Introdução: A endometriose, condição inflamatória prevalente, associa-se a alterações da reposta imune na cavidade peritoneal e no útero. Evidências sugerem participação de mediadores inflamatórios, como as células Natural Killer e T-reguladoras na patogênese desta doença. A resposta destas células pode ser controlada pela atividade de algumas quimiocinas. O objetivo deste estudo foi avaliar a expressão gênica das quimiocinas reguladoras das células Natural Killer e T-reguladoras em endométrio tópico em lesões endometrióticas de pacientes com endometriose. Pacientes e Métodos: A expressão gênica das quimiocinas reguladoras da atividade das células Natural Killer (CXCL9, 10, 11, CXCL12, XCL1 e CX3CL1) e T reguladoras (CCL17 e CCL21) foi avaliada por meio de RTPCR no endométrio tópico e lesão endometriótica de 22 pacientes com endometriose de retossigmóide; 10 pacientes com endometriose retrocervical e no endométrio tópico de 32 mulheres sem endometriose comprovada por laparoscopia para laqueadura tubária. Resultados: Dentre as quimiocinas relacionadas às células Natural Killer, encontramos diferença estatística significativa na CX3CL1 e CXCL12, as quais foram mais expressas no foco de endometriose intestinal e retrocervical, quando comparadas ao endométrio tópico das pacientes e controles (p < 0,05). Das relacionadas às células T-reguladoras, a CCL17 foi mais expressa no endométrio tópico de pacientes com lesão em retossigmóide quando comparada aos demais grupos (p < 0,05). Conclusões: As quimiocinas CX3CL1 e CXCL12 foram mais expressas nos focos de endometriose intestinal e a CCL17 foi mais expressa no endométrio tópico de pacientes com lesão de retossigmóide. Estes resultados sugerem que as quimiocinas CX3CL1, CXCL12 e CXCL17 participam da resposta inflamatória que ocorre na endometriose pélvica / Objective: Endometriosis is a highly prevalent inflammatory condition associated with an altered immune response in the peritoneal cavity and uterus. Evidence suggests a participation of inflammatory mediators such as natural killer (NK) and T-regulatory (T-reg) cells in the pathogenesis of this disease while the response of these cells may be controlled by the activity of some chemokines. Patients and Methods: Gene expressions of the chemokines that regulate the activity of NK (CXCL9, CXCL10, CXCL11, CXCL12, XCL1 and CX3CL1) and T-reg cells (CCL17 and CCL21) were evaluated using real time polymerase chain reaction (PCR) in the eutopic and ectopic endometrium of 22 patients with bowel endometriosis, 10 patients with retrocervical endometriosis and 32 controls. Results: Of the chemokines associated with NK cells, the expression of CX3CL1 and CXCL12 was significantly greater in the foci of endometriosis (p < 0.05). Of those associated with T-reg cells, significant differences between groups were found in CCL17. In addition, CCL17 was expressed to a higher degree in the eutopic endometrium of the patients with rectosigmoid lesions when compared to the other groups (p < 0.05). Conclusions: Chemokines CX3CL1 and CXCL12 were more expressed in intestinal endometriosis and CCL17 expression was higher in eutopic endometrium of the patients with rectosigmoid lesions. These results suggest that those chemokines participate in the inflammatory response that occurs in pelvic endometriosis

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Public perceptions about serial homicide are more mythical than fact. Myths about serial homicide are perpetuated through several sources, especially the entertainment media which is a dominant and influential mythmaker. The number of films depicting serial killers and serial killing themes has increased dramatically in recent years. However, the reality of these films is debatable. This research examines the reality, or lack thereof, of the most recent films involving a serial killing theme. Hickey provides a wealth of statistical information on a number of serial killers and serial killings. A content analysis of the fifty top grossing serial killer movies made between 1980 and 2001 was conducted using variables from Hickey research. Research shows similarities and differences between variables, however, results concludes the entertainment media does not accurately portray serial homicide.

