This study aims mainly to investigate what kind of role the public library plays in the regional and local development. The aim is also to investigate how the public library can strengthen the role as a factor of regional and local development. To explore the subject, the study is focused on the Swedish region of Västra Götaland. Three officials along with two policy documents, are included in the study as representatives of the region. Four public library managers are also interviewed but as representatives of the local perspective. To investigate the role of the public library in the regional and local development in more than one dimension, the theoretical framework consists of three different theories, which are used to answer the three research questions of the study. A qualitative analysis is performed to examine the relationships between the rhetorical statements and the theories. The study reveals that the major motives of the public library to work with regional and local development, are following the labels of the theory, the motive of enlightment and the motive of social issues. The study also shows that several functions of the public library, such as being a center of knowledge, a center of culture and a center of social issues, are particularly linked to the regional and local development. It is also clear that the public libraries of Västra Götaland, have the potentials to develop into more powerful factors in the regional and local development. / Program: Bibliotekarie

Taiwan is a small island and there are more than 90% of the ex/import trade of the country is dominated by the shipping transportation. The shipping transportation is very important to the existence and development of the country. Taiwan and China being an official member of WTO since from the year 2002, the coastal shipping transportation between Taiwan and China is still very busy and even if more frequent than before. The direct navigation between Taiwan and China ports is still strict prohibited by the Taiwan government. All the ships must be direct sailing for the third port such as Hong Kong, Ishigaki Jima, Busan for only port clearance purpose after sailed from China or Taiwan ports, vice versa. The exact effect of the mini three links between China and Taiwan is quite limited, when the major three links will come true is still unclear under the political issue across the Taiwan Strait so far. Taiwan shipping industry is encountering some challenges or obstacles in the current circumstance regarding how to penetrate or break through the existing barriers to be successfully survived in the market or develop their business connection in China those are either coming from Taiwan government or China administration being installed to the Taiwan shipping forwarders. Shipping industry is including the ship owners¡Bshipping agents¡Bfreight forwarders (NVOCC). This study will explore the result of the Taiwan shipping industry can better utilize the company¡¦s core competence to smooth run the business in Taiwan and develop its connection in mainland China. Will use Hansen Group as an individual case by using the company¡¦s strategy of its several different stream business divisions to ¡§think global, act locally¡¨, standing in Taiwan¡Bgo to China and take the world.

Made available in DSpace on 2014-12-17T14:46:46Z (GMT). No. of bitstreams: 1 ArieliRNV_DISSERT.pdf: 3124518 bytes, checksum: 88ff5a950b92b75eb57a80c80671484c (MD5) Previous issue date: 2010-10-22 / Hansen's disease, despite significant advances regarding the diagnosis, treatment and control still carries an immense burden of stigma as a result, mainly of its socio-historical marked by prejudice and isolation of patients, translated by suffering, abandonment and psychosocial problems. Thus, the study set out to rescue the life stories of former leprosy patients with a leprosarium history; recovering the life trajectory stories of these former patients and to identify common factors to these life stories. Exploratory-descriptive study with a qualitative approach, using the Life History Research Methodology. The sample was composed by twelve former leprosy patients who lived while undergone treatment in the Colony Hospital St. Francisco de Assis, located in Natal, Rio Grande do Norte. The network was composed without considering sex and age limit, patients that lived in the Colony Hospital for at least six months and who agree to participate freely in the study. The subjects with special physical needs (hearing) or mental disabilities and those who do not agree to participate were excluded. A semi-structured interview was used to data collection, the interviews were recorded in the household context of individual, residents in neighborhoods Felipe Camar?o, Km 6 and Jardim America, more precisely at Nova Vida village, all located in that district. The data collected were subjected to the technique of thematic content analysis. This study had obtained an appropriate consent of the UFRN Research Ethics Committee under the protocol No. 016/2010. After extensive and careful readings of life stories we identified three themes that guided the data analysis: behavioral stages, social exclusion and, stigma and prejudice. Thus, it is clear that the practice of compulsory confinement of patients in nursing homes and