[Truncated abstract] The use of uncertainty analysis is gaining considerable attention in catchment hydrological modeling. In particular, the choice of an appropriate model structure, the identifiability of parameter values, and the reduction of model predictive uncertainty are deemed as essential elements of hydrological modelling. The chosen model structure must be parsimonious, and the parameters used must either be derivable from field measured data or inferred unambiguously from analysis of catchment response data. In this thesis, a long-term water balance model for the Susannah Brook catchment in Western Australia has been pursued using the ?downward approach?, which is a systematic approach to determine the model with the minimum level of complexity, with parameter values that in theory are derivable from existing physiographic data relating to the catchment. Through the analysis of the rainfall-runoff response at different timescales, and the exploration of the climate, soil and vegetation controls on the water balance response, an initial model structure was formulated, and a priori model parameter values estimated. Further investigation with the use of auxiliary data such as deuterium concentration in the stream and groundwater level data exposed inadequacies in the model structure. Two more model structures were then proposed and investigated through formulating alternative hypotheses regarding the underlying causes of observed variability, including those associated with the absence of a contribution of deep groundwater flow to the streamflow, which was indicated by deuterium concentration and internal dynamics characterized by the observed groundwater levels. ... These differences are due to differences in the time delay between rainfall and recharge between upland and riparian regions. The ages of water recharging the groundwater and discharging from the catchment were estimated by assuming a piston flow mechanism. In the deeper, upland soils, the age of recharging water was considerably larger than the unsaturated zone delay would suggest; a recharge response 16 days after an infiltration event may involve water as much as 160 days old. On the other hand, the delay and the age of recharging water were much lower in the shallow riparian zone. Where the upland zone contributes significantly to discharge, the predicted difference between the rainfall-discharge response time and the average age of discharging water can be significant.

Este trabalho analisa o verbo chegar em sentenças do PB, quando ele é seguido de a+infinitivo. Na literatura, não há consenso no tratamento do verbo na perífrase em foco. Enquanto alguns o consideram um auxiliar, outros não. Esta pesquisa retomou essa discussão e mostrou que o verbo chegar, no contexto estabelecido, responde afirmativamente a todos os critérios apontados como caracterizadores de auxiliaridade. Tendo isso estabelecido, observamos que são atribuídos aos auxiliares os valores de tempo, voz, modo e aspecto. Assim, fomos investigando, uma a uma, todas essas possibilidades. Os valores de tempo e voz foram facilmente descartados. Em seguida, buscamos numa descrição genérica de modalidade alguma pista que nos fizesse ir mais a fundo. Não encontramos e, por isso, descartamos também essa possibilidade. A análise de chegar como auxiliar aspectual tomou mais tempo e espaço neste trabalho, porque há alguns autores que assumem uma análise desse tipo. Primeiro, buscamos caracterizar o aspecto gramatical e ver se as sentenças objetos de investigação poderiam denotar as categorias de aspecto incluídas aí. Concluímos que não. Analisamos, depois, a possibilidade de chegar restringir alguma classe acional. Novamente, os resultados foram negativos. Tendo em vista o comportamento da perífrase nos diferentes contextos, afirmamos que não era possível assumir um valor aspectual para o verbo em questão. Por fim, propomos uma análise para esse verbo que leva em conta não apenas os aspectos sintáticos e semânticos, mas também os pragmáticos: mostramos que o falante, ao utilizar o auxiliar chegar deseja apontar para uma escala, mais precisamente para o ponto argumentativo mais forte dessa escala. Dessa forma, teríamos um auxiliar que não é temporal, modal ou aspectual, mas essencialmente pragmático. O corpus desta pesquisa é composto por sentenças do português brasileiro, falado e escrito, além de sentenças criadas para verificar a compatibilidade de chegar em contextos mais específicos. / This work approaches the verb chegar when it is followed by the preposition a and the infinitive form in Brazilian Portuguese. In the literature, there is no consensus about the treatment of the verb in this periphrasis. While some authors consider it an auxiliary verb, others do not. Our research resumed this discussion and showed that chegar, in the context above, confirms all the criteria indicated as indicators of auxiliarity. After that, we noticed that the values of tense, modality, voice and aspect are given to the auxiliaries. Then, we investigated, one by one, all the possibilities. The values of tense and voice were easily rejected. After this, we searched, in a general description of modality, a clue to conduct us deeper in the research. We did not found one and then we rejected this possibility too. The analysis about chegar as an aspectual auxiliary took more time and space in this work, because there are some authors who argues for this kind of analysis. First, we tried to characterize the grammatical aspect and observe whether the sentences could mean the aspectual categories included there. We concluded that they could not. Later, we analyzed the possibility of chegar to restrict some actional class. Again, the conclusions were negative. Bearing in mind the behavior of the periphrasis in the different contexts, we affirm that it was not possible to accept an aspectual value to chegar. At the end, we propose an analysis to this verb that takes into consideration not only the syntactic and semantic aspects, but also the pragmatic one: we show that when the speaker uses the auxiliary chegar, this speaker wishes to point to a scale, more specifically to its strongest argumentative point. In this way, we might have an auxiliary verb which is not temporal, modal or aspectual, but essentially pragmatic. The corpus of this research is composed of sentences from Brazilian Portuguese, spoken and written, and other sentences created to verify the compatibility of chegar in specific contexts.

