Das triple-negative Mammakarzinom exprimiert weder Östrogen- noch Progesteronrezeptoren und es kommt zu keiner Überexprimierung des HER2-neu Gens. Daher haben bei diesem Subtyp des Mammakarzinoms spezifische Therapien, welche gezielt an diesen Rezeptoren wirken, keinerlei Nutzen. Etwa 60% aller Mammakarzinome exprimieren GnRH-Rezeptoren, welche als Ziel genutzt werden könnten. Der GnRH-Rezeptor kann für eine gezielte Chemotherapie mit zytotoxischen GnRH-Agonisten wie AN-152, bei welchem Doxorubicin an [D-Lys6]GnRH gebunden ist, genutzt werden. In der vorliegenden Arbeit habe ich in vitro als auch in vivo analysiert ob der zytotoxische GnRH-Agonist AN-152 Apoptose in triple-negativen Mammakarzinomzellen, welche GnRH-Rezeptoren exprimieren, induziert. Die GnRH-Rezeptorexpression in Tumorbiopsien triple-negativer Mammakarzinome wurde immunhistochemisch getestet. Die Zellproliferation wurde unter Verwendung des AlamarBlue®-Proliferationsassays analysiert. Die Apoptoseinduktion wurde durch die Bestimmung des mitochondrialen Membranpotentialverlustes quantifiziert. Die in vivo Experimente wurden mit Nackmäusen nach Xenotransplantation von humanen Brustkrebszellen durchgeführt. Wir konnten zeigen das die Behandlung triple-negativer aber GnRH-positiver MDA¬ MB 231, HCC 1806 und HCC 1937 Mammakarzinomzellen mit AN-152 in vitro zum apoptotischen Zelltod durch Aktivierung der Caspase-3 führt. Diese Antitumoreffekte konnten im Nacktmausmodell bestätigt werden. AN-152 inhibierte das Wachstum triple-negativer Mammakarzinomxenotransplantate in den Nacktmäusen komplett, ohne offensichtliche Nebenwirkungen. Der zytotoxische GnRH-Agonist AN-152 scheint ein passendes Medikament mit niedriger Toxizität für eine effiziente Therapie des triple-negativen Mammakarzinoms zu sein. (Föst C, Duwe F, Hellriegel M, Schweyer S, Emons G, Gründker C (2011). Targeted chemotherapy for triple-negative breast cancers via LHRH receptor. Oncol Rep, 25, 1481-7.)

This thesis presents the results of the STAMPAS all-sky search for long transient gravitational waves in the 2005-2007 LIGO-Virgo data. Gravitational waves are perturbations of the space-time metric. The Virgo and LIGO experiments are designed to detect such waves. They are Michelson interferometers with 3 km and 4 km long arms, whose light output is altered during the passage of a gravitational wave.Until very recently, transient gravitational wave search pipelines were focused on short transients, lasting less than 1 second, and on binary coalescence signals. STAMPAS is one of the very first pipelines entirely dedicated to the search of long transient gravitational wave signals, lasting from 1s to O(100s).These signals originate, among other sources, from instabilities in protoneutron stars as a result of their violent birth. The standing accretion shock instability in core collapse supernovae or instabilities in accretion disks are also possible mechanisms for gravitational wave long transients. Eccentric black hole binary coalescences are also expected to emit powerful gravitational waves for several seconds before the final plunge.STAMPAS is based on the correlation of data from two interferometers. Time-frequency maps of the data are extracted, and significant pixels are clustered to form triggers. No assumption on the direction, the time or the form of the signals is made.The first STAMPAS search has been performed on the data from the two LIGO detectors, between 2005 and 2007. After a rigorous trigger selection, the analysis revealed that their rate is close to Gaussian noise expectation, which is a significant achievement. No gravitational wave candidate has been detected, and upper limits on the astrophysical rates of several models of accretion disk instability sources and eccentric black holes binary coalescences have been set. The STAMPAS pipeline demonstrated its capabilities to search for any long transient gravitational wave signals during the advanced detector era.Keywords: Gravitational waves, Interferometry, Long transients, Signal Processing, Accretion Disk Instabilities, Eccentric Black Hole Binaries.

