No description available.

No description available.

Promoting values of respect, understanding, empathy and developing in the students the necessary skills to be part of a peaceful and comprehensive society is one of the responsibilities of the educational system. This mission, in the context of the Swedish preschools, is also compatible with the characteristic use of the natural and outdoor environments of the Scandinavian countries as learning and experiential settings. The aim of this research paper is to study how the outdoor spaces can affect the understanding andthe resolution of conflicts between students in the preschool stage from the perspectiveof the teachers. Therefore, the main tool for the collection of the data were the semistructured interviews carried out with different educators from different Swedish preschools. Using thematic analysis as the designated qualitative approach to analyse thedata, different themes and sub-themes were addressed throughout the answers from theinterviews and organized based on 3 different sections: experience in outdoors, conflicts in the preschool, and the outdoors in the resolution of conflicts. The results presented the teachers’ experience regarding outdoor education; their understanding of the differenttypes of conflicts in the preschool stage; the role of the different parts involved, and themethods used to understand, manage, and deal with issues between the students; lastly, how the use of outdoor settings and its benefits can promote conflict-management skillsamong the students. Thus, the outdoor settings possess a beneficial effect on the social, emotional, and personal development of the children, these being key factors for the promotion of peaceful conflict-resolution strategies from an early stage.

Chronic Pseudomonas aeruginosa infections play an important role in the progress of lung disease in patients suffering from cystic fibrosis (CF). Recent studies indicate that polymicrobial microbiome profiles in the airway are associated with less inflammation. Thus, the hypothesis was raised that certain commensal bacteria might protect the host from inflammation. We therefore performed a screening study with commensals isolated from CF airway microbiome samples to identify potential beneficial commensals. We isolated more than 80 aerobic or facultative anaerobic commensal strains, including strains from genera Streptococcus, Neisseria, Actinomyces, Corynebacterium, Dermabacter, Micrococcus and Rothia. Through a screening experiment of co-infection in human epithelial cell lines, we identified multiple commensal strains, especially strains belonging to Streptococcus mitis, that reduced P. aeruginosa triggered inflammatory responses. The results were confirmed by co-infection experiments in ex-vivo precision cut lung slices (PCLS) from mice. The underlying mechanisms of the complex host-pathogen-commensal crosstalk were investigated from both the host and the bacterial sides with a focus on S. mitis. Transcriptome changes in the host in response to co-infection and mono-infection were evaluated, and the results indicated that several signalling pathways mediating inflammatory responses were downregulated by co-infection with S. mitis and P. aeruginosa compared to P. aeruginosa mono-infection, such as neutrophil extracellular trap formation. The genomic differences among S. mitis strains with and without protective effects were investigated by whole genome sequencing, revealing genes only present in the S. mitis strains showing protective effects. In summary, through both in vitro and ex vivo studies, we could identify a variety of commensal strains that may reduce host inflammatory responses induced by P. aeruginosa infection. These findings support the hypothesis that CF airway commensals may protect the host from inflammation.

No description available.

La conception traditionnelle de la notion de sanction pénale est fondée sur un critère fonctionnel que l'on peut synthétiser en deux axiomes : seule la sanction pénale est punitive et toutes les sanctions pénales sont punitives. Cette conception conduit à l'assimilation de la notion de sanction pénale à celle de peine. L'hypothèse de cette réflexion est d'envisager si l'on peut se départir de cette conception en vérifiant si le critère matériel sur lequel elle repose est toujours pertinent. La première partie de la thèse tend à démontrer que le critère fonctionnel traditionnel est remis en cause dès lors que sa confrontation aux données du droit positif contemporain révèle un dualisme de conception de la fonction punitive. En effet, le droit commun interne et le droit des droits de l'homme n'admettent pas une conception unitaire de cette fonction ce qui conduira à un éclatement du jus puniendi qui rend obsolète le critère traditionnel. La seconde partie met en exergue l'admission d'un critère moderne unitaire de la notion de sanction pénale. En effet, le renouvellement du type de sanction à la marge de cette notion, allié à l'établissement d'un critère commun d'exclusion de ces sanctions de la sanction pénale, permettent d'établir que le droit positif contemporain (c'est-à-dire celui ayant pleinement assimilé le dualisme normatif qui prévaut désormais en droit pénal) admet désormais un critère moderne : la nature spécifique de l'intérêt bénéficiaire de la sanction pénale. Le renouvellement du critère permet alors in fine de poser une nouvelle définition de la sanction pénale et de proposer une justification à ses évolutions contemporaines. / The traditional conception of the notion of criminal penalty is based on a functional criterion that can be synthesized in two axioms: only the criminal penalty is punitive and all criminal penalties are punitive. This conception leads to the assimilation of the notion of criminal sanction penalty to that of punishment. The hypothesis of this analysis is to consider whether one can abandon this conception by checking whether the material criterion on which it relies is still relevant. The first part of the thesis tends to demonstrate that the traditional functional criteria is challenged when confronted with contemporary positive law data. It reveals a dualism of conception of the punitive function. Indeed, the internal common law and the law of human rights do not admit a unitary conception of this function which will lead to a split of jus puniendi which obsoletes the traditional criterion. The second part highlights the acceptance of a modern unitary criterion of the criminal penalty notion. Indeed, the renewal of the type of penalty at the edges of this concept, combined with the establishment of a common exclusion criterion of these penalties from the criminal penalty enable to establish that contemporary positive law (that is to say that having fully assimilated the normative dualism that now prevails in criminal law) now admits a modern criterion: the specific nature of the beneficial interest of the criminal penalty. The renewal of the criterion in fine therefore allows to consider a new definition of the criminal sanction and provides a justification for its contemporary developments.