the mythical image of Hansen's disease as being ugly and deformed, contributed to solidifying the historical stigma surrounding the disease and its patients, raising in society and family attitudes and feelings of exclusion, prejudice and fear. Moreover, there are remarkable stories in the lives of these interviewed reporting suffering, denials, anger that reverberate to this day, affecting negatively the social and family reintegration of these individuals. As a result, we see the need for managers and local health professionals, especially nurses, rethink existing strategies for social rehabilitation of the patient and ex-leprosy patient aiming to suppression unjust and harmful stigma rooted in image and stories of these individuals / A hansen?ase, apesar dos significativos avan?os no que concerne a seu diagn?stico, ao controle e tratamento, ainda hoje apresenta uma carga incomensur?vel de estigma em consequ?ncia, principalmente, de sua constru??o s?cio-hist?rica, marcada pelo preconceito e o isolamento dos doentes, traduzidos pelo sofrimento, abandono e pelos problemas psicossociais. Destarte, o estudo objetivou resgatar a trajet?ria de vida de ex-portadores de hansen?ase com hist?rico asilar, recuperar as hist?rias da trajet?ria de vida desses ex-portadores e identificar os fatores comuns a essas hist?rias de vida. Estudo explorat?rio-descritivo, com abordagem qualitativa, utilizando-se como referencial metodol?gico a hist?ria oral de vida. A col?nia do estudo foi formada por doze ex-portadores de hansen?ase que foram asilados na Col?nia S?o Francisco de Assis, locado no munic?pio de Natal, Rio Grande do Norte. A rede foi composta por colaboradores independentes do sexo e sem idade limite m?ximo, que viveram na Col?nia por um per?odo m?nimo de seis meses e, que concordarem em participar livremente do estudo. Foram exclu?dos da rede colaboradores portadores de necessidades f?sicas (audi??o) ou mentais e, que n?o concordarem em participar do estudo. Como instrumento de coleta de dados, utilizou-se a entrevista semiestruturada, gravada individualmente em contexto domiciliar dos colaboradores, residentes nos bairros Felipe Camar?o, Km 6 e Jardim Am?rico, mais precisamente no Conjunto Nova Vida, todos situados no referido munic?pio. Os dados foram analisados segundo a t?cnica de an?lise de conte?do tem?tica. O estudo foi aprovado pelo Comit? de ?tica em Pesquisa da Universidade Federal do Rio Grande do Norte, sob parecer de n? 016/2010. Ap?s sucessivas e cuidadosas leituras das hist?rias de vida foram identificados tr?s eixos tem?ticos norteadores da an?lise dos dados: est?gios comportamentais, exclus?o social e, estigma e preconceito. Dessa forma, percebeu-se que a pr?tica do confinamento compuls?rio dos enfermos em institui??es asilares concomitante a imagem m?tica do leproso como ser repulsivo e deformado, contribuiu para solidifica??o hist?rica do estigma em torno da doen?a e do doente, despertando na sociedade e na fam?lia atitudes e sentimentos de exclus?o, preconceito e medo. Ademais, observou-se nas hist?rias de vidas dos colaboradores relatos marcantes de sofrimento, nega??o, rejei??o, revolta que repercutem at? os dias atuais, interferindo negativamente na reintegra??o social e familiar desses indiv?duos. Com isso, aponta-se a necessidade de gestores e profissionais locais da sa?de, sobretudo enfermeiros, de repensarem as estrat?gias vigentes de reabilita??o social do doente e ex-doente de hansen?ase, visando ? supress?o de uma estigmatiza??o injusta e nociva enraizada na imagem e hist?ria de vida desses indiv?duos

Made available in DSpace on 2014-12-17T14:46:49Z (GMT). No. of bitstreams: 1 VivianneRCS_DISSERT.pdf: 1496250 bytes, checksum: f09db27c037244a4e229920d59aea10a (MD5) Previous issue date: 2011-11-24 / Leprosy is an ancient disease that still stands as a public health problem worldwide, especially in the considered developing countries. Of these, Brazil still has large areas of endemicity. The disease remains high among those younger than 15 years old. In this group, the national index achieves 0.6 every 10 000 inhabitants and reaches 2 in the North and Midwest of Brazil. Therefore, the plan of the Ministry of Health is to prioritize the fight against disease in critical areas, providing early diagnosis and timely treatment, especially for patients under 15 years old. This research aimed to: identify the knowledge of students from three schools of basic education in Parnamirim/RN about the risk of getting ill in leprosy; conduct them health education on this topic. An exploratory-descriptive study with quantitative and qualitative nature. Data collection consists of two steps: questionnaire and health education on leprosy. The study was approved by the Research Ethics Committee (REC) of UFRN through the opinion n? 204/2009. Quantitative data obtained were organized, categorized, typed and submitted to the Microsoft Office - Excel for quantitative analysis with simple percentage. Qualitative data were subjected to a content analysis according to Bardin. The sample consisted of 164 students of basic education, most of which is: 1st year of high school, from 11 to 15 years, in the afternoon shift, female gender, skin color white and residents in the municipality of Parnamirim/RN. Still, each student living with four people curiously