La compréhension des processus catalytiques nécessite de pouvoir corréler la structure à l'échelle atomique des catalyseurs en cours de réaction avec les propriétés macroscopiques observées. Ce travail de thèse s'inscrit dans ce cadre et l'outil principal est la diffraction X de surface. Une partie instrumentale concerne le développement d'un réacteur permettant la caractérisation in situ, par des techniques de diffusion des rayons X, de surfaces de catalyseurs modèles pendant une réaction chimique donnée (jusqu'à 1 bar). Les caractéristiques principales du réacteur ainsi que les premiers tests de validation sous faisceau X sont décrits.<br />En relation avec la problématique précédente, une partie plus fondamentale s'intéresse à l'étude de surfaces modèles bimétalliques à base d'or et de palladium avec d'une part, des dépôts d'or sur Pd(110) et d'autre part, les surfaces (111) et (110) d'un alliage massif Au30Pd70.<br />L'étude du système Au/Pd(110), en ultra-vide, a bénéficié de la complémentarité entre la diffraction X de surface et la microscopie à effet tunnel. Pour des épaisseurs de dépôt jusqu'à 2.5 MC et des températures de recuit atteignant 470°C, nous nous sommes intéressés à la description de la croissance, de la structure et de la morphologie des dépôts d'or.<br />L'étude menée sur l'alliage Au30Pd70 a confirmé l'intérêt de la diffraction X pour caractériser ces surfaces modèles au cours d'une réaction catalytique. La structure des faces (110) et (111) a d'abord été étudiée en ultra-vide, puis en présence de faibles pressions d'hydrogène et d'oxygène, jusqu'à 10-5 mbar. Le réacteur développé par notre équipe, a ensuite permis d'étudier l'hydrogénation sélective du 1,3-butadiène sur la face (111) sous faisceau X avec pour objectif de caractériser la surface à différents stades de la réaction. Un effet très important de l'hydrogène au niveau volumique ainsi qu'à la surface de l'alliage a été mis en évidence. Ces modifications sont discutées en relation avec les propriétés catalytiques.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2018-01-16T17:57:41Z No. of bitstreams: 1 DidoneyFernandesVilhete_DISSERT.pdf: 3676426 bytes, checksum: 8cf7850161dec001a297218aa172a10c (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2018-01-22T11:12:53Z (GMT) No. of bitstreams: 1 DidoneyFernandesVilhete_DISSERT.pdf: 3676426 bytes, checksum: 8cf7850161dec001a297218aa172a10c (MD5) / Made available in DSpace on 2018-01-22T11:12:54Z (GMT). No. of bitstreams: 1 DidoneyFernandesVilhete_DISSERT.pdf: 3676426 bytes, checksum: 8cf7850161dec001a297218aa172a10c (MD5) Previous issue date: 2017-08-08 / Os riscos associados ? ruptura de barragens s?o elevados. Problemas de instabilidade envolvendo estas estruturas trazem consequ?ncias catastr?ficas ? sociedade. A barragem do A?u, ? uma obra geot?cnica de significativa notoriedade e import?ncia no Nordeste, principalmente no estado do Rio Grande do Norte. ? a maior barragem do estado e ganhou destaque na literatura nacional e internacional com o rompimento do talude de montante no final do per?odo construtivo. Em casos de ruptura, a retroan?lise ? uma t?cnica confi?vel para determina??o dos par?metros de resist?ncia ao cisalhamento dos solos de forma a contribuir para que se evite casos semelhantes. A partir da avalia??o de dados de resist?ncia dispon?veis no meio acad?mico, este trabalho teve como objetivo retroanalisar a ruptura ocorrida para obter os par?metros m?dios de resist?ncia ao cisalhamento do material argiloso preto que constitu?a o n?cleo da barragem do A?u antes do acidente ocorrido. Na primeira etapa do trabalho foram realizadas an?lises de estabilidade do talude de montante da barragem e na segunda etapa a retroan?lise determin?stica e probabil?stica. Essas an?lises foram realizadas no software Slide 7.0 pertencente ? plataforma RocScience. Os resultados mostraram que o talude romperia com os par?metros de resist?ncia da argila siltosa preta na condi??o saturada, com valores de probabilidade de ruptura variando de 60 a 97% entre os m?todos de equil?brio limite utilizados nas an?lises. Tamb?m foi poss?vel definir os poss?veis par?metros m?dios de resist?ncia ao cisalhamento da argila siltosa preta e estabelecer as causas de ruptura da barragem. Os valores da coes?o e do ?ngulo de atrito, no instante de ruptura, obtidos na retroan?lise determin?stica para a argila siltosa preta foram cu=47,1 kPa e ?u=0?. Na retroan?lise probabil?stica os valores da coes?o e do ?ngulo de atrito obtidos foram cu=33,8 kPa e ?u=3,1?, com uma probabilidade de ruptura de 52,7%. Com isso, conclui-se que a ruptura do talude de montante da barragem do A?u ocorreu por causa de erros na fase de projeto e de constru??o da barragem acompanhado pela perda de resist?ncia do solo devido aos excessos de poropress?es gerados durante a constru??o. / Risks associated to dam failure are very high. Problems of instability involving these structures bring catastrophic consequences to the social comunity. The A?u dam is a geotechnical work with significant importance in the Northeast, mainly in Rio Grande do Norte state. It is the largest dam of the state and has gained prominence in national and international literature with the slice of the upstream slope at the end of its construction period. In cases of failure, back analysis is a reliable technique used to calculate the shear strength parameters of the soil in order to avoid similar cases to happen. Considering the evaluation of strength data available in the academic environment, this work had as purpose to analyze the failure occurred in order to obtain the average shear strength parameters of the black clayey material that constituted the A?u dam core before the accident. In the first stage of this work the slope stability of the dam was analyzed and in the second stage the deterministic and probabilistic back analysis was performed. These analyzes were performed in Slide 7.0 from Rocscience platform. The results showed that the slope would fail with strength parameters of the black silty clay in the saturated condition, with values of probability of failure ranging from 60 to 97% between the equilibrium limit methods used in the analyzes. It was also possible to define the possible average shear strength values of black silty clay and to establish the causes of the dam failure. The cohesion and the friction angle values obtained at the instant of failure in the deterministic back analysis for black silty clay were cu=47.1 kPa and ?u=0?. For the probabilistic back analysis the cohesion and the friction angle values obtained were cu=33,8 kPa and ?u=3,1?, with a probability of failure of 52,7%. Therefore, it is concluded that the A?u dam upstream slope failure occurred because of errors in the design and construction phase of the dam accompanied by the loss of soil strength due to the excess of poropressures generated during the construction.

