Successful wind power projects start with a realistic representation of the surface, more specifically the surface roughness of the site. This thesis investigates the use of airborne laser scans to model the surface roughness around a new wind farm. Estimations are made to find out how forest management and tree growth affects roughness length and displacement height. Data from scans two years apart for a specific site is provided by the Swedish governmental land registration authority. Next, tree height and plant area index methods are applied and analyzed using MATLAB. The results shows a difference of roughness length between 10.34% and 36.21% during an eight year period. WindPRO/WAsP is used to import roughness lengths for four specific cases. Height contour lines and meteorological data is taken from a long term corrected MESO data set. The results indicate a reduction in uncertainty in annual energy production between 0.79% and 2.89% across four different cases. This effect becomes significantly larger (12.76%) when comparing with classical land cover maps. Further on, effects of turbulence intensity are simulated.Finally, the results of a survey, sent to three large forest land owners in Sweden, show there is an interest in adapting forest management plans in favor of wind energy production if benefits can be shared.

Hydrologiska analyser blir ett allt vanligare tillvägagångssätt för att kunna planera inför eventuella översvämningar. Då naturkatastrofer som dessa kommer öka i framtiden i takt med att temperaturen höjs och nederbörden ökar så har Fagerstakommun påbörjat framtagning av skyfallskartering. Syftet med studien är att undersöka hur resultatet av skyfallskartering och hydrologisk modellering påverkas av dataunderlagetsupplösning. Ytterligare ett mål med arbetet är att undersöka om den nationella höjdmodellen (NH) lämpar sig att användas som underlag vid framtida skyfallskarteringar.Området som berörs av studien ligger beläget i Fagerstas centrala stadskärna och delades uppi ett område nordväst om Bergslagssjukhuset och ett i stadsdelen Västanfors. Fagersta kommun har genomfört en laserskanning som ligger till grund för dataunderlagen i analyserna. Laserpunkterna harförarbetats i Cyclone 3DRochberäknatsi FME Workbenchgenom TIN (Triangulated Irregular Network) och sedan har digitala höjdmodeller (eng. digital elevation model, DEM) skapats i upplösningarna 0,5 m, 1 m, 2 m, 5 m, 10 m, 25 m och 50 m. Även den nyligen framställda NH användes som ett underlag. Denna består av en DEM i upplösning 1 m. Skyfallskartering genomfördes i ArcMap 10.8 medmetoden att lokalisera lågpunkter som riskerar att svämmas över. Hydrologisk modellering tillämpades i syfte att framställa flödesvägar som visar var vattnet rinner vid översvämning. Resultaten jämfördes med hjälp av feature agreement statisticssom visade hur bra dataunderlagen överensstämde mot referensupplösningen på 0,5 m. Ytterligare valideringar gjordes mot en skyfallskartering som tillhandahölls av Fagersta kommun. Denna genomfördes år 2017 av SMHI på uppdrag av Länsstyrelsen och jämfördes mot 0,5 m, 1 m och NH 1 m.Resultat från skyfallskarteringen visade att NH överensstämmer väl med Fagerstas egna skyfallskartering. Det visade att utbredningen generellt ökar och fill-up värdet minskar vid en lägre upplösning. Tvärsnitt från lågpunkterna visade attdetta även generaliserar djupet. De hydrologiska modelleringarna styrker att lägre upplösning generaliserar området. En slutsats kan dras att upplösningarna på 10 m och uppåt inte böranvändas vid en mer noggrann analys. Däremot kan de vara tillräckliga som underlag vid översiktlig kartering. Ytterligare slutsats drogsatt NH lämpar sig som underlag vid skyfallskartering för de flesta ändamålen. Ett underlag med tätare punkttäthet bör dockanvändas vid analyser som kräver ett mer detaljerat resultat. / Hydrological analyses are becoming a more common tool for being able to prepare for eventual floods. As natural disasters such as these will increase in the future as higher temperatures and increased precipitation Fagersta municipality has begun producing cloudburst maps. The aim of this study is to investigate the effects that resolution has on hydrological modelling and cloudburst mapping. Another goal of the study is to examine if the Swedish national height model (NH) is suitable for use in forthcoming cloudburst analyses.The study area is located in the city center of Fagersta and is divided into two areas, one northwest of the hospital named Bergslagssjukhuset and the other over the district Västanfors. Fagersta municipality has carried out a laserscanning which is used to create the different data sets in the analyses. The measured points have been preworked in Cyclone 3DR and calculated in FME Workbench as a TIN (Triangulated Irregular Network). Digital elevation models (DEM) were later on created with the following resolutions;0,5 m, 1 m, 2 m, 5 m, 10 m, 25 m and 50 m. The recently produced NH was also used as a data set. It consists of a DEM with a resolution of 1 m. The cloudburst mapping was implemented in ArcMap 10.8 with the method to locate blue spots that run the risk of being flooded. Hydrological modelling was applied with the aim of producing stream networks which presents where water will flow in case of a flood. The results were compared by using feature agreement statistics which showed how comparable the data sets were to the reference resolution of 0,5 m. Additional validations were made by using Fagersta municipality's own cloudburst map which was carried out in 2017 by SMHI on behalf of Länsstyrelsen. The datawas compared to 0,5 m, 1 m and NH 1 m.Results from the cloudburst mapping showed that NH compares well with Fagerstas data set. It also showed that the spread of blue spots generally increases and the fill-up valuedecreases at a lower resolution. Cross sections from the blue spots showed that this also generalizes depth. The hydrological modellings strengthens that lower resolutions generalizes areas. A conclusion can be drawn that the resolutions of 10 m and up should not be used in a precise analysis. They can however be used for easy-reference mapping. Another conclusion was drawn that NH is suitable for use as a data set in cloudburst mapping for most purposes. A data set with a better point density should however be used in analyses which require a more detailed result.