Malgré sa condamnation post-positiviste et sa réception négative par la gauche, l’empirisme logique regagne en intérêt. Cette thèse est une contribution à la littérature émergente du «Cercle de Vienne de gauche» (CVG). Autour de Neurath et quelques autres personnalités de l’aile gauche du Cercle (Carnap, Frank, Hahn, Zilsel), nous proposons de repenser la relation de l’empirisme logique avec le marxisme. Ces deux courants se rejoignent dans leur défense d’une «conception scientifique du monde» et leur sécularisme radical. Les critiques communistes et néo-marxistes (l’École de Francfort, l’épistémologie féministe) adressées à l’empirisme logique sont recensées et leur pertinence questionnée à travers les données de l’historiographie du CVG. La politique de l’empirisme logique est examinée à travers les textes économiques de Neurath et son œuvre d’infographiste. Son engagement pour l’économie socialiste planifiée et ses efforts en graphisme pour la popularisation des méthodes quantitatives (la méthode Isotype pour la visualisation des statistiques sociales) sont présentés en vue d’une évaluation politique du CVG, ainsi que les connexions de l’empirisme logique avec le mouvement pour une langue auxiliaire internationale. / Despite logical empiricism’s dismissal by ambient postpositivism in academia as well as by the Far Left, a growing interest in its previously unknown socialist origins has resulted in a new topic in the history of philosophy of science : «Left Vienna Circle» (LVC). This thesis dedicated to LVC studies aims to clarify the politics of European logical empiricism. A presentation of its major critics from the Left (from communist parties to neo-Marxist trends like Frankfurt School and feminist epistemology) is followed by more recent arguments about its socialist politics. The «scientific world conceptions» of logical empiricism and Marxism will be compared through the work of Neurath and some other representatives of LVC (Carnap, Frank, Zilsel, Hahn). Alongside the connections of logical empiricism to the movement for an international auxiliary language, Neurath’s economical writings and his efforts to popularize quantitative methods in social sciences (the Isotype method of visual statistics) will be presented in an attempt to evaluate the politics of logical empiricism.

