas frente aos protoescóleces de E. ortleppi previamente identificados, nos tempos de 5, 10, 15 e 30 minutos. Para o teste ex vivo, TTO 10mg/ml e 20mg/ml foi injetado diretamente em cistos hidáticos de E. ortleppi (n=20) nos tempos de 5, 15 e 30 minutos, para cada tempo foi retirada uma alíquota de protoescóleces para detecção da viabilidade e realização do PCR para confirmação da espécie envolvida na parasitose. Os resultados deste estudo in vitro indicaram efeito protoescolicida de M. alternifolia em todas as formulações e concentrações testadas. O Terpinen 4-ol (2mg/ml) obteve uma melhor ação quando comparado com a maior concentração testada do óleo puro (TTO 10mg/ml). As formulações em nanoemulsão (10mg/ml) demonstraram atividade frente aos protoescóleces. Na análise ex vivo, TTO (20mg/ml) apresentou 100% de ação protoescolicida no cisto hidático em 15 minutos. O presente estudo torna-se pioneiro no Brasil a identificar o potente efeito protoescolicida de M. alternifolia frente aos protoescóleces de E. ortleppi, sendo essa espécie do gênero Echinococcus a responsável pela maior parte dos cistos hidáticos férteis analisados em bovinos no RS.

Tea Tree Oil eller TTO som det förkortas, är en olja som utvinns ur en australiensisk buske vid det latinska namnet Melaleuca alternifolia. Oljan har sedan många år använts som antiinflammatoriskt och bakteriedödande ämne. Denna litteraturstudie gjordes på 13 artiklar som svarade på tre sökningar i databasen PubMed. Artiklarna påvisar att TTO har en viss antibakteriell förmåga och kan fungera som antimykotiskt medel, men fler in vivo studer behövs för att säkerställa TTO:s effekt på olika parodontala åkommor.

A inovação é um dos fenômenos mais importantes na economia e nos negócios nos tempos atuais, e, neste contexto, as instituições de pesquisa são cada vez mais vistas como veículos para a transferência de tecnologia e um canal por meio do qual a troca de conhecimento se torna mais eficaz. No Brasil, um grande marco rumo à inovação foi a publicação da lei de inovação em 2004. No âmbito do Estado de São Paulo, a publicação de lei semelhante aconteceu em 2008. Dentre os benefícios trazidos com essas leis, está a criação dos Núcleos de Inovação Tecnológica - NIT. Apesar do interesse crescente no estudo a respeito dos NIT, há poucos estudos que discutem a estrutura desses NIT, e, ainda, no Brasil, não há estudo sobre estruturação e gestão de NIT na administração direta. Assim, este trabalho, através de uma abordagem qualitativa, utilizando-se o estudo de casos múltiplos, discute a estruturação dos NIT na administração direta do estado de São Paulo, de modo que esses NIT possam impactar positivamente nos resultados de inovação do Estado de São Paulo. No que se refere à estrutura dos NIT: compartilhamento, por meio de um escritório central e unidades; estrutura híbrida, ou semicentralizada; utilização das fundações de apoio existentes para fazer a gestão dos recursos financeiros e das atividades dos NIT. As áreas identificadas como prioritárias para os NIT são: propriedade intelectual, transferência de tecnologia ou parceria, e assessoria jurídica. Outros pontos que a autora recomenda que devem ser melhorados para refletir positivamente nos resultados de inovação do Estado de São Paulo são: existência, no âmbito do Estado de São Paulo, de uma Política de Inovação; as Instituições Científicas e Tecnológicas do Estado de São Paulo devem fazer o planejamento estratégico da sua instituição, de modo a orientar as pesquisas que serão realizadas na ICTESP; definição dos objetivos a serem alcançados com a pesquisa, e implantação de um modelo estratégico para gerenciamento da Pesquisa e Desenvolvimento; a atuação do NIT precisa estar alinhada com esse planejamento estratégico da ICTESP; alinhamento e engajamento das instâncias jurídicas; é desejável que o Estado promova a aproximação dos institutos públicos com a iniciativa privada; e existência de linhas de fomento para inovação. / Innovation is one of the most important phenomena in economics and business today. In this context research institutions