did not respond in relation to occupation of the father. But the same answered their mother as a housewife and a family income of one to less than four minimum wages. There have been significant results compared the performance of health education in leprosy. Initially, students possessed little knowledge about leprosy. Subsequent to health education, most knew the answer about the disease, transmission, cause, where to get help in case of suspicion of leprosy and the need for the people who lives with leprosy patients to also seek for help, the understanding about if it is treatable or not. Content analysis has established the following themes: axis I, what I do not know about leprosy: cure, fear and prejudice. Axis II, what I know about leprosy, we identified: cure, effectiveness of health education and social exclusion in the past. It is considered the scope of the proposed objectives by matching the effectiveness of health education on leprosy in basic education in Parnamirim/RN; emphasizes, therefore, the importance of understanding the knowledge of public school students. It is expected of them to detect early cases of leprosy in their communities; encourage adherence to treatment as quickly as possible; prevent disability; reduce the stigma surrounding the disease. / A hansen?ase ? uma doen?a milenar que ainda figura como um problema de sa?de p?blica no mundo, principalmente nos pa?ses considerados em desenvolvimento. Dentre estes, o Brasil ainda apresenta ?reas de grande endemicidade. A doen?a se mant?m alta entre os menores de 15 anos. Nesse grupo, o ?ndice nacional alcan?a 0,6 a cada 10 mil habitantes e chega a 2 nas Regi?es Norte e Centro-Oeste. Por isso, o plano do Minist?rio da Sa?de consiste em priorizar o combate ? doen?a nas ?reas cr?ticas, oferecendo diagn?stico precoce e tratamento oportuno, especialmente aos pacientes com menos de 15 anos. Esta pesquisa teve como objetivos: identificar o conhecimento dos estudantes de tr?s escolas da educa??o b?sica de Parnamirim/RN sobre o risco de adoecer em hansen?ase; realizar educa??o em sa?de sobre o tema para esses estudantes. Estudo do tipo explorat?rio descritivo e de natureza quantiqualitativa. A coleta dos dados comp?s-se de duas etapas: question?rio e educa??o em sa?de sobre hansen?ase. O estudo foi aprovado pelo Comit? de ?tica em Pesquisa (CEP) da UFRN por meio do Parecer de n.? 204/2009. Os dados quantitativos obtidos foram organizados, categorizados, digitados e submetidos ao programa Microsoft Office Excel para an?lise quantitativa com percentagem simples. Os dados qualitativos foram submetidos ? an?lise de conte?do de acordo com Bardin. Entrevistaram-se 164 alunos da educa??o b?sica, sendo que a maioria era: do 1? ano do ensino m?dio, com 11 at? 15 anos, do turno vespertino, do sexo feminino, de cor da pele branca, residentes no Munic?pio de Parnamirim/RN. E, ainda, cada estudante convivendo com quatro pessoas, curiosamente n?o responderam em rela??o ? profiss?o do pai, mas da m?e como dona de casa, e renda familiar de 1 a menos de 4 sal?rios m?nimos. Observaram-se resultados significativos em compara??o ? realiza??o da educa??o em sa?de em hansen?ase. Inicialmente, os alunos detinham pouco conhecimento a respeito da hansen?ase. Posteriormente ? educa??o em sa?de, a maioria soube responder sobre a doen?a, a transmiss?o, a causa, onde procurar ajuda em caso de suspeita de hansen?ase e da necessidade das pessoas que convivem com o doente de hansen?ase tamb?m procurarem ajuda, al?m da compreens?o de que a doen?a tem cura ou n?o. Na an?lise de conte?do estabeleceram-se os seguintes eixos tem?ticos: no eixo I, o que n?o sei sobre hansen?ase: cura, medo e preconceito. No eixo II, o que sei sobre hansen?ase, identificaram-se: cura, efetividade da educa??o em sa?de e exclus?o social no passado. Considera-se o alcance dos objetivos propostos ao corresponder ? efetividade da educa??o em sa?de em hansen?ase na educa??o b?sica de Parnamirim/RN; enfatiza-se, assim, a import?ncia da apreens?o do conhecimento dos estudantes das escolas p?blicas. Espera-se dos mesmos detectar precocemente casos de hansen?ase em suas comunidades; estimular a ades?o ao tratamento o mais r?pido poss?vel; prevenir incapacidades; minimizar o estigma em torno da doen?a.

Made available in DSpace on 2014-12-17T14:47:06Z (GMT). No. of bitstreams: 1 ThayseMSS_DISSERT.pdf: 813585 bytes, checksum: 538003e87d3021fe73d98948aac8c80b (MD5) Previous issue date: 2014-02-27 / Leprosy as a public health problem , there is still quite some time , even with treatment for decades . Your health-disease process is marked by a historical backdrop of stigma , prejudice, social exclusion and authoritarian decisionducts , in order to extinguish the disease milieu under the regime of compulsory confinement of the patient. In this perspective , the Brazilian public health twentieth century adopted policies of compulsory isolation , which meant that those who receive a diagnosis of leprosy were isolated from society and their families in hospitals colonies . Objective is, to the study, rescue the trajectory of health professionals in the Colony Hospital St. Francis of Assisi , in Natal / RN ; Identify the policy was perceived as compulsory institutionalization imposed for leprosy patients by health professionals ; describe the behaviors