L’expression anormale du canal sodique Nav1.5 dans le cancer du sein est corrélée au développement métastatique et à une mortalité augmentée. Le canal Nav1.5 est localisé dans les invadopodes des cellules cancéreuses mammaires humaines MDA-MB-231 et augmente leur activité protéolytique par une modulation allostérique de l’échangeur NHE-1 et l’activation de protéases acides. In vivo, dans un modèle de xénogreffe sur souris NMRI nude, l’expression de Nav1.5 potentialise la colonisation des poumons par les cellules cancéreuses mammaires humaines. Cette colonisation métastatique est inhibée par un traitement à la ranolazine, un inhibiteur pharmacologique des canaux Nav1.5. La sous-unité β4, auxiliaire des canaux Nav, voit son expression diminuer au cours de la progression cancéreuse, ce qui est associé in vitro à une augmentation de l’invasivité cellulaire. Cette augmentation d’invasivité semble indépendante du canal Nav1.5 et pourrait être associée à une transition des cellules vers un phénotype amiboïde. En conclusion, l’expression de Nav1.5 et la perte d’expression de β4 semblent jouer des rôles complémentaires dans l’invasivité des cellules cancéreuses. / The abnormal expression of sodium channel Nav1.5 in breast cancer is correlated with metastatic development and an increased mortality. The Nav1.5 channel is located in invadopodia in human breast cancer cells MDA-MB-231, where it increases proteolytic activity by allosteric modulation of exchanger NHE-1 and activation of acidic proteases. In vivo, in a xenograft model in nude NMRI mice, the expression of Nav1.5 potentiates lung colonization by human breast cancer cells. Metastatic colonization is inhibited by treatment with ranolazine, a pharmacological inhibitor of Nav1.5. The β4 subunit, an auxiliary subunit of Nav channels, is expressed at low levels or lost when tumors are more aggressive, and its suppression in vitro increases celI invasiveness. This increase seems to be independent of Nav1.5 and could be associated with the transition of cells to an amoeboid phenotype. In conclusion, Nav1.5 expression and the loss of β4 expression seem to play complementary roles in the invasiveness of cancer cells.

The aim of this thesis is to describe and further develop estimation strategies for data obtained by stratified sampling. Estimation of the mean and linear regression model are discussed. The possible inclusion of auxiliary variables in the estimation is exam- ined. The auxiliary variables can be transformed rather than used in their original form. A transformation minimizing the asymptotic variance of the resulting estimator is pro- vided. The estimator using an approach from this thesis is compared to the doubly robust estimator and shown to be asymptotically equivalent.

Polyethylene terephthalate (PET) is the most used fibre in the textile industry. PET is also used in other products, e.g. soft-drink bottles and food packaging. Approximately 60% of the globally produced PET is intended for production of textile fibres and the demand for polyester fibres have steadily increased over the last decade. Yet, most of the recycled PET fibres are produced from discarded bottles and not discarded textiles even though the generation of textile waste is increasing year by year. The importance of finding efficient recycling routes for discarded PET textiles is obvious. In thermo-mechanical recycling the thermoplastic characteristic of PET is utilized to re-melt and re-form PET waste into new valuable products. Today, this is used for bottle-to-fibre recycling but not for fibre-to-fibre recycling. The main research question asked in this Master thesis is if the process of exhaust dyeing compromise the possibility to recycle PET textiles through remelt spinning. It is believed that PET degradation through hydrolysis may occur during dyeing. The degradation behaviour of PET has been widely studied. However, degradation during exhaust dyeing has not been investigated.   The process parameters temperature, time and number of dyeing cycles have been investigated. Also, possible effects of different auxiliary chemicals have been studied. Dyeing and characterisation of two PET fabrics with filaments of different titer was performed in order to investigate if the filament titer is also a parameter to consider.   Tensile testing and surface characterisation through demand absorbency test showed that the filament titer seems to affect how the tensile and moisture related properties change due to dyeing. Differential scanning calorimetry showed that the crystallisation rate is affected by the dyeing process. This can be an effect of formation of shorter PET chains during dyeing. The auxiliary chemicals have been shown to be the most critical factor in changes of the crystallisation behaviour. Fourier-Transform infrared spectroscopy indicated that chain scission has occurred during dyeing.   The results have shown that the exhaust dyeing process causes changes in tensile properties, moisture related properties, degree of crystallinity as well as crystallisation behaviour. DSC and FTIR results indicate chain scission. Based on the results it cannot be concluded if the changes are large enough to compromise the possibility to recycle PET textiles thermo-mechanically. Further research is required in order to correlate the observed changes with possible problems in thermomechanical recycling of dyed PET textiles.