<p>Fifty children with hematologic malignancies have been treated with autologous BMT in Uppsala. The aim was to describe late effects in this group with special reference to cataracts, reduced final height, and to hepatic, renal, and pulmonary late effects. </p><p>Cataracts: All patients who received TBI in their conditioning developed posterior subcapsular cataract after BMT. A few patients with visual impairment affecting daily life needed cataract surgery, whereas the visual acuity was well preserved in most of the other patients.</p><p>Final height: There was a decrease in final height relative both to height at BMT and to target height. This decrease was significant both in those who had received TBI only and in those who had been given cranial irradiation. Cranial irradiation, young age at BMT, and short duration of GH treatment were predictors of height loss. </p><p>Hepatic function: Hepatic function was well preserved over a period of 10 years after BMT. TBI did not appear to be a risk factor for hepatic impairment. </p><p>Renal function: Six months after BMT there was a decrease in renal function in patients who had received TBI. It then recovered, albeit incompletely, and stabilized. After the first year there was little change over a period of 10 years after BMT. TBI appeared to be the most important risk factor for the development of chronic renal impairment in a number of patients. Nephrotoxic antibiotics may have contributed.</p><p>Pulmonary function: Six months after BMT there was a decrease in pulmonary function in those who received TBI. It then recovered and stabilized at the pretransplant level. After the first year there was little change over a period of 10 years after BMT. TBI appeared to be the most important risk factor for restrictive pulmonary disease in a number of patients whereas chemotherapy might also have been of importance for impaired gas exchange.</p>

<p>Most human traits and common diseases have a complex genetic makeup involving more than one gene. The work presented in this thesis investigates standing body height and the common disease type 2 diabetes mellitus (T2DM). In study I we analyzed two single nucleotide polymorphisms (SNPs) in the TCF7L2 gene that had been shown to be associated with T2DM. Analysis was performed in the ULSAM population cohort of ~1500 males. We were able to replicate the association to type 2 diabetes and in addition to that we made a novel find, showing association between the risk alleles and increased proinsulin levels. In study II we analyzed four genes identified to be associated with T2DM in a genome-wide association study. We analyzed SNPs in these genes in the ULSAM population cohort and found an association between SNPs in the HHEX gene and insulin responses and insulin levels. </p><p>The aim of studies III-V was to identify genes affecting normal variation in standing body height. Using a candidate gene approach in study III, 17 genes were screened in the ULSAM population cohort using SNPs. A suggestive association of the ESR1 gene with height was found and confirmed as significant in males from the PIVUS population cohort. In study IV, as a part of the GenomEUtwin project, we performed genetic fine mapping of a linked locus for body height on the X-chromosome. By analyzing 1377 SNPs in 780 Finnish twins, we mapped a region spanning 65kb of this locus with linkage to body height in males. This region contains the GPC3 and PHF6 genes that have known connections to syndromes were standing body height is affected. In study V significant linkage and association to standing body height in males was found for the COL1A11 gene, using population cohorts from Finland and Iceland. </p>