are increasingly seen as a vehicle for technology transfer and a channel through which knowledge exchange becomes more effective. In Brazil, a major milestone towards innovation was the publication of the innovation law, in 2004. At the State of Sao Paulo, a similar law was published in 2008. One important benefit brought by these laws is the creation of the Technology Transfer Offices - TTO. Despite the increasing interest in the study about TTO, there is a gap in study about its structure. Moreover, there is no study in Brazil about the implementation and management of TTO in public research institutions. So, this paper, through a qualitative study with multiple cases discuss about structuring TTO in public research institutions in order to these TTO positively impact the innovation results of the State of São Paulo. Regarding the structure of the TTO: sharing the office, through a central office and units; hybrid or semi-centralized structure; using existing research support foundations to manage financial resources and the TTO activities. The main areas identified for the TTO are: intellectual property, technology transfer or partnership, and legal advice. Other recommendations of the author to booster the innovations results of the State of São Paulo are: existence of an Innovation Policy to the State of São Paulo; the scientific institutions must do the strategic planning of their institutions in order to guide the researches that will be conducted at the institution; definition of the objectives to be achieved with the research, and implementation of a strategic management for Research and Development activities; the TTO activities must be aligned with the strategic planning of the research institution; alignment and engagement of legal bodies; it is desirable that the State promote the approximation of public research institutes with private enterprises; and is essential the existence of funding for innovation projects.

This study explains the rise and fall of the Innovations Foundation, the University of Toronto's first office dedicated to the transfer of university-developed technologies to industry. Drawing on extensive archival research, ten interviews with key informants, and other sources, the case study traces the evolution of the Foundation from its launch in 1980 to its closure in 2006. The study delineates three distinct business models under which the Foundation operated from 1980 to 1990, 1990 to 1999, and 1999 to 2006. The reasons for the adoption and failure of each model are explored and a historically grounded, context-sensitive explanation of the university's decision to dismantle the Foundation in 2006 is provided. This explanation emphasizes the importance of managing unrealistic expectations for Canadian university technology transfer, and adds weight to a growing consensus on the importance of historical path-dependence as a conceptual tool for understanding the persistence of differentials in technology transfer performance among universities.

This study explains the rise and fall of the Innovations Foundation, the University of Toronto's first office dedicated to the transfer of university-developed technologies to industry. Drawing on extensive archival research, ten interviews with key informants, and other sources, the case study traces the evolution of the Foundation from its launch in 1980 to its closure in 2006. The study delineates three distinct business models under which the Foundation operated from 1980 to 1990, 1990 to 1999, and 1999 to 2006. The reasons for the adoption and failure of each model are explored and a historically grounded, context-sensitive explanation of the university's decision to dismantle the Foundation in 2006 is provided. This explanation emphasizes the importance of managing unrealistic expectations for Canadian university technology transfer, and adds weight to a growing consensus on the importance of historical path-dependence as a conceptual tool for understanding the persistence of differentials in technology transfer performance among universities.