Professional Hospital adopted in Cologne ; Retrieve information about the existence and functioning of the Hospital and Create a documentary of historical fragments of leprosy from the point of view of professionals from a former colony. Exploratory - descriptive method with a qualitative approach , using the methodological framework thematic oral history was used . Obtained approval by the IRB of the Federal University of Rio Grande do Norte, under Protocol No 461 403 and CAAE 19476913.9.0000.5537 . Be interviewed during the period of November and December 2013 , five health professionals who worked in the hospital colony , using audio recorder and images to capture and record the statements. The interviews were transcribed , textualized, transcriadas and sent to reviewers to step conference of the reports. Subsequently , analysis of the stories was made from the proposed content analysis of Bardin . The results and discussion are presented in the form of article: Opinion of nursing professionals who worked in a hospital for leprosy colony , which aimed to : identify the opinion of nurses who worked in hospital colony on the lives of patients . In this article, three main themes were highlighted and discussed from the reports of colaboradoes : I - The socialization process of internal II - 16 Prejudice , stigma and discrimination III - Social exclusion versus inclusion . We conclude that , in the context of the colony hospital, the performance of health professionals contributed significantly to that stigma , prejudice and social exclusion would be minimized and that the experience of asylum seekers in the colony were not seen more traumatic / A hansen?ase, como problema de sa?de p?blica, ainda persiste h? bastante tempo, mesmo com tratamento h? d?cadas. Seu processo sa?de-doen?a ? marcado por um cen?rio hist?rico de estigma, preconceito, exclus?o social e por tomada de condutas autorit?rias, com o intuito de extinguir a doen?a do meio social sob o regime do enclausuramento obrigat?rio do doente. Nessa perspectiva, a sa?de p?blica brasileira do s?culo XX adotou pol?ticas de isolamento compuls?rio, que fez com que, todos aqueles que recebessem diagn?stico de hansen?ase fossem isolados da sociedade e de seus familiares em hospitais col?nias. Objetiva-se, com o estudo, resgatar a trajet?ria dos profissionais de sa?de no Hospital Col?nia S?o Francisco de Assis, em Natal/RN; Identificar como era vivenciada a pol?tica de asilamento compuls?rio imposta ao portador de hansen?ase pelos profissionais de sa?de; Descrever as condutas profissionais adotadas no Hospital Col?nia; Recuperar informa??es quanto ? exist?ncia, funcionamento e rotinas do Hospital e Criar um document?rio dos fragmentos hist?ricos da hansen?ase sob o ponto de vista de profissionais de uma ex-col?nia. Foi utilizado o m?todo explorat?rio-descritivo, com uma abordagem qualitativa, tendo como referencial metodol?gico a hist?ria oral tem?tica. Obteve-se aprova??o pelo CEP da Universidade Federal do Rio Grande do Norte, sob Protocolo N. 461.403 e CAAE 19476913.9.0000.5537. Entrevistaram-se, durante o per?odo de novembro e 14 dezembro de 2013, cinco profissionais de sa?de que atuaram no hospital col?nia, utilizando-se gravador de ?udio e imagens para capta??o e registro dos depoimentos. As entrevistas foram transcritas, textualizadas, transcriadas e enviadas aos colaboradores para a etapa de confer?ncia dos relatos. Posteriormente, A an?lise das hist?rias foi realizada a partir da proposta de an?lise de conte?do de Bardin. Os resultados e a discuss?o est?o apresentados em forma de artigo: Opini?o de profissionais da enfermagem que atuaram em um hospital col?nia de hansen?ase, que objetivou: identificar a opini?o dos profissionais de enfermagem, que atuaram em hospital col?nia, sobre a vida dos doentes. Nesse artigo, tr?s eixos tem?ticos foram evidenciados e discutidos a partir dos relatos dos colaboradoes: O processo de socializa??o dos internos; O preconceito, o estigma e a discrimina??o; A exclus?o social versus inclus?o social. Conclui-se que, no contexto do hospital col?nia, a atua??o dos profissionais de sa?de contribuiu de forma significativa para que o estigma, o preconceito e a exclus?o social fossem minimizados e para que a viv?ncia dos asilados na col?nia n?o fosse encarada de forma traum?tica

Submitted by Oliveira Santos Dilzaná (dilznana@yahoo.com.br) on 2016-06-27T13:11:37Z No. of bitstreams: 1 Dissertação de Adriano Souza Athayde.pdf: 3988617 bytes, checksum: 86e4906dc0bd7121bfdfc3dc97a3e775 (MD5) / Approved for entry into archive by Juarez Cardoso da Silva (juarez.cardoso@ufba.br) on 2016-07-04T17:16:02Z (GMT) No. of bitstreams: 1 Dissertação de Adriano Souza Athayde.pdf: 3988617 bytes, checksum: 86e4906dc0bd7121bfdfc3dc97a3e775 (MD5) / Made available in DSpace on 2016-07-04T17:16:02Z (GMT). No. of bitstreams: 1 Dissertação de Adriano Souza Athayde.pdf: 3988617 bytes, checksum: 86e4906dc0bd7121bfdfc3dc97a3e775 (MD5) / FAPESB / A presente pesquisa situa-se na área da Sociologia da Arte, uma vez que faz reflexões sociológicas sobre as obras xilográficas do artista plástico alemão Hansen Bahia, interessando-se, principalmente, pelas representações sociais contidas em sua criação plástica erótica. A pesquisa compreende a obra de Hansen enquanto xilogravura e a sua relação com a obra