Important global hydrodynamic relationships for shallow spouted beds of high-density particles were characterized in terms of three features: minimum spouting velocity, overall bed pressure drop at minimum spouting velocity; and fountain height. Spouted bed literature is sparse for shallow beds (static particle depth to bed diameter ≤ 1) and beds with heavy particles (density > 3000 kg/m3). Correlations for such beds were developed here by varying column diameter, static bed height, particle diameter, particle density, gas density and gas flow in an ambient temperature and pressure bed. The degree of correlation between each of the observed hydrodynamic features and a set of selected dimensionless groups from the literature was evaluated with principal components analysis. The minimum spouting velocity correlated strongly with the ratios of particle to bed diameter, of particle to gas density, and of static bed height to particle diameter, and weakly with Archimedes number. Overall bed pressure drop at minimum spouting correlated strongly with Archimedes number, the ratio of static bed height to particle diameter and Froude number. Fountain height correlated strongly with the ratios of the superficial gas velocity to minimum spouting velocity, of static bed height to particle diameter and of the particle to the bed diameter. Principal component regression models were developed for minimum spouting velocity, bed pressure drop, and fountain height with respect to a selected set of dimensionless parameters. All models have regression coefficient values exceeding 85%. Predictions using models developed in this study were compared with correlations in the literature and found to give better results for the experimental conditions studied. Most likely the literature models were less accurate because they were extrapolated. Distinct bed pressure drop relationships with gas flow were observed for certain ranges of particle diameter and static bed height. In addition three dynamical spouting modes were observed, and named as regular, erratic and bimodal. A spouting regime map is proposed based on the spouting regimes defined in this investigation. The correspondence between bed pressure drop relationships and spouting regimes is still unclear.

Fifty children with hematologic malignancies have been treated with autologous BMT in Uppsala. The aim was to describe late effects in this group with special reference to cataracts, reduced final height, and to hepatic, renal, and pulmonary late effects. Cataracts: All patients who received TBI in their conditioning developed posterior subcapsular cataract after BMT. A few patients with visual impairment affecting daily life needed cataract surgery, whereas the visual acuity was well preserved in most of the other patients. Final height: There was a decrease in final height relative both to height at BMT and to target height. This decrease was significant both in those who had received TBI only and in those who had been given cranial irradiation. Cranial irradiation, young age at BMT, and short duration of GH treatment were predictors of height loss. Hepatic function: Hepatic function was well preserved over a period of 10 years after BMT. TBI did not appear to be a risk factor for hepatic impairment. Renal function: Six months after BMT there was a decrease in renal function in patients who had received TBI. It then recovered, albeit incompletely, and stabilized. After the first year there was little change over a period of 10 years after BMT. TBI appeared to be the most important risk factor for the development of chronic renal impairment in a number of patients. Nephrotoxic antibiotics may have contributed. Pulmonary function: Six months after BMT there was a decrease in pulmonary function in those who received TBI. It then recovered and stabilized at the pretransplant level. After the first year there was little change over a period of 10 years after BMT. TBI appeared to be the most important risk factor for restrictive pulmonary disease in a number of patients whereas chemotherapy might also have been of importance for impaired gas exchange.

Most human traits and common diseases have a complex genetic makeup involving more than one gene. The work presented in this thesis investigates standing body height and the common disease type 2 diabetes mellitus (T2DM). In study I we analyzed two single nucleotide polymorphisms (SNPs) in the TCF7L2 gene that had been shown to be associated with T2DM. Analysis was performed in the ULSAM population cohort of ~1500 males. We were able to replicate the association to type 2 diabetes and in addition to that we made a novel find, showing association between the risk alleles and increased proinsulin levels. In study II we analyzed four genes identified to be associated with T2DM in a genome-wide association study. We analyzed SNPs in these genes in the ULSAM population cohort and found an association between SNPs in the HHEX gene and insulin responses and insulin levels. The aim of studies III-V was to identify genes affecting normal variation in standing body height. Using a candidate gene approach in study III, 17 genes were screened in the ULSAM population cohort using SNPs. A suggestive association of the ESR1 gene with height was found and confirmed as significant in males from the PIVUS population cohort. In study IV, as a part of the GenomEUtwin project, we performed genetic fine mapping of a linked locus for body height on the X-chromosome. By analyzing 1377 SNPs in 780 Finnish twins, we mapped a region spanning 65kb of this locus with linkage to body height in males. This region contains the GPC3 and PHF6 genes that have known connections to syndromes were standing body height is affected. In study V significant linkage and association to standing body height in males was found for the COL1A11 gene, using population cohorts from Finland and Iceland.