Local authorities exist to promote the social, economic, environmental, and cultural wellbeing of communities. Parks provide a means of achieving this purpose. This study investigates community preferences for Christchurch parks using the Beneficial Outcomes Approach. Outcomes desired by the community are identified, together with the park settings required to achieve them. Different attitudes and preferences of three socio-economic areas are compared. Information was gathered from a household survey of 600 residents from three diverse socioeconomic areas of Christchurch selected by using the New Zealand Deprivation Index. Results show that the overwhelming majority of Christchurch residents regularly use Christchurch parks for a diverse range of activities. Parks fill many different roles associated with the activity, aesthetic and environmental values ascribed to parks by the Christchurch community. The Christchurch community perceives and wants a diverse range of personal, social/cultural, environmental, and economic benefits from parks. Differences were found between the three socio-economic areas in the way they valued and used parks. Respondents from the low socio-economic area were more inclined to use parks as a special place to visit for weekend outings and relaxation in contrast to respondents from the high socio-economic area who were more likely to use parks for daily exercise. Respondents from the medium socio-economic area had mixed use patterns. The study concludes that a city-wide network approach to park provision is required to cater for the diverse range of experiences, settings and activities preferred by the Christchurch community and to optimise the beneficial outcomes of Christchurch parks. The BOA provides a useful method of prioritising outcomes and guiding management actions to be more responsive to community needs.

Frugivorous insects, specialised herbivores that consume fruit and seeds, are considered detrimental to host plant fitness. Their direct link to genetic fitness via consumption of plant reproductive tissue, and their negative socioeconomic association with agriculture exacerbates their harmful status. However, empirical testing of insect frugivore effects on host plants, and ecological research on the contribution of insect frugivores to multitrophic frugivory systems, is lacking. In the current study, direct effects of a non-mutualistic, insect frugivore/host plant system were tested and results showed variable effects. Beneficial, detrimental, but predominantly neutral effects on germination and seed production were observed between the Queensland fruit fly (Bactrocera tryoni) and tomato and capsicum plants. Significant effects on seed production were unexpected because infestation occurs after seed set. It was also found that eggplant, although a recorded host of B. tryoni, is inconsistent in its ability to sustain B. tryoni larvae through to its final instar. These results confirmed a simplification and presumption associated with insect frugivore (specifically fruit fly)/host plant interactions. Larval movement, infestation-induced fruit decay, pulp removal and germination were then investigated. For all hosts (tomato, apple and paw paw), treatments infested by B. tryoni decayed significantly quicker and to a greater extent than uninfested treatments, with obvious but variable changes to the texture and appearance. The movement of B. tryoni larvae, pattern of infestation-induced decay and pulp removal was unique and host dependent for all hosts. Only seeds from infested tomato were shown to germinate during the experiment. This indicated that host fruit characteristics are responsible, in part, for variable direct effects on host plant fitness by insect frugivores. Variable direct effects between insect frugivores and host plants, combined with the more rapid decay of infested fruits is likely to have implications for seed dispersal and seed predation by a third trophic level. The characteristics of fruit that are changed by infestation by an insect frugivore were then tested for their effect on a vertebrate frugivore, to illustrate the importance of recognising multitrophic interactions and indirect effects in frugivory. Specifically, seed predating rodents were incorporated into the study and their response to infested and uninfested fruits were recorded, as well as their reaction to the changes in fruit caused by insect frugivores (i.e. texture, smell, larvae presence and sound). Apple and pear infested with B. tryoni larvae were found to attract rodents, while infested tomato and paw paw had a neutral effect on the native rats. This differed from the predominant finding in the literature, which was a deterrent effect on avian seed dispersers. Vertebrate response to fruit infested with insect frugivores therefore, is variable. Assessing the indirect effect of insect frugivores on host plant fitness by attracting or deterring another trophic level requires knowledge of the direct effect between the introduced trophic level and the host plant. For example, the attraction of a seed predator may be as detrimental to host plant fitness as the deterrence of a seed disperser. This illustrates the complexity associated with assessing insect frugivore effects on host plant fitness. Results also indicated that differences in pulp texture, caused by infestation, have a significant effect on rodent preference for infested or uninfested treatments. Pulp texture is likely to effect rodent foraging efficiency, whereas the presence of B. tryoni larvae was observed to be inconsequential to rodent response to fruits. For rodents, and indeed any trophic level motivated by foraging efficiency, this finding raises the issue that for long lived fruiting plants, outside factors such as food abundance and competition for food, may cause a variable response to fruits infested by insect frugivores. From these investigations it has become apparent that insect frugivores are not consistently harmful to host plant fitness, as suggested by their negative stigma, but are likely to contribute variable effects, directly and indirectly, on multiple components of plant fitness and multitrophic frugivory systems.