de Jorge Amado, preocupando-se, sobretudo, com a relação da arte com os fenômenos sociais, no caso específico do artista pesquisado centra-se sobe uma leitura plástica das principais obras hansiana, produzidas entre as décadas de cinquenta e setenta do século passado, que apresentam como aspectos unificadores de sua composição a corporeidade e as condições sociais da população marginalizada de Salvador, residente do centro histórico da cidade, criando um paralelo entre sua estética e os textos amadianos.This research is located in the Art Sociology of the area, since it makes sociological reflections on the woodcut works of the German artist Hansen Bahia, interesting, mainly due to the social representations contained in its plastic creation erotic. The research comprises the work of Hansen as woodcut and its relationship with the work of Jorge Amado, concerned above all with the art of grating with social phenomena in the specific case of the artist researched focuses rises a plastic reading hansiana major works produced between the decades of fifty and seventy of the last century, which have the unifying aspects of its composition corporeality and social conditions of the marginalized population of Salvador, resident of the historic city center, creating a parallel between their aesthetic and the amadianos texts. / This research is located in the Art Sociology of the area, since it makes sociological reflections on the woodcut works of the German artist Hansen Bahia, interesting, mainly due to the social representations contained in its plastic creation erotic. The research comprises the work of Hansen as woodcut and its relationship with the work of Jorge Amado, concerned above all with the art of grating with social phenomena in the specific case of the artist researched focuses rises a plastic reading hansiana major works produced between the decades of fifty and seventy of the last century, which have the unifying aspects of its composition corporeality and social conditions of the marginalized population of Salvador, resident of the historic city center, creating a parallel between their aesthetic and the amadianos texts. Key words: Hansen Bahia, Woodcut, Eroticism, Art Sociology

Made available in DSpace on 2014-12-17T14:03:29Z (GMT). No. of bitstreams: 1 SergioRFA.pdf: 2472351 bytes, checksum: daab3b710d9abca3798e5b5314990137 (MD5) Previous issue date: 2008-08-25 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / Background: Leprosy can cause severe disability and disfigurement and is still a major health in different parts of the world. Only a subset of those individuals exposed to the pathogen will go on to develop clinical disease and there is a broad clinical spectrum amongst leprosy patients. The outcome of infection is in part due to host genes that influence control of the initial infection and the host?s immune response to that infection. Aim: Evaluate if polymorphisms type SNP in the 17q118q21 chromosomic region contribute to development of leprosy in Rio Grande do Norte population. Material and methods: A sample composed of 215 leprosy patients and 229 controls drawn from the same population were genotyped by using a Snapshot assay for eight genes (NOS2A, CCL18, CRLF3, CCL23, TNFAIP1, STAT5B, CCR7 and CSF3) located in chromosomic region 17q118q21. The genotype and allele frequency were measured and statistical analysis was performed by chi-square in SPSS version 15 and graph prism pad version 4 software. Results: Ours results indicated that the markers NOS2A8277, NOS2A8rs16949, CCR78rs11574663 and CSF38rs2227322 presented strong association with leprosy and their risk genotype were GG, TT, AA and GG respectively. The risk genotypes for all markers associated to leprosy presented recessive inheritance standard. When we compared the interaction among the markers in different combination we find that the marker NOS2A8277 associated with CCR78rs11574663 presented highest risk probability to development of leprosy. When we evaluated the haplotype of the risk markers it was found a haplotype associated with increase of the protection (CSF38rs22273228CC, CCR78 rs115746638GA, NOS2A8rs169498CT and NOS2A82778GA). The association of the clinical forms paucibacilary and multibacilary with markers showed that to the markers NOS2A8 2778GG, CCR78rs115746638AA and CSF38rs22273228GG there were a strong influence to migration to multibacilary pole and to marker NOS2A8rs169498TT the high proportion was found to the paucibacilary form. Conclusions: Changes in the genes NOS2A, CCR7 and CSF3 can influence the immune response against Mycobacterium leprae. The combination among these polymorphisms alters the risk probability to develop leprosy. The markers type SNP associated to development of the leprosy also are linked to clinical forms and its severity being the polymorphism NOS2A8rs169498TT associated with paucibacilar form and the polymorphisms NOS2A82778GG, CCR78rs115746638AA and CSF38rs22273228GG associated to multibacilar form / Introdu??o: A hansen?ase ? uma doen?a milenar que pode causar incapacidades f?sicas e desfiguramento, sendo ainda imponente em nosso pa?s, um problema de sa?de p?blica em seis pa?ses incluindo o Brasil. Apenas uma fra??o dos indiv?duos expostos ao Mycobacterium leprae desenvolve sintomas caracter?sticos da hansen?ase. Os