?rea de concentra??o: Qu?mica Anal?tica. / Submitted by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2016-01-06T17:04:45Z No. of bitstreams: 2 license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) debora_aparecida_rocha_moreira.pdf: 1871735 bytes, checksum: 71403ce90b6b32e48e7c18b312d74e32 (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2016-01-07T11:59:23Z (GMT) No. of bitstreams: 2 license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) debora_aparecida_rocha_moreira.pdf: 1871735 bytes, checksum: 71403ce90b6b32e48e7c18b312d74e32 (MD5) / Made available in DSpace on 2016-01-07T11:59:23Z (GMT). No. of bitstreams: 2 license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) debora_aparecida_rocha_moreira.pdf: 1871735 bytes, checksum: 71403ce90b6b32e48e7c18b312d74e32 (MD5) Previous issue date: 2015 / A colchicina (CO) ? um medicamento utilizado no tratamento da artrite gotosa com a??o anti-inflamat?ria. Este medicamento pertence a uma classe de compostos chamados de baixo ?ndice terap?utico, cuja dose t?xica ? muito pr?xima da dose terap?utica. Assim, a determina??o de CO em formula??es farmac?uticas e em fluidos biol?gicos ? de maior import?ncia para o controle de qualidade nos estudos farmac?uticos e farmacol?gicos na condu??o da elimina??o da droga. Neste contexto, o presente trabalho apresenta m?todos simples, r?pidos e de baixos custos para determina??o de CO em formula??es farmac?uticas e urina por amperometria de m?ltiplos pulsos (MPA) com an?lise de inje??o em fluxo, sistema (FIA), usando eletrodo de diamante dopado com boro (BDD). O estudo foi realizado em diferentes eletr?litos, Britton-Robinson de pH que variou de 2 a 12, solu??o de hidr?xido de s?dio e ?cido sulf?rico, ambos na concentra??o de 0,1 mol L-1. As melhores condi??es para o eletr?lito de suporte foi em ?cido sulf?rico 0,1 mol L-1, em que a CO apresentou processos de oxida??o em 1,20 e 1,41 V e uma redu??o de detec??o em -0,9 V. MPA foi baseado na aplica??o potencial dos dois impulsos de: (1) para a oxida??o de CO e (2) para a redu??o do produto gerado, o qual foi utilizado para a determina??o das amostras de f?rmacos. Assim, no sistema FIA-MPA foram aplicados pulsos potenciais de 1,7 V / 500 ms e -1,1V / 30 ms. Os demais par?metros foram otimizados como: taxa de fluxo e volume da amostra em 4,5 mL min-1 e 330 ?L, respectivamente. Sob estas condi??es, foi obtida duas faixas lineares de 0,1 ? 2,0 ? mol L-1 e 20 x 10-5 a 500 x 10-4 mol L-1 com coeficiente de correla??o linear de 0,992 e 0,998, respectivamente. O limite de detec??o obtido foi de 2,14 x 10-8 mol L-1 para o CO. O desvio padr?o relativo de inje??es consecutivas de 10 respostas sobre a concentra??o de CO de 1,0 x 10-4 mol L-1 foi de 1,28% em -1.1 V. O sistema foi validado em compara??o com o m?todo oficial (HPLC / UV). Os resultados das recupera??es obtidas por meio do m?todo proposto para ambas as amostras foram pr?ximo a 100%. Portanto, o m?todo proposto por FIA-MPA utilizando eletrodo BDD pode ser aplicado com sucesso para a determina??o de CO em amostras de urina e farmac?uticas, com vantagens em rela??o ao m?todo oficial e outros m?todos descritos na literatura. / Disserta??o (Mestrado) ? Programa de P?s-Gradua??o em Qu?mica, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2015. / ABSTRACT The Colchicine (CO) is a drug used in treatment of gouty arthritis with anti-inflammatory action. This medication belongs to a class of compounds called low therapeutic index, whose toxic dose is much close to the therapeutic dose. Thus, the determination of CO in pharmaceutical formulations and in biological fluids is of the utmost importance for the quality control in pharmaceutical and pharmacological studies in conducting the elimination of the drug. In this context, the present work presents simple, fast and low-cost methods for determination of CO in pharmaceutical formulations and urine by multiple-pulse amperometric (MPA) with flow-injection analysis (FIA) system using boron-doped diamond (BDD) electrode. Study was carried out in different electrolytes, Britton-Robinson buffer pH ranging from 2 to 12, sodium hydroxide solution and sulfuric acid, both at a concentration of 0.1 mol L-1. The best conditions for the support electrolyte was sulfuric acid 0.1 mol L-1, where the CO showed oxidation processes at 1.20 and 1.41 V and one of reduction at -0.9 V. MPA detection was based on the potential application of two pulses: (1) for oxidation of CO and (2) for reduction in the generated product, which was used for the determination of the drug in the samples. Thus, in the FIA-MPA system were applied potential pulses of 1.7 V / 500ms and -1.1V / 30ms. The other parameters were optimized as: flow rate and sample volume in 4.5 mL min-1 and 330 ?L, respectively. Under these conditions, it was achieved two linear ranges of 0.1 to 2.0 ?mol L-1 and of 20 to 500 ?mol L-1 with great linear correlation coefficient for both ranges 0.992 and 0.998 respectively. The limit of detection obtained was of 2.14 x 10-8 mol L-1 for CO. Relative standard deviation of injections of 10 consecutive responses on CO concentration of 1.0 x 10-4 mol L-1 was 1.28% at -1.1 V. The system was validated in comparison with the official method (HPLC / UV). The results of the recoveries obtained through the proposed method for both samples are around 100%. Therefore, the method proposed by FIA-MPA using BDD electrode can be successfully applied for the determination of CO in pharmaceutical and urine samples, with advantages in relationship official method and others methods described in the literature.