The potato (Solanum tuberosum L.) has great importance in human nutrition where it occupies the fourth place among the most consumed foods in the world. It is a highly demanding culture technology especially in the nutritional point of view. Despite the titanium (Ti) is not considered a nutrient, studies have shown beneficial effects of this element when applied to plants. The application of Ti leaf can be an alternative for this element is slightly movable in the soil and is generally present in insoluble forms. Thus, the objective was to evaluate the influence of application rates of Ti foliar in the potato crop. We conducted an experiment in the period from August to November 2014, installed at the experimental station Udi Pesquisa e Development in Uberlândia-MG, with kind Ágata. Variables related to metabolism were evaluated: SPAD chlorophyll content, nitrate reductase activity (NRA), lipid peroxidation (LP), urease, proline, catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD). Nutritional factors such as levels of nutrients nitrogen (N), copper (Cu), iron (Fe), manganese (Mn) and zinc (Zn) present in leaves and tubers were measured stages of growth, tuber and tuber filling. At the end of the crop cycle was quantified the average mass, diameter, commercial classification and productivity of tubers. The design was a randomized block design with four replications and six treatments. The supply of the Ti compound fertilizer was through for 5% of magnesium oxide, 10% sulfur trioxide and 0,85% titanium complex and the treatments was: T1 - without the application of Ti, T2 -10.2; T3 - 15.3; T4 - 20.4; T5 - 22.9 and T6 - 25.5 g Ti ha-1 divided into three equal applications during the growth phase, tuber and tuber filling. It was concluded that in the growth phase the foliar application of Ti reduces the Mn content in the leaves and there is increased activity of POD and ANR and reduced urease activity. In the tuberization phase the Fe absorption, SOD activity and POD response to increasing Ti dose. In tubers filling stage foliar application of Ti increases chlorophyll levels (Spad value). The application of Ti in the leaf growth stages, tuber and tuber filler results in a lower Zn content in the tubers. The average tuber weight, the average diameter of tubers and the total productivity of tubers are affected by foliar application of Ti. The dose Ti foliar applied for further tuber yield is 5.74 g Ti ha-1. / A batata (Solanum tuberosum L.) tem grande importância na alimentação humana onde ocupa o quarto lugar entre os alimentos mais consumido no mundo. É uma cultura altamente exigente em tecnologias especialmente sob o ponto de vista nutricional. Apesar do titânio (Ti) não ser considerado um nutriente, trabalhos demonstram efeitos benéficos deste elemento quando aplicado às plantas. A aplicação de Ti foliar pode ser uma alternativa pois este elemento é pouco móvel no solo e geralmente está presente em formas insolúveis. Desta forma, objetivou-se avaliar a influência da aplicação de doses de Ti via foliar na cultura da batata. Realizou-se um experimento no período de agosto a novembro de 2014, instalado na estação experimental Udi Pesquisa e Desenvolvimento em Uberlândia-MG, com utilização da cultivar Ágata. As variáveis relacionadas ao metabolismo avaliadas foram: teor clorofila SPAD, atividade da nitrato redutase (ANR), peroxidação lipídica (PL), urease, prolina, catalase (CAT), superóxido desmutase (SOD) e peroxidase (POD). Aspectos nutricionais como os teores dos nutrientes nitrogênio (N), cobre (Cu), ferro (Fe), manganês (Mn) e zinco (Zn) presentes em folhas e tubérculos foram mensurados fases de crescimento, tuberização e enchimento de tubérculos. Ao final do ciclo da cultura foi quantificada a massa média, diâmetro médio, classificação comercial e a produtividade dos tubérculos. O delineamento foi o de blocos casualizados, com quatro repetições e seis tratamentos. O fornecimento do Ti foi através de fertilizante composto por 5% de óxido de magnésio, 10% de trioxido enxofre e 0,85% de complexo de titânio com os seguintes tratamentos: T1 sem aplicação de Ti, T2 -10,2; T3 -15,3; T4 - 20,4; T5 - 22,9 e T6 - 25,5 g de Ti ha-1 divididos em três aplicações iguais durante a fase de crescimento, tuberização e enchimento de tubérculos. Concluiu-se que os teores de Cu não são influenciados pelas doses de Ti nas fases avaliadas. Na fase de crescimento a aplicação foliar de Ti reduz o teor de Mn nas folhas e há aumento da atividade da POD e ANR e redução da atividade da urease. Na fase de tuberização a absorção de Fe e atividade de enzimas SOD e POD tem resposta ao aumento da dose de Ti. Na fase de enchimento de tubérculos a aplicação foliar de Ti incrementa os teores de clorofila (valor Spad). A aplicação de Ti foliar nas fases de crescimento, tuberização e enchimento de tubérculos resulta em menor teor de Zn nos tubérculos. A massa média de tubérculos, o diâmetro médio de tubérculos e a produtividade total de tubérculos são influenciados pela aplicação foliar de Ti. A dose de Ti aplicada via foliar para maior produtividade de tubérculos é de 5,74 g de Ti ha-1. / Mestre em Agronomia