O trabalho visa desenvolver uma metodologia para avaliar o impacto do emprego das tecnologias de percepção de uso no ambiente residencial quanto às reduções da demanda por energia elétrica e emissões de CO2. Tais tecnologias são: eliminador de stand-by, gerenciador de energia em computadores e sensor de presença. Inicialmente são selecionadas cargas residenciais e coletados seus dados para compor um banco de dados que será utilizado nas análises. Cada carga e conjunto destas recebe a tecnologia adequada, sendo então calculado o consumo evitado e o investimento relacionado. Foram criados perfis de funcionamento das cargas (6, 8 e 10h) para reproduzir diferentes comportamentos dos usuários e cenários de utilização das cargas (A, B e C) para a análise de sensibilidade. Foram feitos estudos de caso com diferentes modelos residenciais, sendo calculados: consumo e demanda de energia evitados e redução de emissões (considerando um conjunto de residências similares). Também foi realizada a análise de viabilidade econômica da implantação, considerando o Custo Marginal de Expansão do setor elétrico (visão do investidor em infraestrutura) e as tarifas de energia elétrica (visão do consumidor). Os resultados apontam para uma contribuição relevante, em termos de eficiência energética, do emprego de tais tecnologias, representando 35 a 85 MW evitados e redução de emissões de 59 a 145 mil tCO2/ano, dependendo do tipo de modelo residencial adotado, considerando a cidade de São Paulo. A análise de viabilidade econômica por payback simples apontou os seguintes retornos de investimento: 7,2 a 15,5 anos e 2,3 a 7,4 anos para o investidor em infraestrutura e consumidor, respectivamente, dependendo do modelo residencial. Já a análise por Custo da Energia Economizada (CEE) apontou a viabilidade para o consumidor em todos os modelos residenciais, exceto o de tarifa social. Desta forma, o emprego de tais tecnologias pode contribuir de forma importante com a postergação da expansão da matriz energética, resultando em redução de investimentos em expansão e das emissões de CO2 relacionados à geração de energia elétrica, além de poder representar economia na conta de energia dos moradores. / This study aims to develop a methodology to evaluate the utilization impact of the use perception technologies in residential environment in reducing the demand for electricity and CO2 emissions. These technologies are: standby killer, power manager for computers and presence sensor. Initially, residential loads are selected and their data is collected to compose a database that will be used in the analyzes. Each load and load group receives the appropriate technology and then are calculated the avoided consumption and the acquisition investment of the technology. Loads operational profiles (6, 8 and 10h) were created to represent user behaviors and loads usage scenarios (A, B and C) were created to conduct a sensitivity analysis. Case studies were carried out with different residential models, where were calculated: avoided electricity consumption and electric energy demand and CO2 emission reduction (considering a set of similar residences). Also, it was conducted the analysis of economic implantation viability, considering the Expansion Marginal Cost of the electric sector (infrastructure investor view) and the electric energy rates (customer view). The results point out to a relevant contribution, in terms of energy efficiency, of the utilization of such technologies, representing 35 to 85 MW of avoided demand and emission reductions of 59 to 145 thousand tCO2, per year, depending on the residential model type adopted, considering Sao Paulo city region. The analysis of economic implantation viability by payback point out the following investments returns: from 7.2 to 15.5 years and from 2.3 to 7.4 years to infrastructure investor and customer, respectively, depending on the residence model. The analysis by Cost of Saved Energy point out the implementation viability for the costumer in all residential models, except the social tariff. Thus, the use of such technologies can significantly contribute to the postponement of the energetic matrix expansion, resulting in reduction of expansion investments and of CO2 related to electric energy generation, besides can represent savings in the residents energy bill.