In order to understand how waves influence the exchange of momentum, latent heat and other parameters, between the ocean surface and the atmosphere, one can use models. A coupling between a wave model and an atmospheric regional climate model, for the Baltic Sea, will be performed at the Meteorology Institute in Uppsala University. The wave model is a state of the art, third generation wave model called WAM. The new version of the WAM model (cycle 4) needs to be validated. The aim of this thesis is to perform this validation and also to investigate what meteorological forcing one should use to achieve best results. Two different types of forcing are analyzed, ERA40 reanalysis and the RCA climate model. In order to do this, observations from six different buoys in the Baltic Sea will be compared with the model output from WAM. The parameters that will be compared in this study are significant wave height, direction and peak period. A consistent phenomenon for all the buoys is a slightly overestimation by the model of what the rate of this increases with increasing wave height. If one compares the model output when WAM are forced with the RCA climate model and when it is forced with ERA40 reanalysis, the differences between them are notable but not large. ERA40 is slightly better. Significant wave height is quite good and gives a reasonably result. Some buoys and periods are better and some are worse. There are some differences for the significant wave height between the east coast and the west coast of Sweden, when forcing the model with RCA. It is slightly better on the west coast. On the contrary, the results from ERA40 are very coherent. The quality of the hindcast for the direction and the peak period, in contrast to the significant wave height, is not that good. The results are not bad, but it only gives a rough picture of the sea state.

This PhD thesis consists of a summary and five papers which all deal with asymptotic problems on certain homogeneous spaces. In Paper I we prove asymptotic equidistribution results for pieces of large closed horospheres in cofinite hyperbolic manifolds of arbitrary dimension. All our results are given with precise estimates on the rates of convergence to equidistribution. Papers II and III are concerned with statistical problems on the space of n-dimensional lattices of covolume one. In Paper II we study the distribution of lengths of non-zero lattice vectors in a random lattice of large dimension. We prove that these lengths, when properly normalized, determine a stochastic process that, as the dimension n tends to infinity, converges weakly to a Poisson process on the positive real line with intensity 1/2. In Paper III we complement this result by proving that the asymptotic distribution of the angles between the shortest non-zero vectors in a random lattice is that of a family of independent Gaussians. In Papers IV and V we investigate the value distribution of the Epstein zeta function along the real axis. In Paper IV we determine the asymptotic value distribution and moments of the Epstein zeta function to the right of the critical strip as the dimension of the underlying space of lattices tends to infinity. In Paper V we determine the asymptotic value distribution of the Epstein zeta function also in the critical strip. As a special case we deduce a result on the asymptotic value distribution of the height function for flat tori. Furthermore, applying our results we discuss a question posed by Sarnak and Strömbergsson as to whether there in large dimensions exist lattices for which the Epstein zeta function has no zeros on the positive real line.

Groat oil content and composition are important quality traits in oats (Avena sativa L). These traits are controlled by many genes with additive effects. The chromosomal regions containing these genes, known as quantitative trait loci (QTL), can be discovered through their close association with markers. This study investigated total oil content and fatty acid components in an oat breeding population derived from a cross between high oil ('Dal') and low oil ('Exeter') parents. A genetic map consisting of 475 DArT (Diversity Array Technology) markers spanning 1271.8 cM across 40 linkage groups was constructed. QTL analysis for groat oil content and composition was conducted using grain samples grown at Aberdeen, ID in 1997. QTL analysis for multiple agronomic traits was also conducted using data collected from hill plots and field plots in Ottawa, ON in 2010. QTLs for oil content, palmitic acid (16:0), stearic acid (18:0), oleic acid (18:1), linoleic acid (18:2) and linolenic acid (18:3) were identified. Two of the QTLs associated with oil content were also associated with all of the fatty acids examined in this study, and most oil-related QTL showed similar patterns of effect on the fatty acid profile. These results suggest the presence of pleiotropic effects on oil-related traits through influences at specific nodes of the oil synthesis pathway. In addition, 12 QTL-associated markers (likely representing nine unique regions) were associated with plant height, heading date, lodging, and protein content. The results of this study will provide information for molecular breeding as well as insight into the genetic mechanisms controlling oil biosynthesis in oat.