A inovação é um dos fenômenos mais importantes na economia e nos negócios nos tempos atuais, e, neste contexto, as instituições de pesquisa são cada vez mais vistas como veículos para a transferência de tecnologia e um canal por meio do qual a troca de conhecimento se torna mais eficaz. No Brasil, um grande marco rumo à inovação foi a publicação da lei de inovação em 2004. No âmbito do Estado de São Paulo, a publicação de lei semelhante aconteceu em 2008. Dentre os benefícios trazidos com essas leis, está a criação dos Núcleos de Inovação Tecnológica - NIT. Apesar do interesse crescente no estudo a respeito dos NIT, há poucos estudos que discutem a estrutura desses NIT, e, ainda, no Brasil, não há estudo sobre estruturação e gestão de NIT na administração direta. Assim, este trabalho, através de uma abordagem qualitativa, utilizando-se o estudo de casos múltiplos, discute a estruturação dos NIT na administração direta do estado de São Paulo, de modo que esses NIT possam impactar positivamente nos resultados de inovação do Estado de São Paulo. No que se refere à estrutura dos NIT: compartilhamento, por meio de um escritório central e unidades; estrutura híbrida, ou semicentralizada; utilização das fundações de apoio existentes para fazer a gestão dos recursos financeiros e das atividades dos NIT. As áreas identificadas como prioritárias para os NIT são: propriedade intelectual, transferência de tecnologia ou parceria, e assessoria jurídica. Outros pontos que a autora recomenda que devem ser melhorados para refletir positivamente nos resultados de inovação do Estado de São Paulo são: existência, no âmbito do Estado de São Paulo, de uma Política de Inovação; as Instituições Científicas e Tecnológicas do Estado de São Paulo devem fazer o planejamento estratégico da sua instituição, de modo a orientar as pesquisas que serão realizadas na ICTESP; definição dos objetivos a serem alcançados com a pesquisa, e implantação de um modelo estratégico para gerenciamento da Pesquisa e Desenvolvimento; a atuação do NIT precisa estar alinhada com esse planejamento estratégico da ICTESP; alinhamento e engajamento das instâncias jurídicas; é desejável que o Estado promova a aproximação dos institutos públicos com a iniciativa privada; e existência de linhas de fomento para inovação. / Innovation is one of the most important phenomena in economics and business today. In this context research institutions are increasingly seen as a vehicle for technology transfer and a channel through which knowledge exchange becomes more effective. In Brazil, a major milestone towards innovation was the publication of the innovation law, in 2004. At the State of Sao Paulo, a similar law was published in 2008. One important benefit brought by these laws is the creation of the Technology Transfer Offices - TTO. Despite the increasing interest in the study about TTO, there is a gap in study about its structure. Moreover, there is no study in Brazil about the implementation and management of TTO in public research institutions. So, this paper, through a qualitative study with multiple cases discuss about structuring TTO in public research institutions in order to these TTO positively impact the innovation results of the State of São Paulo. Regarding the structure of the TTO: sharing the office, through a central office and units; hybrid or semi-centralized structure; using existing research support foundations to manage financial resources and the TTO activities. The main areas identified for the TTO are: intellectual property, technology transfer or partnership, and legal advice. Other recommendations of the author to booster the innovations results of the State of São Paulo are: existence of an Innovation Policy to the State of São Paulo; the scientific institutions must do the strategic planning of their institutions in order to guide the researches that will be conducted at the institution; definition of the objectives to be achieved with the research, and implementation of a strategic management for Research and Development activities; the TTO activities must be aligned with the strategic planning of the research institution; alignment and engagement of legal bodies; it is desirable that the State promote the approximation of public research institutes with private enterprises; and is essential the existence of funding for innovation projects.