fatores relacionados ? evolu??o da infec??o para doen?a depende em parte de caracter?sticas gen?ticas do hospedeiro que influenciam o controle da infec??o e ? progress?o da resposta imune. Objetivo: Avaliar se polimorfismos localizados na regi?o cromoss?mica 17q118q21 est?o associados ? hansen?ase numa popula??o oriunda do Rio Grande do Norte. Material e m?todos: Foram estudados 215 pacientes de hansen?ase e 229 controles sendo genotipados por Snapshot. Foram estudados varia??es em oito genes (NOS2A, CCL18, CRLF3, CCL23, TNFAIP1, STAT5B, CCR7 e CSF3) localizados na regi?o cromoss?mica 17q118q21. As freq??ncias genot?picas e al?licas foram determinadas por contagem direta e as diferen?as na distribui??o dessas entre os casos e os controles foram avaliadas por qui-quadrado usando o pacote estat?stico SPSS vers?o 15, e Graph Prism Pad vers?o 4.0. Resultados: Nossos resultados mostraram que os marcadores NOS2A8277, NOS2A8rs16949, CCR78rs11574663 e CSF38rs2227322 apresentam forte associa??o com a hansen?ase e seus gen?tipos de risco foram GG, TT, AA e GG respectivamente, apresentando todos padr?o de heran?a recessivo. O marcador NOS2A8277 e CCR78rs11574663 indicou maior probabilidade de risco no desenvolvimento a hansen?ase em (OR = 3,92, p = 0,0001). A avalia??o e hapl?tipos mostrou que CSF38rs22273228CC, CCR78rs115746638GA, NOS2A8rs169498CT e NOS2A82778GA est?o relacionados com a prote??o para o desenvolvimento da doen?a. Quando analisamos a distribui??o genot?pica dos marcadores estudados entre as formas cl?nicas paucibacilar e multibacilar, foram encontrados que os marcadores NOS2A82778 GG, CCR78rs115746638AA e CSF38rs22273228GG apresentavam uma forte associa??o com o polo multibacilar enquanto que o marcador NOS2A8rs169498TT foi associado a forma paucibacilar. Conclus?es: Os genes NOS2A, CCR7 e CSF3 possuiram grande import?ncia na resposta imune contra o Mycobacterium leprae e que modifica??es na seq??ncia nucleot?dica desses genes alteram a forma como agem no controle e desenvolvimento da hansen?ase. Os polimorfismos nesses genes possuem uma maior probabilidade de risco quando analisados combinados. A maior susceptibilidade induzida pelos polimorfismos nesses genes est? ligada a forma como evolui a doen?a sendo alguns deles associados a uma doen?a mais severa e outros a forma mais branda. Estes dados validam que o agregado de genes presentes no cromossomo 17 que expressam mol?culas importantes para manuten??o do equil?brio imune e que contribuem de forma intensa para a prote??o contra microorganismos intracelulares como o Mycobacterium leprae podem ter suas fun??es comprometidas por altera??o de suas seq??ncias nucleot?dicas

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2018-03-21T11:46:13Z No. of bitstreams: 1 AnaElisaPereiraChaves_TESE.pdf: 5421810 bytes, checksum: 16de7481a8bd01f35aa4dd8aa10bd519 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2018-03-22T16:06:30Z (GMT) No. of bitstreams: 1 AnaElisaPereiraChaves_TESE.pdf: 5421810 bytes, checksum: 16de7481a8bd01f35aa4dd8aa10bd519 (MD5) / Made available in DSpace on 2018-03-22T16:06:30Z (GMT). No. of bitstreams: 1 AnaElisaPereiraChaves_TESE.pdf: 5421810 bytes, checksum: 16de7481a8bd01f35aa4dd8aa10bd519 (MD5) Previous issue date: 2017-12-15 / A hansen?ase ? um grande problema de sa?de p?blica no Brasil. O controle da doen?a ? realizado no Sistema ?nico de Sa?de, tendo as Unidades B?sicas, como espa?o priorit?rio para realiza??o das a??es de controle, e as Institui??es de Ensino Superior, como ?rg?os respons?veis pelo ensino da hansen?ase aos futuros profissionais da ?rea da sa?de. Diante disso, esse estudo objetiva identificar as abordagens do ensino da aten??o ? hansen?ase atrav?s dos planos de ensino e discutir as possibilidades e limites relacionados as abordagens do ensino da aten??o ? hansen?ase em Curso de Gradua??o em Enfermagem (CGE) na perspectiva de docentes. Trata-se de um estudo explorat?rio, descritivo, de natureza quanti-qualitativa. Foi empregado tamb?m a pesquisa documental, utilizando-se os planos de ensino. A pesquisa foi realizada em CGE localizados no estado da Para?ba. Participaram do estudo 21 docentes. A coleta de dados ocorreu no per?odo de setembro a outubro de 2016, ap?s aprova??o do Comit? de ?tica e Pesquisa da Universidade Federal do Rio Grande do Norte, CAAE: 57947916.4.0000.5537. Foi utilizado um roteiro para levantamento dos planos de ensino e um roteiro de entrevista aplicado aos docentes. Ap?s o levantamento dos dados dos planos de ensino, os mesmos foram agrupados em quadros, e analisados ? luz da literatura pertinente ao tema investigado. A an?lise do material emp?rico foi realizada por meio do software IRAMUTEQ. Verificou-se nos planos de ensino que existe um n?mero reduzidos de componentes curriculares que abordam a hansen?ase; o estudo da hansen?ase ? realizado na maioria dos CGE a partir do ciclo profissional; os conte?dos abordados n?o priorizam a promo??o e vigil?ncia em sa?de, e a Sistematiza??o da Assist?ncia de Enfermagem, n?o tem sido uma prioridade nos CGE. Nos discursos dos docentes, atrav?s da an?lise do software IRAMUTEQ, a classifica??o hier?rquica das entrevistas referentes ?s possibilidades, produziram as seguintes classes: A hansen?ase ? um problema de sa?de p?blica; utiliza??o de novos m?todos de ensino; realiza??o de aulas