Submitted by Diego dos Santos Borba (dborba@uffs.edu.br) on 2017-04-13T19:55:56Z No. of bitstreams: 1 KOHLER.pdf: 1091434 bytes, checksum: e63c706b96532cd6877f43260b4f9c05 (MD5) / Made available in DSpace on 2017-04-13T19:55:56Z (GMT). No. of bitstreams: 1 KOHLER.pdf: 1091434 bytes, checksum: e63c706b96532cd6877f43260b4f9c05 (MD5) Previous issue date: 2014-06-23 / O presente estudo tem como objeto o discurso do ?novo?, no documento ?Novas perspectivas para o cotidiano escolar? (2011), destinado ao Ensino M?dio em Tempo Integral do Estado de Santa Catarina. Esta pesquisa busca compreender discursividades sobre o sujeito-aluno que o documento produz. Sendo assim, formulamos a hip?tese de que o documento, ao apresentar o discurso de uma ?nova? Proposta Curricular, produz o imagin?rio do sujeito-aluno logoc?ntrico, centrado, que busca a perfei??o e a completude, de acordo com a vontade de verdade do contexto hist?rico. Entendemos ainda que, ao propor uma forma de educa??o diferenciada, o documento apresenta o discurso do ?novo? como dispositivo de produ??o de sujeito-aluno para atuar nesse espa?o. Diante dessa hip?tese, os seguintes questionamentos foram retomados ao longo de nosso gesto interpretativo: I) que sujeito-aluno ? esse que se constitui por meio da discursividade do ?novo? no documento da Escola em Tempo Integral? e II) que sujeito-aluno ? esse que a Escola em Tempo Integral almeja e pretende forma(ta)r? Filiamo-nos ? teoria discursiva formulada por Foucault (1969 [2013], 1970[2010], 1979 [2011], 1975 [1996]). Uma das grandes contribui??es deste autor se refere ? ordem do discurso e sua arqueologia, trata-se de identificar como os discursos, os pequenos acontecimentos, as pequenas rupturas, possibilitam a emerg?ncia de dizeres camuflados por uma s?rie de apar?ncias superficiais. Filiados a essa teoria pretendemos: (I) analisar regularidades e dispers?es nos enunciados do documento, a respeito da constitui??o do sujeito-aluno na Escola em Tempo Integral, por meio do discurso do ?novo?; (II) refletir como o documento ?Novas perspectivas para o cotidiano escolar? (2011) apresenta o ?novo? como dispositivo para produzir um sujeito-aluno moldado em determinados padr?es e modelos; e (III) refletir sobre imagens que o documento produz em rela??o ao sujeito-aluno inserido na Escola em Tempo Integral. Dessa forma, a partir das an?lises, foi poss?vel perceber que tra?os constituintes do documento contribuem para o estabelecimento de um regime de verdade, de tudo que ? novo ? para melhorar, mesmo que essa representa??o do novo j? tenha sido vista em outros momentos, no ensino de tempo regular. O regime de verdade ? assegurado no discurso pol?tico educacional, atribuindo o valor de verdade por meio do status cient?fico do saber institucionalizado, que n?o ? advindo do Estado, mas ? mantido por ele (FOUCAULT, 2011). Entendemos que, na ilus?o de formar o sujeito-aluno integral e completo, o discurso do ?novo? camufla e demarca uma fronteira entre o que j? estava posto e a proposta da escola em tempo integral. Dessa forma, a partir das an?lises, pudemos vislumbrar que o discurso do novo, enquanto elemento que constitui o texto, cria regras, estabelece-se como estrat?gia e produz sujeitos. / This study has as object the discourse of the ?new?, on ?Novas Perspectivas para o cotidiano escolar? (2011), document for the high school in full time of Santa Catarina State. This research seeks to understand discourses about the subject-student produced by the document. Therefore, we have as hypothesis that the document when presents a new discourse on a curricular proposal, produces one imaginary about the subject-student, such as logocentric, centered, seeking perfection and completeness, according to the real historical context. We also believe that, by proposing a form of differentiated education, the document presents the discourse of the "new" as a device to produce a subject-student to work in this space. Given this hypothesis, the following questions will be taken up along our interpretive gesture, I) who is this subject-student that is through by the discourse of the "new" on the School Full-Time document? II) Who