The work is focused on monitoring and detail survey of eventual changes in Ostřice river bed in Horní Planá cadastre area. It was done in two phases in different seasons. The work objective is to outline and secure position of cross sections on the sides of the river polygon, followed by their survey. The work consists of two sections {--} theoretical and practical. The theoretical section first explains establishment of a dot field by geodetic points. This is followed by description of a detail dot field, requirements for the individual points, methods of their survey, detail mapping of these points as well as establishment of water stream lengthwise sections and cross sections. The practical part includes characteristics of the surveyed location. In addition there is description of preparatory work, necessary for land survey and the survey itself, using both existing and newly established points of the dot field. At the end there is explanation of auxiliary and detail points calculation and method of their graphic processing. The conclusion includes assessment of changes between April and August surveys of the subject territory.

The current Auxiliary Power Unit (APU) contributes a lot to the greenhouse effect in terms of emissions, and in the form of noise and also is very heavy. The need for more electricity has increased in aircrafts and therefore major aircraft suppliers like Boeing and Airbus want to switch to more electric aircraft (MEA) which is lighter and has less environmental impacts. The purpose of this work is to investigate the possibilities of replacing today's traditional APU with fuel cells. In this work presents six different common fuel cell types which used commercially in various areas in the market. We have also analyzed and investigated the most suitable fuel cell types and have chosen to apply the SOFC-GT Hybrid Systems. We have investigated and compared both systems with pros and cons. We have used different methods in this work including the FOI3-method and Safran & Honeywell for calculations of emissions for all systems. Finally, we have analyzed and investigated the emissions, noise and weight for both systems. / Nuvarande Auxiliary Power Unit (APU) bidrar mycket negativt till växthuseffekten i form av emissionsutsläpp och även i form av buller och är dessutom mycket tunga. Behovet av mer elektricitet ökar i flygplan och därför vill stora flygplanstillverkare såsom Boeing och Airbus övergå till more electric aircraft (MEA) vilket är lättare och har mindre miljöpåverkan. Syftet med detta arbete är att undersöka möjligheterna av att ersätta dagens traditionella APU mot bränsleceller. I detta arbete presenteras sex olika bränslecellstyper som finns på marknaden och används kommersiellt inom olika områden. Vi har analyserat och undersökt de lämpligaste bränslecellstyper för applicering och därefter har vi valt att implementera SOFC- GT Hybridsystemen. Vi har undersökt och jämfört båda systemens för- och nackdelar. Metodmässigt används bland annat FOI3-Metoden och Safran & Honeywell för beräkningar av utsläpp av emissioner för samtliga system. Slutligen har vi analyserat och undersökt skillnader i utsläpp av emissioner, buller och vikt för båda systemen.

Made available in DSpace on 2016-01-26T18:49:43Z (GMT). No. of bitstreams: 1 dissertacao.pdf: 304700 bytes, checksum: 4a6272e15bcfda82bd953329b083bcbc (MD5) Previous issue date: 2011-06-03 / Whereas the bonding relations are important for child development, resulting in the organization of the child´s personality and in structuring their relationships with others around them, the goal of this research is focused on the importance of bonding between the Auxiliary Child Development ACDs and children´ s nursery and the implications of this link to child development. We tried to also consider the qualification, the planning of teaching activities and teaching practice. The literature search was focused on authors with questions regarding some historical aspects of childhood; Historical aspects of the nursery, and some aspects of the theories about the physical, cognitive and psychosocial. The research was conducted under the qualitative perspective, specifically the type of case study. The methodological procedures involved: 1. Collecting data through interviews with a semi-structured, with eight assistants Child Development working in a nursery to the Public in the city of Presidente Prudente (SP), seeking information about the relationship of these affective eat children from 0 to 4 years. Were also used documents and observation, to enrich the discussion of results. 