te?ricas e pr?ticas; compet?ncia profissional para atuar no controle da hansen?ase; oportunidade do ensino na rede de aten??o ? sa?de; a import?ncia da educa??o em sa?de e o enfermeiro no controle da hansen?ase. Quanto aos limites do ensino, foram evidenciadas as seguintes classes: reduzido n?mero de casos de hansen?ase na Aten??o B?sica; carga hor?ria de aula reduzida; falta de prioridade em a??es educativas sobre hansen?ase na Aten??o B?sica; doen?a relacionada ao preconceito e estigma; inseguran?a dos profissionais da Aten??o B?sica no diagn?stico da hansen?ase, e falta de apoio dos gestores na descentraliza??o das a??es de controle da hansen?ase. Diante dos resultados encontrados, faz-se necess?rio que os CGE cumpram sua miss?o de trabalhar em fun??o de uma forma??o profissional que valorize a promo??o da sa?de e vigil?ncia da doen?a, com vistas a contribuir com a elimina??o da hansen?ase e ? melhoria da qualidade de vida das pessoas.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-04-17T23:08:14Z No. of bitstreams: 1 AnaMicheleDeFariasCabral_TESE.pdf: 1224882 bytes, checksum: 9e47507d83a4ac6b6a8e622c7f1c1804 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-04-20T19:42:21Z (GMT) No. of bitstreams: 1 AnaMicheleDeFariasCabral_TESE.pdf: 1224882 bytes, checksum: 9e47507d83a4ac6b6a8e622c7f1c1804 (MD5) / Made available in DSpace on 2017-04-20T19:42:21Z (GMT). No. of bitstreams: 1 AnaMicheleDeFariasCabral_TESE.pdf: 1224882 bytes, checksum: 9e47507d83a4ac6b6a8e622c7f1c1804 (MD5) Previous issue date: 2016-12-22 / A Hansen?ase ? apresentada como uma das doen?as mais antigas da hist?ria da humanidade, marcada pelo estigma, preconceito e exclus?o social, causando no passado o isolamento compuls?rio de seus portadores e afastamento total ou parcial do v?nculo familiar, ficando os filhos privados desse conv?vio, confinados e criados em prevent?rios/educand?rios. O objetivo geral foi avaliar a autoestima e a qualidade de vida dos filhos separados pela hansen?ase no Estado do Rio Grande do Norte. Trata-se de um estudo descritivo, com abordagem quantitativa realizado com 60 sujeitos, localizados a partir do cadastro do Movimento de Reintegra??o das Pessoas Atingidas pela Hansen?ase (MORHAN) Potiguar. Utilizou-se question?rio s?cio demogr?fico, Escala de autoestima de Rosenberg e Medical Outcomes Study 36 ? item Short Form (SF-36). O projeto de pesquisa foi aprovado sob o n?mero 1.047.792 pelo Comit? de ?tica em Pesquisa/UFRN. Os dados obtidos foram analisados no programa SPSS 20.0, com avalia??o consist?ncia interna das escalas e teste de normalidade. Realizaram-se an?lises descritiva e inferencial nos cruzamentos das vari?veis com testes n?o-param?tricos, Qui-quadrado, U de Mann-Whitney, Friedman e correla??o de Spearman e adotado p<0,05. Os resultados foram organizados em dois artigos. No primeiro, destacam-se o perfil sociodemogr?fico por sexo feminino, faixa et?ria de adultos e idosos, ensino fundamental, casados, renda entre 1 a 3 sal?rios m?nimos, casa pr?pria, dona de casa e aposentados. A qualidade de vida foi considerada boa, significando melhor nos dom?nios dos aspectos sociais (71,3), capacidade funcional (69,3), sa?de mental (68,1), vitalidade (58,3), estado geral de sa?de (57,1) e pior na limita??o por aspectos emocionais (49,4), com diferen?a significativa (p= 0,002), entre os dom?nios avaliados. Os pesquisados apresentaram a qualidade de vida est?vel (35,0%) quando comparado com um ano atr?s. No segundo artigo, destacam-se boa qualidade de vida no sexo masculino com diferen?a entre os dom?nios (p-valor < 0,001) e melhores escores nos aspectos sociais, capacidade funcional e sa?de mental e pior na limita??o por aspectos f?sicos. No feminino, boa qualidade de vida (p-valor = 0,063) e com melhores escores nos dom?nios vitalidade, estado geral de sa?de, dor e limita??o por aspectos f?sicos e pior escore na limita??o por aspecto emocional. Apenas o dom?nio no estado geral de sa?de entre os sexos apresentou diferen?a, sendo melhor nas mulheres (p-valor= 0,015). Autoestima foi boa no geral, sendo um pouco melhor no masculino. Verificou-se correla??es positivas e significantes entre os dom?nios da qualidade de vida e autoestima, sendo moderada nos aspectos sociais, capacidade funcional, sa?de mental, vitalidade, limita??o por aspectos f?sicos e emocionais fracas no estado geral de sa?de e dor, denotando-se que quanto melhor a autoestima melhor a qualidade de vida. Conclus?o: Verificou-se a exist?ncia de correla??es positivas e significantes (p<0,05) entre os dom?nios da qualidade de vida e autoestima, refuta-se a hip?tese nula, se aceita a hip?tese alternativa, h? correla??o entre autoestima e a qualidade de vida dos filhos separados pela hansen?ase no Estado Rio Grande do Norte. / Leprosy is one of the oldest diseases in the history of mankind. It is profoundly marked by stigma, prejudice and social exclusion, causing compulsory isolation of its bearers and total or partial withdrawal from family ties. Children were confined and raised in preventorios / education centers. The general objective was to evaluate the self-esteem and quality of life of children separated by leprosy in Rio Grande do Norte. This is a descriptive study with a quantitative approach carried out with 60 subjects, located from the register of the Movement of Reintegration