is this subject-student that the Full-Time School aims and intends to form and format? We join the discursive theory formulated by Foucault (1969 [2013], 1970 [2010], 1979 [2011], 1975 [1996]). A major contribution of this author refers to the order of discourse and archeology than identifying, as the speeches, small events, and small breaks, permit the emergence of saying camouflaged by a series of surface appearances. Affiliated to this theory we intend to: (i) analyzing regularities and dispersions about the constitution of the subjectstudent on the in school full time document, through the discourse of the "new"; (ii) reflect how the document "Novas perspectivas para o cotidiano escolar" (2011) introduced the "new" as a device for producing a subject-student molded into certain patterns and models; and (iii) reflect about the images, produced by the document in relation to the subject-student in the school full time. Thus, based on the analyzes, was observed that the document trace constituents contribute to the establishment of a regime of truth, of all that is new is to improve, even this representation of the new has already been seen at other moments on regular time. The regime of truth is ensured in educational policy discourse, which assigns truth value through the scientific status of institutionalized knowledge, which is not coming from the state, but is kept by him (Foucault, 2011). We understand that the illusion of full and complete form the subject-student, the discourse of the "new" camouflages and demarcates a boundary between what went down and proposed school full time. Thus, based on the analyzes, we could see that the discourse of the new, as a constitutive element of the text, create rules, establish as strategy and produces subjects.

Made available in DSpace on 2015-03-03T15:36:09Z (GMT). No. of bitstreams: 1 JoseRAB_DISSERT.pdf: 776491 bytes, checksum: bef691e2a550b6345b490b668bd8cb38 (MD5) Previous issue date: 2013-02-22 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / Humans, as well as some animals are born gifted with the ability to perceive quantities. The needs that came from the evolution of societies and technological resources make the the optimization of such counting methods necessary. Although necessary and useful, there are a lot of diculties in the teaching of such methods.In order to broaden the range of available tools to teach Combinatorial Analysis, a owchart is presented in this work with the goal of helping the students to x the initial concepts of such subject via pratical exercises / Os seres humanos, assim como alguns animais, nascem dotados da capacidade de perceber quantidades. Portanto t?cnicas para contar quantidades foi um passo natural no desenvolvimento do homem. As necessidades provindas da evolu??o das sociedades e recursos tecnol?gicos tornam necess?rio a otimiza??o de tais m?todos de contagem. Apesar de necess?rio e ?til, o estudo desses m?todos no Ensino M?dio esbarram em dificuldades did?ticas. Com o objetivo de ampliar o leque de ferramentas dispon?veis aos professores para o ensino de An?lise Combinat?ria apresentamos neste trabalho um fluxograma que pretende dinamizar o processo de fixa??o dos conceito via resolu??o de exerc?cios

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-04-25T21:18:31Z No. of bitstreams: 1 LuisFilipeAzevedoDeOliveira_DISSERT.pdf: 2758518 bytes, checksum: 7f5afec1f5d1f9f925d4aac95380ba09 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-04-27T19:58:21Z (GMT) No. of bitstreams: 1 LuisFilipeAzevedoDeOliveira_DISSERT.pdf: 2758518 bytes, checksum: 7f5afec1f5d1f9f925d4aac95380ba09 (MD5) / Made available in DSpace on 2016-04-27T19:58:21Z (GMT). No. of bitstreams: 1 LuisFilipeAzevedoDeOliveira_DISSERT.pdf: 2758518 bytes, checksum: 7f5afec1f5d1f9f925d4aac95380ba09 (MD5) Previous issue date: 2014-02-24 / No Brasil, o agente regulador do setor de energia el?trica ? representado pela Ag?ncia Nacional de Energia El?trica. A revis?o das tarifas tem sido uma das suas principais atribui??es, ao estabelecer uma pr?tica tarif?ria em um n?vel compat?vel com a cobertura dos custos operacionais eficientes e a remunera??o adequada dos investimentos realizados pelas distribuidoras. As mudan?as nos procedimentos adotados pelo agente regulador para redefini??o dos custos eficientes, bem como os diversos estudos encontrados na literatura sobre os procedimentos utilizados na regula??o desse segmento denotam o desafio enfrentado sobre qual a melhor estrat?gia metodol?gica a ser empregada. Nesse contexto, esta pesquisa tem como objetivo propor um modelo para avalia??o de benchmarking, aplicado ao sistema de regula??o nacional no estabelecimento dos custos operacionais eficientes das concession?rias de distribui??o de energia el?trica. O modelo ? formulado para promover o desenvolvimento do mercado de energia el?trica, associado