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211	Физическая реабилитация лиц, перенесших COVID-19-ассоциированную пневмонию : магистерская диссертация / Physical rehabilitation of survivors of COVID-19-associated pneumonia Конюхова, Д. А., Konyukhova, D. A. January 2022 (has links) Значительная доля людей, столкнувшихся с коронавирусной инфекцией имеют осложнение в виде COVID-19-ассоциированной пневмонии и нуждаются в доступной и квалифицированной реабилитации. Цель работы - оценить влияние программы физической реабилитации на толерантность к физическим нагрузкам и функциональное состояние кардио-респираторной системы пациентов, перенесших COVID-19-ассоциированную пневмонию. В исследовании приняли 20 пациентов, перенесших COVID-19-ассоциированную пневмонию. В работе использовались следующие методы исследования: оценка толерантности к физической нагрузке оценивалась с помощью теста шестиминутной ходьбы, для оценки степени одышки после нагрузки использовалась шкала Борга, определяли сатурацию в покое и после проведения теста шестиминутной ходьбы, оценивалась частота сердечных сокращений до и после тестирования, а также выраженность одышки при повседневной деятельности оценивалась по шкале mMRC. Согласно полученным результатам, разработанная программа реабилитации повлияла на повышение толерантности к физическим нагрузкам, улучшение функционального состояния кардио-респираторной системы и субъективной переносимости физической нагрузки у пациентов, перенесших COVID-19-ассоциированную пневмонию. / A significant proportion of people who have experienced coronavirus infection have a complication in the form of COVID-19-associated pneumonia and need affordable and qualified rehabilitation. The aim of the work was to evaluate the impact of the physical rehabilitation program on exercise tolerance and the functional state of the cardio-respiratory system in patients who had undergone COVID-19-associated pneumonia. The study included 20 patients with COVID-19-associated pneumonia. Research methods were used in the work: assessment of exercise tolerance was assessed using a six-minute walk test, the Borg scale was used to assess the degree of dyspnea after exercise, saturation was determined at rest and after a six-minute walk test, heart rate was assessed before and after testing, as well as the severity of dyspnea during daily activities was assessed using the mMRC scale. According to the results obtained, the developed rehabilitation program influenced the increase in exercise tolerance, the improvement of the functional state of the cardio-respiratory system and the subjective exercise tolerance in patients who underwent COVID-19-associated pneumonia. ОДЫШКА «ДЛИТЕЛЬНЫЙ КОВИД» MASTER'S THESIS COVID-19-ASSOCIATED PNEUMONIA PHYSICAL REHABILITATION SHORTNESS OF BREATH «LONG COVID» RESPIRATORY REHABILITATION
212	Study on the analysis of gastrointestinal positional variations and the efficacy of online adaptive radiation therapy for improving the treatment outcomes of locally advanced pancreatic cancer / 局所進行膵癌に対する放射線治療成績の向上を目的とした消化管位置の変動解析と即時適応放射線治療の有用性に関する研究 Ogawa, Ayaka 25 September 2023 (has links) 京都大学 / 新制・課程博士 / 博士(医学) / 甲第24884号 / 医博第5018号 / 新制\|\|医\|\|1068(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授鈴木実, 教授小濱和貴, 教授中島貴子 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM GI bleeding dosimetric analysis pancreatic cancer PRV margin fiducial marker adaptive radiotherapy cone-beam CT pancreatic cancer dosimetric analysis breath-hold 490
213	From tranquilising to transforming : How can yoga practices address systemic patterns of oppression in order to cultivate liberation? Gobillot, Chloé January 2023 (has links) This study is an exploration of the practices of yoga teachers whose approaches are inscribed in social justice. Indeed, it attempts to understand how they find cohesion between a complex and spiritual discipline and their commitment to participate in anti-oppression. Moreover, it looks at the ways they believe yoga can be used for collective liberation. It is autoethnographical, and is based on semi-qualitative interviews which are then analysed