<p>One must consider cost effectiveness when deciding how resources within the health sector should be distributed. Quality adjusted life years (QALYs) are used to measure the value of different medical treatments. QALY is based on utility maximization theory, which suggests that a QALY is always a QALY regardless of who receives it. Therefore, a produced QALY is worth the same regardless of the age or the initial health of the patient. Previous research has shown that these assumptions do not seem to fit the real preferences of individuals. Further, there are different methods of acquiring QALYs that give different outcomes. Two of these methods are Time Trade Off (TTO), in which respondents are confronted with a valuation of health change in time, and Person Trade Off (PTO), where respondents are confronted with a valuation in persons. Arguably, PTO is the preferred method that takes greater account of how individuals wish to allocate the resources of the society. From a distribution perspective focusing on age and initial health status, this paper aims to empirically identify the differences between TTO and PTO considering the measurement of preferences for life quality. The aim is also to examine whether the results obtained are consistent with the theoretical assumptions that are required for the preference to be accepted as a cardinal utility. A quantitative survey was carried out with 58 medical and 61 economics students. Half of the students received PTO and the other half TTO questions. The data collected was analyzed comparing the methods, the two student groups and men against women.</p><p>The results from the survey show that, both with TTO and PTO, respondents on average believe that patients who are at a lower initial health level should be given priority over patients who are at a higher initial health level, and younger patients should be given priority over older patients. No significant differences were seen between PTO and TTO when it came to the age of the patient. Conversely, there was a significant difference between the methods for the valuation based on initial health status of patients. Measured with PTO a treatment for patients who are at a lower initial level is valued 28% higher than a treatment for those patients who are at a higher initial level, while the corresponding figure for TTO was 8%. Between medical students and economic students, there were significant differences in the question of age in the PTO. Between men and women differences were found in both methods.</p> / <p>Kostnadseffektivitet är en av faktorerna som ska tas i beaktande vid beslut om hur resurser inom hälso- och sjukvården ska fördelas. Kvalitetsjusterade levnadsår (QALY) används för att mäta effekten av olika insatser. Måttet baseras på nyttomaximeringsteori vilket leder till att en QALY alltid är en QALY oavsett vem den tillfaller - med andra ord är en QALY som produceras hos en patient lika mycket värd oavsett exempelvis patientens ålder eller initiala tillstånd. Dessa antaganden har i tidigare undersökningar visat sig stämma dåligt med individers preferenser men olika metoder för att ta fram QALY verkar ta olika mycket hänsyn till dem. Två av flera metoder är Time Trade Off (TTO), där respondenter ställs inför en värdering av hälsoförändringar i tid och Person Trade Off (PTO) där respondenter ställs inför en värdering i personer. PTO har påståtts vara en mer rättvisande metod som tar större hänsyn till hur individer vill att samhälleliga resurser ska fördelas. Denna uppsats syftar till att, utifrån ett fördelningsperspektiv med fokus på ålder och initialt hälsotillstånd, empiriskt kartlägga förekomsten av skillnader i preferenser för livskvalitet mätt med PTO respektive TTO, samt att undersöka om de erhållna resultaten överensstämmer med de teoretiska grundantagandena som krävs för att preferenser ska accepteras som kardinala nyttor. För att svara mot syftet utfördes en kvantitativ undersökning på 58 läkar- samt 61 ekonomistudenter. Hälften av studenterna fick PTO-frågor och den andra hälften TTO-frågor. En statistisk bearbetning av insamlad data har gjorts där svaren har jämförts mellan metoderna samt mellan läkar- och ekonomistudenter och kvinnor och män.</p><p>Resultaten från undersökningen visar att både med TTO och PTO anser respondenterna att patienter som befinner sig på en lägre initial nivå ska prioriteras framför patienter som befinner sig på en högre initial nivå samt yngre patienter ska prioriteras framför äldre patienter. Vad gäller hänsyn till patienters ålder uppmättes inga signifikanta skillnader mellan PTO och TTO. Däremot uppmättes en signifikant skillnad mellan metoderna vad gäller hänsyn till initialt hälsotillstånd hos patienter. Mätt med PTO värderas en behandling för de patienter som befinner sig på en lägre initial nivå 28 % högre än en behandling för de patienter som befinner sig på en högre initial nivå medan motsvarande siffra för TTO var 8%. Mellan läkare och ekonomer fanns signifikanta skillnader i frågan gällande ålder i PTO och mellan kvinnor och män återfanns skillnader i båda metoder.</p>