com pol?ticas governamentais e em benef?cio da sociedade. Para conduzir esta pesquisa, adota-se uma integra??o do modelo de An?lise Envolt?ria de Dados (DEA) com a An?lise de Fronteira Estoc?stica (SFA), em um procedimento que estabelece tr?s est?gios para corrigir a efici?ncia em termos dos efeitos ex?genos: (i) avalia??o por meio de DEA para mensurar as folgas nos custos operacionais das distribuidoras, em que as vari?veis ex?genas s?o omitidas; (ii) as folgas calculadas no primeiro est?gio s?o regredidas sobre um conjunto de vari?veis ambientais, por meio de SFA e os custos operacionais s?o corrigidos para contabilizar o impacto dos efeitos ambientais e o ru?do estat?stico; e, (iii) reavalia??o do desempenho das concession?rias de distribui??o de energia el?trica, respaldado pelo uso de DEA. A partir dessa metodologia foi poss?vel obter- uma avalia??o do desempenho exclusivamente expresso em termos de efici?ncia de gest?o, nos quais s?o controlados pelos efeitos do meio ambiente operacional e do ru?do estat?stico. A metodologia em tr?s est?gios alcan?ou o principal objetivo, ao nivelar os custos das concession?rias em termos do efeito ex?geno e aleat?rio, tornando o desempenho das concession?rias mais homog?neos. / In Brazil, the National Agency of Electric Energy (ANEEL) represents the energy regulator. The rates review have been one of its main tasks, which establish a pricing practice at a level to cover the efficient operating costs and also the appropriate return of the distributors investments. The changes in the procedures to redefine the efficient costs and the several studies on the methodologies employed to regulate this segment denote the challenge faced by regulators about the best methodological strategy to be employed. In this context, this research aims to propose a benchmarking evaluation applied to the national regulation system in the establishment of efficient operating costs of electricity distribution utilities. The model is formulated to promote the electricity market development, partnering with government policies ant to society benefit. To conduct this research, an integration of Data Envelopment Analysis (DEA) with the Stochastic Frontier Analysis (SFA) is adopted in a three stages procedure to correct the efficiency in terms of environmental effects: (i) evaluation by means of DEA to measure operating costs slacks of the utilities, in which environmental variables are omitted; (ii) The slacks calculated in the first stage are regressed on a set of environmental variables by means of SFA and operating costs are adjusted to account the environmental impact and statistical noise effects; and, (iii) reassess the performance of the electric power distribution utilities by means of DEA. Based on this methodology it is possible to obtain a performance evaluation exclusively expressed in terms of management efficiency, in which the operating environment and statistical noise effects are controlled.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-04-26T20:14:33Z No. of bitstreams: 1 WilmaraMartinsDaCosta_DISSERT.pdf: 3825007 bytes, checksum: 3cfefb72f4f5ec52433a40868a116799 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-04-29T21:35:46Z (GMT) No. of bitstreams: 1 WilmaraMartinsDaCosta_DISSERT.pdf: 3825007 bytes, checksum: 3cfefb72f4f5ec52433a40868a116799 (MD5) / Made available in DSpace on 2016-04-29T21:35:46Z (GMT). No. of bitstreams: 1 WilmaraMartinsDaCosta_DISSERT.pdf: 3825007 bytes, checksum: 3cfefb72f4f5ec52433a40868a116799 (MD5) Previous issue date: 2015-05-15 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / Este trabalho prop?e-se a estudar o contexto educacional sob a perspectiva de investiga??o da An?lise de Redes Sociais, no sentido de analisar estrutura relacional das redes pessoais dos alunos da 2? s?rie do Ensino M?dio na Escola Estadual Professora Judith Bezerra de Melo, em termos de apoio e transi??o de informa??o e seus efeitos no processo de aprendizagem. O objetivo geral deste estudo ? investigar os efeitos das redes de rela??es pessoais na forma??o de capital social, bem como, a influ?ncia desse na aprendizagem do aluno no ?mbito escolar. Nesse sentido, o estudo tr?s reflex?es sobre o contexto social, as estruturas das redes em que est?o inseridos esses alunos e os efeitos destas no seu comportamento individual, pois se mostram como aspectos importantes para compreender o campo de rela??es ao qual est?o expostos, podendo trazer elementos que expliquem a sua condi??o educacional recente. Foram analisadas as estruturas das redes dos alunos e um conjunto de fatores associados ? aprendizagem, a fim de descrever como o capital social presente nas rela??es possibilita ou bloqueia o processo de aprendizagem dos conte?dos escolares. Diante disso, parte-se da hip?tese de que, a desigualdade, em termos da distribui??o de capital social presente nas rela??es