thematically. Furthermore, it is analytically framed within theories of intersectionality, affective knowledge and teaching, solidarity and language, and critical future and utopian studies. The analysis then focuses on the teachers’ understanding of yogic practices andphilosophies before unveiling the ways they address and/or avoid issues of oppression and looking at the ways they envision yoga as a tool for collective liberation. affective knowledge affective teaching asana autoethnography breath collective liberation critical future studies critical utopian studies intersectionality language meditation mindfulness oppression solidarity yoga Gender Studies Genusstudier
214	Terahertz Molecular Spectroscopy as a Tool for Analytical Probing of Cellular Metabolism Paul, Mitchell Cameron 30 August 2017 (has links) No description available. Biology Biophysics Cellular Biology Physics Biomedical Research Biomedical Engineering Terahertz THz spectroscopy metabolism cell culture sensor analytical breath analysis molecular acetaldehyde ethanol methanol formaldehyde rotational
215	Generalized estimation of the ventilatory distribution from the multiple‑breath nitrogen washout Motta-Ribeiro, Gabriel Casulari, Jandre, Frederico Caetano, Wrigge, Hermann, Giannella-Neto, Antonio 10 August 2016 (has links) (PDF) Background: This work presents a generalized technique to estimate pulmonary ventilation-to-volume (v/V) distributions using the multiple-breath nitrogen washout, in which both tidal volume (VT) and the end-expiratory lung volume (EELV) are allowed to vary during the maneuver. In addition, the volume of the series dead space (vd), unlike the classical model, is considered a common series unit connected to a set of parallel alveolar units. Methods: The numerical solution for simulated data, either error-free or with the N2 measurement contaminated with the addition of Gaussian random noise of 3 or 5 % standard deviation was tested under several conditions in a computational model constituted by 50 alveolar units with unimodal and bimodal distributions of v/V. Non-negative least squares regression with Tikhonov regularization was employed for parameter retrieval. The solution was obtained with either unconstrained or constrained (VT, EELV and vd) conditions. The Tikhonov gain was fixed or estimated and a weighting matrix (WM) was considered. The quality of estimation was evaluated by the sum of the squared errors (SSE) (between reference and recovered distributions) and by the deviations of the first three moments calculated for both distributions. Additionally, a shape classification method was tested to identify the solution as unimodal or bimodal, by counting the number of shape agreements after 1000 repetitions. Results: The accuracy of the results showed a high dependence on the noise amplitude. The best algorithm for SSE and moments included the constrained and the WM solvers, whereas shape agreement improved without WM, resulting in 97.2 % for unimodal and 90.0 % for bimodal distributions in the highest noise condition. Conclusions: In conclusion this generalized method was able to identify v/V distributions from a lung model with a common series dead space even with variable VT. Although limitations remain in presence of experimental noise, appropriate combination of processing steps were also found to reduce estimation errors. Lungenfunktionstest Atmung Multiple-Breath-Washout Gasauswaschverfahren Lungenvolumen Ausatmen Funktionelle Residualkapazität (FRC) Totraum Lunge Stickstoff Atemvolumen Tikhonov-Regularisierung Pulmonary function tests Ventilatory distributions Multiple-breath washout End-expiratory lung volume Functional residual capacity Dead space Nitrogen Ventilation to volume Tikhonov regularization Common dead space ddc:610