One must consider cost effectiveness when deciding how resources within the health sector should be distributed. Quality adjusted life years (QALYs) are used to measure the value of different medical treatments. QALY is based on utility maximization theory, which suggests that a QALY is always a QALY regardless of who receives it. Therefore, a produced QALY is worth the same regardless of the age or the initial health of the patient. Previous research has shown that these assumptions do not seem to fit the real preferences of individuals. Further, there are different methods of acquiring QALYs that give different outcomes. Two of these methods are Time Trade Off (TTO), in which respondents are confronted with a valuation of health change in time, and Person Trade Off (PTO), where respondents are confronted with a valuation in persons. Arguably, PTO is the preferred method that takes greater account of how individuals wish to allocate the resources of the society. From a distribution perspective focusing on age and initial health status, this paper aims to empirically identify the differences between TTO and PTO considering the measurement of preferences for life quality. The aim is also to examine whether the results obtained are consistent with the theoretical assumptions that are required for the preference to be accepted as a cardinal utility. A quantitative survey was carried out with 58 medical and 61 economics students. Half of the students received PTO and the other half TTO questions. The data collected was analyzed comparing the methods, the two student groups and men against women. The results from the survey show that, both with TTO and PTO, respondents on average believe that patients who are at a lower initial health level should be given priority over patients who are at a higher initial health level, and younger patients should be given priority over older patients. No significant differences were seen between PTO and TTO when it came to the age of the patient. Conversely, there was a significant difference between the methods for the valuation based on initial health status of patients. Measured with PTO a treatment for patients who are at a lower initial level is valued 28% higher than a treatment for those patients who are at a higher initial level, while the corresponding figure for TTO was 8%. Between medical students and economic students, there were significant differences in the question of age in the PTO. Between men and women differences were found in both methods. / Kostnadseffektivitet är en av faktorerna som ska tas i beaktande vid beslut om hur resurser inom hälso- och sjukvården ska fördelas. Kvalitetsjusterade levnadsår (QALY) används för att mäta effekten av olika insatser. Måttet baseras på nyttomaximeringsteori vilket leder till att en QALY alltid är en QALY oavsett vem den tillfaller - med andra ord är en QALY som produceras hos en patient lika mycket värd oavsett exempelvis patientens ålder eller initiala tillstånd. Dessa antaganden har i tidigare undersökningar visat sig stämma dåligt med individers preferenser men olika metoder för att ta fram QALY verkar ta olika mycket hänsyn till dem. Två av flera metoder är Time Trade Off (TTO), där respondenter ställs inför en värdering av hälsoförändringar i tid och Person Trade Off (PTO) där respondenter ställs inför en värdering i personer. PTO har påståtts vara en mer rättvisande metod som tar större hänsyn till hur individer vill att samhälleliga resurser ska fördelas. Denna uppsats syftar till att, utifrån ett fördelningsperspektiv med fokus på ålder och initialt hälsotillstånd, empiriskt kartlägga förekomsten av skillnader i preferenser för livskvalitet mätt med PTO respektive TTO, samt att undersöka om de erhållna resultaten överensstämmer med de teoretiska grundantagandena som krävs för att preferenser ska accepteras som kardinala nyttor. För att svara mot syftet utfördes en kvantitativ undersökning på 58 läkar- samt 61 ekonomistudenter. Hälften av studenterna fick PTO-frågor och den andra hälften TTO-frågor. En statistisk bearbetning av insamlad data har gjorts där svaren har jämförts mellan metoderna samt mellan läkar- och ekonomistudenter och kvinnor och män. Resultaten från undersökningen visar att både med TTO och PTO anser respondenterna att patienter som befinner sig på en lägre initial nivå ska prioriteras framför patienter som befinner sig på en högre initial nivå samt yngre patienter ska prioriteras framför äldre patienter. Vad gäller hänsyn till patienters ålder uppmättes inga signifikanta skillnader mellan PTO och TTO. Däremot uppmättes en signifikant skillnad mellan metoderna vad gäller hänsyn till initialt hälsotillstånd hos patienter. Mätt med PTO värderas en behandling för de patienter som befinner sig på en lägre initial nivå 28 % högre än en behandling för de patienter som befinner sig på en högre initial nivå medan motsvarande siffra för TTO var 8%. Mellan läkare och ekonomer fanns signifikanta skillnader i frågan gällande ålder i PTO och mellan kvinnor och män återfanns skillnader i båda metoder.

