A cetoacidose diabética (CAD) é uma das complicações mais graves do diabetes mellitus (DM) em pequenos animais. A CAD é uma emergência médica caracterizada por alterações metabólicas extremas, incluindo hiperglicemia, acidose metabólica, cetonemia, desidratação e perda de eletrólitos. Embora seja um distúrbio comum e de alta mortalidade, os padrões dos distúrbios ácido-base de cães com CAD ainda não foram avaliados objetivamente. Muitas das assunções sobre a CAD em cães são generalizadas com base em dados de pacientes humanos e estudos experimentais em cães. O objetivo do presente estudo foi descrever os distúrbios ácido-base e eletrolíticos de cães com CAD e cetose diabética (CD) e caracterizá-los segundo a freqüência de ocorrência, adequação dos mecanismos de compensação e ocorrência de distúrbios mistos. Foram avaliados 40 cães diabéticos (22 animais recém diagnosticados e 18 cães em tratamento com insulina) atendidos apresentando cetonúria e hiperglicemia (>250 mg/dL). De acordo com critérios clínicos, esses cães foram distribuídos em dois subgrupos: (CAD, n=22 e CD n=18) e foram determinados o pH e a hemogasometria arteriais e eletrólitos plasmáticos (sódio, cloro, potássio, cálcio ionizado) e o magnésio total e o fósforo inorgânico séricos. As alterações do equilíbrio ácido-base foram avaliadas sistematicamente pelo método de Van Slyke-Henderson-Hasselbalch. Os resultados foram comparados com os obtidos a partir de 37 cães clinicamente hígidos. Com relação aos distúrbios ácido-base, a acidose metabólica foi o mais comumente identificado (n = 27). A maior parte dos animais apresentava acidose normoclorêmica. A acidose hiperclorêmica foi observada em sete pacientes. Dos cães com acidose metabólica, 15 apresentavam alcalose respiratória concomitante. A distribuição dos valores de eletrólitos foi diferente entre o grupo de estudo e o controle, com exceção do magnésio. Não houve diferença na distribuição dos valores dos eletrólitos entre os subgrupos, com exceção do potássio plasmático. A hiponatremia e a hipocloremia foram os distúrbios eletrolíticos mais comumente observados nos 40 cães com DM. A hipocalemia ocorreu com maior freqüência no subgrupo CAD e a hipercalemia no subgrupo CD. Os valores do fósforo inorgânico sérico foram semelhantes entre os subgrupos de estudo. A hiperfosfatemia foi comum em ambos os subgrupos e nenhum paciente apresentou hipofosfatemia. A hipermagnesemia foi observada em sete pacientes com CAD e em apenas um com CD. A maior parte dos pacientes tinha hipocalcemia por ocasião do atendimento inicial. Distúrbios ácido-base mistos, principalmente a acidose metabólica normoclorêmica associada a alcalose respiratória são comuns em cães com cetose ou cetoacidose diabética, assim como distúrbios eletrolíticos como hiponatremia, a hipocloremia e hipocalemia e hiperfosfatemia. / Diabetic ketoacidosis (DKA) is one of the most serious complications of diabetes mellitus (DM) in small animals. DKA is a medical emergency characterized by extreme metabolic abnormalities, including hyperglycemia, metabolic acidosis, ketonemia, dehydration, and electrolyte losses. Despite it is a common disorder and with high mortality, the patterns of the acid-base disturbances in dogs with DKA were not evaluated objectively. Many of the assumptions about DKA in dogs are derived from studies in human beings and experimental studies in dogs. The objective of the present study was to describe the acid-base and electrolytic disturbances in dogs with DKA and diabetic ketosis (DK) according to their frequency, adequacy of the compensatory mechanisms e occurrence of mixed disturbances. Forty dogs with DM (22 with new onset diabetes and 18 insulin-treated dogs) with ketonuria and hyperglycemia (> 250 mg/dL) were enrolled. On the basis of clinical criteria, the dogs were assigned to one of two subgroups: (DKA, n=22 e DK n =18). Arterial blood gases and plasma electrolytes (sodium, chloride, potassium and, ionized calcium), and serum total magnesium and inorganic phosphorus were determined in all dogs. The acid base abnormalities were evaluated systematically by the Van Slyke-Henderson-Hasselbalch method and the results compared to those obtained from 37 healthy dogs (control group). Metabolic acidosis was the most common acid-base disorder identified (n = 27) and most of the dogs had normochloremic acidosis. Hyperchloremic acidosis was observed in seven patients. Fifteen of the dogs with metabolic acidosis had coexisting respiratory alkalosis. The distribuition of the electrolytes values was different between the study group and the control group, with the exception of serum magnesium. The distribution of the electrolytes values was similar between the subgroups, with the exception of plasma potassium. Hyponatremia and hypochloremia were the most common observed electrolyte abnormalities showed in dogs with DK or DKA. Hypokalemia occurred more frequently in dogs with DKA and hyperkalemia in dogs with DK. Serum inorganic phosphorus values were similar between the subgroups. Hyperphosphatemia was a common finding and hypophosphatemia was not observed. Hypermagnesemia was detected in seven patients with DKA and in only one with DK. Most of the dogs were hypocalcemic on admission. Mixed acid-base disorders, mainly metabolic normochloremic acidosis with coexisting respiratory alkalosis are common in dogs with diabetic ketosis or ketoacidosis and electrolytic disturbances, mostly hyponatremia, hypochloremia, hypokalemia, and hyperphosphatemia, were also common.