O trabalho visa desenvolver uma metodologia para avaliar o impacto do emprego das tecnologias de percepção de uso no ambiente residencial quanto às reduções da demanda por energia elétrica e emissões de CO2. Tais tecnologias são: eliminador de stand-by, gerenciador de energia em computadores e sensor de presença. Inicialmente são selecionadas cargas residenciais e coletados seus dados para compor um banco de dados que será utilizado nas análises. Cada carga e conjunto destas recebe a tecnologia adequada, sendo então calculado o consumo evitado e o investimento relacionado. Foram criados perfis de funcionamento das cargas (6, 8 e 10h) para reproduzir diferentes comportamentos dos usuários e cenários de utilização das cargas (A, B e C) para a análise de sensibilidade. Foram feitos estudos de caso com diferentes modelos residenciais, sendo calculados: consumo e demanda de energia evitados e redução de emissões (considerando um conjunto de residências similares). Também foi realizada a análise de viabilidade econômica da implantação, considerando o Custo Marginal de Expansão do setor elétrico (visão do investidor em infraestrutura) e as tarifas de energia elétrica (visão do consumidor). Os resultados apontam para uma contribuição relevante, em termos de eficiência energética, do emprego de tais tecnologias, representando 35 a 85 MW evitados e redução de emissões de 59 a 145 mil tCO2/ano, dependendo do tipo de modelo residencial adotado, considerando a cidade de São Paulo. A análise de viabilidade econômica por payback simples apontou os seguintes retornos de investimento: 7,2 a 15,5 anos e 2,3 a 7,4 anos para o investidor em infraestrutura e consumidor, respectivamente, dependendo do modelo residencial. Já a análise por Custo da Energia Economizada (CEE) apontou a viabilidade para o consumidor em todos os modelos residenciais, exceto o de tarifa social. Desta forma, o emprego de tais tecnologias pode contribuir de forma importante com a postergação da expansão da matriz energética, resultando em redução de investimentos em expansão e das emissões de CO2 relacionados à geração de energia elétrica, além de poder representar economia na conta de energia dos moradores. / This study aims to develop a methodology to evaluate the utilization impact of the use perception technologies in residential environment in reducing the demand for electricity and CO2 emissions. These technologies are: standby killer, power manager for computers and presence sensor. Initially, residential loads are selected and their data is collected to compose a database that will be used in the analyzes. Each load and load group receives the appropriate technology and then are calculated the avoided consumption and the acquisition investment of the technology. Loads operational profiles (6, 8 and 10h) were created to represent user behaviors and loads usage scenarios (A, B and C) were created to conduct a sensitivity analysis. Case studies were carried out with different residential models, where were calculated: avoided electricity consumption and electric energy demand and CO2 emission reduction (considering a set of similar residences). Also, it was conducted the analysis of economic implantation viability, considering the Expansion Marginal Cost of the electric sector (infrastructure investor view) and the electric energy rates (customer view). The results point out to a relevant contribution, in terms of energy efficiency, of the utilization of such technologies, representing 35 to 85 MW of avoided demand and emission reductions of 59 to 145 thousand tCO2, per year, depending on the residential model type adopted, considering Sao Paulo city region. The analysis of economic implantation viability by payback point out the following investments returns: from 7.2 to 15.5 years and from 2.3 to 7.4 years to infrastructure investor and customer, respectively, depending on the residence model. The analysis by Cost of Saved Energy point out the implementation viability for the costumer in all residential models, except the social tariff. Thus, the use of such technologies can significantly contribute to the postponement of the energetic matrix expansion, resulting in reduction of expansion investments and of CO2 related to electric energy generation, besides can represent savings in the residents energy bill.