216	From Macro to Nano : Electrokinetic Transport and Surface Control Pardon, Gaspard January 2014 (has links) Today, the growing and aging population, and the rise of new global threats on human health puts an increasing demand on the healthcare system and calls for preventive actions. To make existing medical treatments more efficient and widely accessible and to prevent the emergence of new threats such as drug-resistant bacteria, improved diagnostic technologies are needed. Potential solutions to address these medical challenges could come from the development of novel lab-on-chip (LoC) for point-of-care (PoC) diagnostics. At the same time, the increasing demand for sustainable energy calls for the development of novel approaches for energy conversion and storage systems (ECS), to which micro- and nanotechnologies could also contribute. This thesis has for objective to contribute to these developments and presents the results of interdisciplinary research at the crossing of three disciplines of physics and engineering: electrokinetic transport in fluids, manufacturing of micro- and nanofluidic systems, and surface control and modification. By combining knowledge from each of these disciplines, novel solutions and functionalities were developed at the macro-, micro- and nanoscale, towards applications in PoC diagnostics and ECS systems. At the macroscale, electrokinetic transport was applied to the development of a novel PoC sampler for the efficient capture of exhaled breath aerosol onto a microfluidic platform. At the microscale, several methods for polymer micromanufacturing and surface modification were developed. Using direct photolithography in off-stoichiometry thiol-ene (OSTE) polymers, a novel manufacturing method for mold-free rapid prototyping of microfluidic devices was developed. An investigation of the photolithography of OSTE polymers revealed that a novel photopatterning mechanism arises from the off-stoichiometric polymer formulation. Using photografting on OSTE surfaces, a novel surface modification method was developed for the photopatterning of the surface energy. Finally, a novel method was developed for single-step microstructuring and micropatterning of surface energy, using a molecular self-alignment process resulting in spontaneous mimicking, in the replica, of the surface energy of the mold. At the nanoscale, several solutions for the study of electrokinetic transport toward selective biofiltration and energy conversion were developed. A novel, comprehensive model was developed for electrostatic gating of the electrokinetic transport in nanofluidics. A novel method for the manufacturing of electrostatically-gated nanofluidic membranes was developed, using atomic layer deposition (ALD) in deep anodic alumina oxide (AAO) nanopores. Finally, a preliminary investigation of the nanopatterning of OSTE polymers was performed for the manufacturing of polymer nanofluidic devices. / <p>QC 20140509</p> / Rappid / NanoGate / Norosensor microsystem nanosystem microfluidic nanofluidic surface modification surface property electrokinetics model simulation material polymer thiol-ene microfabrication nanofabrication micromanufacturing nanomanufacturing breath sampling aerosol precipitation corona discharge electrostatic precipitation grafting chemistry click chemistry nanopore nanoporous membrane photolithography photopatterning photografting microfluidics nanofluidics oste OSTE+ OSTEmer lab-on-chip loc point-of-care poc biocompatibility diagnostics breath analysis fuel cell
217	Monitorování dechu během terapie pacientů / Breath monitoring during motion therapy Koťová, Markéta January 2013 (has links) This semestral thesis deals with continuous monitoring of pulmonary ventilation during the patients' theraphy and focuses especially on monitoring of their ventilation processes. It is necessarry to detect, monitor and differentiate abdominal and thoracic breathing during the theraphy. This thesis describes the very basic and common method, a spirometry. Next, an overview of more advanced state-of-the-art methods based on both, tactile and proximity principles is given. In addition to that, two recently developed methods by BUT are discussed as well -- a tactile-based measurement similar to blood pressure sensor and a proximity-based measurement method employing TOF cameras. The data acquired by these two methods are proccesed and examined in order to evaluate and justify their performance in a real application.
