Das Präfix "trans-" ist aus dem Lateinischen hergeleitet und bedeutet "jenseits". Bezogen auf Geschlecht deutet trans* auf Lebensweisen hin, die nicht in einer (vermeintlich natürlichen und angeborenen) Zweigeschlechtlichkeit aufgehen. Transgeschlechtlichkeit wurde in aktivistischen Zusammenhängen in Abgrenzung zu der medizinisch-psychologisch geprägten Kategorie Transsexualität entwickelt. Seit den späten 1960er Jahren eröffnete sich, vor dem Hintergrund ethnomethodologischer Theoriebildung, ein Feld der sozialwissenschaftlichen Untersuchung transgeschlechtlicher Lebensweisen. Im Gegenzug dazu perspektivieren die Queer- und Gender Studies Transgeschlechtlichkeit in den 1990er Jahren neu.

Das Präfix "trans-" ist aus dem Lateinischen hergeleitet und bedeutet "jenseits". Bezogen auf Geschlecht deutet trans* auf Lebensweisen hin, die nicht in einer (vermeintlich natürlichen und angeborenen) Zweigeschlechtlichkeit aufgehen. Transgeschlechtlichkeit wurde in aktivistischen Zusammenhängen in Abgrenzung zu der medizinisch-psychologisch geprägten Kategorie Transsexualität entwickelt. Seit den späten 1960er Jahren eröffnete sich, vor dem Hintergrund ethnomethodologischer Theoriebildung, ein Feld der sozialwissenschaftlichen Untersuchung transgeschlechtlicher Lebensweisen. Im Gegenzug dazu perspektivieren die Queer- und Gender Studies Transgeschlechtlichkeit in den 1990er Jahren neu.

Ce mémoire présente trois approches différentes vers la synthèse du 3–(trans–2–nitrocyclopropyl)alanine, un intermédiaire synthétique de la hormaomycine. Cette molécule naturelle démontre d’intéressantes activités biologiques et pharmacologiques. Il est intéressant de souligner que ce dérivé donne facilement accès au 3–(trans–2–aminocyclopropyl)alanine, unité centrale de la bélactosine A. Ce composé naturel possédant lui aussi d’intéressantes propriétés biologiques, plusieurs études relationnelles structures-activités menant à des dérivés plus actifs de cette molécule ont été entreprises, démontrant l’intérêt toujours présent de synthétiser de façon efficace et optimale ces dérivés cyclopropaniques. Une méthodologie développée au sein de notre groupe de recherche et basée sur une réaction de cyclopropanation intramoléculaire diastéréosélective sera mise à profit afin d’élaborer une nouvelle voie de synthèse aussi élégante qu’efficace à la construction du 3–(trans–2–nitrocyclopropyl) alanine. En utilisant un carbène de rhodium généré soit par la dégradation d’un dérivé diazoïque, soit par la formation d’un réactif de type ylure d’iodonium, une réaction de cyclopropanation diastéréosélective permettra la formation de deux autres centres contigus et ce, sans même utiliser d’auxiliaire ou de catalyseur énantioenrichis. Ensuite, un réarrangement intramoléculaire précédant deux réactions synchronisées d’ouverture de cycle et de décarboxylation permettront l’obtention du composé d’intérêt avec un rendement global convenable et en relativement peu d’étapes. De cette manière, la synthèse formelle de la bélactosine A et de l’hormaomycine a été effectuée. Cette synthèse se démarque des autres par l’utilisation d’une seule transformation catalytique énantiosélective. / This master’s thesis presents three different approaches toward the synthesis of 3–(trans–2–nitrocyclopropyl)alanine, a key constituent of the natural product hormaomycin. This unusual compound demonstrates interesting biological and pharmaceutical activity. It is noteworthy that this unique amino acid can be readily converted to the corresponding 3–(trans–2–aminocyclopropyl)alanine, the central core of belactosin A, a natural compound exhibiting interesting biological properties. Efficient syntheses of these aminocyclopropane derivatives are of current interest since several structure-activity relationships in syntheses of belactosin A and hormaomycin analogues are currently under study in an effort to discover enhanced biological activity. A methodology developed in our research group based on a diastereoselective intramolecular cyclopropanation reaction will be used to elaborate a unique and elegant pathway to the synthesis of the 3–(trans–2–nitrocyclopropyl)alanine. By using a rhodium carbene generated either by the degradation of a diazoic derivative or by the formation of the corresponding iodonium ylide, a diastereoselective cyclopropanation reaction can be applied in the concerted elaboration of two chiral centers needed in the desired aminocyclopropanes, avoiding in this way the utilisation of chiral reagents. Following this key sequence, an intramolecular rearrangement followed by synchronous ring–opening/decarboxylation reactions will permit a convenient formation of the desired product in an acceptable overall yield and in few ensuing steps. In this manner, the formal synthesis of the hormaomycin and the belactosin A can be achieved. This synthesis is unique since it involves only one asymmetric step in the whole synthetic process.

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Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.

The aim of this thesis was to determine the biomechanical adaptations made by active unilateral trans-tibial amputees when they used a prosthesis incorporating a hydraulically-damped, articulating ankle-foot device compared to non-hydraulically attached devices. Kinematic and kinetic data were recorded while participants ambulated over a flat and level surface at their customary walking speeds and at speeds they perceived to be faster and slower using the hydraulic device and their habitual foot. Use of the hydraulic device resulted in increases in self-selected walking speeds with a simultaneous reduction in intact-limb work per meter travelled. Use of the device also attenuated inappropriate fluctuations in the centre-of-pressure trajectory beneath the prosthetic foot and facilitated increased residual-knee loading-response flexion and prosthetic-limb load bearing during stance. These changes occurred despite the hydraulic device absorbing more, and returning less, energy than the participants’ habitual ankle-foot devices. The changes were present across all walking speeds but were greatest at customary walking speeds. The findings suggest that a hydraulic ankle-foot device has mechanical benefits, during overground gait, for active unilateral trans-tibial amputees compared to other attachment methods. The findings also highlight that prosthetic ankle-foot device ‘performance’ can be evaluated using surrogate measures and without modelling an ‘ankle joint’ on the prosthetic limb.

Approved for public release, distribution is unlimited / This thesis explores international and domestic factors that constitute continuities in U.S. foreign and security policy regarding trans-Atlantic relations. Since the founding of the Atlantic Alliance burden sharing has been one of the major sources of conflict between the United States and its European NATO allies. Despite the reluctance to spend more than minimal amounts on military capabilities in most European NATO countries the issue did not become a major concern in the U.S. Congress between 1951 and 1966. It was only in the late 1960s and early 1970s that proposals - including the Mansfield Resolutions and Amendments - were introduced in the Senate calling for a substantial reduction in the number of U.S. troops in Europe. The debates provoked by these proposals threw light on the various determinants of U.S. policy towards Europe. The contemporary relevance of the issue resides in the fact that most of the elements responsible for the emergence of the Mansfield Amendments are still influential in U.S. foreign and security policy. This circumstance might lead to comparable proposals and debates in the near future. / Civilian, Hungarian Ministry of Defense

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This paper examines the conditions under which self-identified trans* men disclose of their transgender identity or past gender history. Drawing upon theories of identity formation, passing and disclosing of stigmatic identities is used to understand when and how disclosure processes happen for trans*men. Drawing on interviews I examine the circumstances surrounding when disclosure or pressure to disclose becomes salient for individuals. I also consider how individuals use and negotiate systems of gender, along other inequalities such as class, race, education, and health care access.