Este trabalho tem por objetivo o estudo e o desenvolvimento de uma solução de engenharia para o mapeamento e caracterização da oclusão dentária, não somente no âmbito de sua distribuição ao longo da arcada, mas também através da mensuração da intensidade de pressão nos pontos de contato oclusal interarco. Neste sentido, empregaram-se esforços no aprofundamento do conhecimento neste campo da Odontologia, assim como, na elaboração de um sistema experimental que, utilizando sensores de pressão/força resistivos (FSR) específicos para uso odontológico, viabilizou a análise do estado da oclusão, atuando como agente facilitador no diagnóstico de desequilíbrios oclusais. Inicialmente, são apresentados e esclarecidos os principais conceitos da esfera odontológica, os quais são tomados como base para todos os projetos deste trabalho, além da abordagem referente às formas de contato entre os dentes, aos diferentes tipos de oclusão e seus problemas. Em relação ao desenvolvimento do sistema, foram projetadas duas placas de circuito impresso para interface com os sensores e elaborados o firmware de acesso ao hardware, assim como o software de gerenciamento global do sistema. Todos os blocos do circuito de condicionamento foram avaliados e as suas funcionalidades validadas. Do mesmo modo, a caracterização da resposta dos sensores e a sua homogeneidade ao longo da extensão sensível foram analisadas, demonstrando que a resistência elétrica varia de forma análoga em todas as áreas do sensor. Através de ensaios realizados com sujeito envolvido no projeto, estabeleceu-se um comparativo entre a utilização do papel carbono e o sistema desenvolvido, mostrando as vantagens na utilização do segundo, principalmente atreladas à capacidade de avaliação da intensidade dos contatos oclusais. Por fim, ainda se valendo do uso paralelo do papel carbono, foram efetuados ensaios de análise da oclusão em sujeito envolvido no projeto utilizando placa miorrelaxante, possibilitando a utilização da capacidade do sistema desenvolvido para executar ajustes precisos na placa, com a finalidade de manter o balanço de pressões oclusais entre ambos os lados da arcada. / This essay has as objective the study and development of an engineer solution for the dental occlusion mapping and characterization, not only related to the interarch occlusal contact distribution, but also through the pressure magnitude measuring in each. In this sense, was employed effort in the Odontological knowledge increasing and also in the system elaboration allowing the occlusion state evaluation and acting as an easier agent in the occlusion disturbs diagnosing using a specific pressure/force sensing resistor (FSR) for dental use. Initially the main concepts of the Odontological sphere are presented, clarified and took as a base for all the projects in this essay. Besides this, different teeth contacts shapes are shown, as well as the occlusion’s types and its problems. In the system development, two printed circuit boards were designed for sensor interfacing. The hardware access through the firmware was elaborated, even as the global system managing software. All the conditioning circuit blocks and functionalities were evaluated and validated. In the same way, the sensor’s output and its homogeneity through all the sensible extension were evaluated, showing that the sensor’s electric resistance changes in the same form in all the sensor’s areas. In addition, it was showed the advantages of the developed system over the articulation paper through trials with a subject that is part of the project, showing the capacity of the system in the occlusion contacts magnitude evaluation. Ultimately, also in an articulation paper versus the developed system comparison, it was made occlusion analysis trials with subject using a night guard for teeth grinding (bruxism), showing the system capacity of precisely adjust the night guards for pressure balance between the both arch sides.