L'innovation financière tire avantage de la déconnexion entre forme juridique et substance économique. Les contrats financiers sur actions permettent de répliquer synthétiquement les attributs économiques de la propriété des actions sans organiser le transfert des droits sur la chose. Tandis que le droit des sociétés reconnaît le principe d'autonomie juridique des contrats financiers à l'égard des actions sous-jacentes en attribuant les droits politiques et pécuniaires de l'associé aux seuls titulaires de la propriété juridique des titres financiers, les principes directeurs du droit boursier conduisent à y faire exception face aux perturbations engendrées par ces techniques de dissociation de la forme juridique et de la substance économique. Affichant son pragmatisme, le régulateur boursier saisit la complexité de cette réalité dérivée pour appréhender, au-delà des catégories juridiques formelles, la substance économique des opérations réalisées. Le droit boursier adopte une approche substantielle de l'avoir et du pouvoir au sein des sociétés par actions, pour déterminer notamment l'application des régimes de déclaration des prises de participations significatives et d'offre publique obligatoire. Apparaissent alors les contours d'une méthode raisonnée de régulation de l'innovation financière en droit des sociétés cotées. La démarche que nous proposons opère tant ex ante sur le plan normatif qu'ex post au stade de la sanction. Elle suppose une réflexion d'ensemble sur l'élaboration de la norme en droit des sociétés cotées et les conditions de son application par le régulateur boursier. dans sa double fonction normative et contentieuse. / The dissociation of legal form and economic substance is one of the main drivers of financial innovation. Equity derivatives allow parties to replicate the economic substance of share ownership without transferring the legal title itself. Whereas corporate law acknowledges the autonomy of the financial contract with respect to the underlying shares by granting voting and dividend rights to their sole legal owner, core principles of securities regulation are challenged by transactions taking advantage of the dissociation between form and substance. Taking a pragmatic stance, the regulator addresses the complexity of this derivative reality by grasping the economic substance of such transactions beyond their mere legal form. Recent developments in the major shareholding notification regime and the mandatory tender offer rule indicate an increasing focus on the substance of beneficial ownership and voting power in listed companies. From this evolution emerge the contours of a regulatory approach aiming to tackle the specific issues raised by financial innovation. The approach we advocate operates both ex ante at the normative stage and ex post at the enforcement stage of the regulatory process. It is an invitation to rethink the determinants of securities regulation as well as the role of the securities regulator in the exercise of its dual power to establish norms and to impose sanctions.