2. Analysis and discussion of data, worked through the interpretation of the meaning of the responses provided by subjects based on content analysis, which were separated by Main and categories, and related to the objectives proposed by the research. The results indicate that ACDs have teaching qualification to work in the nursery with children, seeking additional courses to qualify. It can be seen that the bonding between ACD within the nursery and children is a reality that has been proven through situations experienced and reported by them. One can also observe the kindergarten as a dynamic environment with respect to the evolution of changes, not only as a site for the care of children, but as an environment that promotes learning them. As for the professional development of the ADI, let me make a suggestion to seek more skilled, making Specializations in the area relevant to their work with children. Another suggestion would be to participate in the same events that they can collaborate with professional work developed, contributing to society, because if the ADI seek knowledge of other professionals will be better able to deal with day to day in the nursery. In this sense the experience summed and divided contribute to the learning of children, caregivers and society in general. The appreciation of the exchange of ideas, reflecting on the position of information among others are some attitudes that ADI should possess. Understand the facts that pervade this universe, people sensitive and yet so strong, I gave hope of better days, a relationship of harmony with life. / Considerando que as relações vinculares são importantes para o desenvolvimento infantil, implicando na organização da personalidade da criança e na estruturação de suas relações com as demais pessoas ao seu redor; o objetivo da presente pesquisa focalizou a importância do vínculo afetivo entre as Auxiliares de Desenvolvimento Infantil ADI e crianças de creche e as implicações deste vínculo para o desenvolvimento infantil. Buscou-se também analisar a qualificação profissional; o planejamento da ação docente e a prática pedagógica. A pesquisa bibliográfica esteve centrada em autores com questões referentes a Alguns aspectos históricos da infância; Aspectos históricos da creche; alguns aspectos das teorias acerca do desenvolvimento físico, cognitivo e psicossocial. A pesquisa foi desenvolvida sob a ótica qualitativa, especificamente do tipo estudo de caso. Os procedimentos metodológicos envolveram: 1. Coleta de dados, através de entrevistas com roteiro semi-estruturado, com 8 Auxiliares do Desenvolvimento Infantil que atuam em uma Creche da Rede Pública da cidade de Presidente Prudente (SP), procurando obter informações sobre a relação afetiva destas coma as crianças de 0 a 4 anos. Também foram utilizados documentos e a observação, para o enriquecimento da discussão dos resultados. 2. Análise e discussão dos dados obtidos, trabalhados através da interpretação do significado das respostas apresentadas pelos sujeitos, com base na análise de conteúdo; as quais foram separadas por Eixos e Categorias, e relacionadas com os objetivos propostos pela pesquisa. Os resultados sinalizam que as ADI possuem qualificação pedagógica para atuação na creche com as crianças, buscando cursos para qualificação complementar. Porém, isto não invalida a necessidade de se buscar por mais cursos de aperfeiçoamento e especializações como também a participações em eventos da área. Constatou-se que a formação do vínculo dentro da creche entre ADI e crianças é uma realidade que foi comprovada por meio de situações vivenciadas e relatadas pelas mesmas. Pode-se também observar a creche como um ambiente dinâmico que tange a evolução das mudanças ocorridas, não só como um local destinado ao cuidado das crianças, mas enquanto ambiente que promove a aprendizagem destas.

Este trabalho trata da organização de sintagmas nominais no armênio, revelando uma interação peculiar entre a expressão de definitude e a marcação morfológica de Caso e as conseqüências dessa relação para a organização estrutural desta língua. Mostra se que os sintagmas nominais são interpretados como definidos como resultado de atribuição de Caso estrutural, e que existe uma assimetria entre os Casos estruturais e os Casos inerentes quanto à atribuição de definitude. Como ponto de partida, discute-se o estatuto do sufixo n/y, chamado de artigo definido pela gramática tradicional do armênio. A investigação das propriedades morfossintáticas desse sufixo mostra que o mesmo é uma marca com características mistas, que atua na atribuição de definitude e Caso de uma maneira não atestada nas línguas naturais e questiona o recorte entre as funções de Caso e os meios de expressão de definitude. Baseando-nos nos trabalhos de Chomsky (1986b), Longobardi (1994) e Giusti (2002), propomos a reanálise do sufixo -n/y como uma marca de Caso estrutural, que transforma os sintagmas nominais em argumentos sintáticos, e é associada ao nível DP na estrutura frasal. Ademais, mostra-se que a ausência de marcação de Caso estrutural resulta numa série de restrições semântico-sintáticas nos sintagmas nominais (nus), a mais proeminente sendo o movimento desses sintagmas para uma posição