Masters of Science - Msc (Physiotherapy) / Extrinsic factors like terrain, hard running surfaces or incorrect shoes have been known to be contributing factors to injury, and intrinsic factors such as poor flexibility, mal-alignment anthropometry, previous injury and running experience have been identified in playing a role too. Little is known about the factors associated with injuries among marathon runners in Eldoret, Kenya. It is therefore important to identify the possible risk factors associated with running injuries in order to prevent further injury and severe long-term complications

The thesis deals with the effect of sports aerobics on correct body posture. Two groups of probands will be compared based on testing. One group has been actively practicing sports aerobics for several years. On the other hand, the second group will include girls who do reacreational sports only. The first group consists of girls representing the Czech Republic at international competitions and practicing sports aerobics in the 1st performance class. The second group of probands consists of students of the 3rd year of the Secondary Vocational School, Sedlčany, Petra Bezruče 364. The thesis will focus on the comparison of the effect of sports aerobics on body posture. In addition, compensatory exercises will be designed to help to eliminate muscle imbalance. The thesis will introduce common exercise aids, which can affect the correct body posture and which can be used in exercises not only for sports aerobics training, but also within the classes of school physical education.

Despite many important advances since the “Bretton Woods” agreement, the state of Third World development remains extremely unsatisfactory. About a billion people live in extreme poverty and more than 800 million do not get adequate nutrition. Third World Debt looms large on the horizons of most underdeveloped nations and development continues to benefit the Third World elites, the developed nations, and their multinational corporations. The North-South divide continues to widen with very little “tricking down” to the poor majority in many nations. It is strongly believed that one-third of the world’s poor are getting poorer. The conventional approach to development theory and practice, focusing on economic growth, investment, trade and free markets continues to benefit developed nations. Even in nations where free trade and markets have spurred growth, the net results of globalization have not reached the majority. Globalization defined as the “economic, social, political and environmental integration of nations” creates some major imbalances in a world system increasingly based on liberal market economies. Ultimately, the IMF-WTO corporate globalization model has failed to deliver for developing countries, severely punishing those least capable of protecting themselves – the billions living on $ 400 million annually. Market access is only useful to countries at a stage of development that allows for their engagement in world markets, in a manner that promotes improved standards of living for their populations. The promise of market access is a distraction that has served to create a myth of prosperity. This research seeks to raise issues regarding the impact of globalization on North-South imbalances highlighting the crucial gaps in the globalization process. Initially, the research outlines the parameters and theories surrounding the globalization process and then progresses on to demonstrate the imbalances of the global system, highlighting the key areas of impact that adversely affect the development of Southern nations. Using India’s economic liberalization as a case in point, this thesis attempts to unveil the growing myth of prosperity that is being propagated in relation to the issues of globalization and the South. Finally, the thesis attempts to draw pertinent theoretical lessons that would contribute towards a better understanding of the effects of globalization on the South. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1311650 / Thesis (Ph.D.) -- University of Adelaide, School of History and Politics, 2008

<p>The social imbalance recruitment has been a current topic for years. Since much research has focused on the higher education's problems with this, this thesis aims to investigate if you are already at the high school choice were influenced by your social background. To get a further dimension to this topic, the French sociologist Bourdieus thoughts on people's possession of, what he calls cultural capital was used, and we made use of it in the sense of parental education. Through a survey conducted in four ninth grades in two municipalities with different characteristics in terms of socio-economic conditions, we asked questions about their choice to high school. What programs did they choose? What factors were important? And which person had influenced them? The results showed a pretty clear dividing line between the pupils who came from homes with strong cultural capital to those who did not in the same sense. Students from these homes selected by an overwhelming majority a study preparatory program, the school's reputation was important and they had parents who were very active along with the student. Students who chose vocational programs, prioritized to a higher degree to begin work after high school, had discussed a lot with their parents but they (the parents) had not otherwise been so active. Conclusions of the study is that it largely follows the previous literature found on the subject, i.e. that the social background largely affects how we choose in specific situations. The parents' influence is great, which is useful for counsellors to know about and make use of in meeting with students and their families in school.</p> / <p>Den sociala snedrekryteringen har varit en aktuell fråga i många år. Eftersom mycket av forskningen har fokuserat på den högre utbildnings problem med detta, syftar denna studie till att undersöka om du redan vid gymnasievalet påverkas av din sociala bakgrund. För att få en ytterligare dimension till detta ämne, använder vi oss av den franska sociologen Bourdieus tankar om människors innehav av, vad han kallar kulturellt kapital, i betydelsen av föräldrarnas utbildning. Genom en undersökning som genomfördes i fyra nionde klasser i två kommuner med olika förutsättningar i fråga om socioekonomiska förhållanden, ställde vi frågor om deras val till gymnasiet. Vilket program har de valt? Vilka faktorer var viktiga? Och vilken person hade påverkat dem? Resultaten visade en ganska tydlig skiljelinje mellan de elever som kom från hem med starka kulturella kapital till dem som inte hade det i samma utsträckning. Studenter från dessa "kulturstarka" hem valde en överväldigande majoritet ett studieförberedande program, skolans rykte var viktigt och de hade föräldrar som var mycket aktiva tillsammans med eleven. Elever som valde yrkesinriktade program, prioriterade i högre grad att börja arbeta efter gymnasiet, hade diskuterat mycket med sina föräldrar men de (föräldrarna) hade inte annars varit så aktiva. Slutsatsen av studien är att det i stort sett följer det tidigare litteratur på området kommit fram till, nämligen att den sociala bakgrunden till stor del påverkar hur vi väljer i specifika situationer. Föräldrarnas inflytande är stort, vilket är användbart för vägledare att känna till och använda sig av i mötet med elever och deras familjer i skolan.</p>