Made available in DSpace on 2014-06-11T19:29:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-10-27Bitstream added on 2014-06-13T19:39:21Z : No. of bitstreams: 1 piva_pc_me_arafcl.pdf: 1100531 bytes, checksum: 6e334cdac43570120198fac9eff22173 (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Essa dissertação dispõe-se a estudar o romance O perfume do escritor alemão Patrick Süskind, publicado pela primeira vez em 1985. Tem-se o objetivo de demonstrar como essa obra, que antecipa no subtítulo ser a história de um assassino, se configura em romance policial. Para viabilizar o trabalho, busca-se subsídio na teoria da literatura policial e na história desse gênero, permitindo então estabelecer semelhanças e distinções. Antes, porém, discorre-se brevemente sobre os variados gêneros que compõem O perfume, que leva ao extremo a definição de romance, ou seja, uma composição híbrida por excelência. A obra em questão mescla, além das duas categorias principais do romance policial, a saber, enigma e negro, os gêneros predecessores a ele. O perfume rompe as convenções da ficção policial, com isso, aproximá-lo do gênero possibilita que outros romances sejam analisados pelo mesmo viés e possam eventualmente ser considerados também romances policiais, embora aparentemente estejam distantes do romance policial tradicional / This essay intends to study one of Patrick Süskind’s novels, Perfume, published for the first time in 1985. Our goal is to show how this work, which subtitle foresees the story of a killer, is configured in a crime novel. To make this concrete, we look for some data in the theories of the crime novel and in the history of this gender, which allow us to establish similarities and distinctions. Previously, however, we briefly expose the several literary genders that compose Perfume, carrying the definition of the novel too far; in other words, a hybrid composition par excellence. The work at issue blends, besides the two main categories of the crime novel (the mystery and the noir one) the predecessor genders to it. Perfume tears the conventions of crime fiction; then, approaching this novel to the gender makes it possible for other novels to be analyzed the same way, so that they can occasionally be considered crime novels as well, although apparently far from the traditional crime stories

The phenomenon of serial killers is increasing world wide. During the past decade the most memorable cases of serial homicide in South Africa have been those of the "Norwood serial killer", the "Station Strangler", the "Cleveland serial killer", "The Gaunteng serial killer" and the "St Charles serial killer". The enigma surrounding serial killers is the so-called "lack of motive'' for the murders. No extrinsic motive such as robbery, financial gain, revenge or passion exists as there usually would be in the case of other murders. The available literature indicates that several theories have been proposed to explain the origin of serial homicide, but none can explain sufficiently to the author why one person with a certain type of background and exposed to a certain environment becomes a serial killer, whilst another, with a similar background and circumstances does not. The theories that are discussed are the socio-cultural factors, Ressler's motivational model, systemic factors, demonic possession, neurological factors, psychogenic factors and fantasy. In this thesis the author attempts to answer the question "What is the origin of serial homicide" by applying selected aspects of the psychoanalytic theories of Freud and Melanie Klein on two case studies of South African serial killers. The author formulates twenty nine statements of her own, based on the theories of Freud and Klein which she applies to the two case studies. The cases of the "Station Strangler" in Mitchell's Plain, Cape province, and the "St Charles serial killer" in Donnybrook, KwaZulu Natal are selected. Both of these serial killers are organized in their modus operandi, but the "Station Strangler" is a ego-dystonic killer and the "St Charles serial killer" a ego-syntonic serial killer. The method of research is a qualitative case study method. The author divides the selected aspects of Freud and Klein's theories into categories and analyses the two cases presented according to these categories. In the final chapter she draws maps to illustrate the psychoanalytical developmental paths of serial killers in general and for each of the two cases. Multiple data sources are used for example interviews with the serial killers and their families, police dockets, court proceedings and psychiatric records. Multiple data sources, explanation building and replication by way of multiple case studies are employed to ensure construct validity, internal validity and external validity respectively. Reliability is supported by entering the data in a South African Police Service data base. In conclusion the author compares the differences and similarities between the two case studies, and discusses the statements which are supported by this research. She also recommends that those statements which are not supported, be discussed in consecutive case studies. The statements are generalized to all serial killers. / Thesis (PhD)--University of Pretoria, 1996. / gm2013 / Psychology / unrestricted