Made available in DSpace on 2016-06-02T19:16:26Z (GMT). No. of bitstreams: 1 3267.pdf: 3998722 bytes, checksum: 5c5655c026a695d92bfc0186d0eef186 (MD5) Previous issue date: 2010-08-16 / The objective of this study consisted of collecting and analyzing data with teachers of the various Academic Centers of UFSCar about their understanding of the term "innovation", knowledge of intellectual property policy in UFSCar, and the performance of its Innovation Agency. The Innovation Agency of UFSCar was established to meet the requirements of the Law of Innovation (10.973/04), which states in its Article 16 that every Science and Technology Institution (from the Portuguese acronym ICT) is expected to have a Technological Innovation Center (from the Portuguese acronym NIT) with the purpose of managing the innovation policy of the University. In practice, the NIT has the mission of managing all intellectual property generated by the ICT, encompassing the protection of intellectual property and technology transfer, and linking the University with businesses in order to boost technological innovation in Brazil. The methodology included a questionnaire as an instrument of data collection which consisted of open questions, multiple choice, marking scale. The questionnaire was divided into three main issues: 1) Innovation, 2) Domestic regulation UFSCar, and 3) Innovation Agency UFSCar. It was sent via e-mail to 935 teachers, 94 of whom responded to it. Thus, an overview on the perception of teachers on the theme of innovation, the internal rules of UFSCar and the Innovation Agency was obtained by the compilation of these data. The data analysis resulted in the development of a set of recommendations for structuring and operation of the Agency for innovation to be developed based on the perceptions of teachers, and this is the main contribution of the dissertation. / O objetivo desta dissertação consistiu no levantamento e análise dos dados coletados a partir da compreensão dos docentes dos diversos Centros Acadêmicos da UFSCar sobre o entendimento do termo inovação , o conhecimento da política de propriedade intelectual dentro da UFSCar e da atuação de sua Agência de Inovação. A Agência de Inovação da UFSCar foi instituída em conformidade com a Lei de Inovação (10.973/04) que estabelece em seu Artigo 16 que toda Instituição Científica e Tecnológica (ICT) deverá dispor de um Núcleo de Inovação Tecnológica (NIT), com a finalidade de gerir a política de inovação da Universidade. Na prática, os NIT têm a atribuição de gerenciar toda a propriedade intelectual gerada pela ICT que os constitui, englobando a proteção da propriedade intelectual e a transferência de tecnologia e promover a articulação entre a Universidade e as empresas com o intuito de estimular a inovação tecnológica no Brasil. A metodologia empregada para a realização do trabalho usou como instrumento de coleta de dados um questionário composto por perguntas abertas, de múltipla escolha e de marcação de escala. Tal questionário se dividiu em três principais assuntos: 1) Inovação; 2) Regulamentação interna da UFSCar; e 3) Agência de Inovação da UFSCar e foi encaminhado para 935 docentes vinculados a UFSCar. Dos 935 professores que receberam o questionário via e-mail, 94 responderam. Assim, a compilação desses dados permitiu obter um panorama sobre a percepção dos docentes sobre o tema inovação, a regulamentação interna da UFSCar e da Agência de Inovação. A análise dos dados resultou na elaboração de um conjunto de recomendações para estruturação e operação da Agência de Inovação a ser desenvolvido com base nas percepções dos docentes, sendo essa a principal contribuição da dissertação.

The university technology transfer coach has an important role in supporting the commercialization of research results. This thesis has studied the technology transfer coach and their needs in the coaching process. The goal has been to investigate information needs of the technology transfer coach as a preliminary for the design of computer aids.Using a grounded theory approach, we interviewed 17 coaches working in the Swedish technology transfer environment. Extracted quotes from interviews were openly coded and categorized. The analysis show three main problem areas related to the information needs of the technology transfer coach; awareness, communication, and resources. Moreover, 20 features for future computer aids were extracted from the interview data and scenarios and personas where developed to exemplify the future use of computer aids.We conclude that there is a need for computer support in the coaching process. Such systems should aid the coach in; awareness, aiding the coach to focus on meetings; communication, aid the coach to transfer commercialisation knowledge; and resources, aid the coach in accessing and delivering of resources to the coachee. However, it is imperative that the computer aids do not interfere with the coach current process; and that the computer aid is not seen as the sole solution.