<p>Important candidate genes to human bone phenotypes are those involved in the regulation of hormonal action, such as the vitamin D receptor (VDR) and the estrogen receptor-α (ERα) genes and their cofactors. RIZ1 is a specific ERα cofactor proved to strongly enhance the function of the ERα. </p><p>The main focus of this thesis has been to study genetic variants in the VDR and RIZ genes and their associations to human bone phenotypes using candidate gene and functional approaches. Specifically, polymorphisms in the VDR 3’ untranslated region (UTR) and a deletion/insertion polymorphism of a proline in the RIZ gene were investigated.</p><p>The candidate gene approach was applied to large-scale population-based cohorts of pre-and post-menopausal women from Sweden and of elderly men from Sweden and Hong Kong. VDR 3’ UTR polymorphisms were associated with peak bone mass and body composition in young women. Further analysis of common VDR 3’ UTR haplotypes confirmed the association with BMD and risk of fractures in elderly men from Sweden and Hong Kong. The VDR polymorphisms were investigated for cis-acting effects, affecting allelic expression in the normal chromosomal context of human bone cells. The VDR allelic transcripts in the bone samples were unequally expressed, suggesting presence of regulatory variants in the 3’ UTR. </p><p>The polymorphism in the RIZ gene was strongly associated to BMD in pre- and postmenopausal women and in elderly men. The functional analyses included reporter constructs containing the RIZ polymorphic variants transfected in a cell line and its abilities in coactivating the ERα were examined. The variants were functionally different in coactivating the ERα-receptor complex. </p><p>To summarize, the results of this thesis show novel evidence for functional relevant polymorphisms in candidate genes to human bone phenotypes. These polymorphisms may contribute to the variation seen in BMD and risk of fractures in the population.</p>

Important candidate genes to human bone phenotypes are those involved in the regulation of hormonal action, such as the vitamin D receptor (VDR) and the estrogen receptor-α (ERα) genes and their cofactors. RIZ1 is a specific ERα cofactor proved to strongly enhance the function of the ERα. The main focus of this thesis has been to study genetic variants in the VDR and RIZ genes and their associations to human bone phenotypes using candidate gene and functional approaches. Specifically, polymorphisms in the VDR 3’ untranslated region (UTR) and a deletion/insertion polymorphism of a proline in the RIZ gene were investigated. The candidate gene approach was applied to large-scale population-based cohorts of pre-and post-menopausal women from Sweden and of elderly men from Sweden and Hong Kong. VDR 3’ UTR polymorphisms were associated with peak bone mass and body composition in young women. Further analysis of common VDR 3’ UTR haplotypes confirmed the association with BMD and risk of fractures in elderly men from Sweden and Hong Kong. The VDR polymorphisms were investigated for cis-acting effects, affecting allelic expression in the normal chromosomal context of human bone cells. The VDR allelic transcripts in the bone samples were unequally expressed, suggesting presence of regulatory variants in the 3’ UTR. The polymorphism in the RIZ gene was strongly associated to BMD in pre- and postmenopausal women and in elderly men. The functional analyses included reporter constructs containing the RIZ polymorphic variants transfected in a cell line and its abilities in coactivating the ERα were examined. The variants were functionally different in coactivating the ERα-receptor complex. To summarize, the results of this thesis show novel evidence for functional relevant polymorphisms in candidate genes to human bone phenotypes. These polymorphisms may contribute to the variation seen in BMD and risk of fractures in the population.