pessoais, tende a ser um dos fatores explicativos para compreender as dificuldades referentes ao processo de aprendizagem dos alunos no ambiente da escola. Como m?todo de investiga??o das rela??es estabelecidas pelos indiv?duos estudados, foi utilizado o aporte te?rico e metodol?gico da An?lise de Redes Sociais, no sentido de investigar o aspecto estrutural das redes individuais e ao explorar o potencial explicativo destas redes e do capital social que surge da sua disposi??o estrutural na an?lise da aprendizagem do aluno. Foi realizado o estudo de caso para explorar em profundidade os aspectos relevantes ao problema da pesquisa dentro de um per?odo de tempo limitado, que abrange o ano de 2014. Para o levantamento do campo de rela??es foi solicitado a cada aluno que indicasse outras pessoas para compor a sua rede, tanto ao qualificar a rela??o em referente ao tipo e ao grau de relacionamento com esses contatos como tamb?m a rela??o entre eles. O question?rio utilizado nessa fase foi classificado como gerador de nomes, tal instrumento serviu de base para a constru??o da matriz relacional e dos grafos utilizados na an?lise dos dados. Al?m de responder a um bloco de quest?es sociodemogr?ficas que serviram para gerar atributos, caracterizar a estrutura de rela??es e para constru??o das vari?veis relacionadas com a aprendizagem. Com essa discuss?o, percebe-se que a An?lise de Redes Sociais ? uma ferramenta significante para compreender as estruturas relacionais e que apesar da abstra??o do conceito de aprendizagem, foi observado que o capital social tem influencia relativamente baixa sobre ela, por?m deve-se destacar que o tamanho da amostra ? pequeno o que limitaria os resultados encontrados. / This work considers to study it the educational context under the perspective of inquiry of the Analysis of Social Networks, in the direction to analyze relationship structure of the personal nets of the pupils of 2? series of High School in the State School Teacher Judith Bezerra de Melo, in terms of support and transition of information and its effect in the learning process. The general objective of this study is to investigate the effect of the nets of personal relations in the formation of social capital, well as, the influence of this in the learning of the pupil in the pertaining to school scope. In this direction, the study backwards reflections on the social context, the structures of the nets where these pupils are inserted and the effect of these in its individual behavior, therefore if they show as aspects important to understand the field of relations which are displayed, being able to bring elements that explain its recent educational condition. The structures of the nets of the pupils had been analyzed and a set of factors associates to the learning, in order to describe as the present social capital in the relations makes possible or blocks the process of learning of the pertaining to school contents. Ahead of this, it has been broken of the hypothesis of that, the inequality, in terms of the distribution of present capital stock in the personal relations, tends to be one of the clarifying factors to understand the referring difficulties to the process of learning of the pupils in the environment of the school. As method of inquiry of the relations established for the studied individuals, it was used arrives in port theoretician and procedure of the Analysis of Social Networks, in the direction to investigate the structural aspect of the individual nets and when exploring the clarifying potential of these nets and of the social capital that appears of its structural disposal in the analysis of the learning of the pupil. The case study was carried through to inside explore in depth the excellent aspects to the problem of the research of a period of limited time, which encloses the year of 2014. For the survey of the field of relations he was requested to each pupil who indicated other people to compose its net, as much to as well as characterize the referring relation in to the type and the degree of relationship with these contacts the relation between them, the questionnaire used in this phase was classified as generating of names, such instrument served of base for the construction of the relationship matrix and the graphs used in the analysis of the data. Beyond answering a block of sociodemographic questions that had served to generate attributes, to characterize the structure of relations and for construction of the variable related with the learning. With this quarrel, one perceives that the Analysis of Social Networks is a significant tool to understand the relationship structures and that although the abstraction of the learning concept was observed that the social capital has influences relatively low on it, however must be detached that the size of the sample is small what would limit the joined results.