of People Affected by Leprosy (MORHAN) Potiguar. A socio-demographic questionnaire, Rosenberg Self-Esteem Scale and the short-form health survey questionnaire (SF-36) were used. The research project was approved under number 1,047,792 by the Institutional Review Board/UFRN. Data was analyzed in SPSS 20.0 program with internal evaluation of the scales and normality test. Descriptive and inferential analyzes were performed with correlation of variables on non-parametric tests, Chi-square, Mann-Whitney U, Friedman and Spearman. Statistical significance was considering at p <0.05. Results are organized in two manuscripts. The first highlights the socio-demographic profile showing predominance of female sex, age group of adults and elderly, elementary school, married, income between 1 and 3 minimum wages, home, housewife and retirees. The quality of life was good. While it was better in social aspects (71.3), functional capacity (69.3), mental health (68.1), vitality (58.3), general health status (57,1), it was worst in emotional aspects (49.4) with significant difference (p = 0.002) among the evaluated domains. The participants presented stable quality of life (35.0%) when compared to a year ago. The second manuscript indicates a good quality of life in males with difference between domains (p-value <0.001) with better scores on social aspects, functional capacity, and mental health, but worse scores on physical aspects limitation. In females, good quality of life (p-value = 0.063) with better scores in domains of vitality, general health, pain and limitation by physical aspects, but worse scores in the limitation by emotional aspect. Only the general state of health domain presented differencebetween the sexes, being better in the women (p-value = 0,015). Self-esteem was good overall, being slightly better in male. There were positive and significant correlations between the domains of quality of life and self-esteem. Moderate correlations in social aspects, functional capacity, mental health, vitality, limitation by physical and emotional aspects. Poor correlations of poor general health and pain, showing better self-esteem relates to better quality of life. Conclusion: There were positive and significant correlations between the domains of quality of life and self-esteem (p <0.05). The null hypothesis was refuted, accepting the alternative hypothesis which proposes correlation between self-esteem and quality of life of children separated by leprosy in Rio Grande do Norte.

Made available in DSpace on 2014-07-29T15:30:34Z (GMT). No. of bitstreams: 1 AlessandraVidal-2006.pdf: 283380 bytes, checksum: d7693c2215d294fc9c4fa407894ee661 (MD5) Previous issue date: 2006-03-31 / Hansen s disease (leprosy) is an endemic infectious disease in underdeveloped countries Disease s burden and reaction episodes can lead to anxious and depressive symptoms relatively frequent although poorly explored in leprosy To 90 patients presenting leprosy and 30 without the disease, but under the same environmental stress conditions in Goiânia-GO Brazil were applied the Hamilton Depression Rating Scale (HAM-D) Patients with leprosy were distributed in three groups of 30: group 1 without reactions; group 2: outpatients with reactions; group 3: inpatients with reactions The group 4 was composed by individuals without the disease Higher scores were found in leprosy patients than in the group without the disease with statistically significant differences specially between groups 3 and 4 Leprosy patients without reactions had lower scores (60%) Depressive symptoms were more common in reactions 83.3% in outpatients and 96.7% in medical inpatients The most symptoms found were anxiety depression lack of labor capacity and insomnia We concluded that anxious and depressive symptoms were more frequent in leprosy patients mainly in those with severe reactions / A hanseníase apresenta elevada endemicidade em países subdesenvolvidos O impacto da doença e de seus episódios reacionais gera sintomas ansiosos e depressivos pouco estudados em seus aspectos qualitativos e quantitativos embora freqüentemente observados na prática clínica A uma amostra constituída por 90 pacientes e 30 acompanhantes em Goiânia-GO foi aplicada a Escala de Hamilton para avaliação de sintomas depressivos (HAM-D). Os pacientes com hanseníase foram distribuídos em 3 grupos de 30: grupo 1 sem reações; grupo 2 reações em tratamento ambulatorial; grupo 3 reações em tratamento hospitalar O grupo 4 foi composto por 30 acompanhantes sem a doença Os sintomas ansiosos e depressivos foram mais acentuados em pacientes com hanseníase do que em acompanhantes sem a doença A diferença foi estatisticamente significativa principalmente entre os grupos 3 e 4 A freqüência dos sintomas ansiosos e depressivos foi menor no grupo sem reações (60%) aumentando nos pacientes com reações tratados ambulatorialmente (83,3%) e mais acentuadamente naqueles com reações em tratamento hospitalar (96,7%) Os sintomas mais freqüentes foram os de ansiedade seguidos dos de depressão abandono do trabalho e insônia em ordem decrescente Conclui-se que os sintomas ansiosos e depressivos são mais acentuados nos pacientes com hanseníase do que nos acompanhantes e que ocorrem em maior intensidade nos pacientes com reações sobretudo naqueles em tratamento hospitalar