Kvinnor begår färre våldsbrott än män, och endast en tiondel av alla mord begås av kvinnor. Detta speglas i att relativt lite forskning om kvinnor som begår dödligt våld har genomförts. När kvinnor dödar är det ofta en nuvarande, eller före detta, intim partner som faller offer. Men varför dödar kvinnor en person som de tidigare valt att spendera sitt liv med? Finns det några likheter mellan dessa kvinnor? Denna systematiska litteraturstudie visar att en majoritet av de kvinnor som tar livet av sin partner, gör det efter att ha utsatts för fysiskt och psykiskt våld av sin partner under lång tid. Tidigare partnervåld, och den överhängande risken att utsättas för ännu en episod av grovt våld, leder till att dessa kvinnor lever med ständig skräck, rädsla och ångest. Många av dessa kvinnor upplever även en känsla av isolation, vilket förstärks av att mannen ofta förbjuder dem att arbeta utanför hemmet. Kvinnor som dödar sin partner gör det ofta i, vad de själva anser är, självförsvar. Många av dessa kvinnor menar att de dödade sin partner för att de var tvungna. Hade de inte gjort det hade de själva förmodligen blivit mördade. / Women commit fewer violent crimes than men, with only one tenth of all murders committed by females. This is reflected in the fact that relatively little research has been conducted about women who kill. When women kill, the victim is often a current or former intimate partner. But why do some women kill an individual whom they have previously chosen to spend their life with? Are there any similarities between these women? This systematic literature review shows that a majority of women who take the life of an intimate partner, do it after having been subjected to physical and psychological violence by their partner for a long period of time. Former partner violence, and the imminent risk of being subjected to yet another episode of serious violence, leads to these women living with constant fear, horror and anxiety. Many of these women also experience a sense of isolation, which is reinforced by the fact they their partner often forbids them to work outside of the home. Women who kill their intimate partner often do so in, what they feel is, self-defence. Many of these women say that they killed their partner because they had to. Had they not killed him, they themselves would probably have been murdered.

I takt med att intresset för true crime- och infotainment i media växer sig större ökar behovet av att studera nyhetsmediernas påverkan på skapandet av könsbaserade maktrelationer. Syftet med denna studie är att få en ökad förståelse för hur maktrelationer produceras genom tryckt nyhetsmedias rapportering kring kvinnor som mördar. Fokus ligger på att identifiera vilka diskursiva strategier och uteslutningsmekanismer som används för att skapa dessa maktrelationer. Studien genomförs genom en foucaultiansk diskursanalys på 38 artiklar från svensk tryckt nyhetsförmedling som berör kvinnor som mördat. Vidare används ett teoretiskt ramverk bestående av genusperspektiv samt gestaltningsteori för att bidra till en djupare förståelse för analysens resultat. Studien fann att de diskursiva strategier som primärt används var klassificeringar, språkbruk och anspråk på galenskap. Genom dessa strategier identifierade studien vidare två diskursiva utrymmen för kvinnor som mördar - den “goda” och den “onda” mördaren. Studien fann att dessa två utrymmen var starkt kopplade till hur mördarens femininitet var porträtterad, där de “goda” blev porträtterade som feminina till skillnad från de “onda”. / As the true crime and infotainment industries grow larger, the need to study the news media's impact on the creation of gendered power relations grow larger. The aim of this study is to gain a deeper understanding of how power relations are produced by news media in their reporting on female killers. Of special interest is identifying which discursive strategies and mechanisms of exclusion that are used in order create these power relations. The study achieves this by analyzing 38 articles from Swedish news media about female murderers using a Foucauldian discourse analysis. Furthermore, a theoretical framework consisting of gender theory and framing theory is used to further understand the findings. The study found that the main discursive strategies that were used were categorization, rhetorical strategies and similaes, and references to madness. From these strategies the study identified two discursive spaces for female murderers to populate - the ‘good’ murderer and the ‘evil’ one. These two spaces were found to be strictly linked with how the femininity of the murderer was portrayed, where the ‘good’ were portrayed as feminine and the ‘evil’ weren’t.