The social imbalance recruitment has been a current topic for years. Since much research has focused on the higher education's problems with this, this thesis aims to investigate if you are already at the high school choice were influenced by your social background. To get a further dimension to this topic, the French sociologist Bourdieus thoughts on people's possession of, what he calls cultural capital was used, and we made use of it in the sense of parental education. Through a survey conducted in four ninth grades in two municipalities with different characteristics in terms of socio-economic conditions, we asked questions about their choice to high school. What programs did they choose? What factors were important? And which person had influenced them? The results showed a pretty clear dividing line between the pupils who came from homes with strong cultural capital to those who did not in the same sense. Students from these homes selected by an overwhelming majority a study preparatory program, the school's reputation was important and they had parents who were very active along with the student. Students who chose vocational programs, prioritized to a higher degree to begin work after high school, had discussed a lot with their parents but they (the parents) had not otherwise been so active. Conclusions of the study is that it largely follows the previous literature found on the subject, i.e. that the social background largely affects how we choose in specific situations. The parents' influence is great, which is useful for counsellors to know about and make use of in meeting with students and their families in school. / Den sociala snedrekryteringen har varit en aktuell fråga i många år. Eftersom mycket av forskningen har fokuserat på den högre utbildnings problem med detta, syftar denna studie till att undersöka om du redan vid gymnasievalet påverkas av din sociala bakgrund. För att få en ytterligare dimension till detta ämne, använder vi oss av den franska sociologen Bourdieus tankar om människors innehav av, vad han kallar kulturellt kapital, i betydelsen av föräldrarnas utbildning. Genom en undersökning som genomfördes i fyra nionde klasser i två kommuner med olika förutsättningar i fråga om socioekonomiska förhållanden, ställde vi frågor om deras val till gymnasiet. Vilket program har de valt? Vilka faktorer var viktiga? Och vilken person hade påverkat dem? Resultaten visade en ganska tydlig skiljelinje mellan de elever som kom från hem med starka kulturella kapital till dem som inte hade det i samma utsträckning. Studenter från dessa "kulturstarka" hem valde en överväldigande majoritet ett studieförberedande program, skolans rykte var viktigt och de hade föräldrar som var mycket aktiva tillsammans med eleven. Elever som valde yrkesinriktade program, prioriterade i högre grad att börja arbeta efter gymnasiet, hade diskuterat mycket med sina föräldrar men de (föräldrarna) hade inte annars varit så aktiva. Slutsatsen av studien är att det i stort sett följer det tidigare litteratur på området kommit fram till, nämligen att den sociala bakgrunden till stor del påverkar hur vi väljer i specifika situationer. Föräldrarnas inflytande är stort, vilket är användbart för vägledare att känna till och använda sig av i mötet med elever och deras familjer i skolan.

African American women living in the U.S. face immense challenges to protect themselves from HIV infection. One in every 32 African American women is diagnosed with the disease and heterosexual contact is the primary mode of transmission. A better understanding of the African American woman’s beliefs and decisions related to safe sex practices can give direction to strategies to promote safer sexual behaviors. The purpose of this study was to explore the association of the African American woman’s attitudinal beliefs, normative beliefs, and relationship control beliefs with self-reported sexual behaviors. The Theory of Planned Behavior served as the study’s theoretical framework, supporting the premise beliefs are precursors to explanations and understanding human behavior. Using a cross-sectional, correlational design, a convenience sample of 95 African American women from the southeastern United States was obtained. Results confirmed a statistically significant 1) positive relationship between gender role beliefs and relationship power, (r = 0.354, p < .001); 2) negative relationship between gender ratio imbalance beliefs and relationship power, (r = -0.472, p < 0.001); 3) positive association between relationship power and avoidance of risky sexual behavior, (r = 0.340, p = 0.001); 4) negative correlation between gender ratio imbalance beliefs and risky sexual behaviors, (r = -0.235, p = 0.022); and 5) positive correlation between safer sexual behavior and peer perceptions of safer sex behaviors, (r = 0.475, p < 0.001). Results from a stepwise multiple regression indicated that relationship power (p = 0.001) and peer perception (p < 0.001) were significant predictors of sexual behavior, accounting for 31% (p < 0.001) of the variance.