218	Generalized estimation of the ventilatory distribution from the multiple‑breath nitrogen washout Motta-Ribeiro, Gabriel Casulari, Jandre, Frederico Caetano, Wrigge, Hermann, Giannella-Neto, Antonio January 2016 (has links) Background: This work presents a generalized technique to estimate pulmonary ventilation-to-volume (v/V) distributions using the multiple-breath nitrogen washout, in which both tidal volume (VT) and the end-expiratory lung volume (EELV) are allowed to vary during the maneuver. In addition, the volume of the series dead space (vd), unlike the classical model, is considered a common series unit connected to a set of parallel alveolar units. Methods: The numerical solution for simulated data, either error-free or with the N2 measurement contaminated with the addition of Gaussian random noise of 3 or 5 % standard deviation was tested under several conditions in a computational model constituted by 50 alveolar units with unimodal and bimodal distributions of v/V. Non-negative least squares regression with Tikhonov regularization was employed for parameter retrieval. The solution was obtained with either unconstrained or constrained (VT, EELV and vd) conditions. The Tikhonov gain was fixed or estimated and a weighting matrix (WM) was considered. The quality of estimation was evaluated by the sum of the squared errors (SSE) (between reference and recovered distributions) and by the deviations of the first three moments calculated for both distributions. Additionally, a shape classification method was tested to identify the solution as unimodal or bimodal, by counting the number of shape agreements after 1000 repetitions. Results: The accuracy of the results showed a high dependence on the noise amplitude. The best algorithm for SSE and moments included the constrained and the WM solvers, whereas shape agreement improved without WM, resulting in 97.2 % for unimodal and 90.0 % for bimodal distributions in the highest noise condition. Conclusions: In conclusion this generalized method was able to identify v/V distributions from a lung model with a common series dead space even with variable VT. Although limitations remain in presence of experimental noise, appropriate combination of processing steps were also found to reduce estimation errors. info:eu-repo/classification/ddc/610 ddc:610
219	Performance of two different types of inhalers : influence of flow and spacer on emitted dose and aerodynamic characterisation Almeziny, Mohammed Abdullah N. January 2009 (has links) This thesis is based around examination of three mainstream inhaled drugs Formoterol, Budesonide and Beclomethasone for treatment of asthma and COPD. The areas investigated are these which have been raised in reports and studies, where there are concern, for drug use and assessment of their use. In reporting this work the literature study sets out a brief summary of the background and anatomy and physiology of the respiratory system and then discuses the mechanism of drug deposition in the lung, as well as the methods of studying deposition and pulmonary delivery devices. This section includes the basis of asthma and COPD and its treatment. In addition, a short section is presented on the role of the pharmacist in improving asthma and COPD patient's care. Therefore the thesis is divided into 3 parts based around formoterol, budesonide and beclomethasone. In the first case the research determines the in-vitro performance of formoterol and budesonide in combination therapy. In the initial stage a new rapid, robust and sensitive HPLC method was developed and validated for the simultaneous assay of formoterol and the two epimers of budesonide which are pharmacologically active. In the second section, the purpose was to evaluate the aerodynamic characteristics for a combination of formoterol and the two epimers of budesonide at inhalation flow rates of 28.3 and 60 L/min. The aerodynamic characteristics of the emitted dose were measured by an Anderson cascade impactor (ACI) and the next generation cascade impactor (NGI). In all aerodynamic characterisations, the differences between flow rates 28.3 and 60 were statistically significant in formoterol, budesonide R and budesonide S, while the differences between ACI and NGI at 60 were not statistically significant. Spacers are commonly used especially for paediatric and elderly patients. However, there is considerable discussion about their use and operation. In addition, the introduction of the HFAs propellants has led to many changes in the drug formulation characteristics. The purpose of the last section is to examine t h e performance of different types of spacers with different beclomethasone pMDIs. Also, it was to examine the hypothesis of whether the result of a specific spacer with a given drug/ brand name can be extrapolated to other pMDIs or brand names for the same drug. The results show that there are different effects on aerodynamic characterisation and there are significant differences in the amount of drug available for inhalation when different spacers are used as inhalation aids. Thus, the study shows that the result from experiments with a combination of a spacer and a device cannot be extrapolated to other combination. 615.19
220	Skyddande enhet till kontaktlös alkoholmätare för utomhusbruk : Fallstudie och konstruktion av skyddande enhet Oderstad, Hampus, Heikinaho, William January 2016 (has links) No description available. alkoholmätare alkomätare alkosensor IR-teknologi infraröd infraröd sensor kontaktlös breath alcohol analyzer skyddande enhet utomhusbruk NDIR vattenavvisande konstruktion aerodynamik identifikationsmoduler identifikationspassager IR sensor NDIR antropometri ergonomi IR teknologi

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