antes do verbo, seguidos imediatamente pelo auxiliar. Isso leva a diferentes ordens superficiais para sintagmas marcados por Caso estrutural (SVO) e sintagmas nus (SOauxV). Tal evidência, junto com o quadro das características dos sintagmas nus no armênio, leva à análise dos mesmos como pseudo-incorporados, conforme proposto por Massam (2001) para o niueano, com a diferença de que o sintagma nu se adjunge à projeção funcional TP no armênio, sem passar pela operação de alçamento do predicado. Quanto à expressão de definitude nos Casos inerentes, mostramos que em contraste com os sintagmas nos Casos estruturais, que podem aparecer com ou sem marcação aberta de Caso e ter, respectivamente, leitura definida ou indefinida, os inerentes devem sempre carregar a morfologia casual e são ambíguos quanto à definitude. Nesse aspecto, analisamos as projeções nominais Genitivas e constatamos que, apesar da aparente semelhança superficial, as mesmas exibem propriedades distintas que correspondem a duas estruturas internas diferentes do sintagma nominal, viii podendo ser caracterizadas como duas classes distintas: o Genitivo Referencial, que aparece em Spec/DP e é interpretado como definido por se associar ao nível DP, e o Genitivo Modificador, que permanece no domínio do NP no percurso da derivação. As conclusões a que chegamos provam que mesmo sem possuir um artigo definido canônico, o armênio oferece evidências a favor da postulação do nível DP como universal, responsável pelas interpretações definidas dos sintagmas nominais. Nos Casos estruturais, a definitude vem da atribuição de Caso, enquanto no Genitivo (um exemplo de Caso inerente) vem da posição ocupada dentro do sintagma nominal. Por conseguinte, o presente trabalho traz uma contribuição teórica valiosa para a análise unificada das projeções nominais, além de auxiliar na elucidação de alguns assuntos empíricos controversos do armênio e abrir caminho para pesquisas futuras. / This thesis investigates the structural organization of noun phrases in Armenian, an Indo-European language with mixed properties, focusing on the interaction between Case and (in)definiteness. The main claim of the study is that, contrary to traditional view, Armenian has no (definite) article, and definiteness in this language is a result of structural Case marking on NPs. This claim has implications for the analysis of bare nominals as NPs that lack both Case and referential properties and are syntactically restricted to a peculiar configuration, resulting in different superficial orders for Case-marked (SVO) and bare noun phrases (SOauxV). Moreover, this analysis casts light on a rather intriguing question of how definiteness is expressed in inherent Cases. It is shown that, unlike structural Cases, which express a direct correlation between definiteness and Case, inherent Cases, more precisely Genitive NPs, are interpreted as (in)definite by associating themselves to distinct structural positions. The starting point of our discussion is the re-analysis of the suffix -n/y, traditionally classified as a definite article. Highlighting Case and (in)definiteness as two independent conditions on argumenthood (Chomsky (1986b), Longobardi (1994), Giusti (2002)) that are closely correlated in Armenian, we argue that this suffix is in fact a structural Case marker, which turns nominals into syntactic arguments, and is associated with DP level. Focusing on the morpho-syntactic behavior of bare nominals in Armenian, it is shown that in the absence of structural Case marking, their distribution is syntactically restricted to a position in which they appear to the left of the verb and must be adjacent to the auxiliary. This distribution is accounted for by adopting the pseudo-incorporation analysis of Massam (2001). We show that bare nouns in Armenian exhibit typical properties of pseudo-incorporated nominals, as lack of reference, number-neutrality, phrasal nature, among others. Turning our attention to Genitive constructions, which always appear with Case morphology, we analyze a number of properties that superficially distinguish two (main) types, which we propose to call Referential and Modifying Genitives. The difference between them is syntactic, as they have different structural representations: Spec/DP for Referential and NP domain for Modifying Genitive. x As a result, we conclude that there exists an asymmetry between inherent and structural Cases as to how they express definiteness. Moreover, we conclude that in spite of the fact that Armenian does not have canonical (definite) article, a DP level must be postulated for this language, as a projection responsible for the referentiality/definiteness of the noun phrases. Thus, this study contributes to the outgoing debates about the precise functions of D as universal category and provides a valuable theoretical contribution to the cross-linguistic investigations of nominal projections.