Made available in DSpace on 2014-12-17T15:06:50Z (GMT). No. of bitstreams: 1 CristianeMPSN_DISSERT.pdf: 706513 bytes, checksum: c1a69ee89ffbeef2df661482204120c5 (MD5) Previous issue date: 2010-04-08 / Cette recherche s'inscrit dans la linguistique de texte et vise ? identifier, d?crire, analyser et interpr?ter les ?v?nements de l'anaphore pronominale et de la r?p?tition, exposer le montant et le pourcentage d?s phenom?nes respectifs dans Le corpus ?tudi?s, que l accent sur le fonctionnement coh?rente de ces ph?nom?nes dans la construction du texte en termes de continuit? et de progression th?matique. Nous avons utilis? des proc?dures ethnographiques pour construire notre corpus d'enqu?te, compos? essentiellement de textes produits par les ?tudiants de 9 ans d'?cole ?l?mentaire de l'Etat, a la ville de Santa Cruz / RN. La recherche a ?t? men?e ? partir des ?tudes sur l'anaphore pronominale faites par Milner (1982), Koch e Marcuschi (1998), Marcuschi (2000; 2005 e 2008), Koch (2002), Antunes (2005) e Adam (2008), et par des ?tudes sur la r?p?tition pr?sent?s par Halliday e Hassan (1976), Beaugrande e Dressler (1997), Marcuschi (1992) et Antunes (2005). Comme le support technique, ont ?galement utilis? les notions de coh?sion d?finis par Halliday e Hasan (1976), Beaugrande e Dressler (1997), Marcuschi (2008) e Koch (2003). Dans l'analyse des textes, nous avons constat? que l'incidence de l'anaphore pronominale et de la r?p?tition a ?t? importante parce que les ressources ?taient principalement utilis?s par les ?tudiants pour promouvoir l'articulation coh?rente des textes. Constat? que dans les textes narratifs ou argumentatifs anaphore pronominale promu l'entretien et la progression th?matique pr?vu. Sur la r?p?tition, nous avons observ? que le maintien et la progression th?matiques ont ?t? conditionn?s ? la connaissance du sujet en discussion. M?me si nous avons constat? que la r?p?tition excessive de ces ph?nom?nes dans le m?me texte, bien que la relation de promouvoir la coh?sion, peut affecter le degr? de caractere informatif / Esta pesquisa se insere no ?mbito da Lingu?stica de Texto e tem por objetivo identificar, descrever, analisar e interpretar as ocorr?ncias da an?fora pronominal e da repeti??o, expondo a quantidade e o percentual dos respectivos fen?menos no corpus investigado; assim como focalizar o funcionamento coesivo desses fen?menos na constru??o da trama textual, em termos de continuidade e de progress?o tem?tica. Para tanto, utilizamos procedimentos etnogr?ficos para construirmos o nosso corpus investigativo, constitu?do, principalmente, por textos produzidos por alunos de um 9? ano de uma escola de ensino fundamental da rede estadual, na cidade de Santa Cruz/RN. A pesquisa foi orientada a partir dos estudos sobre an?fora pronominal, realizados por Milner (1982), Koch e Marcuschi (1998), Marcuschi (2000; 2005 e 2008), Koch (2002), Antunes (2005) e Adam (2008), e por estudos sobre a repeti??o apresentados por Hallyday e Hassan (1976), Beaugrande e Dressler (1997), Marcuschi (1992) e Antunes (2005). Como suporte te?rico, tamb?m foram utilizados os conceitos de coes?o definidos por Hallyday e Hassan (1976), Beaugrande e Dressler (1997), Marcuschi (2008) e Koch (2003). Nas an?lises dos textos, constatamos que a incid?ncia da an?fora pronominal e da repeti??o foi significativa porque foram os recursos mais utilizados pelos alunos para promover a articula??o coesiva dos textos. Verificamos que em textos narrativos ou argumentativos a an?fora pronominal promoveu a manuten??o e a progress?o tem?tica esperadas. Quanto ? repeti??o, observamos que a manuten??o e progress?o tem?tica estavam condicionadas ao conhecimento do tema em foco. Ainda verificamos que a recorr?ncia excessiva desses fen?menos em um mesmo texto, apesar de promoverem a articula??o coesiva, pode prejudicar o seu grau de informatividade